Identification of methylation markers for the prediction of nodal metastasis in oral and oropharyngeal squamous cell carcinoma

References

• Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014; 64:9-29; PMID:24399786; http://dx.doi.org/10.3322/caac.21208
   PubMed Web of Science ®Google Scholar
• Arduino PG, Carrozzo M, Chiecchio A, Broccoletti R, Tirone F, Borra E, Bertolusso G, Gandolfo S. Clinical and histopathologic independent prognostic factors in oral squamous cell carcinoma: A retrospective study of 334 cases. J Oral Maxillofac Surg 2008; 66:1570-9.; http://dx.doi.org/10.1016/j.joms.2007.12.024
   PubMed Web of Science ®Google Scholar
• Liao LJ, Lo WC, Hsu WL, Wang CT, Lai MS. Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck-a meta-analysis comparing different imaging modalities. BMC Cancer 2012; 12:236, 2407-12-236; PMID:22691269; http://dx.doi.org/10.1186/1471-2407-12-236
   PubMed Web of Science ®Google Scholar
• Vorburger MS, Broglie MA, Soltermann A, Haerle SK, Haile SR, Huber GF, Stoeckli SJ. Validity of frozen section in sentinel lymph node biopsy for the staging in oral and oropharyngeal squamous cell carcinoma. J Surg Oncol 2012; 106:816-9; PMID:22585742; http://dx.doi.org/10.1002/jso.23156
   PubMed Web of Science ®Google Scholar
• Terada A, Hasegawa Y, Goto M, Sato E, Hyodo I, Ogawa T, Nakashima T, Yatabe Y. Sentinel lymph node radiolocalization in clinically negative neck oral cancer. Head Neck 2006; 28:114-20; PMID:16155916; http://dx.doi.org/10.1002/hed.20305
   PubMed Web of Science ®Google Scholar
• Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 2011; 11:726-34; PMID:21941284; http://dx.doi.org/10.1038/nrc3130
   PubMed Web of Science ®Google Scholar
• Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007; 8:286-98; PMID:17339880; http://dx.doi.org/10.1038/nrg2005
   PubMed Web of Science ®Google Scholar
• Roossink F, de Jong S, Wisman GB, van der Zee AG, Schuuring E. DNA hypermethylation biomarkers to predict response to cisplatin treatment, radiotherapy or chemoradiation: The present state of art. Cell Oncol (Dordr) 2012; 35:231-41; PMID:22836879; http://dx.doi.org/10.1007/s13402-012-0091-7
   PubMed Web of Science ®Google Scholar
• Smiraglia DJ, Smith LT, Lang JC, Rush LJ, Dai Z, Schuller DE, Plass C. Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC). J Med Genet 2003; 40:25-33; PMID:12525538.; http://dx.doi.org/10.1136/jmg.40.1.25
   PubMed Web of Science ®Google Scholar
• Rius M, Lyko F. Epigenetic cancer therapy: Rationales, targets and drugs. Oncogene 2012; 31:4257-65; PMID:22179827; http://dx.doi.org/10.1038/onc.2011.601
   PubMed Web of Science ®Google Scholar
• Cock-Rada A, Weitzman JB. The methylation landscape of tumour metastasis. Biol Cell 2013; 105:73-90; PMID:23198959; http://dx.doi.org/10.1111/boc.201200029
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Hansen LL. PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clin Chem 2009; 55:1471-83; PMID:19520761; http://dx.doi.org/10.1373/clinchem.2008.121962
   PubMed Web of Science ®Google Scholar
• Jacinto FV, Esteller M. MGMT hypermethylation: A prognostic foe, a predictive friend. DNA Repair (Amst) 2007; 6:1155-60; PMID:17482895; http://dx.doi.org/10.1016/j.dnarep.2007.03.013
   PubMed Web of Science ®Google Scholar
• Gasche JA, Goel A. Epigenetic mechanisms in oral carcinogenesis. Future Oncol 2012; 8:1407-25; PMID:23148615; http://dx.doi.org/10.2217/fon.12.138
   PubMed Web of Science ®Google Scholar
• Jithesh PV, Risk JM, Schache AG, Dhanda J, Lane B, Liloglou T, Shaw RJ. The epigenetic landscape of oral squamous cell carcinoma. Br J Cancer 2013; 108:370-9; PMID:23287992; http://dx.doi.org/10.1038/bjc.2012.568
   PubMed Web of Science ®Google Scholar
• Gonzalez-Ramirez I, Garcia-Cuellar C, Sanchez-Perez Y, Granados-Garcia M. DNA methylation in oral squamous cell carcinoma: Molecular mechanisms and clinical implications. Oral Dis 2011; 17:771-8; PMID:21781230; http://dx.doi.org/10.1111/j.1601-0825.2011.01833.x
   PubMed Web of Science ®Google Scholar
• Mascolo M, Siano M, Ilardi G, Russo D, Merolla F, De Rosa G, Staibano S. Epigenetic disregulation in oral cancer. Int J Mol Sci 2012; 13:2331-53; PMID:22408457; http://dx.doi.org/10.3390/ijms13022331
   PubMed Web of Science ®Google Scholar
• Borges S, Doppler H, Perez EA, Andorfer CA, Sun Z, Anastasiadis PZ, Thompson EA, Geiger XJ, Storz P. Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. Breast Cancer Res 2013; 15:R66; PMID:23971832; http://dx.doi.org/10.1186/bcr3460
   PubMedGoogle Scholar
• Li Y, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, et al. Investigation of tumor suppressing function of CACNA2D3 in esophageal squamous cell carcinoma. PLoS One 2013; 8:e60027; PMID:23560067; http://dx.doi.org/10.1371/journal.pone.0060027
   PubMedGoogle Scholar
• Xing X, Cai W, Shi H, Wang Y, Li M, Jiao J, Chen M. The prognostic value of CDKN2A hypermethylation in colorectal cancer: A meta-analysis. Br J Cancer 2013; 108:2542-8; PMID:23703248; http://dx.doi.org/10.1038/bjc.2013.251
   PubMed Web of Science ®Google Scholar
• Roepman P, Wessels LF, Kettelarij N, Kemmeren P, Miles AJ, Lijnzaad P, Tilanus MG, Koole R, Hordijk GJ, van d V, et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet 2005; 37:182-6.; http://dx.doi.org/10.1038/ng1502
   PubMed Web of Science ®Google Scholar
• Schmalbach CE, Chepeha DB, Giordano TJ, Rubin MA, Teknos TN, Bradford CR, Wolf GT, Kuick R, Misek DE, Trask DK, et al. Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2004; 130:295-302.; http://dx.doi.org/10.1001/archotol.130.3.295
   PubMed Web of Science ®Google Scholar
• Mendez E, Houck JR, Doody DR, Fan W, Lohavanichbutr P, Rue TC, Yueh B, Futran ND, Upton MP, Farwell DG, et al. A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival. Clin Cancer Res 2009; 15:1353-61.; http://dx.doi.org/10.1158/1078-0432.CCR-08-1816
   PubMed Web of Science ®Google Scholar
• O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, et al. Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene 2005; 24:1244-51.; http://dx.doi.org/10.1038/sj.onc.1208285
   PubMed Web of Science ®Google Scholar
• Ongenaert M, Wisman GB, Volders HH, Koning AJ, van der Zee AG, van Criekinge W, Schuuring E. Discovery of DNA methylation markers in cervical cancer using relaxation ranking. BMC Med Genomics 2008; 1:57.; http://dx.doi.org/10.1186/1755-8794-1-57
   PubMed Web of Science ®Google Scholar
• Cao VT, Jung TY, Jung S, Jin SG, Moon KS, Kim IY, Kang SS, Park CS, Lee KH, Chae HJ. The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas. Neurosurgery 2009; 65:866, 75; discussion 875; PMID:19834398; http://dx.doi.org/10.1227/01.NEU.0000357325.90347.A1
   PubMed Web of Science ®Google Scholar
• de Meneses IS, de Souza RR, Jeraldo Verónica de Lourdes Sierpe, Rodrigues D, Cavalcante R, Reis FP, de Albuquerque Júnior, Ricardo Luiz Cavalcanti, MENESES I, SOUZA R, JERALDO V. Death-associated protein kinase is underexpressed in high-grade oral squamous cell carcinoma. Int J Morphol 2010; 28:609-13.; http://dx.doi.org/10.4067/S0717-95022010000200044
   Web of Science ®Google Scholar
• Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001; 61:3225-9; PMID:11309270.
   PubMed Web of Science ®Google Scholar
• Ingold B, Schraml P, Heppner FL, Moch H. Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors. PLoS One 2009; 4:e4775; PMID:19274096; http://dx.doi.org/10.1371/journal.pone.0004775
   PubMedGoogle Scholar
• Noordhuis MG, Fehrmann RS, Wisman GB, Nijhuis ER, van Zanden JJ, Moerland PD, Ver Loren van Themaat E, Volders HH, Kok M, ten Hoor KA, et al. Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer. Clin Cancer Res 2011; 17:1317-30; PMID:21385933; http://dx.doi.org/10.1158/1078-0432.CCR-10-2320
   PubMed Web of Science ®Google Scholar
• Rastetter M, Schagdarsurengin U, Lahtz C, Fiedler E, Marsch WC, Dammann R, Helmbold P. Frequent intra-tumoural heterogeneity of promoter hypermethylation in malignant melanoma. Histol Histopathol 2007; 22:1005-15; PMID:17523078.
   PubMed Web of Science ®Google Scholar
• Braakhuis BJ, Brakenhoff RH, Leemans CR. Gene expression profiling in head and neck squamous cell carcinoma. Curr Opin Otolaryngol Head Neck Surg 2010; 18:67-71; PMID:20084003; http://dx.doi.org/10.1097/MOO.0b013e32833693ce
   PubMed Web of Science ®Google Scholar
• Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009; 41:178-86; PMID:19151715; http://dx.doi.org/10.1038/ng.298
   PubMed Web of Science ®Google Scholar
• Gozuacik D, Kimchi A. DAPk protein family and cancer. Autophagy 2006; 2:74-9; PMID:17139808.; http://dx.doi.org/10.4161/auto.2.2.2459
   PubMed Web of Science ®Google Scholar
• Sanchez-Cespedes M, Esteller M, Wu L, Nawroz-Danish H, Yoo GH, Koch WM, Jen J, Herman JG, Sidransky D. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 2000; 60:892-5.
   PubMed Web of Science ®Google Scholar
• Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Tamiya S, Iwamoto Y, Tsuneyoshi M. Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression. Hum Pathol 2004; 35:1266-71; PMID:15492995.; http://dx.doi.org/10.1016/j.humpath.2004.07.007
   PubMed Web of Science ®Google Scholar
• Chen WT, Hung WC, Kang WY, Huang YC, Chai CY. Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase. Histopathology 2007; 51:785-92; PMID:17953697; http://dx.doi.org/10.1111/j.1365-2559.2007.02871.x
   PubMed Web of Science ®Google Scholar
• Wang WJ, Kuo JC, Yao CC, Chen RH. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol 2002; 159:169-79; PMID:12370243; http://dx.doi.org/10.1083/jcb.200204050
   PubMed Web of Science ®Google Scholar
• Kuo JC, Wang WJ, Yao CC, Wu PR, Chen RH. The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. J Cell Biol 2006; 172:619-31; PMID:16476779; http://dx.doi.org/10.1083/jcb.200505138
   PubMed Web of Science ®Google Scholar
• Olson RA, Brastianos PK, Palma DA. Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: A systematic review and meta-analysis. J Neurooncol 2011; 105:325-35; PMID:21523485; http://dx.doi.org/10.1007/s11060-011-0594-5
   PubMed Web of Science ®Google Scholar
• Supic G, Kozomara R, Brankovic-Magic M, Jovic N, Magic Z. Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patients. Oral Oncol 2009; 45:1051-7; PMID:19665921; http://dx.doi.org/10.1016/j.oraloncology.2009.07.007
   PubMedGoogle Scholar
• Su PF, Huang WL, Wu HT, Wu CH, Liu TY, Kao SY. p16(INK4A) promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner. Oral Oncol 2010; 46:734-9; PMID:20729138; http://dx.doi.org/10.1016/j.oraloncology.2010.07.002
   PubMed Web of Science ®Google Scholar
• Dikshit RP, Gillio-Tos A, Brennan P, De Marco L, Fiano V, Martinez-Penuela JM, Boffetta P, Merletti F. Hypermethylation, risk factors, clinical characteristics, and survival in 235 patients with laryngeal and hypopharyngeal cancers. Cancer 2007; 110:1745-51; PMID:17786935; http://dx.doi.org/10.1002/cncr.22975
   PubMed Web of Science ®Google Scholar
• Zeilinger S, Kuhnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, Weidinger S, Lattka E, Adamski J, Peters A, et al. Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS One 2013; 8:e63812; PMID:23691101; http://dx.doi.org/10.1371/journal.pone.0063812
   PubMed Web of Science ®Google Scholar
• Christmann M, Kaina B. O(6)-methylguanine-DNA methyltransferase (MGMT): Impact on cancer risk in response to tobacco smoke. Mutat Res 2012; 736:64-74; PMID:21708177; http://dx.doi.org/10.1016/j.mrfmmm.2011.06.004
   PubMed Web of Science ®Google Scholar
• Lassen P. The role of human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. Radiother Oncol 2010; 95:371-80; PMID:20493569; http://dx.doi.org/10.1016/j.radonc.2010.04.022
   PubMed Web of Science ®Google Scholar
• Weiss D, Basel T, Sachse F, Braeuninger A, Rudack C. Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation. Mol Carcinog 2011; 50:680-8; PMID:21563216; http://dx.doi.org/10.1002/mc.20798
   PubMed Web of Science ®Google Scholar
• van Hooff SR, Leusink FK, Roepman P, Baatenburg de Jong RJ, Speel EJ, van den Brekel MW, van Velthuysen ML, van Diest PJ, van Es RJ, Merkx MA, et al. Validation of a gene expression signature for assessment of lymph node metastasis in oral squamous cell carcinoma. J Clin Oncol 2012; 30:4104-10; PMID:23045589; http://dx.doi.org/10.1200/JCO.2011.40.4509
   PubMed Web of Science ®Google Scholar
• Alkureishi LW, Ross GL, Shoaib T, Soutar DS, Robertson AG, Thompson R, Hunter KD, Sorensen JA, Thomsen J, Krogdahl A, et al. Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a european multicenter trial. Ann Surg Oncol 2010; 17:2459-64; PMID:20552410; http://dx.doi.org/10.1245/s10434-010-1111-3
   PubMed Web of Science ®Google Scholar
• Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996; 93:9821-6.; http://dx.doi.org/10.1073/pnas.93.18.9821
   PubMed Web of Science ®Google Scholar
• Bock C, Tomazou EM, Brinkman AB, Muller F, Simmer F, Gu H, Jager N, Gnirke A, Stunnenberg HG, Meissner A. Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat Biotechnol 2010; 28:1106-14; PMID:20852634; http://dx.doi.org/10.1038/nbt.1681
   PubMed Web of Science ®Google Scholar
• Erdem NF, Carlson ER, Gerard DA. Characterization of gene expression profiles of 3 different human oral squamous cell carcinoma cell lines with different invasion and metastatic capacities. J Oral Maxillofac Surg 2008; 66:918-27; PMID:18423281; http://dx.doi.org/10.1016/j.joms.2007.12.036
   PubMed Web of Science ®Google Scholar
• Martin TA, Mansel RE, Jiang WG. Loss of occludin leads to the progression of human breast cancer. Int J Mol Med 2010; 26:723-34; PMID:20878095.; http://dx.doi.org/10.3892/ijmm_00000519
   PubMed Web of Science ®Google Scholar
• Blanco D, Vicent S, Elizegi E, Pino I, Fraga MF, Esteller M, Saffiotti U, Lecanda F, Montuenga LM. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Lab Invest 2004; 84:999-1012; PMID:15195114; http://dx.doi.org/10.1038/labinvest.3700129
   PubMed Web of Science ®Google Scholar
• Perez A, Neskey DM, Wen J, Pereira L, Reategui EP, Goodwin WJ, Carraway KL, Franzmann EJ. CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression. Oral Oncol 2013; 49:306-13; PMID:23265944; http://dx.doi.org/10.1016/j.oraloncology.2012.11.009
   PubMed Web of Science ®Google Scholar
• Puri SK, Si L, Fan CY, Hanna E. Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. Am J Otolaryngol 2005; 26:12-7; PMID:15635575.; http://dx.doi.org/10.1016/j.amjoto.2004.06.007
   PubMed Web of Science ®Google Scholar
• Tawfik HM, El-Maqsoud NM, Hak BH, El-Sherbiny YM. Head and neck squamous cell carcinoma: Mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene. Am J Otolaryngol 2011; 32:528-36; PMID:21353335
   PubMed Web of Science ®Google Scholar
• Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J, Sidransky D. Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 2001; 61:939-42; PMID:11221887.
   PubMed Web of Science ®Google Scholar
• Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999; 59:793-7; PMID:10029064.
   PubMed Web of Science ®Google Scholar
• Melchers LJ, Bruine de Bruin L, Schnell U, Slagter-Menkema L, Mastik MF, de Bock GH, van Dijk BAC, Giepmans BNG, van der Laan BFAM, van der Wal JE, et al. Lack of claudin-7 is a strong predictor of regional recurrence in oral and oropharyngeal squamous cell carcinoma. Oral Oncol 2013; 49:998-1005; http://dx.doi.org/10.1016/j.oraloncology.2013.07.008
   PubMed Web of Science ®Google Scholar
• Federation of Medical Scientific Societies. Code for proper secondary use of human tissue in the netherlands. 2011; 2012.
   Google Scholar
• Melchers L, Mastik M, Cameron BS, van Dijk B, de Bock G, van der Laan B, van der Vegt B, Speel E, Roodenburg J, Witjes M. Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: More than meets the eye. Br J Cancer 2015; 112(8):1349-57; http://dx.doi.org/10.1038/bjc.2015.99
   PubMed Web of Science ®Google Scholar
• van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, Garcia-Sanz R, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 concerted action BMH4-CT98-3936. Leukemia 2003; 17:2257-317; PMID:14671650; http://dx.doi.org/10.1038/sj.leu.2403202
   PubMed Web of Science ®Google Scholar
• Grafstrom RC, Pegg AE, Trump BF, Harris CC. O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res 1984; 44:2855-7; PMID:6722814.
   PubMed Web of Science ®Google Scholar
• Santa Cruz Biotechnology I. Datasheet DAPK (H-300). 2013; 2013.
   Google Scholar
• Rodriguez MJ, Acha A, Ruesga MT, Rodriguez C, Rivera JM, Aguirre JM. Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool? Cancer Lett 2007; 245:263-8; PMID:16517062; http://dx.doi.org/10.1016/j.canlet.2006.01.015
   PubMed Web of Science ®Google Scholar
• Sawhney M, Rohatgi N, Kaur J, Gupta SD, Deo SV, Shukla NK, Ralhan R. MGMT expression in oral precancerous and cancerous lesions: Correlation with progression, nodal metastasis and poor prognosis. Oral Oncol 2007; 43:515-22; PMID:16996781; http://dx.doi.org/10.1016/j.oraloncology.2006.05.007
   PubMed Web of Science ®Google Scholar
• Huang SH, Lee HS, Mar K, Ji DD, Huang MS, Hsia KT. Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109:883-9; PMID:20451846; http://dx.doi.org/10.1016/j.tripleo.2009.12.019
   PubMed Web of Science ®Google Scholar