Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals – a randomized intervention trial

References

• Chang H, Zhang T, Zhang Z, et al. Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects. J Nutr Biochem. 2011;22(12):1172–10. doi: 10.1016/j.jnutbio.2010.10.003
   PubMed Web of Science ®Google Scholar
• Choi S-W, Friso S. Nutrients and Epigenetics [Internet]. 1st. CRC Press; 2009 . Available from10.1201/9781420063561
   Google Scholar
• Bailey LB. Folate in Health and disease [Internet]. 2nd. CRC Press; 2009 . Available from10.1201/9781420071252
   Google Scholar
• Crider KS, Yang TP, Berry RJ, et al. Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Adv Nutr. 2012;3(1):21–38. doi: 10.3945/an.111.000992
   PubMed Web of Science ®Google Scholar
• Martiniak Y, Heuer T, Hoffmann I. Intake of dietary folate and folic acid in Germany based on different scenarios for food fortification with folic acid. Eur J Nutr. 2015;54(7):1045–1054. doi: 10.1007/s00394-014-0781-1
   PubMed Web of Science ®Google Scholar
• Folat [Internet]. https://www.dge.de/wissenschaft/referenzwerte/folat/?L=0 [cited 2023 Mar 3]; Available from: https://www.dge.de/wissenschaft/referenzwerte/folat/?L=0
   Google Scholar
• Dietary Supplement Fact Sheets [Internet]. https://ods.od.nih.gov/factsheets/list-all/[cited 2023 Mar 3]; Available from: https://ods.od.nih.gov/factsheets/list-all/
   Google Scholar
• Fransquet PD, Wrigglesworth J, Woods RL, et al. The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis. Clin Epigenetics. 2019;11(1):62. doi: 10.1186/s13148-019-0656-7
   PubMed Web of Science ®Google Scholar
• Lind L, Ingelsson E, Sundström J, et al. Methylation-based estimated biological age and cardiovascular disease. Eur J Clin Invest. 2018;48(2):48. doi: 10.1111/eci.12872
   Web of Science ®Google Scholar
• Roetker NS, Pankow JS, Bressler J, et al. Prospective study of epigenetic age acceleration and incidence of cardiovascular disease outcomes in the ARIC study (atherosclerosis risk in communities). Circ Genom Precis Med. 2018;11(3):e001937. doi: 10.1161/CIRCGEN.117.001937
   PubMed Web of Science ®Google Scholar
• Si J, Chen L, Yu C, et al. Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease. Clin Epigenetics. 2023;15(1):52. doi: 10.1186/s13148-023-01464-2
   PubMed Web of Science ®Google Scholar
• Ammous F, Zhao W, Ratliff SM, et al. Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans. Clin Epigenetics. 2021;13(1):55. doi: 10.1186/s13148-021-01035-3
   PubMed Web of Science ®Google Scholar
• Joyce BT, Gao T, Zheng Y, et al. Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health. Circ Res. 2021;129(8):770–781. doi: 10.1161/CIRCRESAHA.121.318965
   PubMed Web of Science ®Google Scholar
• Li Y, Huang T, Zheng Y, et al. Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Heart Assoc. 2016;5(8):e003768. doi: 10.1161/JAHA.116.003768
   PubMed Web of Science ®Google Scholar
• Wang Z-M, Zhou B, Nie Z-L, et al. Folate and risk of coronary heart disease: a meta-analysis of prospective studies. Nutr Metab Cardiovasc Dis. 2012;22(10):890–899. doi: 10.1016/j.numecd.2011.04.011
   PubMed Web of Science ®Google Scholar
• Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14(1):6. doi: 10.1186/1475-2891-14-6
   PubMed Web of Science ®Google Scholar
• Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111–113. doi: 10.1038/ng0595-111
   PubMed Web of Science ®Google Scholar
• Fortin J-P, Triche TJ, Hansen KD, et al. Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi. Bioinformatics. 2017;33(4):558–560. doi: 10.1093/bioinformatics/btw691
   PubMed Web of Science ®Google Scholar
• Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115. doi: 10.1186/gb-2013-14-10-r115
   PubMed Web of Science ®Google Scholar
• Hannum G, Guinney J, Zhao L, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–367. doi: 10.1016/j.molcel.2012.10.016
   PubMed Web of Science ®Google Scholar
• Lu AT, Seeboth A, Tsai P-C, et al. DNA methylation-based estimator of telomere length. Aging. 2019;11(16):5895–5923. doi: 10.18632/aging.102173
   PubMedGoogle Scholar
• Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4):573–591. doi: 10.18632/aging.101414
   PubMedGoogle Scholar
• Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303–327. doi: 10.18632/aging.101684
   PubMedGoogle Scholar
• Lu AT, Binder AM, Zhang J, et al. DNA methylation GrimAge version 2. Aging. 2022;14:9484–9549. doi: 10.18632/aging.204434
   PubMedGoogle Scholar
• Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. Elife. 2022;11:e73420. doi: 10.7554/eLife.73420
   PubMed Web of Science ®Google Scholar
• Houseman EA, Accomando WP, Koestler DC, et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinf. 2012;13(1):86. doi: 10.1186/1471-2105-13-86
   PubMedGoogle Scholar
• Koestler DC, Jones MJ, Usset J, et al. Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL). BMC Bioinf. 2016;17(1):120. doi: 10.1186/s12859-016-0943-7
   PubMedGoogle Scholar
• Osterhues A, Holzgreve W, Michels KB. Shall we put the world on folate? Lancet. [cited 2012 Oct 12] 2009;374(9694):959–961. Available from http://www.ncbi.nlm.nih.gov/pubmed/19766871 10.1016/S0140-6736(09)61646-9
   PubMed Web of Science ®Google Scholar
• Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007;297(21):2351–2359. doi: 10.1001/jama.297.21.2351
   PubMed Web of Science ®Google Scholar
• Ebbing M, Bønaa KH, Nygård O, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009;302(19):2119–2126. doi: 10.1001/jama.2009.1622
   PubMed Web of Science ®Google Scholar
• Kim Y-I. Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Gut. 2006;55(10):1387–1389. doi: 10.1136/gut.2006.095463
   PubMed Web of Science ®Google Scholar
• Pufulete M. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut. 2005;54(5):648–653. doi: 10.1136/gut.2004.054718
   PubMed Web of Science ®Google Scholar
• Cravo M, Fidalgo P, Pereira AD, et al. DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev. 1994;3(6):473–480. doi: 10.1097/00008469-199411000-00004
   PubMedGoogle Scholar
• Figueiredo JC, Grau MV, Wallace K, et al. Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1041–1049. doi: 10.1158/1055-9965.EPI-08-0926
   PubMed Web of Science ®Google Scholar
• van den Donk M, van Engeland M, Pellis L, et al. Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2007;16(2):327–333. doi: 10.1158/1055-9965.EPI-06-0810
   PubMed Web of Science ®Google Scholar
• Kok DEG, Dhonukshe-Rutten RAM, Lute C, et al. The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. Clin Epigenetics. 2015;7(1):121. doi: 10.1186/s13148-015-0154-5
   PubMedGoogle Scholar
• Kim Y-I. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. 2007;51(3):267–292. doi: 10.1002/mnfr.200600191
   PubMed Web of Science ®Google Scholar
• Smith AD, Kim Y-I, Refsum H. Is folic acid good for everyone? Am J Clin Nutr. 2008;87(3):517–533. doi: 10.1093/ajcn/87.3.517
   PubMed Web of Science ®Google Scholar
• Amenyah SD, Hughes CF, Ward M, et al. Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults—a systematic review and meta-analysis. Nutr Rev. 2020;78(8):647–666. doi: 10.1093/nutrit/nuz094
   PubMed Web of Science ®Google Scholar
• Sae-Lee C, Corsi S, Barrow TM, et al. Dietary intervention modifies DNA methylation age assessed by the epigenetic clock. Mol Nutr Food Res. 2018;62(23):e1800092. doi: 10.1002/mnfr.201800092
   PubMed Web of Science ®Google Scholar
• In: Michels KB. editor. Epigenetic epidemiology. 2nd. Cham, Switzerland: Springer International Publishing; 2022. [cited 2023 Mar 3]. Available from https://link.springer.com/10.1007/978-3-030-94475-9
   Google Scholar
• Allis CD, Jenuwein T, Reinberg D, et al. , editors. Epigenetics. 1st ed. Cold Spring Harbour, New York: Cold Spring Harbor Laboratory Press; 2007. Overview and Concepts; p. 23–61.
   Google Scholar
• Yamagata Y, Szabó P, Szüts D, et al. Rapid turnover of DNA methylation in human cells. Epigenetics. 2012;7(2):141–145. doi: 10.4161/epi.7.2.18906
   PubMed Web of Science ®Google Scholar
• Pacis A, Mailhot-Léonard F, Tailleux L, et al. Gene activation precedes DNA demethylation in response to infection in human dendritic cells. Proc Natl Acad Sci U S A. 2019;116(14):6938–6943. doi: 10.1073/pnas.1814700116
   PubMed Web of Science ®Google Scholar