499
Views
6
CrossRef citations to date
0
Altmetric
Basic Research

In vitro study of pharmacobezoar formation in simulated acetaminophen overdose

, , &
Pages 900-906 | Received 21 Aug 2019, Accepted 09 Dec 2019, Published online: 26 Dec 2019

References

  • Stack PE, Thomas E. Pharmacobezoar: an evolving new entity. Dig Dis. 1995;13(6):356–364.
  • Cereda JM, Scott J, Quigley EM. Endoscopic removal of pharmacobezoar of slow release theophylline. Br Med J. 1986;293(6555):1143–1143.
  • Haider F, De Carli C, Dhanani S, et al. Emergency laparoscopic-assisted gastrotomy for the treatment of an iron bezoar. J Laparoendosc Adv Surg Tech A. 2009;19(s1):S141–S143.
  • Buckley NA, Dawson AH, Reith DA. Controlled release drugs in overdose, clinical considerations. Drug Saf. 1995;12(1):73–84.
  • Hoegberg LCG, Refsgaard F, Pedersen SH, et al. Potential pharmacobezoar formation of large size extended-release tablets and their dissolution – an in vitro study. Clin Toxicol. 2019;57(4):271–281.
  • Bunchorntavakul C, Reddy KR. Acetaminophen (APAP or N-acetyl-p-aminophenol) and acute liver failure. Clin Liver Dis. 2018;22(2):325–346.
  • Hendrickson RG, McKeown NJ, West PL, et al. Bactrian (“double hump”) acetaminophen pharmacokinetics: a case series and review of the literature. J Med Toxicol. 2010;6(3):337–344.
  • Steingoetter A, Fox M, Treier R, et al. Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study. Scand J Gastroenterol. 2006;41(10):1155–1164.
  • Bai G, Wang Y, Armenante PM. Velocity profiles and shear strain rate variability in the USP Dissolution Testing Apparatus 2 at different impeller agitation speeds. Int J Pharm. 2011;403(1–2):1–14.
  • Moore JW, Flanner HH. Mathematical comparison of curves with an emphasis on in vitro dissolution profiles. Pharm Tech. 1996;20:64–74.
  • Guidance for Industry. Dissolution testing of immediate release solid oral dosage forms. Washington (DC): U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), U.S. Government Printing Office; 1997.
  • Smith SW, Howland MA, Hoffman RS, et al. Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. Ann Pharmacother. 2008;42(9):1333–1339.
  • Watari N, Iwai M, Kaneniwa N. Pharmacokinetic study of the fate of acetaminophen and its conjugates in rats. J Pharmacokinet Biopharm. 1983;11(3):245–272.
  • Ameer B, Divoll M, Abernethy DR, et al. Absolute and relative bioavailability of oral acetaminophen preparations. J Pharm Sci. 1983;72(8):955–958.
  • Chiew AL, Isbister GK, Page CB, et al. Modified release paracetamol overdose: a prospective observational study (ATOM-3). Clin Toxicol. 2018;56(9):810–819.
  • Chiew AL, Isbister GK, Kirby KA, et al. Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clin Toxicol. 2017;55(10):1055–1065.
  • Wong A, Sivilotti MLA, Graudins A. Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. Clin Toxicol. 2017;55(5):346–351.
  • Caraccio TR, Mofenson HC, Lawless MJ. Delayed peak acetaminophen (APAP) levels. J Toxicol Clin Toxicol. 1997;35:563.
  • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40:3–20.
  • Hendrickson RG. What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose? Clin Toxicol. 2019;57(8):686–691.
  • Wong A, Landersdorfer C, Graudins A. Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. Eur J Clin Pharmacol. 2017;73(9):1103–1110.
  • Skoog DA, West Dm J, Holler F, et al. Fundamentals of analytical chemistry. 8th ed.; Brooks/Cole Pub Co, 2003.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.