Genetic and epigenetic analysis of the serotonin 2A receptor in the context of cocaine abuse

References

• National Institute on Drug Abuse. Costs of substance abuse. 2015. Available from: https://archives.drugabuse.gov/trends-statistics/costs-substance-abuse
   Google Scholar
• What is the scope of cocaine use in the United States? [Internet]. 2016. Available from: https://www.drugabuse.gov/publications/research-reports/cocaine/what-scope-cocaine-use-in-united-states
   Google Scholar
• Nestler EJ. The neurobiology of cocaine addiction. Science & practice perspectives/a publication of the National Institute on Drug Abuse, National Institutes of Health; 2005;3:4–10.
   Google Scholar
• Sofuoglu M, Sewell RA. Norepinephrine and stimulant addiction. Addict Biol. 2009;14(2):119–129.
   Google Scholar
• Filip M, Frankowska M, Zaniewska M, et al. The serotonergic system and its role in cocaine addiction. Pharmacological Reports; 2005;57:685–700.
   Google Scholar
• Paquette AG, Marsit CJ. The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes. J Cell Biochem. 2014;115(12):2065–2072.
   Google Scholar
• Keys Lawler AC, Torres-Yaghi Y, Amjad F, et al. Reader response: pimavanserin: a novel therapeutic option for Parkinson disease psychosis. Neurol Clin Pract. 2018;8(3):175.
   Google Scholar
• Fletcher PJ, Phil D, Grottick AJ, et al. Differential Effects of the 5-HT 2A Receptor Antagonist M100, 907 and the 5-HT 2C Receptor Antagonist SB242, 084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding. 2002;2.
   Google Scholar
• Cao J, Liu X, Han S, et al. Association of the HTR2A gene with alcohol and heroin abuse. Hum Genet. 2014;133(3):357–365.
   Google Scholar
• Ruble CL, Smith RM, Calley J, et al. Genomic structure and expression of the human serotonin 2A receptor gene (HTR2A) locus : identification of novel HTR2A and antisense (HTR2A-AS1) exons. BMC Genet. 2016;17(Suppl 2):1–15.
   Google Scholar
• Smith RM, Papp AC, Webb A, et al. Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex. Biol Psychiatry. 2013;73(6):546–554.
   Google Scholar
• HTR2A - 5-hydroxytryptamine receptor 2A - Homo sapiens (Human) [Internet]. HTR2A gene & protein. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004. Available from: https://www.ncbi.nlm.nih.gov/gene/3356
   Google Scholar
• Fernàndez-Castillo N, Roncero C, Grau-Lopez L, et al. Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. Genes, Brain Behav. 2013;12(1):39–46.
   Google Scholar
• Filip M, Bubar MJ, Cunningham KA. Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther. 2004;310(3):1246–1254.
   Google Scholar
• Pockros LA, Pentkowski NS, Swinford SE, et al. Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2011;213(2–3):307–320.
   Google Scholar
• Nic Dhonnchadha BA, Fox RG, Stutz SJ, et al. Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model. Behav Neurosci. Internet]. 2009;123(2):382–396.
   Google Scholar
• Paquette AG, Lesseur C, Armstrong DA, et al. Placental HTR2A methylation is associated with infant neurobehavioral outcomes. Epigenetics. 2013;8(8):796–801.
   Google Scholar
• Ghadirivasfi M, Nohesara S, Ahmadkhaniha H-R, et al. Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet Part B Neuropsychiatr Genet. 2011;156(5):536–545.
   Google Scholar
• Parade SH, Novick AM, Parent J, et al. Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers. Dev Psychopathol. 2017;29(5):1619–1626.
   Google Scholar
• Smith RM, Alachkar H, Papp AC, et al. Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms. Eur J Hum Genet. 2011;19(1):76–83.
   Google Scholar
• Wu TD, Fast NS. and SNP-tolerant detection of complex variants and splicing in short reads. Bioinformatics. 2010;26(7):873–881.
   Google Scholar
• Signorell A, Aho K, Alfons A, et al. {DescTools}: tools for Descriptive Statistics. 2021. Available from: https://cran.r-project.org/package=DescTools
   Google Scholar
• Shabalin AA. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics. 2012;28(10):1353–1358.
   Google Scholar
• Pierce RC, Fant B, Swinford-Jackson SE, et al. Environmental, genetic and epigenetic contributions to cocaine addiction. Vol. 43. Neuropsychopharmacology. Springer US; 2018. p. 1471–1480.
   Google Scholar
• Smith RM, Banks W, Hansen E, et al. Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder. Autism Res. 2014;7(4):459–467.
   Google Scholar
• Kato M, Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry. 2010;15(5):473–500.
   Google Scholar
• Cheah S-Y, Lawford BR, Young RM, et al. mRNA expression and DNA methylation analysis of serotonin receptor 2A (HTR2A) in the human schizophrenic brain. Genes (Basel). 2017;8(1):1.
   Google Scholar
• Land MA, Ramesh D, Miller AL, et al. Methylation Patterns of the HTR2A associate with relapse-related behaviors in cocaine-dependent participants. Front Psychiatry. 2020;11:532.
   Google Scholar
• Abdolmaleky HM, Yaqubi S, Papageorgis P, et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res. 2011;129(2–3):183–190.
   Google Scholar