References
- Limbergen JV, Russel RK, Drummond HE, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease [Internet]. Science Direct. Gastroenterology; 2008 [cited 2022 Nov 22]. Available from: https://www.sciencedirect.com/science/article/pii/S0016508508012018
- Gupta N, Bostrom AG, Kirschner BS, et al. Presentation and disease course in early- compared to later-onset pediatric crohn’s disease [Internet]. U.S. National Library Of Medicine. The American Journal Of Gastroenterology; 2008 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258513/
- Kim J, Ye BD Successful transition from pediatric to adult care in inflammatory bowel disease: what is the key? [Internet]. U.S. National Library of Medicine. Pediatric Gastroenterology, Hepatology & Nutrition; 2019 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333582/
- Ostrowski J, Paziewska A, Lazowska I, et al. Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population [Internet]. Nature Publishing Group. Nature Communications; 2016 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/srep39831
- Ruel J, Ruane D, Mehandru S, et al. IBD across the age spectrum—is it the same disease? [Internet]. Nature Reviews Gastroenterology & Hepatology. Nature Reviews Gastroenterology & Hepatology; 2014 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/nrgastro.2013.240
- Vermeire S, Asscheg V, Rutgeerts P Laboratory markers in IBD: useful, magic, or unnecessary toys? [Internet]. National Center for Biotechnology Information. Gut; 2006 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856093/
- Mendoza JL, Abreu MT Biological markers in inflammatory bowel disease: practical consideration for clinicians [Internet]. Elsevier Masson. Gastroentérologie Clinique et Biologique; 2009 [cited 2022 Nov 22]. Available from: https://www.sciencedirect.com/science/article/pii/S0399832009731513
- Vermeire S, Assche GV, Rutgeerts P C-Reactive protein as a marker for inflammatory bowel disease [Internet]. Oxford Academic. Inflammatory Bowel Diseases; 2004 [cited 2022 Nov 22]. Available from: https://academic.oup.com/ibdjournal/article/10/5/661/4718266
- Yang DH, Yang SK, Park SH, et al. Usefulness of C-reactive protein as a disease activity marker in crohn’s disease according to the location of disease [Internet]. U.S. National Library of Medicine. Gut and liver; 2015 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282861/
- Chen P, Zhou G, Lin J, et al. Serum biomarkers for inflammatory bowel disease [Internet]. U.S. National Library of Medicine. Frontiers in Medicine; 2020 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188783/
- Somineni HK, Venkateswaran S, Kilaru V, et al. Blood-derived DNA methylation signatures of crohn’s disease and severity of intestinal inflammation [Internet]. U.S. National Library of Medicine. Gastroenterology; 2019 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529254/
- Taman H, Fenton CG, Hensel IV, et al. Genome-wide DNA methylation in treatment-naïve ulcerative colitis [Internet]. U.S. National Library Of Medicine. Journal Of Crohn’s & Colitis; 2018 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236200/
- Ventham NT, Kennedy NA, Adams AT, et al. Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease [Internet]. Nature Communications. Nature Publishing Group; 2016 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/ncomms13507
- Salas LA, Zhang Z, Koestler DC, et al. Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling [Internet]. Nature Communications. Nature Publishing Group; 2022 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/s41467-021-27864-7#citeas
- Salas LA, Koestler DC, Butler RA, et al. An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the illumina HumanMethylationEPIC beadarray [Internet]. Genome Biology. BioMed Central; 2018 [cited 2022 Nov 22]. Available from: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1448-7
- Koestler DC, Jones MJ, Usset J, et al. Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (idol) [Internet]. BMC Bioinformatics. BioMed Central; 2016 [cited 2022 Nov 22]. Available from: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-0943-7
- Houseman EA, Accomando WP, Koestler DC, et al. DNA methylation arrays as surrogate measures of cell mixture distribution [Internet]. BioMed Bioinformatics. BioMed Central; 2012 [cited 2022 Nov 22]. Available from: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-13-86
- Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications [Internet]. Gut. U.S. National Library of Medicine; 2006 [cited 2023Jan24]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856208/
- Hansen KD Illuminahumanmethylationepicanno.ilm10b4.hg19 [Internet]. Bioconductor. Bioconductor; 2017 [cited 2022 Nov 22]. Available from: https://bioconductor.org/packages/release/data/annotation/html/IlluminaHumanMethylationEPICanno.ilm10b4.hg19.html
- Durinck S, Spellman PT, Birney E, et al. Mapping Identifiers For The Integration Of Genomic Datasets With The R/Bioconductor Package Biomart [Internet]. Nature Protocols. Nature Publishing Group; 2009 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/nprot.2009.97
- Phipson B, Maksimovic J, Oshlack A missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform [Internet]. Oxford Academic. Bioinformatics; 2016 [cited 2022 Nov 22]. Available from: https://academic.oup.com/bioinformatics/article/32/2/286/1744111?login=false
- Petagna L, Antonelli A, Ganini C, et al. Pathophysiology of crohn’s disease inflammation and recurrence [Internet]. Biology Direct. BioMed Central; 2020 [cited 2022 Nov 22]. Available from: https://biologydirect.biomedcentral.com/articles/10.1186/s13062-020-00280-5
- Rosales C. Neutrophil: a cell with many roles in inflammation or several cell types? [Internet]. U.S. National Library of Medicine. Frontiers in physiology; 2018 [cited 2022 Nov 22]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826082/
- Langley BO, Guedry SE, Goldenberg JZ, et al. Inflammatory bowel disease and neutrophil–lymphocyte ratio: a systematic scoping review. J Clin Med. 2021;10(18):4219. doi: 10.3390/jcm10184219
- Gao SQ, Huang LD, Dai RJ, et al. Neutrophil-lymphocyte ratio: a controversial marker in predicting Crohn’s disease severity. Int J Clin Exp Pathol. 2015;8(11):14779–11.
- Jaeger N, Gamini R, Cella M, et al. Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions. Nat Commun. 2021;12(1):1921.
- Ziller MJ, Gu H, Müller F, et al. Charting a dynamic DNA methylation landscape of the human genome [Internet]. Nature. Nature Publishing Group; 2013 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/nature12433
- Peranzoni E, Zilio S, Marigo I, et al. Myeloid-derived suppressor cell heterogeneity and subset definition [Internet]. Science Direct. Current Opinion In Immunology; 2010 [cited 2022 Nov 22]. Available from: https://www.sciencedirect.com/science/article/pii/S0952791510000221?via%3Dihub
- Gabrilovich DI, Nagaraj S Myeloid-derived suppressor cells as regulators of the immune system [Internet]. Nature Reviews Immunology. Nature Publishing Group; 2009 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/nri2506
- Jaeger N, Gamini R, Cella M, et al. Single-cell analyses of crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions [Internet]. Nature Communications. Nature Publishing Group; 2021 [cited 2022 Nov 22]. Available from: https://www.nature.com/articles/s41467-021-22164-6