Mechanisms of toxic cardiomyopathy

References

• Elliott P, Andersson B, Arbustini E. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J. 2007;29:270–276.
   PubMed Web of Science ®Google Scholar
• Ghadri J-R, Wittstein IS, Prasad A, et al. International expert consensus document on takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J. 2018; 39:2032–2046.
   PubMed Web of Science ®Google Scholar
• Pelliccia F, Sinagra G, Elliott P, et al. Takotsubo is not a cardiomyopathy. Int J Cardiol. 2018;254:250–253.
   PubMed Web of Science ®Google Scholar
• Montastruc G, Favreliere S, Sommet A, et al. Drugs and dilated cardiomyopathies: a case/noncase study in the French PharmacoVigilance Database. Br J Clin Pharmacol. 2010;69:287–294.
   PubMed Web of Science ®Google Scholar
• Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer 2003; 97:2869–2879.
   PubMed Web of Science ®Google Scholar
• Deidda M, Madonna R, Mango R, et al. Novel insights in pathophysiology of antiblastic drugs-induced cardiotoxicity and cardioprotection. J Cardiovasc Med. 2016;17:e76–e83.
   Google Scholar
• McGowan JV, Chung R, Maulik A, et al. Anthracycline Chemotherapy and Cardiotoxicity. Cardiovasc Drugs Ther. 2017;31:63–75.
   PubMed Web of Science ®Google Scholar
• Mercurio V, Pirozzi F, Lazzarini E, et al. Models of heart failure based on the cardiotoxicity of anticancer drugs. J Card Fail. 2016;22:449–458.
   PubMed Web of Science ®Google Scholar
• Varga ZV, Ferdinandy P, Liaudet P, et al. Drug-induced mitochondrial dysfunction and cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015;309:H1453–H1467.
   PubMed Web of Science ®Google Scholar
• Kankeu C, Clarke K, Passante E, et al. Doxorubicin-induced chronic dilated cardiomyopathy—the apoptosis hypothesis revisited. J Mol Med. 2017;95:239–248.
   PubMed Web of Science ®Google Scholar
• Bloom MW, Hamo CE, Cardinale D, et al. Cancer therapy-related cardiac dysfunction and heart failure part 1: definitions, pathophysiology, risk factors, and imaging. Circ Heart Fail. 2016; 9:e002661.
   PubMed Web of Science ®Google Scholar
• Henriksen PA. Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention. Heart. 2018;104:971–977. pii: heartjnl-2017-312103.
   PubMed Web of Science ®Google Scholar
• Wojnowski L, Kulle B, Schirmer M, et al. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation. 2005;112:3754–3762.
   PubMed Web of Science ®Google Scholar
• Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783–792.
   PubMed Web of Science ®Google Scholar
• Baron KB, Brown JR, Heiss BL, et al. Trastuzumab-induced cardiomyopathy: incidence and associated risk factors in an inner-city population. J Card Fail. 2014;20:555–559.
   PubMed Web of Science ®Google Scholar
• ElZarrad MK, Mukhopadhyay P, Mohan N, et al. Trastuzumab alters the expression of genes essential for cardiac function and induces ultrastructural changes of cardiomyocytes in mice. PLoS One. 2013;8:e79543.
   PubMed Web of Science ®Google Scholar
• Rainbolt TK, Saunders JM, Wiseman RL. Stress-responsive regulation of mitochondria through the ER unfolded protein response. Trends Endocrinol Metab. 2014;25:528–537.
   PubMed Web of Science ®Google Scholar
• Maharsy W, Aries A, Mansour O, et al. Ageing is a risk factor in imatinib mesylate cardiotoxicity. Eur J Heart Fail. 2014;16:367–376.
   PubMed Web of Science ®Google Scholar
• Hasinoff BB, Patel D, O'Hara KA. Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib. Mol Pharmacol. 2008;74:1722–1728.
   PubMed Web of Science ®Google Scholar
• Kerkela R, Woulfe KC, Durand J-B, et al. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2009;2:15–25.
   PubMed Web of Science ®Google Scholar
• Gao RY, Mukhopadhyay P, Mohanraj R, et al. Resveratrol attenuates azidothymidine-induced cardiomyopathy by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes. Mol Med Rep. 2011;4:151–155.
   PubMed Web of Science ®Google Scholar
• Kohler JJ, Cucoranu I, Fields E, et al. Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy. Lab Invest. 2009;89:782–790.
   PubMed Web of Science ®Google Scholar
• Lee YH, Goh WW, Ng CK, et al. Integrative toxiproteomics implicates impaired mitochondrial glutathione import as an off-target of troglitazone. J Proteome Res. 2013;12:2933–2945.
   PubMed Web of Science ®Google Scholar
• Nadanaciva S, Dykens JA, Bernal A, et al. Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration. Toxicol Appl Pharmacol. 2007;223:277–287.
   PubMed Web of Science ®Google Scholar
• Vinetti M, Haufroid V, Capron A, et al. Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms. Clin Toxicol. 2011;49:865–869.
   Web of Science ®Google Scholar
• Haufroid V, Hantson P. CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants. Clin Toxicol. 2015;53:501–510.
   PubMed Web of Science ®Google Scholar
• Frustaci A, Russo MA, Morgante E, et al. Oxidative myocardial damage in human cocaine-related cardiomyopathy. Eur J Heart Fail. 2015;17:283–290.
   PubMed Web of Science ®Google Scholar
• Havakuk O, Rezkalla SH, Kloner RA. The cardiovascular effects of cocaine. J Am Coll Cardiol. 2017;70:101–113.
   PubMed Web of Science ®Google Scholar
• Hale SL, Alker KJ, Rezkalla S, et al. Adverse effects of cocaine on cardiovascular dynamics, myocardial blood flow, and coronary artery diameter in an experimental model. Am Heart J. 1989;118:927–933.
   PubMed Web of Science ®Google Scholar
• Pitts WR, Vongpatanasin W, Cigarroa JE, et al. Effects of the intracoronary infusion of cocaine on left ventricular systolic and diastolic function in humans. Circulation. 1998;97:1270–1273.
   PubMed Web of Science ®Google Scholar
• Perreault CL, Hague NL, Ransil BJ, et al. The effects of cocaine on intracellular Ca2+ handling and myofilament Ca2+ responsiveness of ferret ventricular myocardium. Br J Pharmacol. 1990;101:679–685.
   PubMed Web of Science ®Google Scholar
• Arora S, Alfayoumi F, Srinivasan V. Transient left ventricular apical ballooning after cocaine use: is catecholamine cardiotoxicity the pathologic link? Mayo Clin Proc. 2006;81:829–832.
   PubMed Web of Science ®Google Scholar
• Li G, Xiao Y, Zhang L. Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways. J Pharmacol Exp Ther. 2005;312:112–119.
   PubMed Web of Science ®Google Scholar
• Kovacic P. Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer. Med Hypotheses. 2005;64:350–356.
   PubMed Web of Science ®Google Scholar
• Isabelle M, Vergeade A, Moritz F, et al. NADPH oxidase inhibition prevents cocaine-induced up-regulation of xanthine oxidoreductase and cardiac dysfunction. J Mol Cell Cardiol. 2007;42:326–332.
   PubMed Web of Science ®Google Scholar
• Virmani R, Robinowitz M, Smialek JE, et al. Cardiovascular effects of cocaine: an autopsy study of 40 patients. Am Heart J. 1988;115:1068–1076.
   PubMed Web of Science ®Google Scholar
• Paratz ED, Cunningham NJ, Mac Isaac AI. The cardiac complications of methamphetamines. Heart Lung Circ. 2016;25:325–332.
   PubMed Web of Science ®Google Scholar
• Islam MN, Kuroki H, Hongcheng B, et al. Cardiac lesions and their reversibility after long term administration of methamphetamine. Forensic Sci Int. 1995;75:29–43.
   PubMed Web of Science ®Google Scholar
• Nishida N, Ikeda N, Kudo K, et al. Sudden unexpected death of a methamphetamine abuser with cardiopulmonary abnormalities: a case report. Med Sci Law. 2003;43:267–271.
   PubMed Web of Science ®Google Scholar
• Ito H, Yeo KK, Wijetunga M, et al. A comparison of echocardiographic findings in young adults with cardiomyopathy: with and without a history of methamphetamine abuse. Clin Cardiol. 2009;32:E18– E22.
   PubMedGoogle Scholar
• Sutter ME, Gaedigk A, Albertson TE, et al. Polymorphisms in CYP2D6 may predict methamphetamine related heart failure. Clin Toxicol. 2013;51:540–544.
   PubMed Web of Science ®Google Scholar
• Steiner JL, Lang CH. Etiology of alcoholic cardiomyopathy: mitochondria, oxidative stress and apoptosis. Int J Biochem Cell Biol. 2017;89:125–135.
   PubMed Web of Science ®Google Scholar
• Laurent D, Edwards JG. Alcoholic cardiomyopathy: multigenic changes underlie cardiovascular dysfunction. J Cardiol Clin Res. 2014;2:1022.
   PubMedGoogle Scholar
• Leibing E, Meyer T. Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy. Herz. 2016;41:478–483.
   PubMed Web of Science ®Google Scholar
• Li SY, Gilbert SA, Li Q, et al. Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress. J Mol Cell Cardiol. 2009;47:247–255.
   PubMed Web of Science ®Google Scholar
• Hung CL, Chang SC, Chang SH, et al. Genetic polymorphisms of alcohol metabolizing enzymes and alcohol consumption are associated with asymptomatic cardiac remodeling and subclinical systolic dysfunction in large community-dwelling Asians. Alcohol Alcohol. 2017;52:638–646.
   PubMed Web of Science ®Google Scholar
• Ma H, Yu L, Byra EA, et al. Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J Mol Cell Cardiol. 2010;49:322–329.
   PubMed Web of Science ®Google Scholar
• Husemoen LL, Fenger M, Friedrich N, et al. The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. Alcohol Clin Exp Res. 2008;32:1984–1091.
   PubMed Web of Science ®Google Scholar
• Schröder J, Hamada S, Altiok E, et al. Detection of acute changes in left ventricular function by myocardial deformation analysis after excessive alcohol ingestion. J Am Soc Echocardiogr. 2017;30:235–243.
   PubMed Web of Science ®Google Scholar
• Guzzo-Merello G, Cobo-Marcos M, Gallego-Delgado M, et al. Alcoholic cardiomyopathy. World J Cardiol. 2014;6:771–781.
   PubMedGoogle Scholar
• Mirijello A, Tarli C, Vassallo GA, et al. Alcoholic cardiomyopathy: what is known and what is not known. Eur J Intern Med. 2017;43:1–5.
   PubMed Web of Science ®Google Scholar
• Ren J, Wold LE. Mechanisms of alcoholic heart disease. Ther Adv Cardiovasc Dis. 2008;2:497–506.
   PubMedGoogle Scholar
• Piano MR, Phillips SA. Alcoholic cardiomyopathy: pathophysiologic insights. Cardiovasc Toxicol. 2014;14:291–308.
   PubMed Web of Science ®Google Scholar
• Jung YS, Lee JS, Min YG, et al. Carbon monoxide-induced cardiomyopathy. Circ J. 2014;78:1437–1444.
   PubMed Web of Science ®Google Scholar
• Cha YS, Kim H, Hwang SO, et al. Incidence and patterns of cardiomyopathy in carbon monoxide-poisoned patients with myocardial injury. Clin Toxicol. 2016;54:481–487.
   PubMed Web of Science ®Google Scholar
• Kjeldsen K, Thomsen HK, Astrup P. Effects of carbon monoxide on myocardium. Ultrastructural changes in rabbits after moderate, chronic exposure. Circ Res. 1974;34:339–348.
   PubMed Web of Science ®Google Scholar
• Cha YS, Kim H, Lee Y, et al. Evaluation of relationship between coronary artery status evaluated by coronary computed tomography angiography and development of cardiomyopathy in carbon monoxide poisoned patients with myocardial injury: a prospective observational study. Clin Toxicol. 2018;56:30–36.
   PubMed Web of Science ®Google Scholar
• Prockop LD, Chichkova RI. Carbon monoxide intoxication: an updated review. J Neurol Sci. 2007;262:122–130.
   PubMed Web of Science ®Google Scholar
• Thom SR. Carbon monoxide-mediated brain lipid peroxidation in the rat. J Appl Physiol. 1990;68:997–1003.
   PubMed Web of Science ®Google Scholar
• Fitzgerald RS, Dehghani GA, Kiihl S. Autonomic control of the cardiovascular system in the cat during hypoxemia. Auton Neurosci. 2013;174:21–30.
   PubMed Web of Science ®Google Scholar
• Takahashi K. Cardiac disturbances due to CO poisoning in experimental animals. II. Changes of the heart excitability due to acute CO poisoning. Tohoku J Exp Med. 1961;74:224–233.
   PubMed Web of Science ®Google Scholar
• Cooper CE, Brown GC. The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J Bioenerg Biomembr. 2008;40:533–539.
   PubMed Web of Science ®Google Scholar
• Lippi G, Rastelli G, Meschi T, et al. Pathophysiology, clinics, diagnosis and treatment of heart involvement in carbon monoxide poisoning. Clin Biochem. 2012;45:1278–1285.
   PubMed Web of Science ®Google Scholar
• Chen KC, McGrath JJ. Response of the isolated heart to carbon monoxide and nitrogen anoxia. Toxicol Appl Pharmacol. 1985;81:363–370.
   PubMed Web of Science ®Google Scholar
• Suner S, Jay G. Carbon monoxide has direct toxicity on the myocardium distinct from effects of hypoxia in an ex vivo rat heart model. Acad Emerg Med. 2008;15:59–65.
   PubMed Web of Science ®Google Scholar
• Meyer G, André L, Kleindienst A, et al. Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2015;308:H759–H767.
   PubMed Web of Science ®Google Scholar
• Motterlini R, Foresti R. Biological signaling by carbon monoxide and carbon monoxide-releasing molecules. Am J Physiol, Cell Physiol. 2017;312:C302–C313.
   PubMed Web of Science ®Google Scholar
• Alvarez M, Malécot CO, Gannier F, et al. Antimony-induced cardiomyopathy in guinea-pig and protection by l-carnitine. Br J Pharmacol. 2005;144:17–27.
   PubMed Web of Science ®Google Scholar
• Tirmenstein MA, Plews PI, Walker CV, et al. Antimony-induced oxidative stress and toxicity in cultured cardiac myocytes. Toxicol Appl Pharmacol. 1995;130:41–47.
   PubMed Web of Science ®Google Scholar
• Grice HC, Munro IC, Wiberg GS, et al. The pathology of experimentally induced cobalt cardiomyopathies. A comparison with beer drinkers’ cardiomyopathy. Clin Toxicol.1969;2:273–287.
   Web of Science ®Google Scholar
• Packer M. Cobalt cardiomyopathy: a critical reappraisal in light of a recent resurgence. Circ Heart Fail. 2016;9:e003604. pii: e003604.
   PubMed Web of Science ®Google Scholar
• Bradberry SM, Wilkinson JM, Ferner RE. Systemic toxicity related to metal hip prostheses. Clin Toxicol. 2014;52:837–847.
   PubMed Web of Science ®Google Scholar
• Prentice JR, Clark MJ, Hoggard N, et al. Metal-on-metal hip prostheses and systemic health: a cross-sectional association study 8 years after implantation. PLoS One. 2013;8:e66186
   PubMed Web of Science ®Google Scholar
• Harrow JA, Das PK, Dhalla NS. Influence of some divalent cations on heart sarcolemmal bound enzymes and calcium binding. Biochem Pharmacol. 1978;27:2605–2609.
   PubMed Web of Science ®Google Scholar
• Kleinfeld M, Stein E. Action of divalent cations on membrane potentials and contractility in rat atrium. Am J Physiol. 1968;215:593–599.
   PubMedGoogle Scholar
• Hervouet E, Pecina P, Demont J, et al. Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun. 2006;344:1086–1093.
   PubMed Web of Science ®Google Scholar
• Clyne N, Hofman-Bang C, Haga Y, et al. Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium. Scand J Clin Lab Invest. 2001;61:609–614.
   PubMed Web of Science ®Google Scholar
• Lewis CP, Demedts M, Nemery B. Indices of oxidative stress in hamster lung following exposure to cobalt(II) ions: in vivo and in vitro studies. Am J Respir Cell Mol Biol. 1991;5:163–169.
   PubMed Web of Science ®Google Scholar
• Hatori N, Pehrsson SK, Clyne N, et al. Acute cobalt exposure and oxygen radical scavengers in the rat myocardium. Biochim Biophys Acta. 1993;1181:257–260.
   PubMed Web of Science ®Google Scholar
• Singer I, Rotenberg D. Mechanisms of lithium action. N Engl J Med. 1973;289:254–260.
   PubMed Web of Science ®Google Scholar
• Abdel-Zaher AO, Abdel-Rahman MM. Lithium chloride-induced cardiovascular changes in rabbits are mediated by adenosine triphosphate-sensitive potassium channels. Pharmacol Res. 1999;39:275–282.
   PubMed Web of Science ®Google Scholar
• Serinken M, Karcioglu O, Korkmaz A. Rarely seen cardiotoxicity of lithium overdose: complete heart block. Int J Cardiol. 2009;132:276–278.
   PubMed Web of Science ®Google Scholar
• Asim K, Selman Y, Suleyman Y, et al. Heart attack in the course of lithium overdose. Iran Red Crescent Med J. 2016;18:e21731.
   PubMed Web of Science ®Google Scholar
• Anantha Narayanan M, Mahfood Haddad T, Bansal O, et al. Acute cardiomyopathy precipitated by lithium: is there a direct toxic effect on cardiac myocytes?. Am J Emerg Med. 2015;33:1330.e1–1335.
   Web of Science ®Google Scholar
• Kitami M, Oizumi H, Kish SJ, et al. Takotsubo cardiomyopathy associated with lithium intoxication in bipolar disorder: a case report. J Clin Psychopharmacol. 2014;34:410–411.
   PubMed Web of Science ®Google Scholar
• Aichhorn W, Huber R, Stuppaeck C, et al. Cardiomyopathy after long-term treatment with lithium - more than a coincidence? J Psychopharmacol. 2006;20:589–591.
   PubMed Web of Science ®Google Scholar
• Rosero Enríquez ÁS, Ballesteros Prados A, Petcu AS. Cardiomyopathy secondary to long-term treatment with lithium: a case report and literature review. J Clin Psychopharmacol. 2018;38:157–159.
   PubMed Web of Science ®Google Scholar
• Perez AL, Tang WH. Contribution of environmental toxins in the pathogenesis of idiopathic cardiomyopathies. Curr Treat Options Cardiovasc Med. 2015;17:381.
   PubMedGoogle Scholar
• Frustaci A, Magnavita N, Chimenti C, et al. Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction. J Am Coll Cardiol. 1999;33:1578–1583.
   PubMed Web of Science ®Google Scholar
• Cupo P. Clinical update on scorpion envenoming. Rev Soc Bras Med Trop. 2015;48:642–649.
   PubMed Web of Science ®Google Scholar
• Abroug F, Souheil E, Ouanes I, et al. Scorpion-related cardiomyopathy: Clinical characteristics, pathophysiology, and treatment. Clin Toxicol. 2015;53:511–518.
   PubMed Web of Science ®Google Scholar
• Nouira S, Elatrous S, Besbes L, et al. Neurohormonal activation in severe scorpion envenomation: correlation with hemodynamics and circulating toxin. Toxicol Appl Pharmacol. 2005;208:111–116.
   PubMed Web of Science ®Google Scholar
• Ouanes-Besbes L, El Atrous S, Nouira S, et al. Direct vs. mediated effects of scorpion venom: an experimental study of the effects of a second challenge with scorpion venom. Intensive Care Med. 2005;31:441–446.
   PubMed Web of Science ®Google Scholar
• Padilla A, Govezensky T, Possani LD, et al. Experimental envenoming of mice with venom from the scorpion Centruroides limpidus limpidus: differences in mortality and symptoms with and without antibody therapy relating to differences in age, sex and strain of mouse. Toxicon. 2003;41:959–965.
   PubMed Web of Science ®Google Scholar
• Quintero-Hernández V, Jiménez-Vargas JM, Gurrola GB, et al. Scorpion venom components that affect ion-channels function. Toxicon. 2013;76:328–342.
   PubMed Web of Science ®Google Scholar
• Abroug F, Ouanes I, Maatouk M, et al. Inverted takotsubo syndrome in Androctonus australis scorpion envenomation. Clin Toxicol. 2018;56:381–383.
   PubMed Web of Science ®Google Scholar
• Madias JE. Scorpion envenomation cardiomyopathy: a promising model for takotsubo syndrome. Clin Toxicol. 2015;53:787.
   Web of Science ®Google Scholar
• Madias JE. Voltage attenuation of the electrocardiogram QRS complexes in a patient with “scorpion envenomation”-induced takotsubo syndrome. Am J Emerg Med. 2015;33:838.
   PubMed Web of Science ®Google Scholar
• Miranda CH, Braggion-Santos MF, Schmidt A, et al. Evolution of the electrocardiogram QRS complexes voltage in scorpion envenomation-induced takotsubo syndrome. Am J Emerg Med. 2015;33:837–838.
   PubMed Web of Science ®Google Scholar
• Miranda CH, Braggion-Santos MF, Schmidt A, et al. The first description of cardiac magnetic resonance findings in a severe scorpion envenomation: Is it a stress-induced (takotsubo) cardiomyopathy like? Am J Emerg Med. 2015;33:862.e5–867.
   Web of Science ®Google Scholar