Advanced search
Publication Cover
Clinical Toxicology Volume 57, 2019 - Issue 12
Submit an article Journal homepage
699
Views
8
CrossRef citations to date
0
Altmetric
Short Communication

A case of accidental neonatal paracetamol overdose with prolonged half-life and measured metabolites

Monica AbadierMonash Toxicology Unit and Emergency Medicine Service, Monash Health, Victoria, Australia; View further author information
,
Anselm WongMonash Toxicology Unit and Emergency Medicine Service, Monash Health, Victoria, Australia; ;Department of Medicine, School of Clinical Sciences, Monash University, Victoria, Australia; ;Austin Health, Austin Toxicology Service, Victoria, Australia; ;Department of Medicine and Radiology, Centre for Integrated Clinical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australia; Correspondence[email protected]
View further author information
,
Paul StathakisSEALS Laboratory, Prince of Wales Hospital, Sydney, Australia; View further author information
,
John SingsitDepartment of Paediatrics, Dandenong Hospital, Monash Health, Victoria, AustraliaView further author information
,
Melanie PillayDepartment of Paediatrics, Dandenong Hospital, Monash Health, Victoria, AustraliaView further author information
&
Andis GraudinsMonash Toxicology Unit and Emergency Medicine Service, Monash Health, Victoria, Australia; ;Department of Medicine, School of Clinical Sciences, Monash University, Victoria, Australia; View further author information
Pages 1154-1156 | Received 23 Jan 2019, Accepted 21 Feb 2019, Published online: 11 Mar 2019

References

  • An JH, Lee HJ, Jung BH. Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry. Biomed Chromatogr. 2012;26:1596–1604.
  • Isbister GK, Bucens IK, Whyte IM. Paracetamol overdose in a preterm neonate. Arch Dis Child Fetal Neonatal Ed. 2001;85:F70–F72.
  • Anderson BJ, Woollard GA, Holford NH. A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children. Br J Clin Pharmacol. 2000;50:125–134.
  • Prescott LF. Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharm. 1980;10:291S–298S.
  • Levy G, Khanna NN, Soda DM, et al. Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Paediatrics. 1975;55:818–825.
  • Chiew A, Buckley NA, Pao LT, et al. Pharmacokinetics of acetaminophen and metabolites after accidental acute overdose in a neonate. Abstracts from the North American Congress of Clinical Toxicology (NAACT) Chicago 2018. Clin Toxicol. 2018; 56:912–1092.
  • Ogilvie JD, Rieder MJ, Rodrick L. Acetaminophen overdose in children. CMAJ. 2012;184:1492–1496.
  • De Jong L, Knapen DG, Munnink THO, et al. False positive acetaminophen concentrations in icteric serum. Practical Lab Med. 2016;4:38–40.
  • Emit®tox Acetaminophen assay. Beckman Coulter product information 2012

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.