519
Views
29
CrossRef citations to date
0
Altmetric
Review Article

The importance of minipigs in dermal safety assessment: an overview

, , , &
Pages 105-113 | Received 04 Mar 2016, Accepted 11 Apr 2016, Published online: 10 May 2016

References

  • Gross CG. Galen and the squealing pig. Neuroscientist 1998;4:216–221
  • Brown LD, Stricker-Krongrad A, Bouchard GF. Minipigs: applications in toxicology. In: Current protocols in toxicology, vol. 56:1.11:1.11.1–1.11.19. Hoboken, NJ: John Wiley & Sons, Inc.; 2013
  • Gad SC, Stricker-Krongrad A, Skaanild MT. The minipig. In: Gad SC, ed. Animal models in toxicology. 3rd ed. Boca Raton, FL: CRC Press:763–808
  • Fujii M, Yamanouchi S, Hori N, et al. Evaluation of Yucatan micropig skin for use as an in vitro model for skin permeation study. Biol Pharm Bull 1997;20:249–254
  • Monteiro-Riviere NA, Riviere J. The pig as a model for cutaneous pharmacology and toxicology research. In: Tumbleson ME, Schook LB, eds. Advances in swine in biomedical research, vol. 2. New York: Plenum Press; 1996:425–458
  • Svendsen O. The minipig in toxicology. Exp Toxicol Pathol 2006;57:335–339
  • Swindle MM. Swine in the laboratory: surgery, anesthesia, imaging, and experimental techniques. 2nd ed. Boca Raton, Florida: CRC Press; 2007
  • EMA (European Medicines Agency). Draft guideline on non-clinical local tolerance testing of medical products. London, UK: EMA; 2014
  • FDA (US Food and Drug Administration). Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Rockville, MD: U.S. Department of Health and Human Services Center for Drug Evaluation and Research; 2005
  • OECD (Organisation for Economic Co-operation and Development) (2012). Guidance Document on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453. 2nd ed. 116, Paris, France: OECD, Environment Directorate
  • Ganderup NC, Harvey W, Mortensen JT, Harrouk W. The minipig as nonrodent species in toxicology – where are we now? Int J Toxicol 2012;31:507–528.
  • Monteiro-Riviere NA. Comparative anatomy, physiology, and biochemistry of mammalian skin. In: Hobson DW, ed. Dermal and ocular toxicology: fundamentals and methods. New York, NY: CRC Press, Inc; 1991:3–71
  • Monteiro-Riviere NA, Riviere J. The pig as a model for human skin. 56th AALAS National Meeting; 2005; St. Louis, Missouri, pp. 17–22
  • Monteiro-Riviere NA. Integument. In: Pond WG, Mersmann HJ, eds. Biology of the domestic pig. Ithaca, NY: Cornell University Press; 2001:625–652
  • Gore AV, Liang AC, Chien YW. Comparative biomembrane permeation of tacrine using Yucatan minipigs and domestic pigs as the animal model. J Pharm Sci 1998;87:441–447
  • Xing QF, Lin S, Chien YW. Transdermal testosterone delivery in castrated Yucatan minipigs: pharmacokinetics and metabolism. J Control Release 1998;52:89–98
  • Sharma V, McNeill JH. To scale or not to scale: the principles of dose extrapolation. Br J Pharmacol 2009;157:907–921
  • Montagna W. Comparative anatomy and physiology of the skin. Arch Dermatol 1967;96:357–363
  • Bronaugh RL, Stewart RF, Congdon ER. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol Appl Pharmacol 1982;62:481–488
  • Tregear RT. Relative penetrability of hair follicles and epidermis. J Physiol (Lond) 1961;156:307–313
  • Bartek MJ, LaBudde JA, Maibach HI. Skin permeability in vivo: comparison in rat, rabbit, pig and man. J Invest Dermatol 1972;58:114–123
  • Mahl JA, Vogel BE, Court M, et al. The minipig in dermatotoxicology: methods and challenges. Exp Toxicol Pathol 2006;57:341–345
  • Qvist MH, Hoeck U, Kreilgaard B, et al. Evaluation of Göttingen minipig skin for transdermal in vitro permeation studies. Eur J Pharm Sci 2000;11:59–68
  • Swindle MM, Makin A, Herron AJ, et al. Swine as models in biomedical research and toxicology testing. Vet Pathol 2012;49:344–356
  • Jacobs A. Use of nontraditional animals for evaluation of pharmaceutical products. Expert Opin Drug Metab Toxicol 2006;2:345–349
  • Harvey W, Danks A. The use of the minipig in the safety evaluation of topical drug products. In: Skin forum. Edinburgh, UK: Charles River Laboratories; 2010
  • Panchagnula R, Stemmer K, Ritschel WA. Animal models for transdermal drug delivery. Methods Find Exp Clin Pharmacol 1997;19:335–341
  • Simon GA, Maibach HI. The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations – an overview. Skin Pharmacol Appl Skin Physiol 2000;13:229–234
  • Eggleston TA, Roach WP, Mitchell MA, et al. Comparison of two porcine (Sus scrofa domestica) skin models for in vivo near-infrared laser exposure. Comp Med 2000;50:391–397
  • Monteiro-Riviere NA, Bristol DG, Manning TO, et al. Interspecies and interregional analysis of the comparative histologic thickness and laser Doppler blood flow measurements at five cutaneous sites in nine species. J Invest Dermatol 1990;95:582–586
  • Spector WS. Handbook of biological data. Philadelphia, PA: W.B. Saunders Company; 1956
  • Wachtel TL, McCahan GR Jr., Watson WI, Gorman M. Determining the surface areas of miniature swine and domestic swine by geometric design – a comparative study. Fort Rucker, AL: Army Aeromedical Research Lab; 1972
  • Draize JH. Appraisal of the toxicity of sunscreen preparations. AMA Arch Derm Syphilol 1951;64:585–587
  • Dincer Z, Gad SC, Skaanild MT, Svendsen O. The minipig. In: Gad SC, ed. Animal models in toxicology. 2nd ed. Boca Raton, FL: CRC Press; 2007:731–771

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.