Chicken egg yolk antibodies (IgY)-based antivenom for neutralization of snake venoms: a review

References

• Aguilar, I., et al., 2014. Coral snake antivenom produced in chickens (Gallus domesticus)). Revista Do Instituto de Medicina Tropical de Sao Paulo, 56 (1), 61–66.
   PubMed Web of Science ®Google Scholar
• Akita, E.M. and Nakai, S., 1993. Production and purification of Fab′ fragments from chicken egg yolk immunoglobulin Y (IgY). Journal of immunological methods, 162 (2), 155–164.
   PubMed Web of Science ®Google Scholar
• Almeida, C.M.C., et al., 1998. Development of snake antivenom antibodies in chickens and their purification from yolk. The veterinary record, 143 (21), 579–584.
   PubMed Web of Science ®Google Scholar
• Alvarez, A., et al., 2013. Poultry IgY alternatives to Antivenom production. Toxinology, 4, 1–16. doi 10.1007/978-94-007-6647-1_1-1.
   Google Scholar
• Arap, M.A., 2005. Phage display technology – applications and innovations. Genetics and molecular biology, 28 (1), 1–9.
   Web of Science ®Google Scholar
• Araújo, A.S., et al., 2010. Brazilian IgY-Bothrops antivenom: studies on the development of a process in chicken egg yolk. Toxicon: official journal of the international society on toxinology, 55 (4), 739–744.
   PubMed Web of Science ®Google Scholar
• de Almeida, C.M.C., et al., 2008. Development of process to produce polyvalent IgY antibodies anti-African snake venom. Toxicon : official journal of the international society on toxinology, 52 (2), 293–301.
   PubMed Web of Science ®Google Scholar
• de Andrade, F.G., et al., 2013. The production and characterization of anti-bothropic and anti-crotalic IgY antibodies in laying hens: a long term experiment. Toxicon : official journal of the international society on toxinology, 66, 18–24.
   PubMed Web of Science ®Google Scholar
• Brunda, G., Sashidhar, R.B., and Sarin, R.K., 2006. Use of egg yolk antibody (IgY) as an immunoanalytical tool in the detection of Indian cobra (Naja naja naja) venom in biological samples of forensic origin. Toxicon : official journal of the international society on toxinology, 48 (2), 183–194.
   PubMed Web of Science ®Google Scholar
• Cai, Y.C., et al., 2012. Chicken egg yolk antibodies (IgY) for detecting circulating antigens of Schistosoma japonicum. Parasitology international, 61 (3), 385–390.
   PubMed Web of Science ®Google Scholar
• Cardoso, D.F., et al., 2000. Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library. Scandinavian journal of immunology, 51 (4), 337–344.
   PubMed Web of Science ®Google Scholar
• Carlander, D., 2002. Avian IgY antibody. In vitro and in vivo. Uppsala University (53).
   Google Scholar
• Carmen, S. and Jermutus, L., 2002. Concepts in antibody phage display. Briefings in functional genomics & proteomics, 1 (2), 189–203.
   PubMedGoogle Scholar
• Chalghoumi, R., et al., 2009. Hen egg yolk antibodies (IgY), production and use for passive immunization against bacterial enteric infections in chicken: a review. Biotechnologie, Agronomie, Société et Environnement/Biotechnology, agronomy, society and environment 13 (2), 295–308.
   Web of Science ®Google Scholar
• Chiou, V.Y.N., 2008. The development of IgY(DeltaFc) antibody based neuro toxin antivenoms and the study on their neutralization efficacies. Clinical toxicology (Philadelphia, PA), 46 (6), 539–544.
   PubMed Web of Science ®Google Scholar
• Chang, H.M., et al., 1999. Productivity and some properties of immunoglobulin specific against Streptococcus mutans serotype c in chicken egg yolk (IgY). Journal of agricultural and food chemistry, 47 (1), 61–66.
   PubMed Web of Science ®Google Scholar
• Choraria, A., et al., 2020. Experimental Antivenoms from chickens and rabbits and their comparison with commercially available equine antivenom against the venoms of Daboia russelii and Echis carinatus snakes. Tox reviews, 1–12.
   Google Scholar
• Choudhury, M., et al., 2017. Comparison of proteomic profiles of the venoms of two of the 'Big Four' snakes of India, the Indian cobra (Naja naja) and the common krait (Bungarus caeruleus), and analyses of their toxins. Toxicon : official journal of the international society on toxinology, 135, 33–42.
   PubMed Web of Science ®Google Scholar
• Diaz, P., et al., 2014. IgY pharmacokinetics in rabbits: implications for IgY use as antivenoms. Toxicon : official journal of the international society on toxinology, 90, 124–133.
   PubMed Web of Science ®Google Scholar
• Duan, H.L., et al., 2016. Anti-Trimeresurus albolabris venom IgY antibodies: preparation, purification and neutralization efficacy. Journal of venomous animals and toxins including tropical diseases, 22 (1), 4–9.
   PubMedGoogle Scholar
• Gasanov, S.E., 2014. Snake venom cytotoxins, phospholipase A2s, and Zn2+-dependent metalloproteinases: mechanisms of action and pharmacological relevance. Journal of clinical toxicology, 4 (1), 1–14.
   Google Scholar
• Gilgunn, S., et al., 2016. Comprehensive N-glycan profiling of Avian Immuoglobulin Y. Plos One, 11(7).
   Google Scholar
• Girish, K.S., et al., 2004. Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom. Biochimie, 86 (3), 193–202.
   PubMed Web of Science ®Google Scholar
• Guo, G., et al., 2016. Screening, tandem expression and immune activity appraisal of Deinagkistrodon acutus (pit viper) venom mimotopes from a phage display 12-mer peptide library. Biotechnology letters, 38 (11), 1867–1873.
   PubMed Web of Science ®Google Scholar
• Gutiérrez, J.M., 2012. Improving antivenom availability and accessibility: science, technology, and beyond. Toxicon, 60 (4), 676–687.
   PubMed Web of Science ®Google Scholar
• Gutiérrez, J.M., 2018. Preclinical assessment of the neutralizing efficacy of snake antivenoms in Latin America and the Caribbean: a review. Toxicon, 146, 138–150.
   PubMed Web of Science ®Google Scholar
• Gutiérrez, J.M., et al., 2011. Antivenoms for snakebite envenomings. Inflammation & allergy drug targets, 10 (5), 369–380.
   PubMedGoogle Scholar
• Gutiérrez, J.M., et al., 2017. Snakebite envenoming. Nature reviews. Disease primers, 3, 17063.
   PubMed Web of Science ®Google Scholar
• Gutiérrez, J.M., Leon, G., and Lomonte, B., 2003. Pharmacokinetic – pharmacodynamic relationships of immunoglobulin therapy for envenomation. Clinical pharmacokinetics, 42 (8), 721–741.
   PubMed Web of Science ®Google Scholar
• Habib, A.G. and Brown, N.I., 2018. The snakebite problem and antivenom crisis from a health-economic perspective. Toxicon : official journal of the international society on toxinology, 150, 115–123.
   PubMed Web of Science ®Google Scholar
• Hiremath, V., et al., 2016. Differential action of medically important Indian BIG FOUR snake venoms on rodent blood coagulation. Toxicon : official journal of the international society on toxinology, 110, 19–26.
   PubMed Web of Science ®Google Scholar
• Hoogenboom, H.R., et al., 1998. Antibody phage display technology and its applications. Immunotechnology, 4 (1), 1–20.
   PubMedGoogle Scholar
• Isbister, G.K., et al., 2015. Population pharmacokinetics of an Indian F (ab’)2 snake antivenom in patients with Russell’s viper (Daboia russelii) bites. PLoS neglected tropical diseases, 9 (7), 1–13.
   Web of Science ®Google Scholar
• Kalita, B., Patra, A., and Mukherjee, A.K., 2017. Unraveling the proteome composition and immuno-profiling of Western India Russell’s Viper Venom for in-depth understanding of its pharmacological properties, clinical manifestations, and effective antivenom treatment. Journal of proteome research, 16 (2), 583–598.
   PubMed Web of Science ®Google Scholar
• Kang, T.S., et al., 2011. Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis. The FEBS journal, 278 (23), 4544–4576.
   PubMed Web of Science ®Google Scholar
• Karlsson, M., Kollberg, H., and Larsson, A., 2004. Chicken IgY: utilizing the evolutionary advantage. World's poultry science journal, 60 (3), 341–348.
   Web of Science ®Google Scholar
• Kiem TX. 2000. The production of Calloselasma rhodostoma antivenom (C.R.A.V.) from egg yolk of hens immunized with venom: its application for treatment of snake bite patients in Vietnam. In: Proceedings of the XIIIth World Congress of the International Society of Toxinology. Paris International Society of Toxinology.
   Google Scholar
• Kini, R.M., Sidhu, S.S., and Laustsen, A.H., 2018. Biosynthetic oligoclonal antivenom (BOA) for snakebite and next-generation treatments for snakebite victims. Toxins, 10 (12), 534.
   Web of Science ®Google Scholar
• Klemperer, F., 1893. Archiv für die Experimentelle Pathologie und Pharmakologie. Ueber Natürliche Immunität Und Ihre Verwerthung Für Die Immunisirungstherapie, 31, 356–382.
   Google Scholar
• Kovacs-Nolan, J. and Mine, Y., 2012. Egg yolk antibodies for passive immunity. Annual review of food science and technology, 3 (1), 163–182.
   PubMedGoogle Scholar
• Krishnan, L.K., et al., 2015. Rabbit snake-bite model to assess safety and efficacy of anti viper chicken antibodies (IgY). American journal of clinical and experimental medicine, 3 (1), 32–38.
   Google Scholar
• Kularatne, S.A.M. and Senanayake, N., 2014. Venomous snake bites, scorpions, and spiders. Handbook of clinical neurology, 120 (1), 987–1001.
   PubMedGoogle Scholar
• Laustsen, A., et al., 2016. From fangs to pharmacology: the future of snakebite envenoming therapy. Current pharmaceutical design, 22 (34), 5270–5293.
   PubMed Web of Science ®Google Scholar
• Laustsen, A.H., et al., 2017. Pitfalls to avoid when using phage display for snake toxins. Toxicon : official journal of the international society on toxinology, 126, 79–89.
   PubMed Web of Science ®Google Scholar
• Laustsen, A.H., et al., 2018. Pros and cons of different therapeutic antibody formats for recombinant antivenom development. Toxicon : official journal of the international society on toxinology, 146, 151–175.
   PubMed Web of Science ®Google Scholar
• Ledsgaard, L., et al., 2018. Basics of antibody phage display technology. Toxins, 10 (6), 236.
   PubMed Web of Science ®Google Scholar
• Lee, C.H., et al., 2016a. Antibodies against venom of the snake Deinagkistrodon acutus. Applied and environmental microbiology, 82 (1), 71–80.
   PubMed Web of Science ®Google Scholar
• Lee, C.H., et al., 2016b. Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom. Applied and environmental microbiology, 82 (23), 6973–6982.
   PubMed Web of Science ®Google Scholar
• Lee, C.H., et al., 2017a. Single chain antibody fragment against venom from the snake Daboia russelii formosensis. Toxins (Toxins), 9 (11), 347.
   PubMed Web of Science ®Google Scholar
• Lee, C.H., et al., 2018. Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra. Toxins (Toxins), 10 (10), 383.
   Web of Science ®Google Scholar
• Lee, W., et al., 2017b. Insights into the chicken IgY with emphasis on the generation and applications of chicken recombinant monoclonal antibodies. Journal of immunological methods, 447, 71–85.
   PubMed Web of Science ®Google Scholar
• Leiva, C.L., et al., 2019. IgY-based antivenom against Bothrops alternatus: production and neutralization efficacy. Toxicon, 163, 84–92.
   PubMed Web of Science ®Google Scholar
• Leiva, C.L., et al., 2020. IgY-technology (egg yolk antibodies) in human medicine: a review of patents and clinical trials. International immunopharmacology, 81, 106269.
   PubMed Web of Science ®Google Scholar
• León, G., et al., 2013. Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms. Toxicon, 76, 63–76.
   PubMed Web of Science ®Google Scholar
• Leslie, G.A. and Clem, L.W., 1969. Phylogen of immunoglobulin structure and function. 3. Immunoglobulins of the chicken. The journal of experimental medicine, 130 (6), 1337–1352.
   PubMed Web of Science ®Google Scholar
• Lin, J.-H., et al., 2020. Collocation of avian and mammal antibodies to develop a rapid and sensitive diagnostic tool for Russell’s Vipers Snakebite. PLOS neglected tropical diseases, 14 (9), e0008701–19.
   PubMed Web of Science ®Google Scholar
• Liu, J., et al., 2017. Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom. The journal of venomous animals and toxins including tropical diseases, 23 (1), 1–9.
   Web of Science ®Google Scholar
• Liu, S., Dong, W., and Kong, T., 2010. Preparation and characterization of immunoglobulin yolk against the venom of Naja naja atra. Indian journal of experimental biology, 48 (8), 778–785.
   PubMed Web of Science ®Google Scholar
• Manjula, J., et al., 2006. Toxicological studies on snake venom specific antibodies (IgY) from chicken egg. Journal of cell and tissue research, 6 (2), 733–738.
   Google Scholar
• Manjula, J., Paul, K., and Subba Rao, P.V., 2008. Fractionation and detoxification of Naja Naja venom, preparation of anti toxoid – IgY antibodies and in vitro neutralization studies. Journal of cell and tissue culture, 8 (2), 1463–1470.
   Google Scholar
• Maya Devi, C., et al., 2002. An improved method for isolation of anti-viper venom antibodies from chicken egg yolk. Journal of biochemical and biophysical methods, 51 (2), 129–138.
   PubMedGoogle Scholar
• Meenatchisundaram, S., et al., 2008a. Studies on pharmacological effects of Russell's viper and Saw-scaled viper venom and its neutralization by chicken egg yolk antibodies . International immunopharmacology, 8 (8), 1067–1073.
   PubMed Web of Science ®Google Scholar
• Meenatchisundaram, S., et al., 2008b. Neutralization of the pharmacological effects of Cobra and Krait venoms by chicken egg yolk antibodies. Toxicon, 52 (2), 221–227.
   PubMed Web of Science ®Google Scholar
• Meenatchisundaram, S. and Michael, A., 2010. Comparison of four different purification methods for isolation of anti Echis carinatus antivenom antibodies from immunized chicken egg yolk. Iranian journal of biotechnology, 8 (1), 50–55.
   Google Scholar
• Meng, J., John, T.R., and Kaiser, I.I., 1995. Specificity and binding affinity of an anticrotoxin combinatorial antibody selected from a phage-displayed library. Biochemical pharmacology, 50, 1969–1977.
   PubMed Web of Science ®Google Scholar
• Mendoza, J.C., et al., 2012. Experimental efficacy of IgY antibodies produced in eggs against the venom of the Peruvian snake Bothrops atrox. Revista Peruana de Medicina Experimental y Salud Publica, 29 (1), 69–75.
   PubMedGoogle Scholar
• Moussa, I.M., et al., 2012. Evaluation of the protective efficacy of immunoglobulin Y (IgY- antibodies) prepared against Walterinnesia aegyptia snake venom in Saudi Arabia. African journal of biotechnology, 11 (72), 13726–13731.
   Google Scholar
• Munhoz, L.S., et al., 2014. Anticorpos IgY aviário: Características e aplicações em imunodiagnóstico. Ciência rural, 44 (1), 153–160.
   Web of Science ®Google Scholar
• Nakamura, N., et al., 2003. Two expression vectors for the phage-displayed chicken monoclonal antibody. Journal of immunological methods, 280 (1–2), 157–164.
   PubMed Web of Science ®Google Scholar
• Navarro, D., et al., 2016. Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom. Toxicon : official journal of the international society on toxinology, 120, 1–8.
   PubMed Web of Science ®Google Scholar
• Nikapitiya, B. and Maduwage, K., 2018. Pharmacodynamics and pharmacokinetics of snake antivenom. Sri Lanka journal of medicine, 27 (1), 54.
   Google Scholar
• Oliveira, J.G., et al., 2009. Expression of human recombinant antibody fragments capable of partially inhibiting the phospholypase activity of crotalus durissus terrificus venom. Basic & clinical pharmacology & toxicology, 105 (2), 84–91.
   PubMed Web of Science ®Google Scholar
• Paul, K., et al., 2007. Anti-Echis carinatus venom antibodies from chicken egg yolk: isolation, purification and neutralization efficacy. Toxicon : official journal of the international society on toxinology, 50 (7), 893–900.
   PubMed Web of Science ®Google Scholar
• Pauly, D., et al., 2011. Igy technology: extraction of chicken antibodies from egg yolk by polyethylene glycol (PEG) precipitation. Journal of visualized experiments, 1 (51), 2–7.
   Google Scholar
• Pereira, E.P.V., et al., 2019. Egg yolk antibodies (IgY) and their applications in human and veterinary health: a review. International immunopharmacology, 73, 293–303.
   PubMed Web of Science ®Google Scholar
• Pla, D., et al., 2019. Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka. Journal of proteomics, 207, 103443.
   PubMed Web of Science ®Google Scholar
• Prabhu, R.R., Ramamurty, N., and Mathiyalagan, A., 2010. Extraction and characterization of polyclonal egg yolk antibodies (IgY) in chicken against cobra (Naja naja) venom. Current science, 98 (2), 237–239.
   Web of Science ®Google Scholar
• Ren, H., et al., 2016. A comparative evaluation of six principal IgY antibody extraction methods. Alternatives to laboratory animals, 44 (1), 11–20.
   PubMed Web of Science ®Google Scholar
• da Rocha, D.G., et al., 2017. Development of IgY antibodies against anti-snake toxins endowed with highly lethal neutralizing activity. European journal of pharmaceutical sciences, 106, 404–412.
   PubMed Web of Science ®Google Scholar
• Roncolato, E.C., et al., 2013. Human antibody fragments specific for Bothrops jararacussu venom reduce the toxicity of other Bothrops sp. venoms. Journal of immunotoxicology, 10 (2), 160–168.
   PubMed Web of Science ®Google Scholar
• Roncolato, E.C., et al., 2015. Phage display as a novel promising antivenom therapy: a review. Toxicon : official journal of the international society on toxinology, 93, 79–84.
   PubMed Web of Science ®Google Scholar
• Schade, R., et al., 2005. Chicken egg yolk antibodies (IgY-technology): a review of progress in production and use in research and human and veterinary medicine. Alternatives to laboratory animals : ATLA, 33 (2), 129–154.
   PubMed Web of Science ®Google Scholar
• Scheske, L., Ruitenberg, J., and Bissumbhar, B., 2015. Needs and availability of snake antivenoms: relevance and application of international guidelines. International journal of health policy and management, 4 (7), 447–457.
   PubMed Web of Science ®Google Scholar
• Seifert, S.A. and Boyer, L.V., 2001. Recurrence phenomena after immunoglobulin therapy for snake envenomations: Part 1. Pharmacokinetics and pharmacodynamics of immunoglobulin antivenoms and related antibodies. Annals of emergency medicine, 37 (2), 189–195.
   PubMed Web of Science ®Google Scholar
• Senji Laxme, R.R., et al., 2019. Beyond the ‘Big four’: venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies. PLoS neglected tropical diseases, 13 (12), 1–31.
   Web of Science ®Google Scholar
• Sevcik, C., et al., 2012. Horse IgG- and Ostrich IgY-F(ab') groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulness. Toxicon, 60 (6), 1215–1221.
   PubMed Web of Science ®Google Scholar
• Silva, A. and Isbister, G.K., 2020. Current research into snake antivenoms, their mechanisms of action and applications. Biochemical society transactions, 48 (2), 537–546.
   PubMed Web of Science ®Google Scholar
• Smith, G.P., 1985. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science (New York, N.Y.), 228 (4705), 1315–1317.
   PubMed Web of Science ®Google Scholar
• Somasundaram, R., Choraria, A., and Antonysamy, M., 2020. An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: a review. International immunopharmacology, 85, 106654.
   PubMed Web of Science ®Google Scholar
• Souza, J.B., et al., 2020. Generation and In-planta expression of a recombinant single chain antibody with broad neutralization activity on Bothrops pauloensis snake venom. International journal of biological macromolecules, 149, 1241–1251.
   PubMed Web of Science ®Google Scholar
• Spillner, E., et al., 2012. Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy. Biologicals : journal of the international association of biological standardization, 40 (5), 313–322.
   PubMed Web of Science ®Google Scholar
• Tanwar, P.D., et al., 2017. Production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of Rajasthan, India. Toxicon : official journal of the international society on toxinology, 134, 1–5.
   PubMed Web of Science ®Google Scholar
• Tamarozzi, M.B., et al., 2006. Expression of recombinant human antibody fragments capable of inhibiting the phospholipase and myotoxic activities of Bothrops jararacussu venom. Biochimica et biophysica acta, 1760 (9), 1450–1457.
   PubMed Web of Science ®Google Scholar
• Thalley, B.S. and Carroll, S.B., 1990. Rattlesnake and scorpion antivenoms from the egg yolks of immunized hens. Bio/technology (Nature Publishing Company), 8 (10), 934–938.
   PubMedGoogle Scholar
• Thirumalai, D., et al., 2019. Chicken egg yolk antibody (IgY) as diagnostics and therapeutics in parasitic infections – a review. International journal of biological macromolecules, 136, 755–763.
   PubMed Web of Science ®Google Scholar
• Tini, M., et al., 2002. Generation and application of chicken egg-yolk antibodies. Comparative biochemistry and physiology. Part A, molecular & integrative physiology, 131 (3), 569–574.
   PubMed Web of Science ®Google Scholar
• Titus, J.K., et al., 2017. Application of phage display for the development of a novel inhibitor of PLA2 activity in western cottonmouth venom. Journal of business research, 8, 19–24.
   Google Scholar
• Warrell, D.A., 2010. Snake bite. The lancet, 375 (9708), 77–88.
   PubMed Web of Science ®Google Scholar
• Warr, G.W., Magor, K.E., and Higgins, D.A., 1995. IgY: clues to the origins of modern antibodies. Immunology today, 16 (8), 392–398.
   PubMedGoogle Scholar
• Zhang, W.W., 2003. The use of gene-specific IgY antibodies for drug target discovery. Drug discovery today, 8 (8), 364–371.
   PubMed Web of Science ®Google Scholar
• Zhang, X., et al., 2010. Chicken monoclonal IgY antibody: a novel antibody development strategy. Avian biology research, 3 (3), 97–106.
   Web of Science ®Google Scholar
• Zolfagharian, H. and Dounighi, N.M., 2015. Study on development of Vipera lebetina snake anti-venom in chicken egg yolk for passive immunization. Human vaccines & immunotherapeutics, 11 (11), 2734–2739.
   PubMed Web of Science ®Google Scholar