ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway

References

• Sakurai Y, Kubota N, Yamauchi T, et al. Role of insulin resistance in MAFLD. Int J Mol Sci. 2021;22(8):22. doi: 10.3390/ijms22084156
   Web of Science ®Google Scholar
• Araujo AR, Rosso N, Bedogni G, et al. Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future. Liver Int. 2018;38(Suppl 1):47–19. doi: 10.1111/liv.13643
   PubMed Web of Science ®Google Scholar
• Petaja EM, Yki-Jarvinen H. Definitions of normal liver fat and the association of insulin sensitivity with acquired and genetic NAFLD—A Systematic Review. Int J Mol Sci. 2016;17(5):17. doi: 10.3390/ijms17050633
   Web of Science ®Google Scholar
• Calzadilla Bertot L, Adams LA. The natural course of non-alcoholic fatty liver disease. Int J Mol Sci. 2016;17(5):17. doi: 10.3390/ijms17050774
   Web of Science ®Google Scholar
• Nd AM. Non-alcoholic fatty liver disease, an overview. Integr Med (Encinitas). 2019;18(2):42–49.
   PubMedGoogle Scholar
• Ma X, McKeen T, Zhang J, et al. Role and mechanisms of mitophagy in liver diseases. Cells. 2020;9(4):9. doi: 10.3390/cells9040837
   Web of Science ®Google Scholar
• Caldwell SH, Swerdlow RH, Khan EM, et al. Mitochondrial abnormalities in non-alcoholic steatohepatitis. J Hepatol. 1999;31(3):430–434. doi: 10.1016/S0168-8278(99)80033-6
   PubMed Web of Science ®Google Scholar
• Yamada T, Murata D, Adachi Y, et al. Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease. Cell Metab. 2018;28(4):588–604.e5. doi: 10.1016/j.cmet.2018.06.014
   PubMed Web of Science ®Google Scholar
• Urbina-Varela R, Castillo N, Videla LA. Del campo a: impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old pathologies: sarcopenia and non-alcoholic fatty liver disease. Int J Mol Sci. 2020;21(20):21. doi: 10.3390/ijms21207704
   Web of Science ®Google Scholar
• Zhou T, Chang L, Luo Y, et al. Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy. Redox Biol. 2019;21:101120. doi: 10.1016/j.redox.2019.101120
   PubMed Web of Science ®Google Scholar
• Hirooka Y, Shimokawa H. Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases. Am J Cardiovasc Drugs. 2005;5(1):31–39. doi: 10.2165/00129784-200505010-00005
   PubMedGoogle Scholar
• Wang J, Jiang W. The effects of RKI-1447 in a mouse model of nonalcoholic fatty liver disease induced by a high-fat diet and in hepg2 human hepatocellular carcinoma cells treated with oleic acid. Med Sci Monit. 2020;26:e919220. doi: 10.12659/MSM.919220
   PubMed Web of Science ®Google Scholar
• Moskal N, Riccio V, Bashkurov M, et al. ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway. Nat Commun. 2020;11(1):88. doi: 10.1038/s41467-019-13781-3
   PubMed Web of Science ®Google Scholar
• Ye B, Yang G, Li Y, et al. ZNF143 in chromatin looping and gene regulation. Front Genet. 2020;11:338. doi: 10.3389/fgene.2020.00338
   PubMed Web of Science ®Google Scholar
• Izumi H, Wakasugi T, Shimajiri S, et al. Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes. Cancer Sci. 2010;101(12):2538–2545. doi: 10.1111/j.1349-7006.2010.01725.x
   PubMed Web of Science ®Google Scholar
• Ge J, Bai Y, Tang B, et al. The gene signature associated with hepatocellular carcinoma in patients with nonalcoholic fatty liver disease. J Oncol. 2021;2021:1–9. doi: 10.1155/2021/6630535
   Web of Science ®Google Scholar
• Chen X, Tan XR, Li SJ, et al. LncRNA NEAT1 promotes hepatic lipid accumulation via regulating miR-146a-5p/ROCK1 in nonalcoholic fatty liver disease. Life Sci. 2019;235:116829. doi: 10.1016/j.lfs.2019.116829
   PubMed Web of Science ®Google Scholar
• Wang X. Down-regulation of lncRNA-NEAT1 alleviated the non-alcoholic fatty liver disease via mTOR/S6K1 signaling pathway. J of Cell Biochem. 2018;119(2):1567–1574. doi: 10.1002/jcb.26317
   PubMed Web of Science ®Google Scholar
• Hu MJ, Long M, Dai RJ. Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p/GRIA3. Mol Cell Biochem. 2022;477(1):191–203. doi: 10.1007/s11010-021-04269-0
   PubMed Web of Science ®Google Scholar
• Yang DY, Zhou X, Liu ZW, et al. LncRNA NEAT1 accelerates renal tubular epithelial cell damage by modulating mitophagy via miR-150-5p–DRP1 axis in diabetic nephropathy. Exp Physiol. 2021;106(7):1631–1642. doi: 10.1113/EP089547
   PubMed Web of Science ®Google Scholar
• Ferre F, Colantoni A, Helmer-Citterich M. Revealing protein–lncRNA interaction. Brief Bioinform. 2016;17(1):106–116. doi: 10.1093/bib/bbv031
   PubMed Web of Science ®Google Scholar
• Garcia-Arcos I, Rueda Y, Gonzalez-Kother P, et al. Association of SND1 protein to low density lipid droplets in liver steatosis. J Physiol Biochem. 2010;66(1):73–83. doi: 10.1007/s13105-010-0011-0
   PubMed Web of Science ®Google Scholar
• Del Rio-Moreno M, Alors-Perez E, Gonzalez-Rubio S, et al. Dysregulation of the splicing machinery is associated to the development of nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2019;104(8):3389–3402. doi: 10.1210/jc.2019-00021
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Shimanaka Y, Caddeo A, et al. LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover. Gut. 2021;70(1):180–193. doi: 10.1136/gutjnl-2020-320646
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zong C, Jiang M, et al. Hepatic HuR modulates lipid homeostasis in response to high-fat diet. Nat Commun. 2020;11(1):3067. doi: 10.1038/s41467-020-16918-x
   PubMed Web of Science ®Google Scholar
• Zhang L, Huo Q, Ge C, et al. ZNF143-mediated H3K9 trimethylation upregulates CDC6 by activating MDIG in hepatocellular carcinoma. Cancer Res. 2020;80(12):2599–2611. doi: 10.1158/0008-5472.CAN-19-3226
   PubMed Web of Science ®Google Scholar
• Lake AD, Chaput AL, Novak P, et al. Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis. Biochem Pharmacol. 2016;122:62–71. doi: 10.1016/j.bcp.2016.11.006
   PubMed Web of Science ®Google Scholar
• Bailey SD, Zhang X, Desai K, et al. ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Nat Commun. 2015;6(1):6186. doi: 10.1038/ncomms7186
   Google Scholar
• Fu X, Zhu J, Zhang L, et al. Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells. Artif Cells Nanomed Biotechnol. 2019;47(1):1782–1787. doi: 10.1080/21691401.2019.1604536
   PubMed Web of Science ®Google Scholar
• Jin SS, Lin XF, Zheng JZ, et al. lncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506/GLI3. Eur Cytokine Netw. 2019;30(3):98–106. doi: 10.1684/ecn.2019.0432
   PubMed Web of Science ®Google Scholar
• Jin SS, Lin CJ, Lin XF, et al. Silencing lncRNA NEAT1 reduces nonalcoholic fatty liver fat deposition by regulating the miR-139-5p/c-Jun/SREBP-1c pathway. Ann Hepatol. 2021;27(2):100584. doi: 10.1016/j.aohep.2021.100584
   PubMed Web of Science ®Google Scholar
• Sinha RA, Yen PM. Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell Biosci. 2016;6(1):46. doi: 10.1186/s13578-016-0113-7
   PubMedGoogle Scholar
• Haq S, Das S, Kim DH, et al. The stability and oncogenic function of LIN28A are regulated by USP28. Biochim Biophys Acta Mol Basis Dis. 2019;1865(3):599–610. doi: 10.1016/j.bbadis.2018.12.006
   PubMed Web of Science ®Google Scholar
• Chen R, Zhang X, Wang C. LncRNA HOXB-AS1 promotes cell growth in multiple myeloma via FUT4 mRNA stability by ELAVL1. J Cell Biochem. 2020;121(10):4043–4051. doi: 10.1002/jcb.29573
   PubMed Web of Science ®Google Scholar
• Feng Y, Gao L, Cui G, et al. LncRNA NEAT1 facilitates pancreatic cancer growth and metastasis through stabilizing ELF3 mRNA. Am J Cancer Res. 2020;10(1):237–248.
   PubMed Web of Science ®Google Scholar
• Guttman M, Donaghey J, Carey BW, et al. Lander ES: lincRnas act in the circuitry controlling pluripotency and differentiation. Nature. 2011;477(7364):295–300. doi: 10.1038/nature10398
   PubMed Web of Science ®Google Scholar
• Mang Y, Li L, Ran J, et al. Long noncoding RNA NEAT1 promotes cell proliferation and invasion by regulating hnRNP A2 expression in hepatocellular carcinoma cells. Onco Targets Ther. 2017;10:1003–1016. doi: 10.2147/OTT.S116319
   PubMed Web of Science ®Google Scholar
• Tang X, Guo D, Lin C, et al. hCLOCK causes rho-kinase-mediated endothelial dysfunction and NF-kappaB-Mediated inflammatory responses. Oxid Med Cell Longev. 2015;2015:671839. doi: 10.1155/2015/671839
   PubMed Web of Science ®Google Scholar
• Hu X, Yu D, Zhuang L, et al. Geniposide improves hepatic inflammation in diabetic db/db mice. Int Immunopharmacol. 2018;59:141–147. doi: 10.1016/j.intimp.2018.03.035
   PubMed Web of Science ®Google Scholar
• Xue W, Fan Z, Li Y, et al. Alkannin inhibited hepatic inflammation in diabetic Db/Db mice. Cell Physiol Biochem. 2018;45(6):2461–2470. doi: 10.1159/000488264
   PubMedGoogle Scholar
• Eiyama A, Okamoto K. Pink1/parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol. 2015;33:95–101. doi: 10.1016/j.ceb.2015.01.002
   PubMed Web of Science ®Google Scholar