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Letter to the Editor

Is it really safe to withhold folinic acid when less than 1000 mg/m2 methotrexate is ingested?

, , ORCID Icon, ORCID Icon &
Page 1018 | Received 06 Mar 2017, Accepted 10 Mar 2017, Published online: 26 Apr 2017

References

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  • Warren RD, Nichols AP, Bender RA. Membrane transport of methotrexate in human lymphoblastoid cells. Cancer Res. 1978;38:668–671.
  • Ogungbenro K, Aarons L. Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate. J Pharmacokinet Pharmacodyn. 2014;41:159–171.
  • Balit CR, Daly FFS, Little M, et al. Abstracts of the European Association of Poisons Centres and Clinical Toxicologists XXVI International Congress. Clin Toxicol. 2006;44:401–586.
  • Howard SC, McCormick J, Pui CH, et al. Preventing and managing toxicities of high-dose methotrexate. Oncologist. 2016;21:1471–1482.

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