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Epigenetics Volume 13, 2018 - Issue 2
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Research Paper

The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types

Ahrim YounDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, U.S.A;The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, U.S.A
&
Shuang WangDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, U.S.ACorrespondence[email protected]
Pages 192-206 | Received 23 Jun 2017, Accepted 04 Oct 2017, Published online: 06 Feb 2018

References

  • Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015;347:78–81. doi:10.1126/science.1260825. PMID:25554788
  • Wu S, Powers S, Zhu W, et al. Substantial contribution of extrinsic risk factors to cancer development. Nature. 2016;529:43–47. doi:10.1038/nature16166. PMID:26675728
  • Yang Z, Wong A, Kuh D, et al. Correlation of an epigenetic mitotic clock with cancer risk. Genome Biol. 2016;17:205. doi:10.1186/s13059-016-1064-3. PMID:27716309
  • Bromham L, Penny D. The modern molecular clock. Nat Rev Genet. 2003;4(3):216–224. doi:10.1038/nrg1020. PMID:12610526
  • Shibata D. Inferring human stem cell behaviour from epigenetic drift. J Pathol. 2009;217(2):199–205. doi:10.1002/path.2461. PMID:19031430
  • Shibata D, Tavar S. Counting Divisions in a Human Somatic Cell Tree: How, What and Why. Cell Cycle. 2006;5(6):610–614. doi:10.4161/cc.5.6.2570. PMID:16582617
  • Genereux DP, Miner BE, Bergstrom CT, et al. A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns. Proc Natl Acad Sci U S A. 2005;102:5802–5807. doi:10.1073/pnas.0502036102. PMID:15827124
  • Ehrlich M.. DNA methylation in cancer cells. Epigenomics. 2010;1(2):239–259. doi:10.2217/epi.09.33.
  • Wilson AS, Power BE, Molloy PL. DNA hypomethylation and human diseases. Biochimica et Biophysica Acta. 2007;1775:138–162. PMID:17045745
  • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene. 2002;21(35):5400–5413. doi:10.1038/sj.onc.1205651. PMID:12154403
  • Kulis M, Esteller M. DNA methylation and cancer. Adv Genet. 2010;70:27–56. PMID:20920744
  • Ehrlich M. Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol. 2006;310:251–274. PMID:16909914
  • Shahrzad S, Bertrand K, Minhas K, et al. Induction of DNA Hypomethylation by Tumor Hypoxia. Epigenetics. 2007;2:119–125. doi:10.4161/epi.2.2.4613. PMID:17965619
  • Hon GC, Hawkins RD, Caballero OL, et al. Global DNA nypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res. 2012;22:246–258. doi:10.1101/gr.125872.111. PMID:22156296
  • Jones PA. DNA methylation and cancer. Cancer Res. 1986;46:461–466. PMID:2416425
  • Lin Q, Wagner W. Epigenetic aging signature are coherently modified in cancer. PLoS Genet. 2015;11(6):e1005334. doi:10.1371/journal.pgen.1005334. PMID:26110659
  • Nazor KL, Altun G, Lynch C, et al. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell stem cell. 2012;10:620–634. doi:10.1016/j.stem.2012.02.013. PMID:22560082
  • Alexandrov LB, Jones PH, Wedge DC, et al. Clock-like mutational processes in human somatic cells. Nat Genet. 2015;47(12):1402–1407. doi:10.1038/ng.3441. PMID:26551669
  • Cooper GM, Hausman RE. The cell: A molecular approach. 6th edition. Sunderland (Massachusetts): Sinauer Associates. 2013.
  • Laird CD, Pleasant ND, Clark AD, et al. Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proc Natl Acad Sci USA. 2004;101(1):204–209. doi:10.1073/pnas.2536758100. PMID:14673087
  • Youn A, Simon R. Using passenger mutations to estimate the timing of driver mutations and identify mutator alterations. BMC Bioinformatics. 2013;14:363. doi:10.1186/1471-2105-14-363. PMID:24330428
  • Lawrence MS, Stojanov P, Polak P, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499:214–218. doi:10.1038/nature12213. PMID:23770567
  • Pencina MJ, D'Agostino RB. Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Stat Med. 2004;23:2109–2123. doi:10.1002/sim.1802. PMID:15211606

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