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Clinical Research

A cluster of lysergic acid diethylamide (LSD) poisonings following insufflation of a white powder sold as cocaine

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Pages 969-974 | Received 19 Jan 2021, Accepted 10 Mar 2021, Published online: 13 Apr 2021

References

  • Cole C, Jones L, McVeigh J, et al. Adulterants in illicit drugs: a review of empirical evidence. Drug Test Anal. 2011;3(2):89–96.
  • Shesser R, Jotte R, Olshaker J. The contribution of impurities to the acute morbidity of illegal drug use. Am J Emerg Med. 1991;9(4):336–342.
  • Broséus J, Gentile N, Esseiva P. The cutting of cocaine and heroin: a critical review. Forensic Sci Int. 2016;262:73–83.
  • Zawilska JB, Kacela M, Adamowicz P. NBOMes-highly potent and toxic alternatives of LSD. Front Neurosci. 2020;14:78.
  • Devgun JM, Rasin A, Kim T, et al. An outbreak of severe coagulopathy from synthetic cannabinoids tainted with Long-Acting anticoagulant rodenticides. Clin Toxicol. 2019;2020:1–8.
  • Navon L, Moritz E, Austin C, et al. The public health response to a large poisoning outbreak involving an illicit substance: synthetic cannabinoids contaminated with a long-acting anticoagulant rodenticide, Illinois, March-July, 2018. J Public Health Manag Pract. 2020;26(6):e1–e7.
  • Villar Núñez M, Sánchez Morcillo J, Ruíz Martínez MA. Purity and adulteration in cocaine seizures and drug market inspection in Galicia (Spain) across an eight-year period. Drug Test Anal. 2018;10(2):381–391.
  • Armenian P, Whitman JD, Badea A, et al. Notes from the field: unintentional fentanyl overdoses among persons who thought they were snorting Cocaine – Fresno, California, January 7, 2019. MMWR Morb Mortal Wkly Rep. 2019;68(31):687–688.
  • COCAINE may contain the dangerous opioids fentanyl and acetylfentanyl: NSW Health 2020 ; [cited 2021 Jan 5]. Available from: https://www.health.nsw.gov.au/aod/public-drug-alerts/Pages/cocaine-may-contain-fentanyl-acetylfentanyl.aspx.
  • AIHW. National Drug Strategy Household Survey 2019. Drug Statistics series no. 32. PHE 270. Canberra: Australian Institute of Health and Welfare (AIHW); 2020.
  • Peacock A, Karlsson A, Uporova J, et al. Australian Drug Trends 2019: Key Findings from the National Ecstasy and Related Drugs Reporting System (EDRS) Interviews. Sydney, Australia; 2019.
  • Passie T, Halpern JH, Stichtenoth DO, et al. The pharmacology of lysergic acid diethylamide: a review. CNS Neurosci Ther. 2008;14(4):295–314.
  • Rickli A, Luethi D, Reinisch J, et al. Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology. 2015;99:546–553.
  • Nichols DE. Psychedelics. Pharmacol Rev. 2016;68(2):264–355. Apr
  • Preller KH, Herdener M, Pokorny T, et al. The fabric of meaning and subjective effects in LSD-induced states depend on serotonin 2A receptor activation. Curr Biol. 2017;27(3):451–457.
  • Vollenweider FX, Vollenweider-Scherpenhuyzen MF, Bäbler A, et al. Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport. 1998;9(17):3897–3902.
  • Liechti ME. Modern clinical research on LSD. Neuropsychopharmacology. 2017;42(11):2114–2127.
  • Steuer AE, Poetzsch M, Stock L, et al. Development and validation of an ultra-fast and sensitive microflow liquid chromatography-tandem mass spectrometry (MFLC-MS/MS) method for quantification of LSD and its metabolites in plasma and application to a controlled LSD administration study in humans. Drug Test Anal. 2017;9(5):788–797.
  • Dolder PC, Schmid Y, Steuer AE, et al. Pharmacokinetics and pharmacodynamics of lysergic acid diethylamide in healthy subjects. Clin Pharmacokinet. 2017;56(10):1219–1230.
  • Nichols DE, Grob CS. Is LSD toxic? Forensic Sci Int. 2018;284:141–145.
  • Devlin RJ, Henry JA. Clinical review: major consequences of illicit drug consumption. Crit Care. 2008;12(1):202.
  • Berrens Z, Lammers J, White C. Rhabdomyolysis after LSD ingestion. Psychosomatics. 2010;51(4):356–356.e3.
  • Klock JC, Boerner U, Becker CE. Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases. West J Med. 1974;120(3):183–188.
  • Holze F, Vizeli P, Ley L, et al. Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacol. 2021;46(3):537–544.
  • Araújo AM, Carvalho F, Bastos Mde L, et al. The hallucinogenic world of tryptamines: an updated review. Arch Toxicol. 2015;89(8):1151–1173.
  • Dolder PC, Liechti ME, Rentsch KM. Development and validation of a rapid turboflow LC-MS/MS method for the quantification of LSD and 2-oxo-3-hydroxy LSD in serum and urine samples of emergency toxicological cases. Anal Bioanal Chem. 2015;407(6):1577–1584.
  • Gugelmann H, Rowley F, Graglia S, et al. Lysergic acid diethylamide (LSD) causing grand mal seizures: a case report with xenobiotic quantification [abstract]. Clin Toxicol. 2014;52(7):2.
  • Martin R, Schürenkamp J, Gasse A, et al. Determination of psilocin, bufotenine, LSD and its metabolites in serum, plasma and urine by SPE-LC-MS/MS. Int J Legal Med. 2013;127(3):593–601.
  • Vizeli P, Liechti ME. Safety pharmacology of acute MDMA administration in healthy subjects. J Psychopharmacol. 2017;31(5):576–588.
  • Cairns R, Raubenheimer J, Brown JA, et al. 2,4-dinitrophenol exposures and deaths in Australia after the 2017 up-scheduling. Med J Aust. 2020;212(9):434–434.e1.
  • Black E, Govindasamy L, Auld R, et al. Toxicological analysis of serious drug-related harm among electronic dance music festival attendees in New South Wales, Australia: a consecutive case series. Drug Alcohol Depend. 2020;213:108070.

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