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Research Paper

Methylation of imprinted IGF2 regions is associated with total, visceral, and hepatic adiposity in postmenopausal women

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Pages 858-865 | Received 20 Jun 2018, Accepted 22 Aug 2018, Published online: 02 Oct 2018

References

  • Apovian CM. The obesity epidemic–understanding the disease and the treatment. N Engl J Med. 2016;374:177–179.
  • Caballero B. The global epidemic of obesity: an overview. Epidemiol Rev. 2007;29:1–5.
  • Garcia-Jimenez C, Gutierrez-Salmeron M, Chocarro-Calvo A, et al. From obesity to diabetes and cancer: epidemiological links and role of therapies. Br J Cancer. 2016;114:716–722.
  • Pi-Sunyer X. The medical risks of obesity. Postgrad Med. 2009;121:21–33.
  • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579–591.
  • Zhang Y, Liu H, Yang S, et al. Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int J Biol Markers. 2014;29:e21–e29.
  • Neuhouser ML, Aragaki AK, Prentice RL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the women’s health initiative randomized clinical trials. JAMA Oncol. 2015;1:611–621.
  • Lauby-Secretan B, Scoccianti C, Loomis D, et al. International agency for research on cancer handbook working G. Body fatness and cancer–viewpoint of the IARC working group. N Engl J Med. 2016;375:794–798.
  • McAdams MA, Van Dam RM, Hu FB. Comparison of self-reported and measured BMI as correlates of disease markers in US adults. Obesity. 2007;15:188–196.
  • Deurenberg P, Yap M, van Staveren WA. Body mass index and percent body fat: a meta analysis among different ethnic groups. J Int Assoc Study Obesity. 1998;22:1164–1171.
  • Jensen MD. Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008;93:S57–S63.
  • InterAct C, Langenberg C, Sharp SJ, et al. Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med. 2012;9:e1001230.
  • Zong G, Zhang Z, Yang Q, et al. Total and regional adiposity measured by dual-energy X-ray absorptiometry and mortality in NHANES 1999–2006. Obesity. 2016;24:2414–2421.
  • Rosenquist KJ, Massaro JM, Pedley A, et al. Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality. J Clin Endocrinol Metab. 2015;100:227–234.
  • Ladeiras-Lopes R, Sampaio F, Bettencourt N, et al. The ratio between visceral and subcutaneous abdominal fat assessed by computed tomography is an independent predictor of mortality and cardiac events. Rev Esp Cardiol. 2017;70:331–337.
  • Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93:359–404.
  • Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011;53:1883–1894.
  • Pirola CJ, Sookoian S. Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity. World J Gastroenterol. 2018;24:1601–1615.
  • Souren NY, Paulussen AD, Steyls A, et al. Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors. Int J Obes. 2009;33:962–970.
  • Su R, Wang C, Feng H, et al. Alteration in expression and methylation of IGF2/H19 in placenta and umbilical cord blood are associated with macrosomia exposed to intrauterine hyperglycemia. PloS One. 2016;11:e0148399.
  • Huang RC, Galati JC, Burrows S, et al. DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults. Clin Epigenetics. 2012;4:21.
  • Murphy R, Ibanez L, Hattersley A, et al. IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance. BMC Med Genet. 2012;13:42.
  • Dejeux E, Olaso R, Dousset B, et al. Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression. Endocr Relat Cancer. 2009;16:939–952.
  • Morita S, Horii T, Kimura M, et al. Paternal allele influences high fat diet-induced obesity. PloS One. 2014;9:e85477.
  • Shepherd JA, Ng BK, Sommer MJ, et al. Body composition by DXA. Bone. 2017;104:101–105.
  • Klopfenstein BJ, Kim MS, Krisky CM, et al. Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans. Br J Radiol. 2012;85:e826–e830.
  • Bohte AE, van Werven JR, Bipat S, et al. The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. Eur Radiol. 2011;21:87–97.
  • Lim U, Turner SD, Franke AA, et al. Predicting total, abdominal, visceral and hepatic adiposity with circulating biomarkers in Caucasian and Japanese American women. PloS One. 2012;7:e43502.
  • Lim U, Ernst T, Buchthal SD, et al. Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass index. Nutr Diabetes. 2011;1:e6.
  • Lim U, Ernst T, Wilkens LR, et al. Susceptibility variants for waist size in relation to abdominal, visceral, and hepatic adiposity in postmenopausal women. J Acad Nutr Diet. 2012;112:1048–1055.
  • World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1–452.
  • Guiu B, Loffroy R, Petit JM, et al. Mapping of liver fat with triple-echo gradient echo imaging: validation against 3.0-T proton MR spectroscopy. Eur Radiol. 2009;19:1786–1793.
  • Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab. 2005;288:E462–E468.
  • Kuk JL, Saunders TJ, Davidson LE, et al. Age-related changes in total and regional fat distribution. Ageing Res Rev. 2009;8:339–348.
  • Ahmed A, Wong RJ, Harrison SA. Nonalcoholic fatty liver disease review: diagnosis, treatment, and outcomes. Clin Gastroenterol Hepatol. 2015;13:2062–2070.
  • Willyard C. Heritability: the family roots of obesity. Nature. 2014;508:S58–S60.
  • Herrera BM, Lindgren CM. The genetics of obesity. Curr Diab Rep. 2010;10:498–505.
  • Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197–206.
  • Fall T, Xie W, Poon W, et al. Using genetic variants to assess the relationship between circulating lipids and Type 2 diabetes. Diabetes. 2015;64:2676–2684.
  • Li E, Zhang Y. DNA methylation in mammals. Cold Spring Harb Perspect Biol. 2014;6:a019133.
  • Peters J. The role of genomic imprinting in biology and disease: an expanding view. Nat Rev Genet. 2014;15:517–530.
  • Soubry A, Schildkraut JM, Murtha A, et al. Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med. 2013;11:29.
  • Bell AC, Felsenfeld G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature. 2000;405:482–485.
  • Kaffer CR, Srivastava M, Park KY, et al. A transcriptional insulator at the imprinted H19/Igf2 locus. Genes Dev. 2000;14:1908–1919.
  • Dimas AS, Deutsch S, Stranger BE, et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science. 2009;325:1246–1250.
  • van Dijk SJ, Molloy PL, Varinli H, et al., Members of Epi S. Epigenetics and human obesity. Int J Obes. 2015;39:85–97.
  • King K, Murphy S, Hoyo C. Epigenetic regulation of Newborns’ imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status. J Epidemiol Commun Health. 2015;69:639–647.
  • Shea JL, Randell EW, Sun G. The prevalence of metabolically healthy obese subjects defined by BMI and dual-energy X-ray absorptiometry. Obesity. 2011;19:624–630.
  • Kennedy AP, Shea JL, Sun G. Comparison of the classification of obesity by BMI vs. dual-energy X-ray absorptiometry in the Newfoundland population. Obesity. 2009;17:2094–2099.
  • Shah NR, Braverman ER. Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin. PloS One. 2012;7:e33308.
  • Perkins E, Murphy SK, Murtha AP, et al. Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. J Pediatr. 2012;161:31–39.
  • St-Pierre J, Hivert MF, Perron P, et al. IGF2 DNA methylation is a modulator of newborn’s fetal growth and development. Epigenetics. 2012;7:1125–1132.
  • Marchal C, Miotto B. Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns. J Cell Physiol. 2015;230:743–751.
  • Laggai S, Kessler SM, Boettcher S, et al. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res. 2014;55:1087–1097.
  • Chiappini F, Barrier A, Saffroy R, et al. Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Lab Invest. 2006;86:154–165.
  • Tovar V, Alsinet C, Villanueva A, et al. IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J Hepatol. 2010;52:550–559.
  • Singh P, Lee DH, Szabo PE. More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain. Front Genet. 2012;3:214.
  • Ulaner GA, Yang Y, Hu JF, et al. CTCF binding at the insulin-like growth factor-II (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues. Endocrinology. 2003;144:4420–4426.

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