1,477
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

DNA hypermethylation of Kiss1r promoter and reduction of hepatic Kiss1r in female rats with type 2 diabetes

, , , , , , , ORCID Icon & ORCID Icon show all
Pages 2332-2346 | Received 11 May 2022, Accepted 19 Aug 2022, Published online: 12 Sep 2022

References

  • Lee JH, Miele ME, Hicks DJ, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst. 1996;88:1731–1737.
  • de Roux N, Genin E, Carel JC, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A. 2003; 100:10972–10976. doi:10.1073/pnas.1834399100.
  • Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349:1614–1627.
  • Lehman MN, Coolen LM, Goodman RL. Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology. 2010;151:3479–3489.
  • Hrabovszky E. Neuroanatomy of the human hypothalamic kisspeptin system. Neuroendocrinology. 2014;99:33–48.
  • Rometo AM, Krajewski SJ, Voytko ML, et al. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab. 2007;92:2744–2750.
  • Finley JC, Maderdrut JL, Roger LJ, et al. The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system. Neuroscience. 1981;6:2173–2192.
  • Funahashi H, Takenoya F, Guan JL, et al. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anat Sci Int. 2003;78:123–138.
  • Luque RM, Kineman RD, Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology. 2007;148:4601–4611.
  • Tolson KP, Garcia C, Yen S, et al. Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J Clin Invest. 2014;124:3075–3079.
  • Song WJ, Mondal P, Wolfe A, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014;19:667–681.
  • Dudek M, Kolodziejski PA, Pruszynska-Oszmalek E, et al. Effects of high-fat diet-induced obesity and diabetes on Kiss1 and GPR54 expression in the hypothalamic-pituitary-gonadal (HPG) axis and peripheral organs (fat, pancreas and liver) in male rats. Neuropeptides. 2016;56:41–49.
  • Brown RE, Imran SA, Ur E, et al. KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake. Mol Cell Endocrinol. 2008;281:64–72.
  • Beetch M, Harandi-Zadeh S, Shen K, et al. Dietary antioxidants remodel DNA methylation patterns in chronic disease. Br J Pharmacol. 2020;177:1382–1408.
  • Jones PA, Ohtani H, Chakravarthy A, et al. Epigenetic therapy in immune-oncology. Nat Rev Cancer. 2019;19:151–161.
  • Motti ML, Meccariello R. Minireview: the epigenetic modulation of KISS1 in reproduction and cancer. Int J Environ Res Public Health. 2019;16:2607.
  • Aylwin CF, Vigh-Conrad K, Lomniczi A. The emerging role of chromatin remodeling factors in female pubertal development. Neuroendocrinology. 2019;109:208–217.
  • Uenoyama Y, Tomikawa J, Inoue N, et al. Molecular and epigenetic mechanism regulating hypothalamic Kiss1 gene expression in mammals. Neuroendocrinology. 2016;103:640–649.
  • Yamazaki J, Meagawa S, Jelinek J, et al. Obese status is associated with accelerated DNA methylation change in peripheral blood of senior dogs. Res Vet Sci. 2021;139:193–199.
  • Navarro VM. Metabolic regulation of kisspeptin - the link between energy balance and reproduction. Nat Rev Endocrinol. 2020;16:407–420.
  • Ziarniak K, Kolodziejski PA, Pruszynska-Oszmalek E, et al. High-fat diet and type 2 diabetes induced disruption of the oestrous cycle and alteration of hormonal profiles, but did not affect subpopulations of KNDy neurons in female rats. J Neuroendocrinol. 2018;30:e12651.
  • Goldman JM, Murr AS, Cooper RL. The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res Part B, Dev Reprod Toxicol. 2007;80:84–97.
  • Paccola CC, Resende CG, Stumpp T, et al. The rat estrous cycle revisited: a quantitative and qualitative analysis. Anim Reprod. 2013;10:677–683.
  • Lubecka K, Kurzava L, Flower K, et al. Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity. Carcinogenesis. 2016;37:656–668.
  • Barrett T, Wilhite SE, Ledoux P, et al. NCBI GEO: archive for functional genomics data sets–update. Nucleic Acids Res. 2013;41:D991–5.
  • Skovso S. Modeling type 2 diabetes in rats using high fat diet and streptozotocin. J Diabetes Investig. 2014;5:349–358.
  • Kleinert M, Clemmensen C, Hofmann SM, et al. Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. 2018;14:140–162.
  • Leitner DR, Fruhbeck G, Yumuk V, et al. Obesity and Type 2 diabetes: two diseases with a need for combined treatment strategies - EASO can lead the way. Obes Facts. 2017;10:483–492.
  • Shen Y, Zhao H, Zhang L, et al. The roles of DNA methylation and hydroxymethylation at short interspersed nuclear elements in the hypothalamic arcuate nucleus during puberty. Mol Ther Nucleic Acids. 2021;26:242–252.
  • Wyatt AK, Zavodna M, Viljoen JL, et al. Changes in methylation patterns of kiss1 and kiss1r gene promoters across puberty. Genet Epigenet. 2013;5:51–62.
  • Kang HS, Baba T, Mandai M, et al. GPR54 is a target for suppression of metastasis in endometrial cancer. Mol Cancer Ther. 2011;10:580–590.
  • Rodriguez-Rodero S, Fernandez AF, Fernandez-Morera JL, et al. DNA methylation signatures identify biologically distinct thyroid cancer subtypes. J Clin Endocrinol Metab. 2013;98:2811–2821.
  • Taiwo O, Wilson GA, Emmett W, et al. DNA methylation analysis of murine hematopoietic side population cells during aging. Epigenetics. 2013;8:1114–1122.
  • Vazquez MJ, Toro CA, Castellano JM, et al. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nat Commun. 2018;9:4194.
  • Velasco I, Leon S, Barroso A, et al. Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis. Metabolism. 2019;98:84–94.
  • Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science. 2001;293:1068–1070.
  • Semaan SJ, Dhamija S, Kim J, et al. Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice. Endocrinology. 2012;153:1875–1886.
  • Gebauer F, Hentze MW. Molecular mechanisms of translational control. Nat Rev Mol Cell Biol. 2004;5:827–835.
  • Song P, Yang F, Jin H, et al. The regulation of protein translation and its implications for cancer. Signal Transduct Target Ther. 2021;6:68.
  • Subramaniam D, Ramalingam S, Linehan DC, et al. RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells. PloS One. 2011;6:e16958.
  • Link JC, Reue K. Genetic basis for sex differences in obesity and lipid metabolism. Annu Rev Nutr. 2017;37:225–245.
  • Jeffery E, Wing A, Holtrup B, et al. The adipose tissue microenvironment regulates depot-specific adipogenesis in obesity. Cell Metab. 2016;24:142–150.
  • De Bond JP, Tolson KP, Nasamran C, et al. Unaltered hypothalamic metabolic gene expression in Kiss1r knockout mice despite obesity and reduced energy expenditure. J Neuroendocrinol. 2016;28(10).
  • Dudek M, Kolodziejski PA, Pruszynska-Oszmalek E, et al. Effects of orchidectomy and testosterone replacement on numbers of kisspeptin-, neurokinin B-, and dynorphin A-immunoreactive neurons in the arcuate nucleus of the hypothalamus in obese and diabetic rats. J Neuroendocrinol. 2017;29. DOI:10.1111/jne.12453
  • Ziarniak K, Kolodziejski PA, Pruszynska-Oszmalek E, et al. Effects of ovariectomy and sex hormone replacement on numbers of kisspeptin-, neurokinin B- and dynorphin A-immunoreactive neurons in the arcuate nucleus of the hypothalamus in obese and diabetic rats. Neuroscience. 2020;451:184–196.
  • Cockwell H, Wilkinson DA, Bouzayen R, et al. KISS1 expression in human female adipose tissue. Arch Gynecol Obstet. 2013;287:143–147.