References
- Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018;19(6):371–384.
- Meissner A, Mikkelsen TS, Gu H, et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 2008;454(7205):766–770.
- Oh G, Ebrahimi S, Carlucci M, et al. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Nat Commun. 2018;9(1):644.
- Wilson V, Jones P. DNA methylation decreases in aging but not in immortal cells. Science. 1983;220(4601):1055–1057.
- Garagnani P, Bacalini MG, Pirazzini C, et al. Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell. 2012;11(6):1132–1134.
- Wang Y, Karlsson R, Lampa E, et al. Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins. Epigenetics. 2018;13(9):975–987.
- Gopalan S, Carja O, Fagny M, et al. Trends in DNA methylation with age replicate across diverse human populations. Genetics. 2017;206(3):1659–1674.
- Johansson A, Enroth S, Gyllensten U. Continuous aging of the human DNA methylome throughout the human lifespan. PloS One. 2013;8(6):e67378.
- Bacalini M. G, Delen J, Pirazzini C, et al. Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process. The Journals Of Gerontology Series A: Biological Sciences and Medical Sciences 2017;72(8):1015–1023. http://dx.doi.org/10.1093/gerona/glw185
- Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.
- Hannum G, Guinney J, Zhao L, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–367.
- Weidner CI, Lin Q, Koch CM, et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol. 2014;15(2):R24.
- Zhang Y, Wilson R, Heiss J, et al. DNA methylation signatures in peripheral blood strongly predict all-cause mortality. Nat Commun. 2017;8:14617.
- Li X, Li W, Xu Y. Human age prediction based on DNA methylation using a gradient boosting regressor. Genes (Basel). 2018;9:9.
- Tigges J, Krutmann J, Fritsche E, et al. The hallmarks of fibroblast ageing. Mech Ageing Dev. 2014;138:26–44.
- van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509(7501):439–446.
- Correia‐Melo C, Marques FDM, Anderson R, et al. Mitochondria are required for pro‐ageing features of the senescent phenotype. Embo J. 2016;35(7):724–742.
- Franzen J, Zirkel A, Blake J, et al. Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells. Aging Cell. 2017;16(1):183–191. Retrieved from: https://onlinelibrary.wiley.com/doi/abs/10.1111/acel.12544
- Koch CM, Joussen S, Schellenberg A, et al. Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell. 2012;11(2):366–369. Retrieved from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1474-9726.2011.00784.x
- Bork S, Pfister S, Witt H, et al. DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell. 2010;9(1):54–63.
- Horvath S, Oshima J, Martin GM, et al. Epigenetic clock for skin and blood cells applied to hutchinson gilford progeria syndrome and studies. Aging (Albany NY). 2018;10(7):1758–1775.
- Kabacik S, Horvath S, Cohen H, et al. Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression. Aging (Albany NY). 2018;10(10):2800–2815.
- Lowe D, Horvath S, Raj K. Epigenetic clock analyses of cellular senescence and ageing. Oncotarget. 2016;7(8):8524–8531.
- Braam B, Langelaar-Makkinje M, Verkleij A, et al. Anti-oxidant sensitivity of donor age-related gene expression in cultured fibroblasts. Eur J Pharmacol. 2006;542(1–3):154–161.
- Johnson BD, Page RC, Narayanan AS, et al. Effects of donor age on protein and collagen synthesis in vitro by human diploid fibroblasts. Lab Invest. 1986;55(4):490–496. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/3762067
- Unnikrishnan A, Hadad N, Masser DR, et al. Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci. 2018;1418(1):69–79.
- Levine M. E., Lu A. T., Quach A., Chen B. H., Assimes T. L., Bandinelli S.Horvath S. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4),573–591. http://sci-hub.tw/10.18632/aging.101414
- Horvath S, Erhart W, Brosch M, et al. Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A. 2014;111(43):15538–15543.
- Youn A, Wang S. The MiAge calculator: a DNA methylation-based mitotic age calculator of human tissue types. Epigenetics. 2018;13(2):192–206.
- Lu AT, Xue L, Salfati EL, et al. GWAS of epigenetic aging rates in blood reveals a critical role for TERT. Nat Commun. 2018. DOI:10.1038/s41467-017-02697-5
- Kananen L, Marttila S, Nevalainen T, et al. Aging-associated DNA methylation changes in middle-aged individuals: the young finns study. BMC Genomics. 2016;17:103.
- Heyn H, Li N, Ferreira HJ, et al. Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A. 2012;109(26):10522–10527.
- Day K, Waite LL, Thalacker-Mercer A, et al. Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol. 2013;14(9):R102.
- Cruickshanks HA, McBryan T, Nelson DM, et al. Senescent cells harbour features of the cancer epigenome. Nat Cell Biol. 2013;15(12):1495–1506.
- Hu H, Li B, Duan S. The alteration of subtelomeric DNA methylation in aging-related diseases. Front Genet. 2018;9:697.
- Benayoun BA, Pollina EA, Brunet A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol. 2015;16(10):593–610.
- Olova N, Simpson DJ, Marioni RE, et al. Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity. Aging Cell. 2019;18(1):e12877.
- Spalding KL, Bhardwaj RD, Buchholz BA, et al. Retrospective birth dating of cells in humans. Cell. 2005;122(1):133–143.
- Mitchell SJ, Scheibye-Knudsen M, Longo DL, et al. Animal models of aging research: implications for human aging and age-related diseases. Annu Rev Anim Biosci. 2015;3:283–303.
- Hunter P. The paradox of model organisms. The use of model organisms in research will continue despite their shortcomings. EMBO Rep. 2008;9(8):717–720.
- de Magalhães JP. Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research. Cell Cycle. 2014;13(17):2671–2673.
- Chen BH, Marioni RE, Colicino E, et al. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY). 2016;8(9):1844–1865.
- Schübeler D. Function and information content of DNA methylation. Nature. 2015;517(7534):321–326.
- Alisch RS, Barwick BG, Chopra P, et al. Age-associated DNA methylation in pediatric populations. Genome Res. 2012;22(4):623–632.
- Johnson ND, Wiener HW, Smith AK, et al. Non-linear patterns in age-related DNA methylation may reflect CD4+ T cell differentiation. Epigenetics. 2017;12(6):492–503.
- Lim ASP, Srivastava GP, Yu L, et al. 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. PLoS Genet. 2014;10(11):e1004792.
- Lim ASP, Klein H-U, Yu L, et al. Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease. Nat Commun. 2017;8:14931.
- Oh G, Koncevičius K, Ebrahimi S, et al. Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease. Genome Biol. 2019;20(1):2.
- Slieker RC, Relton CL, Gaunt TR, et al. Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. Epigenetics Chromatin. 2018;11(1):25.
- Wagner W. The link between epigenetic clocks for aging and senescence. Front Genet. 2019;10:303.