Advanced search
Publication Cover
Epigenetics Volume 16, 2021 - Issue 2
Submit an article Journal homepage
1,059
Views
5
CrossRef citations to date
0
Altmetric
Research Paper

Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution

Nathan Rabinovitcha Department of Pediatrics P: 303-398-1992, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaView further author information
,
Meaghan J. Jonesb Department of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaORCID Iconhttps://orcid.org/0000-0003-1593-997XView further author information
ORCID Icon,
Nicole Gladishb Department of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaView further author information
,
Anna V. Fainoc Biostatistics Program P: 206-667-4995, Public Health Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USAView further author information
,
Matthew Strandd Department of Medicine P: 303-398-1862, National Jewish Health, Denver, CO, USAView further author information
,
Alexander M. Morinb Department of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaView further author information
,
Julie MacIsaacb Department of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaView further author information
,
David T. S. Linb Department of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaORCID Iconhttps://orcid.org/0000-0001-5695-9446View further author information
ORCID Icon,
Paul R. Reynoldsd Department of Medicine P: 303-398-1862, National Jewish Health, Denver, CO, USAView further author information
,
Amrit Singhe Department of Pathology and Laboratory Medicine P: 604-764-5827, University of British Columbia, Vancouver, BC, CanadaView further author information
,
Erwin W. Gelfanda Department of Pediatrics P: 303-398-1992, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaView further author information
,
Michael S. Koborb Department of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children’s Hospital Research Institute, Vancouver, BC, CanadaView further author information
&
Christopher Carlstenf Department of Medicine, P: 604-875-4729, University of British Columbia, Vancouver, BC, CanadaCorrespondence[email protected]
View further author information
 show all
Pages 177-185 | Received 26 Feb 2020, Accepted 18 Jun 2020, Published online: 12 Jul 2020

References

  • Rabinovitch N, Strand M, Gelfand EW. Particulate levels are associated with early asthma worsening in children with persistent disease. Am J Respir Crit Care Med. 2006;173. DOI:10.1164/rccm.200509-1393OC
  • Zheng X, Ding H, Jiang L, et al. Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: a systematic review and meta-analysis. PLoS One. 2015;10:e0138146.
  • Rabinovitch N, Silveira L, Gelfand EW, et al. The response of children with asthma to ambient particulate is modified by tobacco smoke exposure. Am J Respir Crit Care Med. 2011;184:1350–1357.
  • Rabinovitch N, Adams CD, Strand M, et al. Within-microenvironment exposure to particulate matter and health effects in children with asthma: a pilot study utilizing real-time personal monitoring with GPS interface. Environ Heal. 2016;15:96.
  • Hoffman BC, Rabinovitch N. Urinary leukotriene E4 as a biomarker of exposure, susceptibility, and risk in asthma: an update. Immunol Allergy Clin North Am. 2018;38:599–610.
  • Rabinovitch N, Zhang L, Gelfand EW. Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction. J Allergy Clin Immunol. 2006;118:635–640.
  • Mostafavi N, Vermeulen R, Ghantous A, et al. Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements: A panel study in four European countries. Environ Int. 2018;120:11–21.
  • Li Z, Li N, Guo C, et al. The global DNA and RNA methylation and their reversal in lung under different concentration exposure of ambient air particulate matter in mice. Ecotoxicol Environ Saf. 2019;172:396–402.
  • Jones MJ, Islam SA, Edgar RD, et al. Adjusting for cell type composition in DNA methylation data using a regression-based approach. Methods Mol Biol. 2017;1589:99–106.
  • Maekawa A, Balestrieri B, Austen KF, et al. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A. 2009;106. DOI:10.1073/pnas.0905364106
  • McGovern T, Goldberger M, Chen M, et al. CysLT1 receptor is protective against oxidative stress in a model of irritant-induced asthma. J Immunol. 2016;197:266–277.
  • Agier J, Różalska S, Wódz K, et al. Leukotriene receptor expression in mast cells is affected by their agonists. Cell Immunol. 2017;317:37–47.
  • Fumagalli M, Lecca D, Coppolino GT, et al. Pharmacological properties and biological functions of the GPR17 receptor, a potential target for neuro-regenerative medicine. Adv Exp Med Biol. 2017;1051:169–192.
  • Qi A-D, Harden TK, Nicholas RA. Is GPR17 a P2Y/leukotriene receptor? Examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. J Pharmacol Exp Ther. 2013;347:38–46.
  • Maekawa A, Xing W, Austen KF, et al. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol. 2010;185:1846–1854.
  • Marschallinger J, Schäffner I, Klein B, et al. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat Commun. 2015;6:8466.
  • Breton CV, Marsit CJ, Faustman E, et al. Small-magnitude effect sizes in epigenetic end points are important in children’s environmental health studies: the children’s environmental health and disease prevention research center’s epigenetics working group. Environ Health Perspect. 2017;125:511–526.
  • Vilcassim MJR, Thurston GD, Chen L-C, et al. Exposure to air pollution is associated with adverse cardiopulmonary health effects in international travellers. J Travel Med. 2019;26. DOI:10.1093/jtm/taz032
  • Armstrong M, Liu AH, Harbeck R, et al. Leukotriene-E4 in human urine: comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:3169–3174.
  • Ramakers C, Ruijter JM, Deprez RHL, et al. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett. 2003;339:62–66.
  • Jiang R, Jones MJ, Sava F, et al. Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics. Part Fibre Toxicol. 2014;11:71.
  • Houseman EA, Accomando WP, Koestler DC, et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012;13:86.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.