Overexpression of human-derived DNMT3A induced intergenerational inheritance of DNA methylation and gene expression variations in rat brain and testis

References

• Li E, Zhang Y. DNA methylation in mammals. Cold Spring Harb Perspect Biol. 2014;6:a019133.
   Web of Science ®Google Scholar
• Jeong M, Sun D, Luo M, et al. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014;46(1):17-+.
   Web of Science ®Google Scholar
• Auclair G, Weber M. Mechanisms of DNA methylation and demethylation in mammals. Biochimie. 2012;94(11):2202–2211.
   PubMed Web of Science ®Google Scholar
• Law JA, Jacobsen SE. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet. 2010;11(3):204–220.
   PubMed Web of Science ®Google Scholar
• Barau J, Teissandier A, Zamudio N, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354(6314):909–912.
   PubMed Web of Science ®Google Scholar
• Goll MG, Kirpekar F, Maggert KA, et al. Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2. Science. 2006;311(5759):395–398.
   PubMed Web of Science ®Google Scholar
• Okano M, Bell DW, Haber DA, et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99(3):247–257.
   PubMed Web of Science ®Google Scholar
• Spencer DH, Russler-Germain DA, Ketkar S, et al. CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. Cell. 2017;168(5):801–816. e13.
   PubMed Web of Science ®Google Scholar
• Qu Y, Mu G, Wu Y, et al. Overexpression of DNA Methyltransferases 1, 3a, and 3b significantly correlates with retinoblastoma tumorigenesis. Am J Clin Pathol. 2010;134(5):826–834.
   PubMed Web of Science ®Google Scholar
• Rahman MM, Qian ZR, Lu Wang E, et al. DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors. Hum Pathol. 2010;41(8):1069–1078.
   PubMed Web of Science ®Google Scholar
• Siddiqui NN, Ul Haq A, Siddiqui OA, et al. DNA methyltransferase 1, 3a, and 3b expression in hepatitis C associated human hepatocellular carcinoma and their clinicopathological association. Tumor Biol. 2016;37(8):10487–10497.
   PubMedGoogle Scholar
• Cao X-, Ma H, Shang Y, et al. DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer. World J Gastroenterol. 2014;20(25):8201–8208.
   PubMed Web of Science ®Google Scholar
• Oh BK, Kim H, Park H-J, et al. DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. Int J Mol Med. 2007;20(1):65–73.
   PubMed Web of Science ®Google Scholar
• Kadriu B, Guidotti A, Chen Y, et al. DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. J Comp Neurol. 2012;520(9):1951–1964.
   PubMed Web of Science ®Google Scholar
• Kaneda M, Okano M, Hata K, et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 2004;429(6994):900–903.
   PubMed Web of Science ®Google Scholar
• Siklenka K, Erkek S, Godmann M, et al. Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science. 2015;350(6261):aab2006.
   PubMed Web of Science ®Google Scholar
• Zheng X, Li Z, Wang G, et al. Overexpression of human-derived DNMT3A induced intergenerational inheritance of active DNA methylation changes in rat sperm. Front Genet. 2017;8:207.
   PubMed Web of Science ®Google Scholar
• Yang X, Han H, De Carvalho D, et al. Gene body methylation can alter gene expression and is a therapeutic target in cancer. Cancer Cell. 2014;26(4):577–590.
   PubMed Web of Science ®Google Scholar
• Uysal F, Ozturk S, Akkoyunlu G. DNMT1, DNMT3A and DNMT3B proteins are differently expressed in mouse oocytes and early embryos. J Mol Histol. 2017;48(5–6):417–426.
   PubMed Web of Science ®Google Scholar
• Leonard S, Pereira M, Fox R, et al. Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas. Gynecol Oncol. 2016;143(2):414–420.
   PubMed Web of Science ®Google Scholar
• Chen BF, Chan WY. The de novo DNA methyltransferase DNMT3A in development and cancer. Epigenetics. 2014;9(5):669–677.
   PubMed Web of Science ®Google Scholar
• Galetzka D, Tralau T, Stein R, et al. Expression of DNMT3A transcripts and nucleolar localization of DNMT3A protein in human testicular and fibroblast cells suggest a role for de novo DNA methylation in nucleolar inactivation. J Cell Biochem. 2006;98(4):885–894.
   PubMed Web of Science ®Google Scholar
• Feng J, Chang H, Li E, et al. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005;79(6):734–746.
   PubMed Web of Science ®Google Scholar
• Gu T, Lin X, Cullen SM, et al. DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells. Genome Biol. 2018;19(1):88.
   PubMedGoogle Scholar
• Zhang R, Erler J, Langowski J. Histone acetylation regulates chromatin accessibility: role of H4K16 in inter-nucleosome interaction. Biophys J. 2017;112(3):450–459.
   PubMed Web of Science ®Google Scholar
• Bustos MA, Salomon MP, Nelson N, et al. Genome-wide chromatin accessibility, DNA methylation and gene expression analysis of histone deacetylase inhibition in triple-negative breast cancer. Genom Data. 2017;12:14–16.
   PubMed Web of Science ®Google Scholar
• Bergman Y, Cedar H. DNA methylation dynamics in health and disease. Nat Struct Mol Biol. 2013;20(3):274–281.
   PubMed Web of Science ®Google Scholar
• Fu X, SONG X, LI Y, et al. Hepatitis B virus X protein upregulates DNA methyltransferase 3A/3B and enhances SOCS-1CpG island methylation. Mol Med Rep. 2016;13(1):301–308.
   PubMed Web of Science ®Google Scholar
• Gapp K, von Ziegler L, Tweedie-Cullen RY, et al. Early life epigenetic programming and transmission of stress-induced traits in mammals: how and when can environmental factors influence traits and their transgenerational inheritance? Bioessays. 2014;36(5):491–502.
   PubMed Web of Science ®Google Scholar