5-Hydroxymethylfurfural (HMF) formation, occurrence and potential health concerns: recent developments

References

• Abdulmalik, O., et al., 2005. 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. British journal of haematology, 128 (4), 552–561.
   PubMed Web of Science ®Google Scholar
• Abraham, K., et al., 2011. Toxicology and risk assessment of 5‐Hydroxymethylfurfural in food. Molecular nutrition & food research, 55 (5), 667–678.
   PubMed Web of Science ®Google Scholar
• Agila, A., and Barringer, S., 2012. Effect of roasting conditions on color and volatile profile including HMF level in sweet almonds (Prunus dulcis). Journal of food science, 77 (4), C461–C468.
   PubMed Web of Science ®Google Scholar
• Akıllıoglu, H.G., Mogol, B.A., and Gökmen, V., 2011. Degradation of 5-hydroxymethylfurfural during yeast fermentation. Food additives & contaminants: part A, 28 (12), 1–1635.
   Google Scholar
• Akpınar, K., et al., 2011. Determination of HMF in roasted flour/oil mixtures and effect of solvent used in the extraction procedure. Food chemistry, 128 (3), 790–794.
   Web of Science ®Google Scholar
• Al-Diab, D., and Jarkas, B., 2015. Effect of storage and thermal treatment on the quality of some local brands of honey from Latakia markets. Journal of entomology and zoology studies, 3 (3), 328–334.
   Google Scholar
• Alizadeh, M., et al., 2017. Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin. Journal of the science of food and agriculture, 97 (12), 3979–3984.
   PubMed Web of Science ®Google Scholar
• Ameur, L.A., et al., 2007. Comparison of the effects of sucrose and hexose on furfural formation and browning in cookies baked at different temperatures. Food chemistry, 101 (4), 1407–1416.
   Web of Science ®Google Scholar
• Anese, M., and Suman, M., 2013. Mitigation strategies of furan and 5-hydroxymethylfurfural in food. Food research international, 51 (1), 257–264.
   Web of Science ®Google Scholar
• Aslanova, D., Bakkalbasi, E., and Artik, N., 2010. Effect of storage on 5-hydroxymethylfurfural (HMF) formation and color change in jams. International journal of food properties, 13 (4), 904–912.
   Web of Science ®Google Scholar
• Baggiolini, M., and Clark-Lewis, I., 1992. Interleukin‐8, a chemotactic and inflammatory cytokine. FEBS letters, 307 (1), 97–101.
   PubMed Web of Science ®Google Scholar
• Balkwill, F., and Mantovani, A., 2001. Inflammation and cancer: back to Virchow? The lancet, 357 (9255), 539–545.
   PubMed Web of Science ®Google Scholar
• Bauer-Marinovic, M., et al., 2012. Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2. Archives of toxicology, 86 (5), 701–711.
   PubMed Web of Science ®Google Scholar
• Burdurlu, H.S., Koca, N., and Karadeniz, F., 2006. Degradation of vitamin C in citrus juice concentrates during storage. Journal of food engineering, 74 (2), 211–216.
   Web of Science ®Google Scholar
• Burdurlu, H.S, and Karadeniz, F., 2003. Effect of storage on nonenzymatic browning of apple juice concentrates. Food chemistry, 80 (1), 91–97.
   Web of Science ®Google Scholar
• Câmara, J.D.S., Alves, M.A., and Marques, J.C., 2006. Changes in volatile composition of Madeira wines during their oxidative ageing. Analytica chimica acta, 563 (1-2), 188–197.
   Web of Science ®Google Scholar
• Cao, G., et al., 2013. Effect of 5-hydroxymethylfurfural derived from processed Cornus officinalis on the prevention of high glucose-induced oxidative stress in human umbilical vein endothelial cells and its mechanism. Food chemistry, 140 (1-2), 273–279.
   PubMed Web of Science ®Google Scholar
• Capuano, E., and Fogliano, V., 2011. Acrylamide and 5-hydroxymethylfurfural (HMF): A review on metabolism, toxicity, occurrence in food and mitigation strategies. Lwt - food science and technology, 44 (4), 793–810.
   Web of Science ®Google Scholar
• Chihara, T., et al., 2013. The effect of preparatory conditions of high temperature-and pressure-treated garlic on 5-hydroxymethyl-2-furfural and S-allylcysteine formation. International journal of analytical bio-science, 36 (2), 186–192.
   Google Scholar
• Danowska-Oziewicz, M., et al., 2007. The effect of cooking in a steam‐convection oven on the quality of selected dishes. Journal of foodservice, 18 (5), 187–197.
   Google Scholar
• Delgado-Andrade, C., et al., 2010. Development of the Maillard reaction in foods cooked by different techniques. Intake of Maillard-derived compounds. Food chemistry, 122 (1), 145–153.
   Web of Science ®Google Scholar
• Ding, X., et al., 2010. Protective effect of 5-hydroxymethylfurfural derived from processed Fructus Corni on human hepatocyte LO2 injured by hydrogen peroxide and its mechanism. Journal of ethnopharmacology, 128 (2), 373–376.
   PubMed Web of Science ®Google Scholar
• Du, Y., et al., 2005. U.S. Patent Application No. 10/930, 887.
   Google Scholar
• Ertekin Filiz, B., and Seydim, A.C., 2018. Kinetic changes of antioxidant parameters, ascorbic acid loss, and hydroxymethyl furfural formation during apple chips production. Journal of food biochemistry, 42 (6), e12676.
   Web of Science ®Google Scholar
• Fallico, B., Arena, E., and Zappalà, M., 2003. Roasting of hazelnuts. Role of oil in colour development and hydroxymethylfurfural formation. Food chemistry, 81 (4), 569–573.
   Web of Science ®Google Scholar
• Fromowitz, M., et al., 2012. Bone marrow genotoxicity of 2, 5‐dimethylfuran, a green biofuel candidate. Environmental and molecular mutagenesis, 53 (6), 488–491.
   PubMed Web of Science ®Google Scholar
• Galli, S.J., Tsai, M., and Piliponsky, A.M., 2008. The development of allergic inflammation. Nature, 454 (7203), 445–454.
   PubMed Web of Science ®Google Scholar
• Gao, H.-F., Wen, X.-S., and Xian, C.J., 2015. Hydroxymethyl furfural in chinese herbal medicines: Its formation, presence, metabolism, bioactivities and implications. African journal of traditional, complementary and alternative medicines, 12 (2), 43–54.
   Google Scholar
• Gao, K., et al., 2017. Evaluation of browning ratio in an image analysis of apple slices at different stages of instant controlled pressure drop‐assisted hot‐air drying (AD‐DIC.). Journal of the science of food and agriculture, 97 (8), 2533–2540.
   PubMed Web of Science ®Google Scholar
• Glatt, H., Schneider, H., and Liu, Y., 2005. V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutation research/genetic toxicology and environmental mutagenesis, 580 (1-2), 41–52.
   PubMed Web of Science ®Google Scholar
• Gökmen, V., et al., 2007. Effects of dough formula and baking conditions on acrylamide and hydroxymethylfurfural formation in cookies. Food chemistry, 104 (3), 1136–1142.
   Web of Science ®Google Scholar
• Goldberg, M.A., et al., 1992. Hydroxyurea and erythropoietin therapy in sickle cell anemia. Seminars in oncology, 19 (3), 74–83.
   PubMed Web of Science ®Google Scholar
• Guerra‐Hernandez, E., et al., 2002. Effect of storage on non‐enzymatic browning of liquid infant milk formulae. Journal of the science of food and agriculture, 82 (5), 587–592.
   Web of Science ®Google Scholar
• Helou, C., et al., 2016. The impact of raw materials and baking conditions on Maillard reaction products, thiamine, folate, phytic acid and minerals in white bread. Food & function, 7 (6), 2498–2507.
   PubMed Web of Science ®Google Scholar
• Helyes, L., Pék, Z., and Lugasi, A., 2006. Tomato fruit quality and content depend on stage of maturity. HortScience, 41 (6), 1400–1401.
   Web of Science ®Google Scholar
• HÖie, A.H., et al., 2015. Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environmental and molecular mutagenesis, 56 (8), 709–714.
   PubMed Web of Science ®Google Scholar
• Husøy, T., et al., 2008. Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure. Food and chemical toxicology, 46 (12), 3697–3702.
   PubMed Web of Science ®Google Scholar
• Iijima, M., et al., 2018. Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor-1α. International journal of oncology, 52 (3), 679–686.
   PubMed Web of Science ®Google Scholar
• Janzowski, C., et al., 2000. 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food and chemical toxicology, 38 (9), 801–809.
   PubMed Web of Science ®Google Scholar
• Jorge, A., et al., 2018. Changes in the composition of tomato powder (Lycopersicon esculentum Mill) resulting from different drying methods. Journal of food processing and preservation, 42 (5), e13595.
   Web of Science ®Google Scholar
• Karabournioti, S., and Zervalaki, P., 2001. The effect of heating on honey HMF and invertase. Apiacta, 36 (4), 177–181.
   Google Scholar
• Kim, Y., et al., 2008. Hyaluronic acid targets CD44 and inhibits FcɛRI signaling involving PKCδ, Rac1, ROS, and MAPK to exert anti-allergic effect. Molecular immunology, 45 (9), 2537–2547.
   PubMed Web of Science ®Google Scholar
• Kitts, D.D., Chen, X.M., and Jing, H., 2012. Demonstration of antioxidant and anti-inflammatory bioactivities from sugar–amino acid Maillard reaction products. Journal of agricultural and food chemistry, 60 (27), 6718–6727.
   PubMed Web of Science ®Google Scholar
• Kowalski, S., et al., 2013. 5-Hydroxymethyl-2-Furfural (HMF)–Heat-induced formation, occurrence in food and biotransformation–a Review. Polish journal of food and nutrition sciences, 63 (4), 207–225.
   Web of Science ®Google Scholar
• Kröncke, K.D., Fehsel, K., and Kolb-Bachofen, V., 1998. Inducible nitric oxide synthase in human diseases. Clinical & experimental immunology, 113 (2), 147.
   PubMed Web of Science ®Google Scholar
• Kus, S., Gogus, F., and Eren, S., 2005. Hydroxymethyl furfural content of concentrated food products. International journal of food properties, 8 (2), 367–375.
   Web of Science ®Google Scholar
• Kuster, B.F.M., 1990. 5‐Hydroxymethylfurfural (HMF). A review focussing on its manufacture. Starch - Stärke, 42 (8), 314–321.
   Web of Science ®Google Scholar
• Lachenmeier, D.W., et al., 2018. Potential Antagonistic Effects of Acrylamide Mitigation during Coffee Roasting on Furfuryl Alcohol and 5-Hydroxymethylfurfural. Toxics, 7 (1), 1.
   Web of Science ®Google Scholar
• Lee, C.H., et al., 2019. Recent advances in processing technology to reduce 5-hydroxymethylfurfural in foods. Trends in food science & technology, 93, 271–280.
   Web of Science ®Google Scholar
• Li, Y.X., et al., 2009. In vitro antioxidant activity of 5-HMF isolated from marine red alga Laurencia undulata in free-radical-mediated oxidative systems. Journal of microbiology and biotechnology, 19 (11), 1319–1327.
   PubMed Web of Science ®Google Scholar
• Li, Z., et al., 2019. Formation of 5-hydroxymethylfurfural in industrial-scale apple juice concentrate processing. Food control, 102, 56–68.
   Web of Science ®Google Scholar
• Lin, S.M., et al., 2012. Identification and mode of action of 5-hydroxymethyl-2-furfural (5-HMF) and 1-methyl-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) as potent xanthine oxidase inhibitors in vinegars. Journal of agricultural and food chemistry, 60 (39), 9856–9862.
   PubMed Web of Science ®Google Scholar
• Liu, D.L., et al., 2011. A new triterpenoid saponin from the roots of Ardisia crenata. Chinese chemical letters, 22 (8), 957–960.
   Web of Science ®Google Scholar
• Markowicz, D.B., et al., 2012. Maillard reaction products in processed foods: pros and cons. In: Valdez B, editor. Food industrial processes-methods and equipment. Intech Open; p. 281–300.
   Google Scholar
• Matsuda, K.I., et al., 2006. Epitaxial growth of Co2Cr0. 6Fe0. 4Al Heusler alloy thin films on MgO (0 0 1) substrates by magnetron sputtering. Journal of crystal growth, 286 (2), 389–393.
   Web of Science ®Google Scholar
• Michail, K., et al., 2007. Hydroxymethylfurfural: an enemy or a friendly xenobiotic? A bioanalytical approach. Analytical and bioanalytical chemistry, 387 (8), 2801–2814.
   PubMed Web of Science ®Google Scholar
• Michalak, J., et al., 2016. Effect of storage on acrylamide and 5-hydroxymethylfurfural contents in selected processed plant products with long shelf-life. Plant foods for human nutrition, 71 (1), 115–122.
   PubMed Web of Science ®Google Scholar
• Michalska, A., et al., 2018. Drying-induced physico-chemical changes in cranberry products. Food chemistry, 240, 448–455.
   PubMed Web of Science ®Google Scholar
• Michalska, A., et al., 2016. Physicochemical properties of whole fruit plum powders obtained using different drying technologies. Food chemistry, 207, 223–232.
   PubMed Web of Science ®Google Scholar
• Mikulec, A., Kowalski, S., and Lukasiewicz, M., 2018. The impact of postponed bread baking technology on the quality properties of Kaiser rolls and in vitro starch digestibility. Journal of food process engineering, 41 (1), e12628.
   Web of Science ®Google Scholar
• Miyazawa, M., et al., 2003. Insecticidal compounds against Drosophila melanogaster from Cornus officinalis Sieb. et Zucc. Natural product research, 17 (5), 337–339.
   PubMed Web of Science ®Google Scholar
• Monien, B.H., et al., 2012. Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed. Chemical research in toxicology, 25 (7), 1484–1492.
   PubMed Web of Science ®Google Scholar
• Morales, F.J., and Jiménez-Pérez, S., 2001. Hydroxymethylfurfural determination in infant milk-based formulas by micellar electrokinetic capillary chromatography. Food chemistry, 72 (4), 525–531.
   Web of Science ®Google Scholar
• Morales, F.J., et al., 2007. Degradation of free tryptophan in a cookie model system and its application in commerical samples. Journal of agricultural and food chemistry, 55 (16), 6793–6797.
   PubMed Web of Science ®Google Scholar
• Moßhammer, M.R., Stintzing, F.C., and Carle, R., 2006. Evaluation of different methods for the production of juice concentrates and fruit powders from cactus pear. Innovative food science & emerging technologies, 7 (4), 275–287.
   Web of Science ®Google Scholar
• Mouhoubi-Tafinine, Z., et al., 2018. Effect of storage on hydroxymethylfurfural (HMF) and color of some Algerian honey. International food research journal, 25 (3).
   Web of Science ®Google Scholar
• Murkovic, M., and Pichler, N., 2006. Analysis of 5‐hydroxymethylfurfual in coffee, dried fruits and urine. Molecular nutrition & food research, 50 (9), 842–846.
   PubMed Web of Science ®Google Scholar
• Nebesny, E., and Budryn, G., 2003. Antioxidative activity of green and roasted coffee beans as influenced by convection and microwave roasting methods and content of certain compounds. European food research and technology, 217 (2), 157–163.
   Web of Science ®Google Scholar
• Nguyen, H.T., van der Fels-Klerx, H.J.(I.)., and van Boekel, M.A.J.S., 2017. Acrylamide and 5-hydroxymethylfurfural formation during biscuit baking. Part II: Effect of the ratio of reducing sugars and asparagine. Food chemistry, 230, 14–23.
   PubMed Web of Science ®Google Scholar
• Nguyen, H.T., et al., 2016. Acrylamide and 5-hydroxymethylfurfural formation during baking of biscuits: Part I: Effects of sugar type. Food chemistry, 192, 575–585.
   PubMed Web of Science ®Google Scholar
• Oliviero, T., et al., 2009. Influence of roasting on the antioxidant activity and HMF formation of a cocoa bean model systems. Journal of agricultural and food chemistry, 57 (1), 147–152.
   PubMed Web of Science ®Google Scholar
• Oral, R.A., et al., 2012. 5-hydroxymethyl furfural formation and reaction kinetics of different pekmez samples: effect of temperature and storage. Journal of food engineering, 8 (4).
   Web of Science ®Google Scholar
• Pastoriza de la Cueva, S., et al., 2017. Relationship between HMF intake and SMF formation in vivo: An animal and human study. Molecular nutrition & food research, 61 (3), 1600773.
   Web of Science ®Google Scholar
• Pattinson, K.T., et al., 2005. Acute mountain sickness, vitamin C, free radicals, and HIF-1α. Wilderness & environmental medicine, 16 (3), 172–175.
   PubMed Web of Science ®Google Scholar
• Paulsen, J.E., et al., 2005. Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat. Cancer research, 65 (1), 121–129.
   PubMed Web of Science ®Google Scholar
• Petisca, C., et al., 2013. Study of hydroxymethylfurfural and furfural formation in cakes during baking in different ovens, using a validated multiple-stage extraction-based analytical method. Food chemistry, 141 (4), 3349–3356.
   PubMed Web of Science ®Google Scholar
• Rada-Mendoza, M., et al., 2004. Formation of hydroxymethylfurfural and furosine during the storage of jams and fruit-based infant foods. Food chemistry, 85 (4), 605–609.
   Web of Science ®Google Scholar
• Rahimzadeh, N., Alizadeh, M., and Ghaemmaghami Hezaveh, S.J., 2018. Estimated bioaccessibility to 5-hydroxymethylfurfural from frequently consumed dried fruits in Iran. Journal of chemical health risks, 4 (3).
   Google Scholar
• Rivero-Cruz, J.F., et al., 2008. Antimicrobial constituents of Thompson seedless raisins (Vitis vinifera) against selected oral pathogens. Phytochemistry letters, 1 (3), 151–154.
   Web of Science ®Google Scholar
• Rosatella, A.A., et al., 2011. 5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications. Green chemistry, 13 (4), 754–793.
   Web of Science ®Google Scholar
• Rufian-Henares, J.A., and De la Cueva, S.P., 2008. Assessment of hydroxymethylfurfural intake in the Spanish diet. Food additives & contaminants: part a, 25 (11), 1306–1312.
   Web of Science ®Google Scholar
• Sabater, C., et al., 2018. Furosine and HMF determination in prebiotic-supplemented infant formula from Spanish market. Journal of food composition and analysis, 66, 65–73.
   Web of Science ®Google Scholar
• Sachse, B., et al., 2016. Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study. Archives of toxicology, 90 (1), 137–148.
   PubMed Web of Science ®Google Scholar
• Severin, I., et al., 2010. Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays. Toxicology letters, 192 (2), 189–194.
   PubMed Web of Science ®Google Scholar
• Shapla, U.M., et al., 2018. 5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health. Chemistry central journal, 12 (1), 35.
   PubMedGoogle Scholar
• Sharma, V.K., et al., 2004. In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata. Phytotherapy research, 18 (10), 841–844.
   PubMed Web of Science ®Google Scholar
• Sies, H., 2015. Oxidative stress: a concept in redox biology and medicine. Redox biology, 4, 180–183.
   PubMed Web of Science ®Google Scholar
• Smith, R.M., 1981. Determination of 5-hydroxymethylfurfural and caffeine in coffee and chicory extracts by high performance liquid chromatography. Food chemistry, 7 (1), 41–45.
   Web of Science ®Google Scholar
• Sung, H.K., et al., 2013. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell metabolism, 17 (1), 61–72.
   PubMed Web of Science ®Google Scholar
• Surh, Y.J., et al., 1994. 5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural. Carcinogenesis, 15 (10), 2375–2377.
   PubMed Web of Science ®Google Scholar
• Svendsen, C., et al., 2009. 5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice. Anticancer research, 29 (6), 1921–1926.
   PubMed Web of Science ®Google Scholar
• Tas, N.G., and Gokmen, V., 2017. Maillard reaction and caramelization during hazelnut roasting: A multiresponse kinetic study. Food chemistry, 221, 1911–1922.
   PubMed Web of Science ®Google Scholar
• Tontul, I., and Topuz, A., 2017. Effects of different drying methods on the physicochemical properties of pomegranate leather (pestil). LWT, 80, 294–303.
   Web of Science ®Google Scholar
• Tosi, E., et al., 2002. Honey thermal treatment effects on hydroxymethylfurfural content. Food chemistry, 77 (1), 71–74.
   Web of Science ®Google Scholar
• Ulbricht, R.J., Northup, S.J., and Thomas, J.A., 1984. A review of 5-hydroxymethylfurfural (HMF) in parenteral solutions. Toxicological sciences, 4 (5), 843–853.
   Google Scholar
• Van Der Fels-Klerx, H.J., et al., 2014. Acrylamide and 5-hydroxymethylfurfural formation during baking of biscuits: NaCl and temperature–time profile effects and kinetics. Food research international, 57, 210–217.
   Web of Science ®Google Scholar
• Vardin, H., and Yilmaz, F.M., 2017. The effect of blanching pretreatment on the drying kinetics, thermal degradation of phenolic compounds and hydroxymethyl furfural formation in pomegranate arils. Italian journal of food science, 30 (1), 156.
   Web of Science ®Google Scholar
• Viegas, O., et al., 2018. Parameters affecting 5-hydroxymethylfurfural exposure from beer. Food additives & contaminants: part A, 35 (8), 1464–1471.
   PubMed Web of Science ®Google Scholar
• Vignoli, J.A., et al., 2014. Roasting process affects differently the bioactive compounds and the antioxidant activity of arabica and robusta coffees. Food research international, 61, 279–285.
   Web of Science ®Google Scholar
• Vorbach, C., Harrison, R., and Capecchi, M.R., 2003. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends in immunology, 24 (9), 512–517.
   PubMed Web of Science ®Google Scholar
• Wang, S., et al., 2012. Mechanism research on cellulose pyrolysis by Py-GC/MS and subsequent density functional theory studies. Bioresource technology, 104, 722–728.
   PubMed Web of Science ®Google Scholar
• Wang, Z., et al., 2010. Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. American journal of physiology-gastrointestinal and liver physiology, 298 (5), G634–G642.
   PubMed Web of Science ®Google Scholar
• Wilhelm, I., Fazakas, C., and Krizbai, I.A., 2011. In vitro models of the blood-brain barrier. Acta neurobiologiae experimentalis, 71 (1), 113–128.
   PubMed Web of Science ®Google Scholar
• Wu, L.X., et al., 2011. Protective effects of novel single compound, Hirsutine on hypoxic neonatal rat cardiomyocytes. European journal of pharmacology, 650 (1), 290–297.
   PubMed Web of Science ®Google Scholar
• Ya, B., et al., 2012. 5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain ischemia. Neural regeneration research, 7 (22), 1722.
   PubMed Web of Science ®Google Scholar
• Yamada, P., et al., 2011. Isolation of 5-(hydroxymethyl) furfural from Lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells. Planta medica, 77 (05), 434–440.
   PubMed Web of Science ®Google Scholar
• Youn, U.J., et al., 2018. Variation of main components according to the number of steaming and drying of Rehmanniae radix preparata. Journal of pharmacopuncture, 21 (2), 112–119.
   PubMed Web of Science ®Google Scholar
• Yuan, J.P., and Chen, F., 1998. Separation and identification of furanic compounds in fruit juices and drinks by high-performance liquid chromatography photodiode array detection. Journal of agricultural and food chemistry, 46 (4), 1286–1291.
   Web of Science ®Google Scholar
• Zappala, M., et al., 2005. Methods for the determination of HMF in honey: a comparison. Food control., 16 (3), 273–277.
   Web of Science ®Google Scholar
• Zhang, X.M., et al., 1993. Initiation and promotion of colonic aberrant crypt foci in rats by 5-hydroxymethy1-2-furaldehyde in thermolyzed sucrose. Carcinogenesis, 14 (4), 773–775.
   PubMed Web of Science ®Google Scholar
• Zhang, Y.Y., et al., 2012. Effects of sugars in batter formula and baking conditions on 5-hydroxymethylfurfural and furfural formation in sponge cake models. Food research international, 49 (1), 439–445.
   Web of Science ®Google Scholar
• Zhang, Z., Li, J., and Fan, L., 2019. Evaluation of the composition of Chinese bayberry wine and its effects on the color changes during storage. Food chemistry, 276, 451–457.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., et al., 2016. Chlorogenic acid increased 5-hydroxymethylfurfural formation when heating fructose alone or with aspartic acid at two pH levels. Food chemistry, 190, 832–835.
   PubMed Web of Science ®Google Scholar