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Clinical Research

Comparison of clinical characteristics between meth/amphetamine and synthetic cathinone users presented to the emergency department

, ORCID Icon, , , , , , , ORCID Icon & ORCID Icon show all
Pages 926-932 | Received 22 Jan 2022, Accepted 31 Mar 2022, Published online: 19 Apr 2022

References

  • Guirguis A. New psychoactive substances: a public health issue. Int J Pharm Pract. 2017;25(5):323–325.
  • Goncalves JL, Alves VL, Aguiar J, et al. Synthetic cathinones: an evolving class of new psychoactive substances. Crit Rev Toxicol. 2019;49(7):549–566.
  • UNODC. What are NPS? 2021. [cited 2022 Jan 21]. Available from: https://www.unodc.org/LSS/Page/NPS.
  • German CL, Fleckenstein AE, Hanson GR. Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci. 2014;97(1):2–8.
  • Megarbane B, Oberlin M, Alvarez JC, et al. Management of pharmaceutical and recreational drug poisoning. Ann Intensive Care. 2020;10(1):157.
  • Wood DM, Ceronie B, Dargan PI. Healthcare professionals are less confident in managing acute toxicity related to the use of new psychoactive substances (NPS) compared with classical recreational drugs. QJM. 2016;109(8):527–529.
  • La Maida N, Di Trana A, Giorgetti R, et al. A review of synthetic cathinone-related fatalities from 2017 to 2020. Ther Drug Monit. 2021;43(1):52–68.
  • Chen HY, Chien WC, Huang MN, et al. Analytically confirmed eutylone (bk-EBDB) exposure in emergency department patients. Clin Toxicol. 2021;59(9):846–848.
  • Luethi D, Liechti ME. Designer drugs: mechanism of action and adverse effects. Arch Toxicol. 2020;94(4):1085–1133.
  • O'Connor AD, Padilla-Jones A, Gerkin RD, et al. Prevalence of rhabdomyolysis in sympathomimetic toxicity: a comparison of stimulants. J Med Toxicol. 2015;11(2):195–200.
  • Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol. 2012;8(1):33–42.
  • Borek HA, Holstege CP. Hyperthermia and multiorgan failure after abuse of “bath salts” containing 3,4-methylenedioxypyrovalerone. Ann Emerg Med. 2012;60(1):103–105.
  • Beck O, Backberg M, Signell P, et al. Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats. Clin Toxicol. 2018;56(4):256–263.
  • Feng LY, Li JH. New psychoactive substances in Taiwan: challenges and strategies. Curr Opin Psychiatry. 2020;33(4):306–311.
  • Ling DA, Weng TI, Chen JY, et al. Clinical manifestation and quantitative urinary analysis of N-ethylnorpentylone abuse in patients to the emergency department. Clin Toxicol. 2020;58(9):935–937.
  • Chou HH, Hsieh CH, Chaou CH, et al. Synthetic cathinone poisoning from ingestion of drug-laced “instant coffee packets” in Taiwan. Hum Exp Toxicol. 2021;40(9):1403–1412.
  • Weng TI, Su PI, Chen JY, et al. Analytically confirmed 4-Methyl-N-ethylnorpentedrone (4-MEAP), a synthetic cathinone, in cases presenting to an emergency department. Clin Toxicol. 2020;58(1):65–66.
  • Chen JY, Chen GY, Wang SY, et al. Development of an analytical method to detect simultaneously 219 new psychoactive substances and 65 other substances in urine specimens using LC-QqQ MS/MS with CriticalPairFinder and TransitionFinder. Talanta. 2022;238(Pt 1):122979.
  • Lin CC, Weng TI, Ng CJ, et al. Emergency department visits due to new psychoactive substances and other illicit drugs in Taiwan: preliminary results of the Taiwan emergency department drug abuse surveillance (TEDAS) project. Clin Toxicol. 2022:1–8. DOI:http://doi.org/10.1080/15563650.2022.2038793
  • Weaver MF, Hopper JA, Gunderson EW. Designer drugs 2015: assessment and management. Addict Sci Clin Pract. 2015;10:8.
  • Hill SL, Thomas SH. Clinical toxicology of newer recreational drugs. Clin Toxicol. 2011;49(8):705–719.
  • Valente MJ, Guedes de Pinho P, de Lourdes Bastos M, et al. Khat and synthetic cathinones: a review. Arch Toxicol. 2014;88(1):15–45.
  • Martinez-Clemente J, Lopez-Arnau R, Carbo M, et al. Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics. Psychopharmacology. 2013;229(2):295–306.
  • Simmler LD, Buser TA, Donzelli M, et al. Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol. 2013;168(2):458–470.
  • Papaseit E, Perez-Mana C, Mateus JA, et al. Human pharmacology of mephedrone in comparison with MDMA. Neuropsychopharmacology. 2016;41(11):2704–2713.
  • Bowyer JF, Hanig JP. Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity. Temperature. 2014;1(3):172–182.
  • Rusyniak DE, Sprague JE. Toxin-induced hyperthermic syndromes. Med Clin North Am. 2005;89(6):1277–1296.
  • Forrester MB. Adolescent synthetic cathinone exposures reported to Texas poison centers. Pediatr Emerg Care. 2013;29(2):151–155.
  • Kiyatkin EA, Kim AH, Wakabayashi KT, et al. Effects of social interaction and warm ambient temperature on brain hyperthermia induced by the designer drugs methylone and MDPV. Neuropsychopharmacology. 2015;40(2):436–445.
  • Anneken JH, Angoa-Pérez M, Kuhn DM. 3,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter. J Neurochem. 2015;133(2):211–222.
  • Fantegrossi WE, Gannon BM, Zimmerman SM, et al. In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity. Neuropsychopharmacology. 2013;38(4):563–573.
  • Zaretsky DV, Brown MB, Zaretskaia MV, et al. The ergogenic effect of amphetamine. Temperature. 2014;1(3):242–247.
  • Soares J, Costa VM, Bastos ML, et al. An updated review on synthetic cathinones. Arch Toxicol. 2021;95(9):2895–2940.
  • Marusich JA, Antonazzo KR, Wiley JL, et al. Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV). Neuropharmacology. 2014;87:206–213.
  • Baumann MH, Partilla JS, Lehner KR, et al. Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products. Neuropsychopharmacology. 2013;38(4):552–562.
  • Varner KJ, Daigle K, Weed PF, et al. Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats. Psychopharmacology. 2013;225(3):675–685.
  • Weng TI, Chen LY, Chen JY, et al. Characteristics of analytically confirmed illicit substance-using patients in the emergency department. J Formos Med Assoc. 2020;119(12):1827–1834.
  • Helander A, Backberg M, Hulten P, et al. Detection of new psychoactive substance use among emergency room patients: results from the Swedish STRIDA project. Forensic Sci Int. 2014;243:23–29.
  • George MD, McGill NK, Baker JF. Creatine kinase in the U.S. population: Impact of demographics, comorbidities, and body composition on the normal range. Medicine. 2016;95(33):e4344.
  • Romanek K, Stenzel J, Schmoll S, et al. Synthetic cathinones in Southern Germany – characteristics of users, substance-patterns, co-ingestions, and complications. Clin Toxicol. 2017;55(6):573–578.
  • Schifano F, Corkery J, Ghodse AH. Suspected and confirmed fatalities associated with mephedrone (4-methylmethcathinone, “meow meow”) in the United Kingdom. J Clin Psychopharmacol. 2012;32(5):710–714.

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