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Poison Centre Research

Time to development of metformin-associated lactic acidosis

ORCID Icon, , &
Pages 758-762 | Received 15 Aug 2019, Accepted 25 Oct 2019, Published online: 06 Nov 2019

References

  • Gummin DD, Mowry JB, Spyker DA, et al. 2017 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 35th Annual Report. Clin Toxicol. 2018;56(12):1213–1415.
  • Duong JK, Furlong TJ, Roberts DM, et al. The role of metformin in Metformin-Associated Lactic Acidosis (MALA): case series and formulation of a model of pathogenesis. Drug Saf. 2013;36(9):733–746.
  • Spiller HA, Quadrani DA. Toxic effects from metformin exposure. Ann Pharmacother. 2004;38(5):776–780.
  • Wills BK, Bryant SM, Buckley P, et al. Can acute overdose of metformin lead to lactic acidosis? Am J Emerg Med. 2010;28(8):857–861.
  • Madiraju AK, Erion DM, Rahimi Y, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014;510(7506):542.
  • Wang GS, Hoyte C. Review of biguanide (metformin) toxicity. J Intensive Care Med. 2019;34:863–876.
  • Bosse GM. Antidiabetics and hypoglycemics/antiglycemics. In: Nelson LS, Howland MA, Lewin NA, et al., editors. Goldfrank’s toxicologic emergencies. 11th ed. New York (NY): McGraw-Hill Education; 2019.
  • Olson KR, Anderson IB, Benowitz NL, et al. Metformin in specific poisons and drugs: diagnosis and treatment. In: Brian Belval and Christie Naglieri, editors. Poisoning & drug overdose. 7th ed. New York (NY): McGraw-Hill Education; 2017.
  • Metformin [Internet]. Greenwood Village (CO): 2019. [cited August 13, 2019]. Available from: http://www.micromedexsolutions.com/micromedex2/librarian
  • McNamara K, Isbister GK. Hyperlactataemia and clinical severity of acute metformin overdose. Intern Med J. 2015;45(4):402–408.
  • Kopec KT, Kowalski MJ. Metformin-associated lactic acidosis (MALA): case files of the Einstein Medical Center medical toxicology fellowship. J Med Toxicol. 2013;9(1):61–66.
  • Barrueto F, Meggs WJ, Barchman MJ. Clearance of metformin by hemofiltration in overdose. J Toxicol Clin Toxicol. 2002;40(2):177.
  • Lacher M, Hermanns-Clausen M, Haeffner K, et al. Severe metformin intoxication with lactic acidosis in an adolescent. Eur J Pediatr. 2005;164(6):362–365.
  • Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 1996;30(5):359–371.
  • Al-Abri SA, Hayashi S, Thoren KL, et al. Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. Clin Toxicol. 2013;51(5):444–447.
  • Spiller HA, Weber JA, Winter ML, et al. Multicenter case series of pediatric metformin ingestion. Ann Pharmacother. 2000;34(12):1385–1388.
  • Bartholow M. Top 200 drugs of 2010. Pharmacy Times. 2011 May 16.

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