Low toxicity in hematological and biomedical parameters caused by bupernorphine in lactating female rats and their newborns

References

• Asadikaram, G., et al., 2013. Hematological changes in opium addicted diabetic rats. International journal of high risk behaviors and addiction, 1(4), 141.
   PubMedGoogle Scholar
• Baar, A., and Graaff, B.M.T., 2008. Cognitive development at preschool-age of infants of drug-dependent mothers. Developmental medicine and child neurology, 36(12), 1063–1075.
   Google Scholar
• Bayani, M., et al., 2014. Opium consumption and lipid and glucose parameters in diabetic patients with acute coronary syndrome; a survey in northern Iran. Tunis medicale, 92, 496–500.
   Google Scholar
• Behzadi, M., Joukar, S., and Beik, A., 2018. Opioids and cardiac arrhythmia: a literature review. Medical principles and practice, 27(5), 401.
   PubMed Web of Science ®Google Scholar
• Brown, J.N., et al., 2012. Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels. Molecular and cellular proteomics, 11(9), 605–618.
   PubMed Web of Science ®Google Scholar
• Brown, S.M., et al., 2011. Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology, 115(6), 1251–1260.
   PubMed Web of Science ®Google Scholar
• Burstein, Y., et al., 1979. Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. The journal of pediatrics, 94(6), 895–899.
   PubMed Web of Science ®Google Scholar
• Burstein, Y., et al., 1980. Thrombocytosis in the offspring of female mice receiving DL-methadone. Proceedings of the society for experimental biology and medicine. society for experimental biology and medicine (New York, N.Y.), 164(3), 275–279.
   PubMed Web of Science ®Google Scholar
• Chum, H.H., et al., 2014. Antinociceptive effects of sustained-release buprenorphine in a model of incisional pain in rats (Rattus norvegicus). Journal of the American association for laboratory animal science, 53(2), 193–197.
   PubMed Web of Science ®Google Scholar
• Coe, M.A., Lofwall, M.R., and Walsh, S.L., 2019. Buprenorphine pharmacology review: update on transmucosal and long-acting formulations. Journal of addiction medicine, 13(2), 93–103.
   PubMed Web of Science ®Google Scholar
• Coyle, M.G., et al., 2018. Neonatal abstinence syndrome. Nature reviews disease primers, 4(1), 47.
   PubMedGoogle Scholar
• Curtin, L.I., et al., 2009. Evaluation of buprenorphine in a postoperative pain model in rats. Comparative medicine, 59(1), 60–71.
   PubMed Web of Science ®Google Scholar
• Domeneh, B.H., Tavakoli, N., and Jafari, N., 2014. Blood lead level in opium dependents and its association with anemia: a cross-sectional study from the capital of Iran. Journal of research in medical sciences: the official journal of Isfahan university of medical sciences, 19(10), 939.
   PubMed Web of Science ®Google Scholar
• Fischer, G., Johnson, R.E., and Eder, H., 2000. Treatment of opioid-dependent pregnant women with buprenorphine. Addiction, 95(2), 239–244.
   PubMed Web of Science ®Google Scholar
• Geraghty, B., et al., 1997. Methadone levels in breast milk. Journal of human lactation, 13(3), 227–230.
   PubMedGoogle Scholar
• Gill, A.C., et al., 2007. Strabismus in infants of opiate‐dependent mothers. Acta paediatrica, 92(3), 379–385.
   Google Scholar
• Gopal, S., Tzeng, T.B., and Cowan, A., 2002. Characterization of the pharmacokinetics of buprenorphine and norbuprenorphine in rats after intravenous bolus administration of buprenorphine. European journal of pharmaceutical sciences, 15(3), 287–293.
   PubMed Web of Science ®Google Scholar
• Gozashti, M.H., et al., 2015. Fasting blood glucose and insulin level in opium addict versus non-addict individuals. Addiction and health, 7(1-2), 54.
   PubMedGoogle Scholar
• Griffin, B.A., et al., 2019. In utero exposure to norbuprenorphine, a major metabolite of buprenorphine, induces fetal opioid dependence and leads to neonatal opioid withdrawal syndrome. Journal of pharmacology and experimental therapeutics, 370(1), 9–17.
   PubMed Web of Science ®Google Scholar
• Guarnieri, M., et al., 2012. Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats. Lab animal, 41(11), 337.
   PubMed Web of Science ®Google Scholar
• Guo, X., et al., 1994. Cognitive brain potential alterations in boys exposed to opiates: in utero and lifestyle comparisons. Addictive behaviors, 19(4), 429–441.
   PubMed Web of Science ®Google Scholar
• Gupta, M., et al., 2012. Nystagmus and reduced visual acuity secondary to drug exposure in utero: long-term follow-up. Journal of pediatric ophthalmology and strabismus, 49(1), 58–63.
   PubMed Web of Science ®Google Scholar
• Haghpanah, T., Afarinesh, M., and Divsalar, K., 2010. A review on hematological factors in opioid-dependent people (opium and heroin) after the withdrawal period. Addiction and health, 2(1–2), 9.
   PubMedGoogle Scholar
• Hish, J., et al., 2014. Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis. Journal of the American association for laboratory animal science, 53(5), 485–493.
   PubMed Web of Science ®Google Scholar
• Huang, P., et al., 2001. Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. Journal of pharmacology and experimental therapeutics, 297(2), 688–695.
   PubMed Web of Science ®Google Scholar
• Ilett, K.F., et al., 2012. Estimated dose exposure of the neonate to buprenorphine and its metabolite norbuprenorphine via breastmilk during maternal buprenorphine substitution treatment. Breastfeeding medicine, 7(4), 269–274.
   PubMed Web of Science ®Google Scholar
• Jansson, L.M., Velez, M., and Harrow, C., 2004. Methadone maintenance and lactation: a review of the literature and current management guidelines. Journal of human lactation, 20(1), 62–71.
   PubMed Web of Science ®Google Scholar
• Javadi, H.R., et al., 2014. Opium dependency and in-hospital outcome of acute myocardial infarction. Medical journal of the Islamic Republic of Iran, 28, 122.
   PubMedGoogle Scholar
• Johnson, R., Jones, H.E., and Fischer, G., 2003. Use of buprenorphine in pregnancy: patient management and effects on the neonate. Drug and alcohol dependence, 70(2), S87–S101.
   PubMedGoogle Scholar
• Johnson, R.E., et al., 2001. Buprenorphine treatment of pregnant opioid-dependent women: maternal and neonatal outcomes. Drug and alcohol dependence, 63(1), 97–103.
   PubMed Web of Science ®Google Scholar
• Kahila, H., et al., 2007. A prospective study on buprenorphine use during pregnancy: effects on maternal and neonatal outcome. Acta obstetricia et gynecologica Scandinavica, 86(2), 185–190.
   PubMed Web of Science ®Google Scholar
• Kaur, P., et al., 2016. A methadone user with anaemia, skeletal pain and altered appearance. Tidsskrift for den norske legeforening, 136(10), 925.
   PubMed Web of Science ®Google Scholar
• Kayemba-kays, S., and Laclyde, J.P., 2003. Buprenorphine withdrawal syndrome in newborns: a report of 13 cases. Addiction, 98(11), 1599–1604.
   PubMed Web of Science ®Google Scholar
• Krans, E.E., et al., 2016. Factors associated with buprenorphine versus methadone use in pregnancy. Substance abuse, 37(4), 550–557.
   PubMed Web of Science ®Google Scholar
• Liang, X., et al., 2016. Opioid system modulates the immune function: a review. Translational perioperative and pain medicine, 1(1), 5.
   PubMedGoogle Scholar
• Lindemalm, S., et al., 2009. Transfer of buprenorphine into breast milk and calculation of infant drug dose. Journal of human lactation, 25(2), 199–205.
   PubMed Web of Science ®Google Scholar
• Mahmoodi, M., et al., 2012. Opium withdrawal and some blood biochemical factors in addicts’ individuals. Advances in biological chemistry, 2(2), 167–170.
   Google Scholar
• Mami, S., et al., 2011. Effect of opium addiction on some serum parameters in rabbit. Global veterinaria, 7(3), 310–314.
   Google Scholar
• Marquet, P., et al., 1997. Buprenorphine withdrawal syndrome in a newborn. Clinical pharmacology and therapeutics, 62(5), 569–571.
   PubMed Web of Science ®Google Scholar
• Masoomi, M., Azdaki, N., and Shahouzehi, B., 2015. Elevated plasma homocysteine concentration in opium-addicted individuals. Addiction and health, 7(3-4), 149.
   PubMedGoogle Scholar
• McCarthy, J.J., and Posey, B.L., 2000. Methadone levels in human milk. Journal of human lactation, 16(2), 115–120.
   PubMedGoogle Scholar
• Messinger, D.S., et al., 2004. The maternal lifestyle study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of age. Pediatrics, 113(6), 1677–1685.
   PubMed Web of Science ®Google Scholar
• Mittal, L., 2014. Buprenorphine for the treatment of opioid dependence in pregnancy. The journal of perinatal and neonatal nursing, 28(3), 178–184.
   PubMed Web of Science ®Google Scholar
• Mohammadi, A., et al., 2009. Effect of opium addiction on lipid profile and atherosclerosis formation in hypercholesterolemic rabbits. Experimental and toxicologic pathology, 61(2), 145–149.
   PubMedGoogle Scholar
• Mohammadi, A., et al., 2012. Effect of opium on lipid profile and expression of liver X receptor alpha (LXRα) in normolipidemic mouse. Food and nutrition sciences, 3, 249–254.
   Google Scholar
• Najafipour, H., and Beik, A., 2016. The impact of opium consumption on blood glucose, serum lipids and blood pressure, and related mechanisms. Frontiers in physiology, 7, 436.
   PubMed Web of Science ®Google Scholar
• Najafipour, H., et al., 2010. Passive opium smoking does not have beneficial effect on plasma lipids and cardiovascular indices in hypercholesterolemic rabbits with ischemic and non-ischemic hearts. Journal of ethnopharmacology, 127(2), 257–263.
   PubMed Web of Science ®Google Scholar
• Noormohammadi, A., et al., 2016. Buprenorphine versus methadone for opioid dependence in pregnancy. Annals of pharmacotherapy, 50(8), 666–672.
   PubMed Web of Science ®Google Scholar
• O’Connor, A., et al., 2011. Observational study of buprenorphine treatment of opioid-dependent pregnant women in a family medicine residency: reports on maternal and infant outcomes. Journal of American board of family medicine, 24(2), 194–201.
   PubMed Web of Science ®Google Scholar
• Orum, M.H., et al., 2018. Complete blood count alterations due to the opioid use: what about the lymphocyte-related ratios, especially in monocyte to lymphocyte ratio and platelet to lymphocyte ratio? Journal of immunoassay and immunochemistry, 39(4), 365–376.
   PubMedGoogle Scholar
• Paul, J.A., et al., 2014. Development of auditory event‐related potentials in infants prenatally exposed to methadone. Developmental psychobiology, 56(5), 1119–1128.
   PubMed Web of Science ®Google Scholar
• Pritham, U.A., Troese, M., and Stetson, A., 2007. Methadone and buprenorphine treatment during pregnancy: what are the effects on infants? Nursing for women's health, 11(6), 558–567.
   PubMedGoogle Scholar
• Rahimi, N., et al., 2014. Potential effect of opium consumption on controlling diabetes and some cardiovascular risk factors in diabetic patients. Addiction and health, 6(1-2), 1.
   PubMedGoogle Scholar
• Rosen, S.F., et al., 2019. Increased pain sensitivity and decreased opioid analgesia in T-cell-deficient mice and implications for sex differences. Pain, 160(2), 358–366.
   PubMed Web of Science ®Google Scholar
• Sadeghian, S., et al., 2009. Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes. Endokrynologia polska, 60(4), 258–262.
   PubMed Web of Science ®Google Scholar
• Sanli, D.B., et al., 2015. Effect of different psychoactive substances on serum biochemical parameters. International journal of high risk behaviors and addiction, 4(2), e22702.
   PubMedGoogle Scholar
• Savov, Y., et al., 2006. Whole blood viscosity and erythrocyte hematometric indices in chronic heroin addicts. Clinical hemorheology and microcirculation, 35(1-2), 129–133.
   PubMed Web of Science ®Google Scholar
• Schindler, S.D., et al., 2003. Neonatal outcome following buprenorphine maintenance during conception and throughout pregnancy. Addiction, 98(1), 103–110.
   PubMed Web of Science ®Google Scholar
• Soykut, B., et al., 2013. Oxidative stress enzyme status and frequency of micronuclei in heroin addicts in Turkey. Toxicology mechanisms and methods, 23(9), 684–688.
   PubMed Web of Science ®Google Scholar
• Sun, J., Guo, W., and Du, X., 2017. Buprenorphine differentially affects M1-and M2-polarized macrophages from human umbilical cord blood. European cytokine network, 28(2), 85–92.
   PubMed Web of Science ®Google Scholar
• Tsai, L.C., and Doan, T.J., 2016. Breastfeeding among mothers on opioid maintenance treatment: a literature review. Journal of human lactation, 32(3), 521–529.
   PubMed Web of Science ®Google Scholar
• van Baar, A.L., et al., 1994. Development after prenatal exposure to cocaine, heroin and methadone. Acta paediatrica, 404, 40–46.
   Google Scholar
• Wakeman, S.E., et al., 2019. Impact of fentanyl use on buprenorphine treatment retention and opioid abstinence. Journal of addiction medicine, 13(4), 253–257.
   PubMed Web of Science ®Google Scholar
• White, A.J., et al., 2018. Peripheral inflammatory response to alpha-synuclein and endotoxin in Parkinson's disease. Frontiers in neurology, 9, 946.
   PubMed Web of Science ®Google Scholar
• Wiles, J.R., et al., 2014. Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure. The journal of pediatrics, 165(3), 440–446.
   PubMed Web of Science ®Google Scholar
• Yang, C., et al., 2017. Altered neuroendocrine immune responses, a two-sword weapon against traumatic inflammation. International journal of biological sciences, 13(11), 1409.
   PubMed Web of Science ®Google Scholar