2,175
Views
3
CrossRef citations to date
0
Altmetric
Research Paper

LncRNA TUG1 promotes pulmonary fibrosis progression via up-regulating CDC27 and activating PI3K/Akt/mTOR pathway

, , , , &
Article: 2195305 | Received 24 Oct 2022, Accepted 07 Feb 2023, Published online: 30 Mar 2023

References

  • Ikeda K, Chiba H, Nishikiori H, et al. Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan. Respir Res. 2020;21:316.
  • Antoniu SA. Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: the role of bosentan. Expert Opin Ther Targets. 2008;12:1077–15.
  • Qian W, Cai X, Qian Q, et al. Angelica sinensis polysaccharide suppresses epithelial-mesenchymal transition and pulmonary fibrosis via a DANCR/AUF-1/FOXO3 regulatory axis. Aging Dis. 2020;11:17–30.
  • Diaz-Pina G, Ordonez-Razo RM, Montes E, et al. The role of ADAR1 and ADAR2 in the regulation of miRNA-21 in idiopathic pulmonary fibrosis. Lung. 2018;196:393–400.
  • Lv X, Li K, Hu Z. Autophagy and pulmonary fibrosis. Adv Exp Med Biol. 2020;1207:569–579.
  • Kim MS, Baek AR, Lee JH, et al. IL-37 attenuates lung fibrosis by inducing autophagy and regulating TGF-beta1 production in mice. J Immunol. 2019;203:2265–2275.
  • Araki K, Kinoshita R, Tomonobu N, et al. The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. J Mol Med (Berl). 2021;99:131–145.
  • Wang YJ, Chen YY, Hsiao CM, et al. Induction of autophagy by pterostilbene contributes to the prevention of renal fibrosis via attenuating NLRP3 inflammasome activation and epithelial-mesenchymal transition. Front Cell Dev Biol. 2020;8:436.
  • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12:861–874.
  • Wang F, Li P, Li FS. Integrated analysis of a gene correlation network identifies critical regulation of fibrosis by lncRnas and TFs in idiopathic pulmonary fibrosis. BioMed Res Int. 2020;2020:6537462.
  • Hadjicharalambous MR, Lindsay MA. Idiopathic pulmonary fibrosis: pathogenesis and the emerging role of long non-coding RNAs. Int J Mol Sci. 2020;21:524.
  • Han X, Hong Y, Zhang K. TUG1 is involved in liver fibrosis and activation of HSCs by regulating miR-29b. Biochem Biophys Res Commun. 2018;503:1394–1400.
  • Zhu Y, Feng Z, Jian Z, et al. Long noncoding RNA TUG1 promotes cardiac fibroblast transformation to myofibroblasts via miR29c in chronic hypoxia. Mol Med Rep. 2018;18:3451–3460.
  • Wang F, Gao X, Zhang R, et al. LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression. Int J Clin Exp Pathol. 2019;12:717–729.
  • Ai Y, Chen M, Liu J, et al. lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions. Int Immunopharmacol. 2020;86:106703.
  • Qi F, Li Y, Yang X, et al. Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27. Aging (Albany NY). 2020;12:14808–14818.
  • Lou MM, Tang XQ, Wang GM, et al. Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons. Nat Commun. 2021;12:4075.
  • Sehgal P, Mathew S, Sivadas A, et al. LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy. Embo J. 2021;40:e107134.
  • Xu Z, Han X, Ou D, et al. Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy. Appl Microbiol Biotechnol. 2020;104:575–587.
  • Cong LH, Li T, Wang H, et al. IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy. J Cell Mol Med. 2020;24:8532–8544.
  • Yu JZ, Ying Y, Liu Y, et al. Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis. Biomed Pharmacother. 2019;118:109293.
  • Zang XJ, Li L, Du X, et al. LncRNA TUG1 inhibits the proliferation and fibrosis of mesangial cells in diabetic nephropathy via inhibiting the PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 2019;23:7519–7525.
  • Ramezani S, Javadi I, Kokhdan EP, et al. Protective and therapeutic effects of ethanolic extract of Nasturtium officinale (watercress) and vitamin E against bleomycin-induced pulmonary fibrosis in rats. Res Pharm Sci. 2021;16:94–102.
  • Wang X, Chen Y, Lv L, et al. Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica-induced lung fibrosis in the rat. Respir Res. 2009;10:36. DOI:10.1186/1465-9921-10-36.
  • Jiang F, Li S, Jiang Y, et al. Fluorofenidone attenuates paraquatinduced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy. Mol Med Rep. 2021;23:405. DOI:10.3892/mmr.2021.12044.
  • Wei J, Zhao Q, Yang G, et al. Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition. J Cell Mol Med. 2021;25:6417–6428.
  • Harada T, Nabeshima K, Hamasaki M, et al. Epithelial-mesenchymal transition in human lungs with usual interstitial pneumonia: quantitative immunohistochemistry. Pathol Int. 2010;60:14–21.
  • Wanas H, El Shereef Z, Rashed L, et al. Ticagrelor ameliorates bleomycin-induced pulmonary fibrosis in rats bythe inhibition of TGF-β1/Smad3 and PI3K/AKT/mTOR pathways. Curr Mol Pharmacol. 2022;15:227–238.
  • Romero Y, Bueno M, Ramirez R, et al. mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts. Aging Cell. 2016;15:1103–1112.
  • Lopez-Otin C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell. 2013;153:1194–1217.
  • Dong Y, Fan G, Li Y, et al. TUG1 represses apoptosis, autophagy, and inflammatory response by regulating miR-27a-3p/slit2 in LPS-Treated vascular endothelial cells. J Surg Res. 2020;256:345–354.
  • Lv D, Xiang Y, Yang Q, et al. Long non-coding RNA TUG1 promotes cell proliferation and inhibits cell apoptosis, autophagy in clear cell renal cell carcinoma via MiR-31-5p/flot1 axis. Onco Targets Ther. 2020;13:5857–5868.
  • Yu L, McPhee CK, Zheng L, et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010;465:942–946.
  • Wang L, Yang J, Wang HN, et al. LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma. Theranostics. 2021;11:925–940.
  • Borthwick LA. The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. Semin Immunopathol. 2016;38:517–534.
  • Kolb M, Margetts PJ, Anthony DC, et al. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest. 2001;107:1529–1536.
  • Yamada A, Aki T, Unuma K, et al. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015;10:e0120192.
  • Zhou W, Mo X, Cui W, et al. Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis. Sci Rep. 2016;6:38646.
  • Hill C, Li J, Liu D, et al. Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. Cell Death Dis. 2019;10:591.
  • Meng Q, Li Y, Ji T, et al. Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor alpha-mediated autophagy. J Adv Res. 2021;28:149–164.
  • Geng Y, Li L, Yan J, et al. PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis. Nat Commun. 2022;13:7114.
  • Xu L, Huan L, Guo T, et al. LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1alpha. Oncogene. 2020;39:7005–7018.
  • Zhao H, Ding F, Zheng G. LncRNA TMPO-AS1 promotes LCN2 transcriptional activity and exerts oncogenic functions in ovarian cancer. Faseb J. 2020;34:11382–11394.