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Review Article

Ecology of Aspergillus flavus, regulation of aflatoxin production, and management strategies to reduce aflatoxin contamination of corn

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Pages 142-153 | Received 06 Mar 2009, Accepted 06 Apr 2009, Published online: 28 Jul 2009

References

  • Abbas HK, Accinelli C, Zablotowicz RM, Abel CA, Bruns HA, Dong Y, Shier WT. (2008a). Dynamics of mycotoxin and Aspergillus flavus levels in aging Bt and non-Bt corn residues under Mississippi no-till conditions. J Agric Food Chem. 56: 7578–7585.
  • Abbas HK, Weaver MA, Zablotowicz RM, Horn BW, Shier WT. (2005). Relationships between aflatoxin production, sclerotia formation and source among Mississippi Delta Aspergillus isolates. Eur J Plant Pathol. 112: 283–287.
  • Abbas HK, Zablotowicz RM. Bruns HA. (2008b). Modelling the colonization of maize by toxigenic and non-toxigenic Aspergillus flavus strains: implications for biological control. World Mycotoxin Journal. 1: 333–340.
  • Abbas HK, Zablotowicz RM, Bruns HA, Abel CA. (2006). Biocontrol of aflatoxin in corn by inoculation with non-aflatoxigenic Aspergillus flavus isolates. Biocontrol Sci Technol. 16: 437–449.
  • Abbas, H. K., Zablotowicz, R. M., Bruns, H. A., and Abel., C. A. (2008c). Development of non-toxigenic strains of Aspergillus flavus for control of aflatoxin in Maize. In: Burton EN, Williams PV, eds. Crop Protection, Research Advances. New York, NY: Nova Sciences Publishers, pp. 181–192.
  • Abbas HK, Zablotowicz RM, Locke MA. (2004a). Spatial variability of Aspergillus flavus soil populations under different crops and corn grain colonization and aflatoxins. Can J Bot. 82: 1768–1775.
  • Abbas HK, Zablotowicz RM, Weaver MA, Horn BW, Xie W, Shier WT. (2004b). Comparison of cultural and analytical methods for determination of aflatoxin production by Mississippi Delta Aspergillus isolates. Can J Microbiol. 50: 193–199.
  • Accinelli C, Abbas HK, Zablotowicz RM, Wilkinson JR. (2008a). Aspergillus flavus aflatoxin occurrence and expression of aflatoxin biosynthesis genes in soil. Can J Microbiol. 54: 371–379.
  • Accinelli C, Abbas HK, Zablotowicz RM, Wilkinson JR. (2008b). Role of Ostrinia nubilalis in vectoring Aspergillus flavus in a corn field in northern Italy. Proceedings of the 235th American Chemical Society (ACS) National Meeting, April 6–10, New Orleans, LA.
  • Anderson HW, Nehring EW, Wichser WR. (1975). Aflatoxin contamination of corn in the field. J Agric Food Chem. 23: 775–782.
  • Angle JS, Dunn KA, Wagner GH. (1982). Effect of cultural practices on the soil population of Aspergillus flavus and Aspergillus parasiticus. Soil Sci Soc Am J. 46: 301–304.
  • Bankole SA, Joda AO. (2004). Effect of lemon grass (Cymbopogon citratus Stapf) powder and essential oil on mould deterioration and aflatoxin contamination of meion seeds (Colocynthis citrullus L.). Afr J Biotechnol. 3: 52–59.
  • Bayman P, and Cotty PJ. (1993). Genetic diversity in Aspergillus flavus: association with aflatoxin production and morphology. Can J Bot. 71: 23–34
  • Benndorf D, Műller A, Bock K, Manuwald O, Herbarth O, Van Bergen M. (2008). Identification of spore allergens from the indoor mold Aspergillus vesicolor. Allergy. 63: 454–460.
  • Bennett JW. (1981). Loss of norsolorinic acid and aflatoxin production by a mutant of Aspergillus parasiticus. J Gen Microbiol. 124: 429–432.
  • Bennett JW, Chang PK, Bhatnagar D. (1997). One gene to whole pathway: the role of norsolorinic acid in aflatoxin research. Adv Appl Microbiol. 45: 1–15.
  • Bhatnagar D, Cary JW, Ehrlich K, Yu J, Cleveland TE. (2006a). Understanding the genetics of regulation of aflatoxin production and Aspergillus flavus development. Mycopathologia. 162: 155–166.
  • Bhatnagar D, Ehrlich KC, Cleveland TE. (2003). Molecular genetic analysis and regulation of aflatoxin biosynthesis. Appl Microbiol Biotechnol. 61: 83–93.
  • Bhatnagar D, Proctor R, Payne GA, Wilkinson J, Yu J, Cleveland TE, Nierman WC. (2006b). Genomics of mycotoxigenic fungi. In: Barug D, Bhatnagar D, van Egmond HP, van der Kamp JW, van Osenbruggen WA, Visconti A, eds. The Mycotoxin Factbook (Food & Feed Topics). Wageningen, The Netherlands: Wageningen Academic Publishers, pp. 157–178.
  • Bhatnagar D, Yu J, Ehrlich KC. (2002). Toxins of filamentous fungi. Chem Immunol. 81: 167–206.
  • Blout WP. (1961). Turkey “X” disease. Turkeys. 52: 55–58.
  • Brun TD, White TJ, Taylor JW. (1991). Fungal molecular systematics. Annual Review of Ecological System. 22: 525–564.
  • Bruns HA. (2003). Controlling aflatoxin and fumonisin in maize by crop management. J Toxicol Toxin Rev. 22: 153–173.
  • Bruns HA, Abbas HK. (2005a). Response of short-season corn hybrids to a humid sub-tropical environment. Agron J. 97: 446–451.
  • Bruns HA, Abbas HK. (2005b). Ultra-high plant populations and N-fertility effects on corn in the Mississippi Valley. Agron J. 97: 1136–1140.
  • Bruns HA, Abbas HK. (2006). Effects of glufosinate – Ammonium and urea on aflatoxin and fumonisin levels in corn. Plant Health Progress. doi:10.1094/PHP-2006-0324-01-RS.
  • Campbell BC, Molyneaux RJ, Schatza BS. (2003) Current research on reducing pre- and post-harvest aflatoxin contamination of U.S. almond, pistachio, and walnut. J Toxicol Toxin Rev. 22: 225–266.
  • Cary JW, Calvo AM. (2008). Regulation of Aspergillus mycotoxin biosynthesis Toxin Reviews 27 (3 & 4) 347–370.
  • Cary JW, Ehrlich K. (2006). Aflatoxigenicity in Aspergillus: molecular genetics, phylogenetic relationships and evolutionary implications. Mycopathologia. 162: 167–177.
  • Catangui MA, Berg RK. (2006). Western bean cutworm, Striacosta albicosta (Smith) (Lepidoptera: Noctuidae), as a potential pest of transgenic Cry1Ab Bacillus thuringiensis corn hybrids in South Dakota. Environ Entomol. 35: 1439–1452.
  • CIMMYT. (2008). Aspergillus ear rot (extended information). http://maizedoctor.cimmyt.org/index.php?option=com_content&task=view&id=227. Accessed October 28, 2008.
  • Cleveland TE, Dowd PF, Desjardins AE, Bhatnagar D, Cotty, PJ. (2003). United States Department of Agriculture-Agricultural Research Service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops. Pest Manag Sci. 59: 629–642.
  • Cotty PJ. (1994). Influence of field application of an atoxigenic strain of Aspergillus flavus on the populations of A. flavus infecting cotton bolls and on the aflatoxin content of cottonseed. Phytopathology. 84: 1270–1277.
  • Cotty PJ, Antilla L, Wakelyn PJ. (2007). Competitive exclusion of aflatoxin producers: farmer driven research and development. In: Vincent C, Goettel N, Lazarovitis G, eds. Biological Control: A Global Perspective. Oxfordshire, UK: CAB International, pp. 241–253.
  • Cotty PJ, Bayman P. (1993). Competitive exclusion of a toxigenic strain of Aspergillus flavus by an atoxigenic strain. Phytopathology. 83: 1283–1287.
  • Criseo G, Bagnara A, Bisignano G. (2001). Differentiation of aflatoxin-producing and non-producing strains of Aspergillus flavus group. Lett Appl Microbiol. 33: 291–295.
  • Das MK, Ehrlich KC, Cotty PJ. (2008). Use of pyrosequencing to quantify incidence of a specific Aspergillus flavus strain within complex fungal communities associated with commercial cotton crops. Phytopathology. 98: 282–288.
  • Degola F, Berni E, Dall’Asta C, Spotti E, Marchelli R, Ferrero I, Restivo FM. (2006). A multiplex RT-PCR approach to detect aflatoxigenic strains of Aspergillus flavus. J Appl Microbiol. 103: 409–417.
  • Denmead OT, Shaw RH. (1960). The effects of soil moisture stress at different stages of growth on the development and yield of corn. Agron J. 52: 272–274.
  • Diener UL, Cole RJ, Sanders TH, Payne GA, Lee LS, Klich MA. (1987). Epidemiology of aflatoxin formation by Aspergillus flavus. Annu Rev Phytopathol. 25: 249–270.
  • Dorner JW. (2008). Management and prevention of mycotoxins in peanuts. Food Addit Contam. 25: 203–208.
  • Dorner JW, Cole RJ, Daigle DJ, McGuire MR, Shasha BS. (2003) Evaluation of biological control formulations to reduce aflatoxin contamination in peanuts. Biol Control. 26: 318–324.
  • Dorner JW, Cole RJ, Wicklow DT. (1999). Aflatoxin reduction in corn through field application of competitive fungi. J Food Protect. 62: 650–656.
  • Dowd PF. (1998). The involvement of arthropods in the establishment of mycotoxigenic fungi under field conditions. In: Sinha KK, Bhatnagar D, eds. Mycotoxins in Agriculture and Food Safety. New York, NY: Marcel Dekker, pp. 307–350.
  • Dowd PF. (2000). Indirect reduction of ear molds and associated mycotoxins in Bacillus thuringiensis in corn under controlled and open field conditions: utility and limitations. J Econ Entomol. 93: 1669–1679.
  • Duvick DN. (1984). Genetic contribution to yield gains of U.S. hybrid maize, 1930 to 1980. In: Genetic Contributions to Yield Gains of Five Major Crop Plants. Madison, WI: ASA, CSSA, pp. 15–47.
  • Fortnum BA. (1986). Effect of environment on aflatoxin development in preharvest maize. In: Zuber MS, Lillehoj EB, eds. Aflatoxin in Maize: A Proceedings of the Workshop. El Batan, Mexico: CIMMYT, pp. 145–151.
  • Garman H, Jewett HH. (1914). The life-history and habits of the corn-ear worm (Chloridea obsoleta). Kentucky Agricultural Experimental Station Bulletin. 187: 513–591.
  • Geisen R. (1996). Multiplex polymerase chain reaction for the detection of potential aflatoxin and sterigmatocystin producing fungi. Syst Appl Microbiol. 19: 388–392.
  • Griffin GJ, Garren KH, Taylor JD. (1981). Influence of crop rotation and minimum tillage on the populations of Aspergillus flavus group in peanut field soil. Plant Dis. 65: 898–900.
  • Heathcote JG, Hibbert JR. (1978). Aflatoxins: Chemical and Biological Aspects. Amsterdam, The Netherlands: Elsevier Scientific Publishing Company.
  • Hesseltine CW, Shotwell OL, Kwolek WF, Lillehoj EB, Jackson WK, Bothast R.J., (1976). Aflatoxin occurrence in 1973 corn at harvest. II. Mycological studies. Mycologia. 68: 341–353.
  • Hill RA, Wilson DM, McMillian WW, Widstrom NW, Cole RJ, Sanders TH, Blankenship PD. (1985). Ecology of the Aspergillus flavus group and aflatoxin formation in maize and groundnut. In: Lacey J, ed. Trichothecenes and Other Mycotoxins. Chichester, UK: John Wiley & Sons, pp. 79–95.
  • Horn BW. (2003). Ecology and population biology of aflatoxigenic fungi in soil. J Toxicol Toxin Rev. 22: 355–383.
  • Horn BW. (2007). Biodiversity of Aspergillus section Flavi in the United States: a review. Food Addit Contam. 24: 1088–1101.
  • Horn BW, Dorner JW. (1998). Soil populations of Aspergillus species from section Flavi along a transect through peanut-growing regions of the United States. Mycologia. 90: 767–776.
  • Horn BW, Greene RL, Dorner JW. (1995). Effect of corn and peanut cultivation on soil populations of Aspergillus flavus and A. parasiticus in southwestern Georgia. Appl Environ Microbiol. 61: 2472–2475.
  • Horn BW, Greene RL, Sobolev S, Dorner JW, Powell JH, Layton RC. (1996). Association of morphology and mycotoxin production with vegetative compatibility groups in Aspergillus flavus, A. parasiticus, and A. tamarii. Mycologia. 88: 574–587.
  • Hugenholtz P and NR Pace. (1996). A molecular phylogenetic approach to the natural microbial world: the biotechnological potential. Trends Biotechnol. 14:190–197.
  • Jaime-Garcia R, Cotty PJ. (2004). Aspergillus flavus in soils and corncobs in South Texas: Implications for management of aflatoxins in corn-cotton rotations. Plant Dis. 88: 1366–1371.
  • Jones RK. (1979). Epidemiology and management of aflatoxins and other mycotoxins. In: Harsfall, JG, Cowling EB, eds. Plant Diseases: An Advanced Treatise. Vol. IV. New York, NY: Academic Press, p. 466.
  • Jones RK, Duncan HE. (1981). Effect of nitrogen fertilizer, planting date, and harvest date on aflatoxin production in corn inoculated with Aspergillus flavus. Plant Dis. 65: 741–744.
  • Jones RK, Duncan HE, Payne GA, Hamilton PB. (1981). Planting date, harvest date, and irrigation effects on infection and aflatoxin production by Aspergillus flavus in field corn. Phytopathology. 66: 675–677.
  • Jones RK, Duncan HE, Payne GA, Leonard KJ. (1980). Factors influencing infection by Aspergillus flavus in silk-inoculated corn. Plant Dis. 64: 859–863.
  • Klich MA. (1986). Mycoflora of cotton seed from the southern United States: a three year study of distribution and frequency. Mycologia. 78: 706–712.
  • Klich MA. (2002). Biogeography of Aspergillus species in soil and litter. Mycologia 94: 21–27.
  • Klich MA. (2007). Aspergillus flavus: the major producer of aflatoxin. Mol Plant Pathol. 8: 713–722.
  • Klich MA, Pitt JI. (1988). Differentiation of Aspergillus flavus from Aspergillus parasiticus and other closely related species. Trans Br Mycol Soc. 91: 99–108.
  • Klich MA, Tiffany LH, Knaphus G. (1992). Ecology of the Aspergilli of soils and litter. In: Bennett JW, Klich MA, eds. Aspergillus: Biology and Industrial Applications. Boston, MA: Butterworth-Heinemann, pp. 329–353.
  • Kumar A, Shukla R, Singh P, Prasad CS, Dubey NK. (2008). Assessment of Thymus vulgaris L. essential oil as a safe botanical preservative against post harvest fungal infestation of food commodities. Innovative Food Science and Emerging Technologies. 9: 575–580.
  • Lee LS, Lillehoj EB, Kwolek WF. (1980). Aflatoxin distribution in individual corn kernels from intact ears. Cereal Chem. 57: 340–343.
  • Lillehoj EB, Fennell DI, Kwolek WF. (1976). Aspergillus flavus and aflatoxin in Iowa corn before harvest. Science. 193: 495–496.
  • Lillehoj EB, Kwolek WF, Horner ES, Widstrom NW, Josephson LM, Franz AO, Catalano A. (1980). Aflatoxin contamination of pre-harvest corn: Role of Aspergillus flavus inoculum and insect damage. Cereal Chem. 57: 255–257.
  • Lillehoj EB, Kwolek WF, Fennell DI, Milburn MS. (1975). Aflatoxin incldence association with bright greenish-yellow fluorescence and insect damage in a limited survey of freshly harvested high-moisture corn. Cereal Chem. 52: 403–412.
  • Lyn ME, Abbas HK, Zablotowicz RM. Johnson, BJ. (2009). Delivery systems for biological control agents to manage aflatoxin contamination of pre-harvest maize. Food Addit Contam.
  • Manonmani HK, Anand S, Chandrashekar A, Rati, ER. (2005). Detection of atoxigenic fungi in selected food commodities by PCR. Process Biochemistry 40: 2859–2864.
  • Manwiller A, Fortnum B. (1979). A comparison of aflatoxin levels on pre-harvest corn from the South Carolina coastal plain for 1977–78. Agron. and Soils Research. Series 201. South Carolina Agric. Exp. Stn., Florence, SC.
  • McMillian WW, Wilson DM, Widstrom NW. (1978). Insect damage, Aspergillus flavus ear mold, and aflatoxin contamination in south Georgia corn fields in 1977. J Environ Qual. 7: 564–566.
  • McMillian WW, Wilson DM, Widstrom NW, Gueldner RC. (1980). Incidence and level of aflatoxin in pre-harvest corn (Zea mays) in south Georgia, USA in 1978. Cereal Chem. 57: 83–84.
  • Minto RE, Townsend CA. (1997). Enzymology and molecular biology of aflatoxin biosynthesis. Chem Rev. 97: 2537–2556.
  • Munkvold GP, Hellmich RL, Rice LG. (1999). Comparison of fumonisin concentrations in kernels of transgenic Bt maize hybrids and non-transgenic hybrids. Plant Dis. 83: 130–138.
  • O’Brian GR, Georgianna DR, Wilkinson JR, Abbas HK, Wu J, Bhatnagar D, Cleveland TE, Nierman W, Payne GA. (2007). The effect of elevated temperature on gene expression and aflatoxin biosynthesis. Mycologia. 90: 232–239.
  • Papa KE. (1986). Heterokaryon incompatibility in Aspergillus flavus. Mycologia. 78: 98–101.
  • Payne GA. (1992). Aflatoxin in maize. CRC Crit Rev Plant Sci. 10: 423–440.
  • Payne GA. (1998). Process of contamination by aflatoxin- producing fungi and their impacts on crops. In: Sinha KK, Bhatnagar D, eds. Mycotoxins in Agriculture and Food Safety, Vol. 9. New York, NY: Marcel Dekker, pp. 279–306.
  • Payne GA, Brown MP. (1998). Genetics and physiology of aflatoxin biosynthesis. Annu Rev Phytopathol. 36: 329–362.
  • Peterson SW. (2008). Phylogenetic analysis of Aspergillus species using DNA sequences from four loci. Mycologia. 100: 205–226.
  • Pildain MB, Vaamonde, G, Cabral D. (2004). Analysis of population structure of Aspergillus flavus from peanut based on vegetative compatibility, geographic origin, mycotoxin and sclerotia production. Int J Food Microbiol. 93: 31–40.
  • Rambo GW, Tuite J, Crane P. (1974). Pre-harvest inoculation and infection of dent corn with Aspergillus flavus and Aspergillus parasiticus. Phytopathology. 64: 797–800.
  • Reddy KN, Abbas HK, Zablotowicz RM, Abel CA, Kroger CH. (2007). Mycotoxin occurrence and Aspergillus flavus soil propagules in a corn and cotton glyphosate-resistant cropping systems. Food Addit Contam. 24(12): 1367–1373.
  • Riley CV. (1882). The boll-worm alias corn-worm (Heliothis armigera Hübn.) order Lepidoptera; family Noctuidae. In: Report of the Commissioner of Agriculture for the years 1881 - 1882. Washington Printing Office, pp. 145–152.
  • Robins JS, Domingo CE. (1953). Some effects of severe soil moisture deficits at specific growth stages in corn. Agron J. 45: 618–621.
  • Rodriguez SB, Mahoney NE. (1994). Inhibition of aflatoxin production by surfactants. Appl Environ Microbiol. 60: 106–110.
  • Scheidegger KA, Payne GA. (2003). Unlocking the secrets behind secondary metabolism: a review of Aspergillus flavus from pathogenicity to functional genomics. J Toxicol Toxin Rev. 22: 423–459.
  • Scherm B, Palomba M, Serra D, Marcello A, Migheli Q. (2005). Detection of transcripts of the aflatoxin genes aflD, aflO, and aflP by reverse transcription-polymerase chain reaction allows differentiation of aflatoxin-producing and non-producing isolates of Aspergillus flavus and Aspergillus parasiticus. Int J Food Microbiol. 98: 201– 210.
  • Scully LR, Bidochka MJ. (2006). A cysteine/methionine auxotroph of the opportunistic fungus Aspergillus flavus is associated with host-range restriction: a model for emerging diseases. Microbiology. 152: 223–232.
  • Sharnma D, Dutta DK, Singh AB, Shome BR. (2007). Aerobiological, biochemical and immunological studies on some of the dominant Aspergillus species of South Assam (India). Aerobiologia. 23: 201–210.
  • Shotwell OL, Goulden ML, Lillehoj EB, Kwolek WF, Hesseltine CW. (1977). Aflatoxin occurrence in 1973 corn at harvest III. Aflatoxin distribution in contaminated, insect-damaged corn. Cereal Chem. 54: 620–626.
  • Smith CA, Woloshuk CP, Robertson D, Payne GA. (2007) Silencing of the aflatoxin gene cluster in a diploid strain of Aspergillus flavus is suppressed by ectopic aflR expression. Genetics. 176: 2077–2086.
  • Teertstra WR, Lugones LG, Wosten HAB. (2004). In situ hybridization in filamenous fungi using peptide nucleic acid probes. Fungal Genet Biol. 41: 1099–1103.
  • Townsend CA. (1997). Progress towards a biosynthetic rationale of the aflatoxin pathway. Pure Appl Chem. 58: 227–238.
  • Tubajika KM, Damann KE Jr. (2002). Glufosinate-ammonium reduces growth and aflatoxin B1 production by Aspergillus flavus. J Food Prot. 65: 1483–1487.
  • Uchimiya H, Iwate M, Nojiri C, Samarajeewa PK, Takamatsu S, Ooba S, Anzai H, Christensen AH, Quail PH, Toki S. (1993). Bialaphos treatment of transgenic rice plants expressing a bar gene prevents infection by the sheath blight pathogen (Rhizoctonia solani). Biotechnology 11: 835–836.
  • Wheeler MH. (1991). Effects of chlobenthiazone on aflatoxin biosynthesis in Aspergillus parasiticus and A. flavus. Pesticide Biochemistry and Physiology 41: 190–197.
  • White TJ, Bruns TD, Lee S, Taylor JW. (1990).. Amplification of direct sequencing of fungal ribosomal RNA genes for phylogenetics. Innis MA, Gelfand DH, Sninsky JJ, eds. In: PCR Protocols: A Guide to Methods and Applications New York, NY: Academic Press, Inc., pp. 315–322.
  • Wicklow DT, Mcalpin CE, Platis CE. (1998). Characterization of the Aspergillus flavus population within an Illinois maize field. Mycol Res. 102: 263–268.
  • Wicklow DT, Wilson DM, Nelsen TE. (1993). Survival of Aspergillus flavus sclerotia and conidia buried in soil in Illinois and Georgia. Phytopathology. 83: 1141–1147.
  • Wicklow DT, Bobell JR, Palmquist DE. (2003). Effect of intraspecific competition by Aspergillus flavus on aflatoxin formation in suspended disc culture. Mycol Res. 107: 617–623.
  • Widstrom NW, Sparks AN Lillehoj EB, Kwolek FW. (1975). Aflatoxin production and lepidopteran insect injury on corn in Georgia. J Econ Entomol. 68: 855–856.
  • Wilkinson JR, Abbas HK. (2008). Aflatoxin, Aspergillus, maize, and the relevance to alternative Fuels (or Aflatoxin: What is it, can we get rid of it, and should the ethanol industry care?). Toxin Rev.. 27 (3&4) 227–260.
  • Williams WP, Buckley PM, Windham GL. (2002). Southwestern corn borer (Lepidoptera: Crambidae) damage and aflatoxin accumulation in maize. J Econ Entomol. 95: 1049–1053.
  • Williams WP, Windham GL, Buckley PM. (2003). Aflatoxin accumulation in maize after inoculation with Aspergillus flavus and infestation with southwestern corn borer. J Genet Breed. 57: 365–369.
  • Wilson DM, Widstrom, NW, Marti LR, Evans BD. (1981). Aspergillus flavus group, aflatoxin, and bright greenish-yellow fluorescence in insect-damaged corn in Georgia. Cereal Chem. 58: 40–42.
  • Windham GL, Williams WP, Davis FM. (1999). Effects of the southern corn borer on Aspergillus flavus kernel infection and aflatoxin accumulation in maize hybrids. Plant Dis. 83: 535–540.
  • Yabe K. (2003). Pathway and genes of aflatoxin biosynthesis. In: Fierro F, Francisco J, eds. Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation. Trivandrum, India: Research Signpost, pp. 227–251.
  • Yu J. (2004). Genetics and biochemistry of mycotoxin synthesis. In: Arora DK, ed. Fungal Biotechnology in Agricultural, Food, and Environmental Applications. New York, NY: Marcel Dekker, Inc., pp. 343–361.
  • Yu J, Bhatnagar D, Ehrlich KC. (2002). Aflatoxin biosynthesis. Rev Iberoam Micol. 19: 191–200.
  • Yu J, Chang P-K, Cary J, Wright WM, Bhatnagar D, Cleveland TE, Payne GA, Linz JE. (1995). Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus. Appl Environ Microbiol. 61: 2365–2371.
  • Yu J, Chang PK, Ehrlich KC, Cary JW, Bhatnagar D, Cleveland TE, Payne GA, Linz JE, Woloshuk CP, Bennett JW. (2004). Clustered pathway genes in aflatoxin biosynthesis. Appl Environ Microbiol. 70: 1253–1262.
  • Yu J, Cleveland TE, Nierman WC, Bennett JW. (2005). Aspergillus flavus genomics: gateway to human and animal health, food safety, and crop resistance to diseases. Rev Iberoam Micol. 22: 194–202.
  • Zablotowicz RM, Abbas HK, Locke MA. (2007). Population ecology of Aspergillus flavus associated with Mississippi Delta soils. Food Addit Contam. 24: 1102–1108.

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