55
Views
0
CrossRef citations to date
0
Altmetric
Articles

Inhibition of phospholipase A2 from Naja haje and Naja nigricollis venoms by active fraction of Moringa oleifera leaves: in vitro and in silico methods

, , , , &
Pages 629-639 | Received 07 Nov 2022, Accepted 18 Apr 2023, Published online: 03 May 2023

References

  • Abubakar, M.S., et al., 2000. The in vitro snake venom detoxifying action of the leaf extract of Guiera senegalensis. Journal of ethnopharmacology, 69 (3), 253–257.
  • Adeyi, A.O., et al., 2020. Antivenom activity of Moringa oleifera leaves against pathophysiological alterations, somatic mutation and biological activities of Naja nigricollis venom. Scientific African, 8, e00356.
  • Adeyi, O.A., et al., 2021. Moringa oleifera leaf fractions attenuated Naja haje venom-induced cellular dysfunctions via modulation of Nrf2 and inflammatory signalling pathways in rats. Biochemistry and biophysics reports, 25, 100890.
  • Akinloye, O.A., et al., 2020. Phytosterols demonstrate selective inhibition of COX-2: In-vivo and in-silico studies of Nicotiana tabacum. Bioorganic chemistry, 102, 104037.
  • Calvete, J.J., 2011. Proteomics in venom research: a focus on PLA2 molecules. Acta chim sloven, 58 (4), 629–637.
  • Caratsch, C.G., et al., 1985. Influence of divalent cations on phospholipase-dependent action of bungarotoxin at frog neuromuscular. The journal of physiology, 319, 179–191.
  • Cavalcante, W.L.G., et al., 2007. Neutralization of snake venom phospholipase A2 toxins by aqueous extract of Casearia sylvestris (Flacourtiaceae) in mouse neuromuscular preparation. Journal of ethnopharmacology, 112 (3), 490–497.
  • Chang, J., Musser, J., and McGregor, H., 1987. Phospholipase A2: function and pharmacological regulation. Biochemical pharmacology., 36, 24–29.
  • Cheng, F., et al., 2012. admetSAR: a comprehensive source and free tool for evaluating chemical ADMET properties. Journal of chemical information and modeling, 52 (11), 3099–3105.
  • da Silva, S.L., et al., 2008. Molecular modeling of the inhibition of enzyme PLA2 from snake venom by dipyrone and 1-phenyl-3-methyl-5-pyrazolone. International journal of quantum chemistry, 108 (13), 2576–2585.
  • Davis, T.P., Sanchez-Covarubias, L., and Tome, M.E., 2014. P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery. Advances in pharmacology, 71, 25–44.
  • Dennis, E.A., et al., 2011. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chemical reviews, 111 (10), 6130–6185.
  • Diogo, L.C., et al., 2009. Inhibition of snake venoms and phospholipases A2 by extracts from native and genetically modified Eclipta alba: isolation of active coumestans. Basic & clinical pharmacology & Toxicology, 104 (4), 293–299.
  • Francis, B., et al., 1995. Aminoacid sequence of a new type of toxic phospholipase A2 from the venom of Australian tiger snake (Notechis scutatus scutatus). Archives of biochemistry and biophysics, 318 (2), 481–488.
  • Goa, J., 1953. A micro biuret method for protein determination. Determination of total protein in cerebrospinal fluid. Scandinavian journal of clinical and laboratory investigation, 5 (3), 218–222.
  • Gutierrez, J.M., and Lomonte, B., 2013. Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins. Toxicon 62, 27–39.
  • Gutierrez, J.M., et al., 2010. Snake bite envenoming from a global perspective: Towards an integrated approach. Toxicon 56 (7), 1223–1235.
  • Habib, A.G., 2013. Public health aspects of snakebite care in West Africa: perspectives from Nigeria. The journal of venomous animals and toxins including tropical diseases, 19 (1), 27–35.
  • Hasson, S.S., et al., 2010. Antisnake venom activity of Hibiscus aethiopicus L. against Echisocellatus and Najanigricollis. Journal of toxicology, 2010, 1–8.
  • Kini, R.M., 2003. Excitement ahead: Structure, function and mechanism of snake venom phospholipase A2 enzymes. Toxicon 42 (8), 827–840.
  • Kunjam, S.R., Jadhav, S.K., and Tiwari, K.L., 2012. Traditional herbal medicine for the treatment of snake bite and scorpion sting by the tribe of South Surguja, Chhattisgarh, India. Med aromat plants, 2, 2.
  • Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of heads of bacteriophage T4. Nature, 227 (5259), 680–685.
  • Laila, M.G., et al., 2019. Biochemical and kinetic properties of crude phospholipase a2 from Naja nigricollis venom. Science world journal, 62, 64.
  • Lipinski, C.A., 2001. Avoiding investment in doomed drugs. Curr drug discov, 1, 17–19.
  • Luiselli, L., Angelici, F.M., and Akani, G.C., 2002. Comparative feeding strategies and dietary plasticity of the sympatric cobras Naja melanoleuca and Naja nigricollis in three diverging Afrotropical habitats. Canadian journal of zoology, 80 (1), 55–63.
  • Mackessy, S. P., 2010. The field of reptile toxinology snakes, lizards, and their venoms, In: Handbook of venoms and toxins of reptiles, S. P. Mackessy, 1st Ed. p. 3–19. Boca Raton, Florida.
  • Mebs, D., 1970. A comparitive study of enzyme activities in snake venoms. International journal of biochemistry, 1 (3), 335–342.
  • Mors, W.B., et al., 2000. Plant natural products active against snake bite—the molecular approach. Phytochemistry, 55 (6), 627–642.
  • Neves-Ferreira, A. G. C., et al., 2010. Natural inhibitors: innate immunity to snake venoms. In Handbook of venoms and toxins of reptiles. Mackessy S.P (Ed.). Boca Raton, Florida: CRC Press, pp. 259–284.
  • O’Shea, M., 2005. Venomous snakes of the world. London: New Holland.
  • Osamudiamen, P.M., et al., 2017. Isolation, characterization, and in-vitro anti-cancer activity of bioactive Cassane Diterpenoids from the roots of Mezoneuron benthamianum (Baill.). Journal of biologically active products from nature, 7 (3), 157–165.
  • Perumal, V., et al., 2014. Spotted nanoflowers’: Gold-seeded zinc oxide nanohybrid for Selective capture. Scientific reports, 5, 12231.
  • Sallau, A.B., et al., 2008. Characterization of phospholipase A2 (PLA2) from Echis ocellatus venom. African journal of biochemistry research, 2, 98–101.
  • Schneider, G., 2013. Prediction of drug-like properties. Madame curie bioscience database [Internet]. Landes Bioscience.; 2000-2013. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6404/
  • Scott, D.L., and Sigler, P.B., 1994. Structure and catalytic mechanism of secretory PLA2. Advances in protein chemistry, 43, 53–58.
  • Shashidharamurthy, R., and Kemparaju, K., 2006. A neurotoxic phospholipase A2 variant: Isolation and characterization from eastern regional Indian cobra (Naja naja). Toxicon, 47 (7), 727–733.
  • Shityakov, S., and Förster, C., 2014. In-silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions. Advances and applications in bioinformatics and chemistry, 7, 1–9.
  • Shuting, L.I., et al., 2004. Proteomic characterization of two snake venoms: Naja najaatra and Agkistrodonhalys. The biochemical journal, 384 (Pt 1), 119–127.
  • Singh, G., et al., 2005. Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution. Protein science: a publication of the protein society, 14 (2), 395–400.
  • St-Germain, M.E., et al., 2004. Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway. Molecular cancer, 3, 7.
  • Theakston, R.D.G., Warrell, D.A., and Griffiths, E., 2003. Report of a WHO workshop on the standardization and control of antivenoms. Toxicon, 41 (5), 541–557.
  • Tohamy, A.A., et al., 2014. Biological effects of Naja haje crude venom on the hepatic and renal tissues of mice. Journal of king saud university, science, 26 (3), 205–212.
  • Wagenen, B.C., et al., 1993. Ulosantoin, a potent insecticide from the sponge Ulosaruetzleri. The journal of organic chemistry, 58 (2), 335–337.
  • Warrell, D.A., 2011. Snake bite. Seminar. Lancet, 375, 1. Archived from the original (PDF) on 29 October 2013.
  • World Health 1998. Organization, WHO monographs on the selected medicinal plants. WHO Geneva.
  • Yamashita, T., Brahmadathan, U.M., and Paramaswaran, M.K., 2010. Traditional poison-healing system in Kerala: An overview. Ejournal indian med, 3, 101–703.
  • Yang, C.C., 1994. Structure-function relationship of PLA2 from snake venoms. Journal of toxicology, 13 (2), 125–177.
  • Ziganshin, R.H., et al., 2015. Quantitative proteomic analysis of Vietnamese krait venoms: neurotoxins are the major components in Bungarus multicinctus and phospholipases A2 in Bungarus fasciatus. Toxicon, 107 (Pt B), 197–209.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.