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Poison Centre Research

An outbreak of severe coagulopathy from synthetic cannabinoids tainted with Long-Acting anticoagulant rodenticides

ORCID Icon, ORCID Icon, , , , , , , , , , & show all
Pages 821-828 | Received 13 Jul 2019, Accepted 25 Oct 2019, Published online: 04 Dec 2019

References

  • Perspectives on Drugs: Synthetic cannabinoids in Europe. European Monitoring Centre for Drugs and Drug Addiction. Lisbon, Portugal; 2017. www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids
  • Mowry JB, Spyker DA, Cantilena LR Jr, et al. 2013 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 31st annual report. Clin Toxicol. 2014;52(10):1032–1283.
  • Mowry JB, Spyker DA, Brooks DE, et al. 2014 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 32nd annual report. Clin Toxicol. 2015;53(10):962–1147.
  • Mowry JB, Spyker DA, Brooks DE, et al. 2015 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 33rd annual report. Clin Toxicol. 2016;54(10):924–1109.
  • Gummin DD, Mowry JB, Spyker DA, et al. 2016 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 34th annual report. Clin Toxicol. 2017;55(10):1072–1252.
  • Gummin DD, Mowry JB, Spyker DA, et al. 2017 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 35th annual report. Clin Toxicol. 2018;56(12):1213–1415.
  • Caravati EM, Erdman AR, Scharman EJ, et al. Long-acting anticoagulant rodenticide poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol. 2007;45(1):1–22.
  • King N, Tran MH. Long-acting anticoagulant rodenticide (superwarfarin) poisoning: a review of its historical development, epidemiology, and clinical management. Transfus Med Rev. 2015;29(4):250–258.
  • La Rosa FG, Clarke SH, Lefkowitz JB. Brodifacoum intoxication with marijuana smoking. Arch Pathol Lab Med. 1997;121(1):67–69.
  • Waien SA, Hayes D Jr, Leonardo JM. Severe coagulopathy as a consequence of smoking crack cocaine laced with rodenticide. N Engl J Med. 2001;345(9):700–701.
  • Spahr JE, Maul JS, Rodgers GM. Superwarfarin poisoning: a report of two cases and review of the literature. Am J Hematol. 2007;82(7):656–660.
  • Dethrage S. Police: synthetic marijuana trafficker in Tuscaloosa was cooking drug with rat poison, plant products. Vol 2019. AL.com, Alabama Media Group; 2014.
  • Denley B. Narcotics agents recover $11,000 of spice in Coker bust. Vol 2019. WBRC FOX6 News; 2014.
  • Moritz E, Austin C, Wahl M, et al. Notes from the field: outbreak of severe illness linked to the vitamin K antagonist brodifacoum and use of synthetic cannabinoids – Illinois, March-April 2018. MMWR Morb Mortal Wkly Rep. 2018;67(21):607–608.
  • System VaMNI, editor. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva (Switzerland): World Health Organization; 2011.
  • Tait RJ, Caldicott D, Mountain D, et al. A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Clin Toxicol. 2016;54(1):1–13.
  • Vandrey R, Dunn KE, Fry JA, et al. A survey study to characterize use of Spice products (synthetic cannabinoids). Drug Alcohol Depend. 2012;120(1–3):238–241.
  • Johnston LD, Miech RA, O’Malley PM, et al. Monitoring the future national survey results on drug use: 1975-2018: overview, key findings on adolescent drug use. Ann Arbor (MI): The University of Michigan; 2019.
  • Kelkar AH, Smith NA, Martial A, et al. An outbreak of synthetic cannabinoid-associated coagulopathy in Illinois. N Engl J Med. 2018;379(13):1216–1223.
  • Ware KM, Feinstein DL, Rubinstein I, et al. Brodifacoum induces early hemoglobinuria and late hematuria in rats: novel rapid biomarkers of poisoning. Am J Nephrol. 2015;41(4–5):392–399.
  • Panigrahi B, Jones BC, Rowe SP. Brodifacoum-contaminated synthetic marijuana: clinical and radiologic manifestations of a public health outbreak causing life-threatening coagulopathy. Emerg Radiol. 2018;25(6):715–718.
  • Hollinger BR, Pastoor TP. Case management and plasma half-life in a case of brodifacoum poisoning. Arch Intern Med. 1993;153(16):1925–1928.
  • Wang JJ, Howland MA, Biary R. Synthetic cannabinoid-associated coagulopathy. N Engl J Med. 2019;380(1):101.
  • Macfarlane V, Christie G. Synthetic cannabinoid withdrawal: a new demand on detoxification services. Drug Alcohol Rev. 2015;34(2):147–153.
  • Ansell J, Hirsh J, Hylek E, et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6):160s–198s.
  • Mi YN, Ping NN, Xiao X, et al. The severe adverse reaction to vitamin K1 injection is anaphylactoid reaction but not anaphylaxis. PLoS One. 2014;9(3):e90199.
  • Riegert-Johnson DL, Volcheck GW. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann Allergy Asthma Immunol. 2002;89:400–406.
  • Vindenes V, Karinen R, Hasvold I, et al. Bromadiolone poisoning: LC-MS method and pharmacokinetic data. J Forensic Sci. 2008;53(4):993–996.
  • Breckenridge AM, Cholerton S, Hart JA, et al. A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit. Br J Pharmacol. 1985;84(1):81–91.
  • Woody BJ, Murphy MJ, Ray AC, et al. Coagulopathic effects and therapy of brodifacoum toxicosis in dogs. J Vet Intern Med. 1992;6(1):23–28.
  • Bachmann KA, Sullivan TJ. Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats. Pharmacology. 1983;27(5):281–288.
  • Rasin A, Devgun JM, Nosal DG, et al. Coagulopathy after synthetic cannabinoid use: a case report. Ann Intern Med. 2019;171(8):595.
  • Gunja N, Coggins A, Bidny S. Management of intentional superwarfarin poisoning with long-term vitamin K and brodifacoum levels. Clin Toxicol. 2011;49(5):385–390.
  • Weitzel JN, Sadowski JA, Furie BC, et al. Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases. Blood. 1990;76(12):2555–2559.

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