Advanced search
Publication Cover
Clinical Toxicology Volume 56, 2018 - Issue 3
Submit an article Journal homepage
525
Views
4
CrossRef citations to date
0
Altmetric
Short Communications

The use of sustained low efficiency dialysis (SLED) in massive paracetamol overdose

Anselm WongMonash Toxicology Service, Program of Emergency Medicine, Monash Health, Melbourne, Australia; ;Monash Emergency Research Collaboration, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; ;Austin Toxicology Service, Austin Health, Heidelberg, Australia; Correspondence[email protected]
View further author information
,
Roger L. K. TongMonash Toxicology Service, Program of Emergency Medicine, Monash Health, Melbourne, Australia; ;Monash Emergency Research Collaboration, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; View further author information
,
Liam RyanMonash Toxicology Service, Program of Emergency Medicine, Monash Health, Melbourne, Australia; ;Monash Emergency Research Collaboration, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; View further author information
,
Tim CrozierIntensive Care Department, Monash Health, Clayton, AustraliaView further author information
&
Andis GraudinsMonash Toxicology Service, Program of Emergency Medicine, Monash Health, Melbourne, Australia; ;Monash Emergency Research Collaboration, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; View further author information
Pages 229-231 | Received 31 May 2017, Accepted 18 Jul 2017, Published online: 16 Aug 2017

References

  • Sivilotti MLA, Juurlink DN, Garland JS, et al. Antidote removal during haemodialysis for massive acetaminophen overdose. Clin Toxicol. 2013;51:855–863.
  • Gaber M, Wong A, Koutsogiannis Z, et al. Massive paracetamol overdose associated with mitochondrial dysfunction and pancytopenia, without hepatotoxicity. Eur J Emerg Med. 2016;23:460–462.
  • Massey TE, Walker RM, McElligott TF, et al. Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. Toxicology. 1982;25:187–200.
  • Flanagan RJ, Mant TG. Coma and metabolic acidosis early in severe acute paracetamol poisoning. Hum Toxicol. 1986;5:179–182.
  • Fannin RD, Russo M, O’Connell TM, et al. Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation. Hepatology. 2010;51:227–236.
  • Prill S, Bavli D, Levy G, et al. Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone. Arch Toxicol. 2016;90:1181–1191.
  • Reddi AS, Kunadi AR. Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease. Am J Emerg Med. 2011;29:962.e3–962.e8.
  • Liss DB, Paden MS, Schwarz ES, et al. What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? Clin Toxicol. 2013;51:817–827.
  • Prescott LF, Donovan JW, Jarvie DR, et al. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol. 1989;37:501–506.
  • Fisher J, Graudins A. Intermittent haemodialysis and sustained low-efficiency dialysis (SLED) for acute theophylline toxicity. J Med Toxicol. 2015;11:359–363.
  • Gosselin S, Juurlink DN, Kielstein JT, et al. Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. Clin Toxicol. 2014;52:856–867.
  • Wiegand TJ, Margaretten M, Olson KR. Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration. Clin Toxicol. 2010;48:156–159.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.