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Clinical Toxicology Volume 57, 2019 - Issue 3
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Poison Centre Research

Utilization of lipid emulsion therapy in fatal overdose cases: an observational study

Susan SmolinskeNew Mexico Poison and Drug Information Center, University of New Mexico, Albuquerque, NM, USA; Correspondence[email protected]
,
Robert S. HoffmanDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU School of Medicine, New York, NY, USA; ORCID Iconhttp://orcid.org/0000-0002-0091-9573
ORCID Icon,
Eric VilleneuveDepartment of Pharmacy, McGill University Health Centre, Montreal, Canada; ORCID Iconhttp://orcid.org/0000-0003-0510-8144
ORCID Icon,
Lotte C. G. HoegbergDepartment of Anesthesiology and the Danish Poisons Information Centre, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark;
&
Sophie GosselinCentre Antipoison du Québec, McGill University Health Centre, Hôpital Charles Lemoyne, Quebec, CanadaORCID Iconhttp://orcid.org/0000-0002-0694-5588
ORCID Icon
Pages 197-202 | Received 02 Apr 2018, Accepted 20 Jul 2018, Published online: 27 Sep 2018

References

  • Kasnavieh MH, Nodoushan SJ, Ghafori HB, et al. Intravenous lipid emulsion for the treatment of tricyclic antidepressant toxicity a randomized controlled trial. VIIth Mediterranean Emergency Medicine Congress 2013; September 8–11; Marseille, France.
  • Taftachi F, Sanaei-Zadeh H, Sepehrian B, et al. Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning-a randomized controlled trial. Eur Rev Med Pharmacol Sci. 2012;16(Suppl 1):38–42.
  • Heinonen JA, Litonius E, Salmi T, et al. Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity. Basic Clin Pharmacol Toxicol. 2015;116:378–383.
  • Dureau P, Charbit B, Nicolas N, et al. Effect of Intralipid® on the dose of ropivacaine or levobupivacaine tolerated by volunteers: a clinical and pharmacokinetic study. Anesthesiology. 2016;125:474–483.
  • Gosselin S, Hoegberg LC, Hoffman RS, et al. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol. 2016;54:899–923.
  • Bronstein AC, Spyker DA, Cantilena LR, Jr, et al. 2008 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 26th Annual Report. Clin Toxicol. 2009;47:911–1084.
  • Hayes BD, Gosselin S, Calello DP, et al. Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration. Clin Toxicol. 2016;54:365–404.
  • Benchimol EI, Smeeth L, Guttmann A, et al. The REporting of studies conducted using observational routinely-collected health data (RECORD) statement. PLoS Med. 2015;12:e1001885.
  • Rosenblatt MA, Abel M, Fischer GW, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006;105:217–218.
  • Hoegberg LC, Bania TC, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol. 2016;54:167–193.
  • Levine M, Hoffman RS, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity. Clin Toxicol. 2016;54:194–221.
  • Perichon D, Turfus S, Gerostamoulos D, et al. An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose. Clin Toxicol. 2013;51:208–215.
  • Cole JB, Stellpflug SJ, Engebretsen KM. Asystole immediately following intravenous fat emulsion for overdose. J Med Toxicol. 2014;10:307–310.
  • Mithani S, Dong K, Wilmott A, et al. A cohort study of unstable overdose patients treated with intravenous lipid emulsion therapy. CJEM. 2017;19:256–264.
  • Grunbaum AM, Gilfix BM, Hoffman RS, et al. Review of the effect of intravenous lipid emulsion on laboratory analyses. Clin Toxicol. 2016;54:92–102.

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