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Letters in Response

Comment on “What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?” by Hendrickson et al.

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Pages 70-71 | Received 26 Feb 2019, Accepted 01 Mar 2019, Published online: 09 May 2019

References

  • Hendrickson RG. What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose? Clin Toxicol. 2019;19:1–6. [Epub ahead of print]. doi: 10.1080/15563650.2019.1579914
  • Bateman DN, Dear JW, Thanacoody HKR, et al. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet 2014;383:697–704.
  • Piperno E, Berssenbruegge DA. Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet 1976;2:738–739.
  • Dear JW. on behalf of the P trial investigators. Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-hour regimen of N-acetylcysteine for paracetamol overdose: The PP100-01 for Overdose of Paracetamol Trial (POP Trial): study protocol for. BMC Trials. 2018;20:27. doi:10.1186/s13063-018-3134-1. In Press.
  • Dear JW, Clarke JI, Francis B, et al. Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. Lancet Gastroenterol Hepatol. 2018;3:104–113.
  • Pettie J, Sandilands EA, Dow MA, et al. Treatment of acetaminophen overdose with a 12 h acetylcysteine regimen: the first report of safety and efficacy in routine clinical practice. Clin Toxicol. 2016;54:666.

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