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Research Articles

Histopathological and biochemical alterations in non-diabetic and diabetic rats following acrylamide treatment

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Pages 277-284 | Received 09 Oct 2018, Accepted 04 Jan 2019, Published online: 22 Feb 2019

References

  • Al-Mosaibih, M.A., 2013. Effects of monosodium glutamate and acrylamide on the liver tissue of adult Wistar rats. Life science journal, 10 (2s), 35–42.
  • Al-Qahtani, F., et al., 2017. Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats. Cellular and molecular biology (biology), 63 (6), 1–6Q.
  • Al Deeb, S., et al., 2000. Attenuation of acrylamide-induced neurotoxicity in diabetic rats. Neurotoxicology and teratology, 22 (2), 247–253.
  • Anzenbacher, P., and Anzenbacherová, E., 2001. Cytochromes P450 and metabolism of xenobiotics. Cellular and molecular life sciences, 58 (5–6), 737–747.
  • Arınç, E., et al., 2005. Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver. Archives of toxicology, 79 (8), 427–433.
  • Arinç, E., et al., 2007. Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung. Food and chemical toxicology: an international journal published for the British industrial biological research association, 45 (1), 107–118.
  • Barber, D.S., et al., 2001. Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing. Neurotoxicology, 22 (3), 341–353.
  • Beland, F.A., et al., 2013. Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 51, 149–159.
  • Beland, F.A., et al., 2015. Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure. Food and chemical toxicology, 86, 104–115.
  • Besaratinia, A., and Pfeifer, G.P., 2004. Genotoxicity of acrylamide and glycidamide. Journal of the National Cancer Institute, 96 (13), 1023–1029.
  • Bowyer, J.F., et al., 2008. The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats. Toxicology and applied pharmacology, 230 (2), 208–215.
  • Calleman, C.J., et al., 1994. Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. Toxicology and applied pharmacology, 126 (2), 361–371.
  • Camacho, L., et al., 2012. Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats. Toxicology Letters, 211 (2), 135–143.
  • Costa, L.G., et al., 1995. Evaluation of the neurotoxicity of glycidamide, an epoxide metabolite of acrylamide: behavioral, neurochemical and morphological studies. Toxicology, 98 (1–3), 151–161.
  • Dearfield, K.L., et al., 1988. Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity. Mutation research/reviews in genetic toxicology, 195 (1), 45–77.
  • Demirci, B., et al., 2014. Protective effect of vitamin B5 (dexpanthenol) on cardiovascular damage induced by streptozocin in rats. Bratislava medical journal, 115 (04), 190–196.
  • Dostalek, M., et al., 2012. Effect of diabetes mellitus on pharmacokinetic and pharmacodynamic properties of drugs. Clinical pharmacokinetics, 51 (8), 481–499.
  • Eman, M., and Amany, Y., 2008. Some studies on acrylamide intoxication in male albino rats. Egyptian journal of comparative pathology and clinical pathology, 21 (4), 222–245.
  • Erdemli, M.E., et al., 2017. The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats. Journal of Turgut Ozal Medical Center, 24 (1), 1–53.
  • Favreau, L.V., and Schenkman, J.B., 1988. Composition changes in hepatic microsomal cytochrome P-450 during onset of streptozocin-induced diabetes and during insulin treatment. Diabetes, 37 (5), 577–584.
  • Friedman, M., 2015. Acrylamide: inhibition of formation in processed food and mitigation of toxicity in cells, animals, and humans. Food & function, 6 (6), 1752–1772.
  • Gedik, S., et al., 2017. Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats. Biomedicine & pharmacotherapy, 95, 764–770.
  • Ghanayem, B., et al., 2005. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect. Mutation research/fundamental and molecular mechanisms of mutagenesis, 578 (1–2), 284–297.
  • Ghorbel, I., et al., 2017. Olive oil abrogates acrylamide induced nephrotoxicity by modulating biochemical and histological changes in rats. Renal failure, 39 (1), 236–245.
  • Guengerich, F.P., 2002. Update information on human P450s. Drug metabolism reviews, 34 (1–2), 7–15.
  • Hagmar, L., et al., 2001. Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose. Scandinavian journal of work, environment & health, 27 (4), 219–226.
  • Horibata, K., et al., 2016. Evaluation of mutagenicity of acrylamide using RBC Pig-a and PIGRET assays by single peroral dose in rats. Mutation research/genetic toxicology and environmental mutagenesis, 811, 54–59.
  • Islam, M.S., and Wilson, R.D., 2012. Experimentally induced rodent models of type 2 diabetes. Animal models in diabetes research, 933, 161–174.
  • Jayachandran, M., et al., 2018. Guava leaf extract diminishes hyperglycemia and oxidative stress, prevents β-cell death, inhibits inflammation, and regulates NF-kB signaling pathway in STZ induced diabetic rats. BioMed research international, 2018, 1.
  • Kim, Y.C., et al., 2005. Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1, 3-dimethyluric acid formation. European journal of pharmaceutical sciences, 26 (1), 114–123.
  • King, A.J., 2012. The use of animal models in diabetes research. British journal of pharmacology, 166 (3), 877–894.
  • Krishnakumari, S., et al., 2011. Ameliorative potential of Coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats. Ancient science of life, 31 (1), 26–30.
  • Lehning, E.J., et al., 2002. Acrylamide neuropathy. I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum. Neurotoxicology, 23 (3), 397–414.
  • Leinster, S., 2017. Peer review report 2 on “Prognostic value of alkaline phosphatase, gamma-glutamyl transpeptidase and lactate dehydrogenase in hepatocellular carcinoma patients treated with liver resection. International journal of surgery, 37 (1), 24.
  • Li, D., et al., 2016. Metabolism of acrylamide: interindividual and interspecies differences as well as the application as biomarkers. Current drug metabolism, 17 (4), 317–326.
  • Lineback, D.R., et al., 2012. Acrylamide in foods: a review of the science and future considerations. Annual review of food science and technology, 3, 15–35.
  • Mehri, S., et al., 2015. Crocin reduced acrylamide-induced neurotoxicity in Wistar rat through inhibition of oxidative stress. Iranian journal of basic medical sciences, 18 (9), 902–908.
  • Mehri, S., et al., 2014. Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats. Iranian journal of basic medical sciences, 17 (12), 1007–1011.
  • Mei, N., et al., 2010. The genotoxicity of acrylamide and glycidamide in big blue rats. Toxicological sciences: an official journal of the society of toxicology, 115 (2), 412–421.
  • Pedreschi, F., et al., 2014. Current issues in dietary acrylamide: formation, mitigation and risk assessment. Journal of the science of food and agriculture, 94 (1), 9–20.
  • Ragbetli, C., and Ceylan, E., 2010. Effect of streptozotocin on biochemical parameters in rats. Asian journal of chemistry, 22 (3), 2375–2378.
  • Rajeh, N.A., and Al-Dhaheri, N.M., 2017. Antioxidant effect of vitamin E and 5-aminosalicylic acid on acrylamide induced kidney injury in rats. Saudi medical journal, 38 (2), 132–137.
  • Raza, H., et al., 2004. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats. Diabetes, 53 (1), 185–194.
  • Rosén, J., and Hellenäs, K.-E., 2002. Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry. Analyst, 127 (7), 880–882.
  • Sakuma, T., et al., 2001. Different expression of hepatic and renal cytochrome P450s between the streptozotocininduced diabetic mouse and rat. Xenobiotica, 31 (4), 223–237.
  • Shimojo, N., et al., 1993. Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes. Biochemical pharmacology, 46 (4), 621–627.
  • Sotaniemi, E.A., et al., 2002. Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement. Pharmacology and toxicology, 90 (3), 155–160.
  • Taeymans, D., et al., 2004. A review of acrylamide: an industry perspective on research, analysis, formation, and control. Critical reviews in food science and nutrition, 44 (5), 323–347.
  • Tareke, E., et al., 2002. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. Journal of agricultural and food chemistry, 50 (17), 4998–5006.
  • Wang, T., et al., 2000. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. Journal of pharmacology and experimental therapeutics, 294, 2. 473–479.
  • Wang, Z., et al., 2003. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. British journal of clinical pharmacology, 55 (1), 77–85.
  • Wild, S., et al., 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care, 27 (5), 1047–1053.
  • Zanger, U.M., and Schwab, M., 2013. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & therapeutics, 138 (1), 103–141.

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