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Original Articles

L-carnosine mitigates interleukin-1α-induced dry eye disease in rabbits via its antioxidant, anti-inflammatory, antiapoptotic, and antifibrotic effects

ORCID Icon &
Pages 241-251 | Received 19 Feb 2021, Accepted 19 May 2021, Published online: 16 Jun 2021

References

  • Kojima T, Wakamatsu TH, Dogru M, et al. Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol 2012;180:1879–1896.
  • Nebbioso M, Evangelista M, Librando A, et al. Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study. Biomed Pharmacother 2013;67:659–663.
  • Sumida T, Azuma N, Moriyama M, et al. Clinical practice guideline for Sjögren's syndrome 2017. Mod Rheumatol 2018;28:383–408.
  • Abbasi M, Karimi H, Gharz A. Preliminary anatomical and histological study of lacrimal gland in Lori sheep. J Vet Sci Technol 2014;5:1–4.
  • Li H, Wei F, Li S, et al. The effect of sinomenine eye drops on experimental dry eye in mice. Cutan Ocul Toxicol 2020;39:389–395.
  • Makarenkova HP, Dartt DA. Myoepithelial cells: their origin and function in lacrimal gland morphogenesis, homeostasis, and repair. Curr Mol Biol Rep 2015;1:115–123.
  • Zoukhri D, Fix A, Alroy J, et al. Mechanisms of murine lacrimal gland repair after experimentally induced inflammation. Invest Ophthalmol Vis Sci 2008;49:4399–4406.
  • Baudouin C, Aragona P, Messmer EM, et al. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf 2013;11:246–258.
  • Li J, Tan G, Ding X, et al. A mouse dry eye model induced by topical administration of the air pollutant particulate matter 10. Biomed Pharmacother 2017;96:524–534.
  • Kartika R, Purnamasari D, Pradipta S, et al. Impact of low interferon-γ and IL-10 levels on TNF-α and IL-6 production by PHA-induced PBMCs in type 2 diabetes mellitus. J Inflamm Res 2020;13:187–193.
  • Wu H, Lin L, Du X, et al. Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease. Biomed Pharmacother 2020;127:110051.
  • Heidari M, Noorizadeh F, Wu K, et al. Dry eye disease: emerging approaches to disease analysis and therapy. JCM 2019;8:1439.
  • Bastian D, Wu Y, Betts BC, et al. The IL-12 cytokine and receptor family in graft-vs.-host disease. Front Immunol 2019;10:988.
  • Maharani W, Ratnaningsih DF, Utami F, et al. Activity disease in sle patients affected IFN-γ in the IGRA results. J Inflamm Res 2020;13:433–439.
  • Bersudsky M, Luski L, Fishman D, et al. Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice. Gut 2014;63:598–609.
  • Mavragani CP, Crow MK. Activation of the type I interferon pathway in primary Sjogren's syndrome. J Autoimmun 2010;35:225–231.
  • Jackson DC, Zeng W, Wong CY, et al. Tear interferon-gamma as a biomarker for evaporative dry eye disease. Invest Ophthalmol Vis Sci 2016;57:4824–4830.
  • Kanaji N, Sato T, Nelson A, et al. Inflammatory cytokines regulate endothelial cell survival and tissue repair functions via nF-κB signaling. J Inflamm Res 2011;4:127–138.
  • Tsoumani A, Theopistos V, Katsanos K, et al. Treatment and non-treatment related ocular manifestations in patients with chronic hepatitis B or C. Eur Rev Med Pharmacol Sci 2013;17:1123–1131.
  • Messina JP, Humphreys I, Flaxman A, et al. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology 2015;61:77–87.
  • Foulks GN, Forstot SL, Donshik PC, et al. Clinical guidelines for management of dry eye associated with Sjögren disease. Ocul Surf 2015;13:118–132.
  • Babizhayev MA. Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products. Life Sci 2006;78:2343–2357.
  • Malaguarnera M, Vacante M, Giordano M, et al. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with peg interferon-α 2b plus ribavirin. WJG 2011;17:4414–4420.
  • Xiao S, Zhuang H, Zhou G, et al. Investigation of inhibition of lipid oxidation by L-carnosine using an oxidized-myoglobin-mediated washed fish muscle system. LWT 2018;97:703–710.
  • Shen L, Li J, Chen Y, et al. L-carnitine's role in KAATSU training- induced neuromuscular fatigue . Biomed Pharmacother 2020;125:109899.
  • Al-Sawalha NA, Alshogran OY, Awawdeh MS, et al. The effects of L-carnosine on development of metabolic syndrome in rats. Life Sci 2019;237:116905.
  • Cripps MJ, Hanna K, Lavilla C, et al. Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake. Sci Rep 2017;7:13313.
  • Helmy AM, Sharaf-El-Din NA, Abd-El-Moneim RA, et al. Histological study of the renal cortical proximal and distal tubules in adult male albino rats following prolonged administration of titanium dioxide nanoparticles and the possible protective role of l-carnosine. Egypt J Histol 2015;38:126–142.
  • Hussien NI, Mousa AM, Shoman AA. Decreased level of plasma nesfatin-1 in rats exposed to cell phone radiation is correlated with thyroid dysfunction, oxidative stress, and apoptosis. Arch Physiol Biochem 2020;1–7.
  • Zoukhri D, Macari E, Kublin CL. A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Exp Eye Res 2007;84:894–904.
  • Noori S, Mahboob T. Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats. Indian J Clin Biochem 2010;25:86–91.
  • Duran M, Güngör İ. The effect of pregnancy on tear osmolarity. Cont Lens Anterior Eye 2019;42:196–199.
  • Horobin RW. Theory of histological staining. In: Bancroft's theory and practice of histological techniques. 8th ed. Elsevier; 2019:114–125.
  • Nagata S. Apoptosis mediated by the Fas system. Prog Mol Subcell Biol 1996;16:87–103.
  • Mousa AM, El-Mahalaway AM, El-Desoky RE. The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: a histological and immunohistochemical study. Egypt J Histol 2018;41:140–149.
  • Li K, Zhang C, Yang Z, et al. Evaluation of a novel dry eye model induced by oral administration of finasteride. Mol Med Rep 2017;16:8763–8770.
  • Patlolla AK, Barnes C, Yedjou C, et al. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol 2009;24:66–73.
  • Figueroa D, Asaduzzaman M, Young F. Real time monitoring and quantification of reactive oxygen species in breast cancer cell line MCF-7 by 2',7'-dichlorofluorescin diacetate (DCFDA) assay. J Pharmacol Toxicol Methods 2018;94:26–33.
  • Khan A, Alhumaydhi FA, Alwashmi ASS, et al. Diallyl sulfide-mediated modulation of the fatty acid synthase (Fasn) leads to cancer cell death in bap-induced lung carcinogenesis in Swiss mice. J Inflamm Res 2020;13:1075–1087.
  • Berczeli O, Vizvári E, Katona M, et al. Novel insight into the role of CFTR in lacrimal gland duct function in mice. Invest Ophthalmol Vis Sci 2018;59:54–62.
  • Yagci A, Gurdal C. The role and treatment of inflammation in dry eye disease. Int Ophthalmol 2014;34:1291–1301.
  • Islam F, Sakirul IKM, Nabeka H, et al. Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats. Histol Histopathol 2020;35:69–81.
  • Beauregard C, Brandt PC, Chiou GCY. Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1beta in cultured lacrimal gland acinar cells. Exp Eye Res 2003;77:109–114.
  • Koonyosying P, Kongkarnka S, Uthaipibull C, et al. Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation. Biomed Pharmacother 2018;108:1694–1702.
  • Hagiwara S, Kudo M, Nakatani T, et al. Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumor cell growth in nude mice by apoptosis of p53. Br J Cancer 2007;97:1532–1537.
  • Takahashi S, Gobe GC, Yoshimura Y, et al. Participation of the Fas and Fas ligand systems in apoptosis during atrophy of the rat submandibular glands. Int J Exp Pathol 2007;88:9–17.
  • Feldmann G, Lamboley C, Moreau A, et al. Fas. Fas-mediated apoptosis of hepatic cells. Biomed Pharmacother 1998;52:378–385.
  • Mousa AM, Salem MM, El-Mahalaway AM. Effect of thymoquinone on cadmium-induced toxicity of Leydig cells in adult male albino rats. Egypt J Histol 2015;38:308–316.
  • Meshkibaf MH, Maleknia M, Noroozi S. Effect of curcumin on gene expression and protein level of methionine sulfoxide reductase A (MSRA), SOD, CAT and GPx in Freund’s adjuvant inflammation-induced male rats. JIR 2019;12:241–249.
  • Hejazi II, Khanam R, Mehdi SH, et al. New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation. Biomed Pharmacother 2017;94:265–279.
  • Pryczynicz A, Guzińska-Ustymowicz K, Kemona A. Fas/FasL expression in colorectal cancer. An immunohistochemical study. Folia Histochem Cytobiol 2010;48:425–429.
  • Zhang Y, Li Y, Ma P, et al. Ficus carica leaves extract inhibited pancreatic β-cell apoptosis by inhibiting AMPK/JNK/caspase-3 signaling pathway and antioxidation. Biomed Pharmacother 2020;122:109689.
  • Seen S, Tong L. Dry eye disease and oxidative stress. Acta Ophthalmol 2018;96:e412–e420.
  • Salma U, Xue M, Ali Sheikh MS, et al. Role of transforming growth factor-β1 and Smads signaling pathway in intrauterine adhesion. Mediators Inflamm 2016;2016:4158287.
  • Zhang C, Li K, Yang Z, et al. The effect of the aqueous extract of Bidens pilosa L. on androgen deficiency dry eye in rats. Cell Physiol Biochem 2016;39:266–277.
  • Toyama EQ, Herzig S, Courchet J, et al. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress . Science 2016;351:275–281.
  • Odashima M, Otaka M, Jin M, et al. Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation. Life Sci 2006;79:2245–2250.
  • Davinelli S, Di MR, Bracale R, et al. Synergistic effect of L-carnosine and EGCG in the prevention of physiological brain aging. CPD 2013;19:2722–2727.
  • Seo H, Ogata-Ikeda I, Ishida S, et al. A comparison of the cellular actions of polaprezinc (zinc-l-carnosine) and ZnCl2. Life Sci 2012;90:1015–1019.
  • Chengappa KNR, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of l-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142:145–152.
  • Aydogan S, Yapislar H, Artis S, et al. Impaired erythrocytes deformability in H2O2-induced oxidative stress: Protective effect of L-carnosine. Clin Hemorheol Microcirc 2008;39:93–98.
  • Di Paola R, Impellizzeri D, Salinaro AT, et al. Administration of carnosine in the treatment of acute spinal cord injury. Biochem Pharmacol 2011;82:1478–1489.

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