339
Views
22
CrossRef citations to date
0
Altmetric
Basic Research

In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol

, , , &
Pages 196-205 | Received 03 Aug 2016, Accepted 02 Dec 2016, Published online: 11 Jan 2017

References

  • Marraffa JM, Holland MG, Stork CM, et al. Diethylene glycol: widely used solvent presents serious poisoning potential. J Emerg Med. 2008;35:401–406.
  • Wax PM. Elixirs, diluents, and the passage of the 1938 Federal Food, Drug and Cosmetic Act. Ann Intern Med. 1995;122:456–461.
  • Sosa NR, Rodriguez GM, Schier JG, et al. Clinical, laboratory, diagnostic, and histopathologic features of diethylene glycol poisoning – Panama, 2006. Ann Emerg Med. 2014;64:38–47.
  • Abubukar A, Awosanya E, Badaru O, et al. Fatal poisoning among young children from diethylene glycol-contaminated acetaminophen – Nigeria, 2008–2009. Morb Mortal Wkly Rep. 2009;58:1345–1347.
  • Alfred S, Coleman P, Harris D, et al. Delayed neurologic sequelae resulting from epidemic diethylene glycol poisoning. Clin Toxicol. 2005;43:155–159.
  • Hasbani MJ, Sansing LH, Perrone J, et al. Encephalopathy and peripheral neuropathy following diethylene glycol ingestion. Neurology. 2005;64:1273–1275.
  • O’Brien KL, Selanikio JD, Hecdivert C, et al. Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. JAMA. 1998;279:1175–1180.
  • Schier JG, Hunt DR, Perala A, et al. Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning. Clin Toxicol. 2013;51:923–929.
  • Leech PN. Elixir of sulfanilamide–massengil: chemical, pharmacologic, pathologic and necropsy reports; preliminary toxicity reports on dielthylene glycol and sulfanilamide. JAMA. 1937;109:1531–1539.
  • Besenhofer LM, Adegboyega PA, Bartels M, et al. Inhibition of metabolism of diethylene glycol prevents target organ toxicity in rats. Toxicol Sci. 2010;117:25–35.
  • Besenhofer L, McLaren M, Latimer B, et al. Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. Toxicol Sci. 2011;123:374–383.
  • Schep LJ, Slaughter RJ, Temple WA, et al. Diethylene glycol poisoning. Clin Toxicol. 2009;47:525–535.
  • Wiener HL, Richardson KE. Metabolism of diethylene glycol in male rats. Biochem Pharmacol. 1989;38:539–541.
  • Landry GM, Martin S, McMartin KE. Diglycolic acid is the nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells in vitro. Toxicol Sci. 2011;124:35–44.
  • Keltner Z, Olejnik N, Stine S, et al. Acute renal toxicity induced by oral exposures to diglycolic acid. Toxicol Sci. 2015;144(S-1):301.
  • Landry GM, Dunning CL, Abreo F, et al. Diethylene glycol-induced toxicities show marked threshold dose response in rats. Toxicol Appl Pharmacol. 2015;282:244–251.
  • Bonventre JV. Kidney injury molecule-1: a translational journey. Trans Am Clin Climatol Assoc. 2014;125:293–299.
  • Ferrari LA, Giannuzzi L. Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol. Forensic Sci Int. 2005;153:45–51.
  • Mathews JM, Parker MK, Matthews HB. Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos. 1991;19:1066–1070.
  • Bonventre J. Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant. 2009;24:3265–3268.
  • Zhang Z, Cai C. Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway. Mol Cell Biochem. 2016;416:109–116.
  • Pajor AM. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014;466:119–130.
  • Wang L, Sweet DH. Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease. AAPS J. 2013;15:53–69.
  • Dantzler W, Wright S. The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules. Biochim Biophys Acta. 2003;1618:185–193.
  • Ritter JK. Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions. Chem Biolog Interact. 2000;129:171–193.
  • Botros M, Sikaris KA. The De Ritis ratio: the test of time. Clin Biochem Rev. 2013;34:117–130.
  • Roscher AA, Jussek E, Nocuchi T, et al. Fatal accidental diglycolic acid intoxication. Bull Soc Pharmacol Environ Pathol. 1975;3:3–13.
  • Heilmair R, Lenk W, Lohr D. Toxicokinetics of diethylene glycol (DEG) in the rat. Arch Toxicol. 1993;67:655–666.
  • Lenk W, Lohr D, Sonnenbichler J. Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat. Xenobiotica. 1989;19:961–979.
  • Landry GM, Dunning CL, Conrad T, et al. Diglycolic acid inhibits succinate dehydrogenase activity in human proximal tubule cells leading to mitochondrial dysfunction and cell death. Toxicol Lett. 2013;221:176–184.
  • Conrad T, Landry GM, Aw TY, et al. Diglycolic acid, the toxic metabolite of diethylene glycol, chelates calcium and produces renal mitochondrial dysfunction in vitro. Clin Toxicol. 2016;54:501–511.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.