DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

References

• Ling C, Groop L. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 2009; 58(12):2718-25; PMID:19940235; http://dx.doi.org/10.2337/db09-1003
   PubMed Web of Science ®Google Scholar
• Dayeh TA, Olsson AH, Volkov P, Almgren P, Rönn T, Ling C. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia 2013; 56(5):1036-46; PMID:23462794; http://dx.doi.org/10.1007/s00125-012-2815-7
   PubMed Web of Science ®Google Scholar
• Olsson AH, Volkov P, Bacos K, Dayeh T, Hall E, Nilsson EA, Ladenvall C, Rönn T, Ling C. Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet 2014; 10(11):e1004735; PMID:25375650; http://dx.doi.org/10.1371/journal.pgen.1004735
   PubMed Web of Science ®Google Scholar
• Lyssenko V, Almgren P, Anevski D, Perfekt R, Lahti K, Nissén M, Isomaa B, Forsen B, Homström N, Saloranta C, et al. Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 2005; 54(1):166-74; PMID:15616025; http://dx.doi.org/10.2337/diabetes.54.1.166
   PubMed Web of Science ®Google Scholar
• Lyssenko, V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, Berglund G, Altshuler D, Nilsson P, Groop L. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008; 359(21):2220-32; PMID:19020324; http://dx.doi.org/10.1056/NEJMoa0801869
   PubMed Web of Science ®Google Scholar
• McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010; 363(24):2339-50; PMID:21142536; http://dx.doi.org/10.1056/NEJMra0906948
   PubMed Web of Science ®Google Scholar
• Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, et al. DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet 2015; 8(2):334-42; PMID:25583993; http://dx.doi.org/10.1161/CIRCGENETICS.114.000804
   PubMed Web of Science ®Google Scholar
• Chambers JC, Loh M, Lehne B, Drong A, Kriebel J, Motta V, Wahl S, Elliott HR, Rota F, Scott WR, et al. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. Lancet Diabetes Endocrinol 2015; 3:526-34; PMID:26095709
   PubMed Web of Science ®Google Scholar
• Kulkarni H, Kos MZ, Neary J, Dyer TD, Kent JW Jr, Göring HH, Cole SA, Comuzzie AG, Almasy L, Mahaney MC, et al. Novel epigenetic determinants of type 2 diabetes in Mexican-American families. Hum Mol Genet 2015; 24(18):5330-44; PMID:26101197; http://dx.doi.org/10.1093/hmg/ddv232
   PubMed Web of Science ®Google Scholar
• Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346(6):393-403; PMID:11832527; http://dx.doi.org/10.1056/NEJMoa012512
   PubMed Web of Science ®Google Scholar
• Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344(18):1343-50; PMID:11333990; http://dx.doi.org/10.1056/NEJM200105033441801
   PubMed Web of Science ®Google Scholar
• Lyssenko V, Laakso M. Genetic screening for the risk of type 2 diabetes: worthless or valuable? Diabetes Care 2013; 36(Suppl 2):S120-6; PMID:23882036; http://dx.doi.org/10.2337/dcS13-2009
   PubMedGoogle Scholar
• Nilsson E, Jansson PA, Perfilyev A, Volkov P, Pedersen M, Svensson MK, Poulsen P, Ribel-Madsen R, Pedersen NL, Almgren P, et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes 2014; 63(9):2962-76; PMID:24812430; http://dx.doi.org/10.2337/db13-1459
   PubMed Web of Science ®Google Scholar
• Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T1, et al. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet 2014; 10(3):e1004160; PMID:24603685; http://dx.doi.org/10.1371/journal.pgen.1004160
   PubMed Web of Science ®Google Scholar
• Ribel-Madsen R, Fraga MF, Jacobsen S, Bork-Jensen J, Lara E, Calvanese V, Fernandez AF, Friedrichsen M, Vind BF, Højlund K, et al. Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One 2012; 7(12):e51302; PMID:23251491; http://dx.doi.org/10.1371/journal.pone.0051302
   PubMed Web of Science ®Google Scholar
• Nitert MD, Dayeh T, Volkov P, Elgzyri T, Hall E, Nilsson E, Yang BT, Lang S, Parikh H, Wessman Y, et al. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes 2012; 61(12):3322-32; PMID:23028138; http://dx.doi.org/10.2337/db11-1653
   PubMed Web of Science ®Google Scholar
• Nilsson E, Matte A, Perfilyev A, de Mello VD, Käkelä P, Pihlajamäki J, Ling C. Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels. J Clin Endocrinol Metab. 2015 November; 100(11):E1491 -E1501; http://dx.doi.org/10.1210/jc.2015-3204.
   Google Scholar
• Matsuo M. ATP-binding cassette proteins involved in glucose and lipid homeostasis. Biosci Biotechnol Biochem 2010; 74(5):899-907; PMID:20460728; http://dx.doi.org/10.1271/bbb.90921
   PubMed Web of Science ®Google Scholar
• Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, et al. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired beta-cell function. Diabetes 2012; 61(3):659-64; PMID:22315310; http://dx.doi.org/10.2337/db11-1341
   PubMed Web of Science ®Google Scholar
• Hidalgo B, Irvin MR, Sha J, Zhi D, Aslibekyan S, Absher D, Tiwari HK, Kabagambe EK, Ordovas JM, Arnett DK. Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study. Diabetes 2014; 63(2):801-7; PMID:24170695; http://dx.doi.org/10.2337/db13-1100
   PubMed Web of Science ®Google Scholar
• Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, et al. Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes 2015; 64(10):3464-74; PMID:26153245; http://dx.doi.org/10.2337/db14-1314
   PubMed Web of Science ®Google Scholar
• Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, et al. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A 2014; 111(38):13924-9; PMID:25201977; http://dx.doi.org/10.1073/pnas.1402665111
   PubMed Web of Science ®Google Scholar
• Serre D, Gurd S, Ge B, Sladek R, Sinnett D, Harmsen E, Bibikova M, Chudin E, Barker DL, Dickinson T, et al. Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. PLoS Genet 2008; 4(2):e1000006; PMID:18454203; http://dx.doi.org/10.1371/journal.pgen.1000006
   PubMedGoogle Scholar
• Schou J, Tybjærg-Hansen A, Møller HJ, Nordestgaard BG, Frikke-Schmidt R. ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population. Diabetes Care 2012; 35(12):2600-6; PMID:NOT_FOUND; http://dx.doi.org/10.2337/dc12-0082
   PubMedGoogle Scholar
• Millan JL. The role of phosphatases in the initiation of skeletal mineralization. Calcif Tissue Int 2013; 93(4):299-306; PMID:23183786; http://dx.doi.org/10.1007/s00223-012-9672-8
   PubMed Web of Science ®Google Scholar
• Bobryshev YV, Orekhov AN, Sobenin I, Chistiakov DA. Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification. Curr Pharm Des 2014; 20(37):5821-8; PMID:24533943; http://dx.doi.org/10.2174/1381612820666140212193011
   PubMed Web of Science ®Google Scholar
• Houston B, Stewart AJ, Farquharson C. PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage. Bone 2004; 34(4):629-37; PMID:15050893; http://dx.doi.org/10.1016/j.bone.2003.12.023
   PubMed Web of Science ®Google Scholar
• Vattikuti R, Towler DA. Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab 2004; 286(5):E686-96; PMID:15102615; http://dx.doi.org/10.1152/ajpendo.00552.2003
   PubMed Web of Science ®Google Scholar
• Ronn T, Volkov P, Gillberg L, Kokosar M, Perfilyev A, Jacobsen AL, Jørgensen SW, Brøns C, Jansson PA, Eriksson KF, et al. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet 2015; 24(13):3792-813; PMID:25861810
   PubMed Web of Science ®Google Scholar
• Bernal AJ, Jirtle RL. Epigenomic disruption: the effects of early developmental exposures. Birth Defects Res A Clin Mol Teratol 2010; 88(10):938-44; PMID:20568270; http://dx.doi.org/10.1002/bdra.20685
   PubMed Web of Science ®Google Scholar
• How Kit A, Nielsen HM, Tost J. DNA methylation based biomarkers: practical considerations and applications. Biochimie 2012; 94(11):2314-37; PMID:22847185; http://dx.doi.org/10.1016/j.biochi.2012.07.014
   PubMed Web of Science ®Google Scholar
• Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, Nissén M, Ehrnström BO, Forsén B, Isomaa B, Snickars B, et al. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 1996; 45(11):1585-93; PMID:8866565; http://dx.doi.org/10.2337/diab.45.11.1585
   PubMed Web of Science ®Google Scholar
• Bork-Jensen J, Scheele C, Christophersen DV, Nilsson E, Friedrichsen M, Fernandez-Twinn DS, Grunnet LG, Litman T, Holmstrøm K, Vind B, et al. Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes. Diabetologia 2015; 58(2):363-73; PMID:25403480; http://dx.doi.org/10.1007/s00125-014-3434-2
   PubMed Web of Science ®Google Scholar