Advanced search
Publication Cover
Clinical Toxicology Volume 60, 2022 - Issue 4
Submit an article Journal homepage
1,294
Views
9
CrossRef citations to date
0
Altmetric
Poison Centre Research

Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion

J. C. Lewisa Sacramento Division, California Poison Control System, Sacramento, CA, USA;b University of California San Francisco School of Pharmacy, San Francisco, CA, USA;c Department of Internal Medicine, University of California Davis Health, Sacramento, CA, USACorrespondence[email protected]
,
M. Limd Department of Pharmacy Services, University of California Davis Health, Sacramento, CA, USA
,
L. Laia Sacramento Division, California Poison Control System, Sacramento, CA, USA
,
E. Mendozab University of California San Francisco School of Pharmacy, San Francisco, CA, USA
,
T. E. Albertsona Sacramento Division, California Poison Control System, Sacramento, CA, USA;b University of California San Francisco School of Pharmacy, San Francisco, CA, USA;c Department of Internal Medicine, University of California Davis Health, Sacramento, CA, USA
&
J. A. Chenowetha Sacramento Division, California Poison Control System, Sacramento, CA, USA;e Department of Emergency Medicine, University of California Davis Health, Sacramento, CA, USA
Pages 507-513 | Received 06 Jul 2021, Accepted 17 Sep 2021, Published online: 28 Sep 2021

References

  • Yoon E, Babar A, Choudhary M, et al. Acetaminophen-induced hepatotoxicity: a comprehensive update. J Clin Transl Hepatol. 2016;4(2):131–142.
  • Rumack BH, Bateman DN. Acetaminophen and acetylcysteine dose and duration: past, present and future. Clin Toxicol. 2012;50(2):91–98.
  • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-Acetylcysteine in the treatment of acetaminophen overdose. N Engl J Med. 1988;319(24):1557–1562.
  • Lin JH, Levy G. Sulfate depletion after acetaminophen administration and replenishment by infusion of sodium sulfate or N-acetylcysteine in rats. Biochem Pharmacol. 1981;30(19):2723–2725.
  • Rumack BH, Peterson RC, Koch GG, et al. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981;141(3 Spec No):380–385.
  • Marks DJB, Dargan PI, Archer JRH, et al. Outcomes from massive paracetamol overdose: a retrospective observational study. Br J Clin Pharmacol. 2017;83(6):1263–1272.
  • Wang GS, Monte A, Bagdure D, et al. Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. Pediatrics. 2011;127(4):e1077–1080.
  • Chiew AL, Isbister GK, Kirby KA, et al. Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clin Toxicol. 2017;55(10):1055–1065.
  • Downs JW, Cumpston KL, Kershner EK, et al. Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. Clin Toxicol. 2021;0(0):1–8.
  • Perry HE, Shannon MW. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: Results of an open-label, clinical trial. J Pediatr. 1998;132(1):149–152.
  • Buckley NA, Whyte IM, O'Connell DL, et al. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol. 1999;37(6):759–767.
  • Cumberland Pharmaceuticals Inc. ACETADOTE (acetylcysteine) Injection [Package Insert]. U.S. Food and Drug Administration; 2013. [cited 2021 May 14]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021539s012lbl.pdf.
  • Prescott L. Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol. 1980;10 Suppl 2(2S):291S–298S.
  • Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med. 2009;16(1):34–39.
  • Singer AJ, Carracio TR, Mofenson HC. The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med. 1995;26(1):49–53.
  • Green TJ, Sivilotti MLA, Langmann C, et al. When do the aminotransferases rise after acute acetaminophen overdose? Clin Toxicol. 2010;48(8):787–792.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.