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Letters in Response

Authors’ reply to Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions

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Pages 663-664 | Received 12 Nov 2021, Accepted 16 Nov 2021, Published online: 14 Dec 2021

References

  • Hodgson SE, Wong A. Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clin Toxicol. 2021;1. DOI: https://doi.org/10.1080/15563650.2021.2004157
  • Shah KR, Beuhler MC. Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clin Toxicol. 2021;1–6. DOI: https://doi.org/10.1080/15563650.2021.1979231
  • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988;319(24):1557–1562.
  • Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med. 2009;16(1):34–39.
  • Downs JW, Cumpston KL, Kershner EK, et al. Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. Clin Toxicol. 2021;59(10):932–936.
  • Lewis JC, Lim M, Lai L, et al. Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion. Clin Toxicol. 2021;1–7. DOI: https://doi.org/10.1080/15563650.2021.1984503
  • Chiew AL, Isbister GK, Kirby KA, et al. Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clin Toxicol. 2017;55(10):1055–1065.

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