Views and perspectives on the indoleamines serotonin and melatonin in plants: past, present and future

References

• Murch SJ, Erland LAE. A systematic review of melatonin in plants: An example of evolution of literature. Front Plant Sci. 2021;12:683047. doi:10.3389/fpls.2021.683047.
   PubMed Web of Science ®Google Scholar
• Yang L, You J, Li J, Wang Y, Chan Z, Sunkar R. Melatonin promotes Arabidopsis primary root growth in an IAA-dependent manner. J Exp Bot. 2021;72(15):5599–18. doi:10.1093/jxb/erab196.
   PubMed Web of Science ®Google Scholar
• Kim M, Seo H, Park C, Park WJ. Examination of the auxin hypothesis of phytomelatonin action in classical auxin assay systems in maize. J Plant Physiol. 2016;190:67–71. doi:10.1016/j.jplph.2015.11.009.
   PubMed Web of Science ®Google Scholar
• Erland LAE, Murch SJ, Reiter RJ, Saxena PK. A new balancing act: The many roles of melatonin and serotonin in plant growth and development. Plant Signal Behav. 2015;10(11):e1096469–15. doi:10.1080/15592324.2015.1096469.
   PubMed Web of Science ®Google Scholar
• Arora D, Singh N, Bhatla SC. Calmodulin and calcium-mediated melatonin signaling mechanisms in plants. Theor Exp Plant Physiol. 2023; 1–11. doi:10.1007/s40626-023-00301-4.
   Web of Science ®Google Scholar
• Arnao MB, Hernández‐Ruiz J, Hu Y. Melatonin as a regulatory hub of plant hormone levels and action in stress situations. Plant Biol. 2020;23(S1). doi:10.1111/plb.13202.
   PubMedGoogle Scholar
• Arnao MB, Hernández-Ruiz J. Melatonin: A new plant hormone and/or a plant master regulator? Trend Plant Sci. 2019;24(1):38–48. doi:10.1016/j.tplants.2018.10.010.
   PubMed Web of Science ®Google Scholar
• Erland LAE, Shukla MR, Singh AS, Murch SJ, Saxena PK. Melatonin and serotonin: Mediators in the symphony of plant morphogenesis. J Pineal Res. 2018;64(2):e12452. doi:10.1111/jpi.12452.
   Web of Science ®Google Scholar
• Kang S, Kang K, Lee K, Back K. Characterization of rice tryptophan decarboxylases and their direct involvement in serotonin biosynthesis in transgenic rice. Planta. 2007;227(1):263–272. doi:10.1007/s00425-007-0614-z.
   PubMed Web of Science ®Google Scholar
• Berlin J, Rügenhagen C, Dietze P, Fecker LF, Goddijn OJM, Hoge JHC. Increased production of serotonin by suspension and root cultures of Peganum harmala transformed with a tryptophan decarboxylase cDNA clone from Catharanthus roseus. Transgenic Res. 1993;2(6):336–344. doi:10.1007/BF01976175.
   Web of Science ®Google Scholar
• Kang S, Kang K, Lee K, Back K. Characterization of tryptamine 5-hydroxylase and serotonin synthesis in rice plants. Plant Cell Rep. 2007;26(11):2009–2015. doi:10.1007/s00299-007-0405-9.
   PubMed Web of Science ®Google Scholar
• Songstad DD, Luca VD, Brisson N, Kurz WGW, Nessler CL. High levels of tryptamine accumulation in transgenic tobacco expressing tryptophan decarboxylase. Plant Physiol. 2008;94(3):1410–1413. doi:10.1104/pp.94.3.1410.
   Google Scholar
• Songstad DD, Kurz WGW, Nessler CL. Tyramine accumulation in Nicotiana tabacum transformed with a chimeric tryptophan decarboxylase gene. Phytochemistry. 1991;30(10):3245–3246. doi:10.1016/0031-9422(91)83185-N.
   Web of Science ®Google Scholar
• Tan D-X, Hardeland R, Back K, Manchester LC, Alatorre-Jimenez MA, Reiter RJ. On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species. J Pineal Res. 2016;61(1):27–40. doi:10.1111/jpi.12336.
   PubMed Web of Science ®Google Scholar
• Reynolds JD, Kimbrough TD, Weekley LB. Evidence for enzymatic 5-hydroxylation of indole-3-acetic acid in vitro by extracts of Sedum morganianum. Zeitschrift Für Pflanzenphysiologie. 1983;112(5):465–470. doi:10.1016/S0044-328X(83)80153-6.
   Google Scholar
• Park S, Byeon Y, Lee HY, Kim Y-S, Ahn T, Back K. Cloning and characterization of a serotonin N-acetyltransferase from a gymnosperm, loblolly pine (Pinus taeda). J Pineal Res. 2014;57(3):348–355. doi:10.1111/jpi.12174.
   PubMed Web of Science ®Google Scholar
• Park S, Byeon Y, Back K. Functional analyses of three ASMT gene family members in rice plants. J Pineal Res. 2013;55(4):409–415. doi:10.1111/jpi.12088.
   PubMed Web of Science ®Google Scholar
• Byeon Y, Lee HY, Lee K, Back K. Caffeic acid O-methyltransferaseis involved in the synthesis of melatonin by methylating N-acetylserotonin in Arabidopsis. J Pineal Res. 2014;57(2):219–227. doi:10.1111/jpi.12160.
   PubMed Web of Science ®Google Scholar
• Back K, Tan D-X, Reiter RJ. Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts. J Pineal Res. 2016;61(4):426–437. doi:10.1111/jpi.12364.
   PubMed Web of Science ®Google Scholar
• Byeon Y, Lee K, Park Y-I, Park S, Back K. Molecular cloning and functional analysis of serotonin N -acetyltransferase from the cyanobacterium Synechocystis sp. PCC 6803. J Pineal Res. 2013;55(4):371–376. doi:10.1111/jpi.12080.
   PubMed Web of Science ®Google Scholar
• Lee HY, Byeon Y, Lee K, Lee H-J, Back K. Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations. J Pineal Res. 2014;57(4):418–426. doi:10.1111/jpi.12181.
   PubMed Web of Science ®Google Scholar
• Dubbels R, Reiter RJ, Klenke E, Goebel A, Schnakenberg E, Ehlers C, Schiwara HW, Schloot W. Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. J Pineal Res. 1995;18(1):28–31. doi:10.1111/j.1600-079X.1995.tb00136.x.
   PubMed Web of Science ®Google Scholar
• Hattori A, Migitaka H, Iigo M, Itoh M, Yamamoto K, Ohtani-Kaneko R, Hara M, Suzuki T, Reiter RJ. Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates. Biochem Mol Biol Int. 1995;35:627–634.
   PubMedGoogle Scholar
• Murch SJ, Simmons CB, Saxena PK. Melatonin in feverfew and other medicinal plants. Lancet. 1997;350(9091):1598–1599. doi:10.1016/S0140-6736(05)64014-7.
   PubMed Web of Science ®Google Scholar
• Erland LAE, Chattopadhyay A, Jones AMP, Saxena PK. Melatonin in Plants and Plant Culture Systems: Variability, stability and efficient quantification. Front Plant Sci. 2016;7:1721. doi:10.3389/fpls.2016.01721.
   PubMed Web of Science ®Google Scholar
• Went FW, Thimann KP. Phytohormones 1937.
   Google Scholar
• Zhang C, Žukauskaitė A, Petřík I, Pěnčík A, Hönig M, Grúz J, Široká J, Novák O, Doležal K. In situ characterisation of phytohormones from wounded Arabidopsis leaves using desorption electrospray ionisation mass spectrometry imaging. Analyst (Lond). 2021;146(8):2653–2663. doi:10.1039/D0AN02118K.
   Web of Science ®Google Scholar
• Erland LAE, Turi CE, Murch SJ. Preliminary assessment of the conservation status of medicinal plant species in Canada1. Botany. 2021;99:1–14.
   Google Scholar
• Erland LAE, Yasunaga A, Li ITS, Susan JM, Saxena PK. Direct visualization of location and uptake of applied melatonin and serotonin in living tissues and their redistribution in plants in response to thermal stress. J Pineal Res. 2019;66(1):e12527. doi:10.1111/jpi.12527.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, David A, Yadav S, Frantisek B, Bhatla SC. Salt stress-induced seedling growth inhibition coincides with differential distribution of serotonin and melatonin in sunflower seedling roots and cotyledons. Physiol Plantarum. 2014;152(4):714–728. doi:10.1111/ppl.12218.
   PubMed Web of Science ®Google Scholar
• Chattopadhyay A, Erland LAE, Jones AMP, Saxena PK. Indoleamines and phenylpropanoids modify development in the bryophyte Plagiomnium cuspidatum (Hedw.) T.J. Kop. Vitro Cell Dev Biol - Plant. 2018;54(4):454–464. doi:10.1007/s11627-018-9904-3.
   Web of Science ®Google Scholar
• Liang S, Xu S, Qu D, Yang L, Wang J, Liu H, Xin W, Zou D, Zheng H. Identification and Functional analysis of the caffeic acid O-Methyltransferase (COMT) gene family in rice (Oryza sativa L.). Int J Mol Sci. 2022;23(15):8491. doi:10.3390/ijms23158491.
   PubMed Web of Science ®Google Scholar
• Byeon Y, Lee H-J, Lee HY, Back K. Cloning and functional characterization of the Arabidopsis N-acetylserotonin O-methyltransferase responsible for melatonin synthesis. J Pineal Res. 2016;60(1):65–73. doi:10.1111/jpi.12289.
   PubMed Web of Science ®Google Scholar
• Zhao D, Yao Z, Zhang J, Zhang R, Mou Z, Zhang X, Li Z, Feng X, Chen S, Reiter RJ. Melatonin synthesis genes N -acetylserotonin methyltransferases evolved into caffeic acid O -methyltransferases and both assisted in plant terrestrialization. J Pineal Res. 2021;71(3):e12737. doi:10.1111/jpi.12737.
   PubMed Web of Science ®Google Scholar
• Erland LAE, Dumigan CR, Forsyth JA, Frolova L, Yasunaga AB, Pun W, Li ITS, Deyholos MK, Murch SJ. Mammalian melatonin agonist pharmaceuticals stimulate rhomboid proteins in plants. Biomolecules. 2022;12(7):882. doi:10.3390/biom12070882.
   PubMed Web of Science ®Google Scholar
• Murch SJ, Campbell SSB, Saxena PK. The role of serotonin and melatonin in plant morphogenesis: Regulation of auxin-induced root organogenesis in in vitro-cultured explants of st. John’s Wort (Hypericum perforatum L.). Vitro Cell Dev Biol - Plant. 2001;37:786–793. doi:10.1007/s11627-001-0130-y.
   Web of Science ®Google Scholar
• Reiter RJ, Tan D-X, Galano A. Melatonin reduces lipid peroxidation and membrane viscosity. Front Physiol. 2014;5:377. doi:10.3389/fphys.2014.00377.
   PubMed Web of Science ®Google Scholar
• Raghuram N, Sopory SK. Evidence for some common signal-transduction events for opposite regulation of nitrate reductase and phytochrome-I gene-expression by light. Plant Mol Biol. 1995;29(1):25–35. doi:10.1007/BF00019116.
   PubMed Web of Science ®Google Scholar
• Raghuram N, Sopory S. Roles of nitrate, nitrite and ammonium ion in phytochrome regulation of nitrate reductase gene expression in maize. IUBMB Life. 1999;47(2):239–249. doi:10.1080/15216549900201253.
   Google Scholar
• Das R, Sopory SK. Evidence of regulation of calcium uptake by phytochrome in maize protoplasts. Biochem Biophys Res Commun. 1985;128(3):1455–1460. doi:10.1016/0006-291X(85)91103-9.
   PubMed Web of Science ®Google Scholar
• Chandok MR, Sopory SK. 5-Hydroxytryptamine affects turnover of polyphosphoinositides in maize and stimulates nitrate reductase in the absence of light. FEBS Lett. 1994;356(1):39–42. doi:10.1016/0014-5793(94)01213-X.
   PubMed Web of Science ®Google Scholar
• Arnao MB, Hernández-Ruiz J, Cano A, Reiter RJ. Melatonin and Carbohydrate Metabolism in Plant Cells. Plants. 2021;10(9):1917. doi:10.3390/plants10091917.
   Google Scholar
• Zhao H, Su T, Huo L, Wei H, Yang J, Xu L, Ma F. Unveiling the mechanism of melatonin impacts on maize seedling growth: Sugar metabolism as a case. J Pineal Res. 2015;59(2):255–266. doi:10.1111/jpi.12258.
   PubMed Web of Science ®Google Scholar
• Hanson J, Smeekens S. Sugar perception and signaling—an update. Curr Opin Plant Biol. 2009;12(5):562–567. doi:10.1016/j.pbi.2009.07.014.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Tan D-X, Lei Q, Chen H, Wang L, Li Q, Gao Y, Kong J. Melatonin and its potential biological functions in the fruits of sweet cherry. J Pineal Res. 2013;55(1):79–88. doi:10.1111/jpi.12044.
   PubMed Web of Science ®Google Scholar
• Ahn H-R, Kim Y-J, Lim Y-J, Duan S, Eom S-H, Jung K-H. Key genes in the melatonin biosynthesis pathway with circadian rhythm are associated with various abiotic stresses. Plants. 2021;10(1):129. doi:10.3390/plants10010129.
   Google Scholar
• Zhang H, Wang L, Shi K, Shan D, Yunpeng Z, Wang C, Bai Y, Yan T, Xiaodong Z, Kong J. Apple tree flowering is mediated by low level of melatonin under the regulation of seasonal light signal. J Pineal Res. 2019;66(2):66. doi:10.1111/jpi.12551.
   Web of Science ®Google Scholar
• Kimbrough TD, Reynolds JD, Humphreys KJ, Weekley LB. Diurnal changes in tissue leaf levels of tryptophan, tyrosine and amine metabolites in sedum morganianum and sedum pachyphyllum. Biochem Physiol Pfl. 1987;182(1):67–72. doi:10.1016/S0015-3796(87)80039-2.
   Google Scholar
• Reynolds JD, Kimbrough TD, Weekley LB. The effect of light quality on 5-hydroxyindole metabolism in leaves of Sedum morganianum (Crassulaceae). Biochem Physiol Pflanzen. 1985;189(5):345–351. doi:10.1016/S0015-3796(85)80085-8.
   Google Scholar
• Lee HY, Back K. Melatonin plays a pivotal role in conferring tolerance against endoplasmic reticulum stress via mitogen-activated protein kinases and bZIP60 in Arabidopsis thaliana. Melatonin Res. 2018;1(1):94–108. doi:10.32794/mr11250006.
   Google Scholar
• Xu L, Xiang G, Sun Q, Ni Y, Jin Z, Gao S, Yao Y. Melatonin enhances salt tolerance by promoting MYB108A-mediated ethylene biosynthesis in grapevines. Hortic Res. 2019;6(1):114. doi:10.1038/s41438-019-0197-4.
   PubMedGoogle Scholar
• Lee HY, Back K. Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants. J Pineal Res. 2016;60(3):327–335. doi:10.1111/jpi.12314.
   PubMed Web of Science ®Google Scholar
• Lee HY, Back K. Melatonin is required for H2O2- and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana. J Pineal Res. 2017;62(2):62. doi:10.1111/jpi.12379.
   Web of Science ®Google Scholar
• Yao J, Ma Z, Ma Y, Zhu Y, Lei M, Hao C, Chen L, Xu Z, Huang X. Role of melatonin in UV‐B signaling pathway and UV‐B stress resistance in Arabidopsis thaliana. Plant, Cell & Environ. 2021;44(1):114–129. doi:10.1111/pce.13879.
   PubMed Web of Science ®Google Scholar
• Shi H, Qian Y, Tan D-X, Reiter RJ, He C. Melatonin induces the transcripts of CBF/DREB1s and their involvement in both abiotic and biotic stresses in Arabidopsis. J Pineal Res. 2015;59(3):334–342. doi:10.1111/jpi.12262.
   PubMed Web of Science ®Google Scholar
• Bajwa VS, Shukla MR, Sherif SM, Murch SJ, Saxena PK. Role of melatonin in alleviating cold stress in Arabidopsis thaliana. J Pineal Res. 2014;56(3):238–245. doi:10.1111/jpi.12115.
   PubMed Web of Science ®Google Scholar
• Wang D, Chen Q, Chen W, Guo Q, Xia Y, Wang S, Jing D, Liang G. Physiological and transcription analyses reveal the regulatory mechanism of melatonin in inducing drought resistance in loquat (Eriobotrya japonica Lindl.) seedlings. Environ Exp Bot. 2021;181:104291. doi:10.1016/j.envexpbot.2020.104291.
   Web of Science ®Google Scholar
• Li G, Liu J, Chen S, Wang P, Liu H, Dong J, Zheng Y, Xie Y, Wang C, Guo T. et al. Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat. J Pineal Res. 2021;70(4):e12727. doi:10.1111/jpi.12727.
   PubMed Web of Science ®Google Scholar
• Zhang T, Tang Y, Luan Y, Cheng Z, Wang X, Tao J, Zhao D. Herbaceous peony AP2/ERF transcription factor binds the promoter of the tryptophan decarboxylase gene to enhance high‐temperature stress tolerance. Plant, Cell & Environ. 2022;45(9):2729–2743. doi:10.1111/pce.14357.
   PubMed Web of Science ®Google Scholar
• Ullah I, A P, Abbas A, Hussain S, Nanda S, a P. Genome-wide identification and expression analysis of the RcYABBY s reveals their potential functions in rose (Rosa chinensis Jacq.). J Hortic Sci Biotechnol. 2022;97(5):593–602. doi:10.1080/14620316.2022.2048207.
   Web of Science ®Google Scholar
• Back K. Melatonin metabolism, signaling, and possible roles in plants. Plant Journal. 2020;105(2):376–391. doi:10.1111/tpj.14915.
   PubMed Web of Science ®Google Scholar
• Abdul Rafiu A, Sovacool BK, Daniels C. The dynamics of global public research funding on climate change, energy, transport, and industrial decarbonisation. Renew Sustain Energy Rev. 2022;162:112420. doi:10.1016/j.rser.2022.112420.
   Web of Science ®Google Scholar
• Anderson R, Bayer PE, Edwards D. Climate change and the need for agricultural adaptation. Curr Opin Plant Biol. 2020;56:197–202. doi:10.1016/j.pbi.2019.12.006.
   PubMed Web of Science ®Google Scholar
• Brummitt NA, Bachman SP, Griffiths-Lee J, Lutz M, Moat JF, Farjon A, Donaldson JS, Hilton-Taylor C, Meagher TR, Albuquerque S. et al. Green plants in the red: A baseline global assessment for the IUCN sampled red list index for plants. PLOS ONE. 2015;10(8):e0135152. doi:10.1371/journal.pone.0135152.
   PubMed Web of Science ®Google Scholar
• Dawson TP, Jackson ST, House JI, Prentice IC, Mace GM. Beyond Predictions: Biodiversity conservation in a changing climate. Science. 2011;332(6025):53–58. doi:10.1126/science.1200303.
   PubMed Web of Science ®Google Scholar
• Foden WB, Butchart SHM, Stuart SN, Vié J-C, Akçakaya HR, Angulo A, DeVantier LM, Gutsche A, Turak E, Cao L. et al. Identifying the World’s Most Climate Change Vulnerable Species: A systematic trait-based assessment of all birds, amphibians and corals. PLOS ONE. 2013;8(6):e65427–13. doi:10.1371/journal.pone.0065427.
   PubMed Web of Science ®Google Scholar
• Darwin C. In: Darwin F, John Murray, editors. The ’Power of movement in plants.’–1880. London, UK: John Murray; 1888. p. 329–338.
   Google Scholar
• Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, Schiweck C, Kurilshikov A, Joossens M, Wijmenga C. et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol. 2019;4(4):623–632. doi:10.1038/s41564-018-0337-x.
   PubMed Web of Science ®Google Scholar
• Saremba BM, Tymm FJM, Baethke K, Rheault MR, Sherif SM, Saxena PK, Murch SJ. Plant signals during beetle (Scolytus multistriatus) feeding in American elm (Ulmus americana Planch). Plant Signal Behav. 2017;12(5):e1296997. doi:10.1080/15592324.2017.1296997.
   PubMed Web of Science ®Google Scholar
• Barrett M, Orchard I. Serotonin-induced elevation of cAMP levels in the epidermis of the blood-sucking bug, Rhodnius prolixus. J Insect Physiol. 1990;36(9):625–633. doi:10.1016/0022-1910(90)90066-O.
   Web of Science ®Google Scholar
• Oyarzabal-Armendariz E, Alquicira-Mireles J, Zúñiga-Ruíz B, Arreola-Ramírez JL, Guevara-Fefer P, Lara-Figueroa CO, Escamilla-Chimal EG. Effect of Azadirachta indica. In: Juss A. Eds. (Meliaceae) on the serotonin rhythm of Spodoptera frugiperda. Vol. 38. Lepidoptera: Noctuidae). Chronobiol Int; 2021. p. 201–211.
   Google Scholar
• O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015;277:32–48. doi:10.1016/j.bbr.2014.07.027.
   PubMed Web of Science ®Google Scholar
• Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264–276. doi:10.1016/j.cell.2015.02.047.
   PubMed Web of Science ®Google Scholar
• Baluška F, Mancuso S, Volkman D, Barlow PW. The ‘root-brain’ hypothesis of Charles and Francis Darwin. Plant Signal Behav. 2009;4(12):1121–1127. doi:10.4161/psb.4.12.10574.
   PubMedGoogle Scholar
• Tonello L, Gashi B, Scuotto A, Cappello G, Cocchi M, Gabrielli F, Tuszynski JA. The gastrointestinal-brain axis in humans as an evolutionary advance of the root-leaf axis in plants: A hypothesis linking quantum effects of light on serotonin and auxin. J Integr Neurosci. 2018;17(2):227–237. doi:10.3233/JIN-170048.
   Web of Science ®Google Scholar
• Pascale A, Proietti S, Pantelides IS, Stringlis IA. Modulation of the Root Microbiome by Plant Molecules: The basis for targeted disease suppression and plant growth promotion. Front Plant Sci. 2020;10:1741. doi:10.3389/fpls.2019.01741.
   PubMed Web of Science ®Google Scholar
• Ma Y, Jiao J, Fan X, Sun H, Ying Z, Jiang J, Liu C. Endophytic bacterium Pseudomonas fluorescens RG11 may transform tryptophan to melatonin and promote endogenous melatonin levels in the roots of four grape cultivars. Front Plant Sci. 2017;7. doi:10.3389/fpls.2016.02068.
   Web of Science ®Google Scholar
• Whiteside MD, Garcia MO, Treseder KK, Bonaventure G. Amino acid uptake in arbuscular mycorrhizal plants. PLOS ONE. 2012;7(10):e47643. doi:10.1371/journal.pone.0047643.
   PubMed Web of Science ®Google Scholar
• Jiao J, Ma Y, Chen S, Liu C, Yuyang S, Qin Y, Yuan C, Liu Y. Melatonin-producing endophytic bacteria from grapevine roots promote the abiotic stress-induced production of endogenous melatonin in their hosts. Front Plant Sci. 2016;7. doi:10.3389/fpls.2016.01387.
   Web of Science ®Google Scholar
• Zhang X, Zhang H, Zhang H, Tang M. Exogenous melatonin application enhances Rhizophagus irregularis symbiosis and induces the antioxidant response of Medicago truncatula under lead stress. Front Microbiol. 2020;11:516. doi:10.3389/fmicb.2020.00516.
   PubMed Web of Science ®Google Scholar
• Riga P, Benedicto L, García-Flores L, Villaño D, Medina S, Á G-I. Rootstock effect on serotonin and nutritional quality of tomatoes produced under low temperature and light conditions. J Food Comp Anal. 2016;46:50–59. doi:10.1016/j.jfca.2015.11.003.
   Web of Science ®Google Scholar
• Bik EM, Ugalde JA, Cousins J, Goddard AD, Richman J, Apte ZS. Microbial biotransformations in the human distal gut: Microbial biotransformations in the distal gut. Br J Pharmacol Chemother. 2017;175(24):4404–4414. doi:10.1111/bph.14085.
   Web of Science ®Google Scholar
• Erland L, Turi CE, Saxena PK, Murch SJ. Metabolomics and hormonomics to crack the code of filbert growth. Metabolomics. 2020;16(5):62. doi:10.1007/s11306-020-01684-0.
   PubMed Web of Science ®Google Scholar
• Israelyan N, Margolis KG. Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacol Res. 2019;140:115–120. doi:10.1016/j.phrs.2018.12.023.
   PubMed Web of Science ®Google Scholar
• Iriti M, Varoni EM. Melatonin in Mediterranean diet, a new perspective. J Sci Food Agricult. 2015;95(12):2355–2359. doi:10.1002/jsfa.7051.
   PubMed Web of Science ®Google Scholar
• Wei J, D-X L, Zhang J-R, Shan C, Zed R, Song Z-B, Chen Q. Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana. J Pineal Res. 2018: 65.
   Google Scholar
• Li D, Wei J, Peng Z, Ma W, Yang Q, Song Z, Sun W, Yang W, Yuan L, Xu X. et al. Daily rhythms of phytomelatonin signaling modulate diurnal stomatal closure via regulating reactive oxygen species dynamics in Arabidopsis. J Pineal Res. 2020;68(3):e12640. doi:10.1111/jpi.12640.
   PubMed Web of Science ®Google Scholar
• Lee HY, Back K. The phytomelatonin receptor (PMRT1) Arabidopsis Cand2 is not a bona fide G protein–coupled melatonin receptor. Melatonin Res. 2020;3(2):177–186. doi:10.32794/mr11250055.
   Google Scholar
• Wang L-F, Lu K-K, Li T-T, Zhang Y, Guo J-X, Song R-F, Liu W-C. Maize PHYTOMELATONIN RECEPTOR1 functions in plant tolerance to osmotic and drought stress. J Exp Bot. 2021.
   Google Scholar
• Bai Y, Wei Y, Yin H, Hu W, Cheng X, Guo J, Dong Y, Zheng L, Xie H, Zeng H. et al. PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava. J Pineal Res. 2022;73(1):e12804. doi:10.1111/jpi.12804.
   PubMed Web of Science ®Google Scholar
• Li X, Rengel Z, Chen Q. Phytomelatonin prevents bacterial invasion during nighttime. Trends Plant Sci. 2022;27(4):331–334. doi:10.1016/j.tplants.2021.12.008.
   PubMed Web of Science ®Google Scholar
• Wang Z, Li L, Khan D, Chen Y, Pu X, Wang X, Guan M, Rengel Z, Chen Q. Nitric oxide acts downstream of reactive oxygen species in phytomelatonin receptor 1 (PMTR1)-mediated stomatal closure in Arabidopsis. J Plant Physiol. 2023;282:153917. doi:10.1016/j.jplph.2023.153917.
   PubMed Web of Science ®Google Scholar
• Ramakrishna A, Giridhar P, Jobin M, Paulose CS, Ravishankar GA. Indoleamines and calcium enhance somatic embryogenesis in Coffea canephora P ex Fr. Plant Cell Tissue Organ Cult. 2011;108(2):267–278. doi:10.1007/s11240-011-0039-z.
   Web of Science ®Google Scholar
• Wan J, Zhang P, Sun L, Li S, Wang R, Zhou H, Wang W, Xu J. Involvement of reactive oxygen species and auxin in serotonin-induced inhibition of primary root elongation. J Plant Physiol. 2018;229:89–99. doi:10.1016/j.jplph.2018.07.004.
   PubMed Web of Science ®Google Scholar
• Roshchina VV., Roshchina VV. Chemical signaling in plant microspore cells. Biol Bull Russ Acad Sci. 2006;33(4):332–338. doi:10.1134/S1062359006040030.
   Web of Science ®Google Scholar
• Roshchina VV. Molecular-cellular mechanisms in pollen allelopathy. 2001.
   Google Scholar
• Roshchina VV. Contractile proteins in chemical signal transduction in plant microspores. Biol Bull Russ Acad Sci. 2005;32(3):229–233. doi:10.1007/s10525-005-0093-3.
   Web of Science ®Google Scholar
• Jenkins GI. Signal Transduction in Responses to UV-B Radiation. Annu Rev Plant Biol. 2009;60(1):407–431. doi:10.1146/annurev.arplant.59.032607.092953.
   PubMedGoogle Scholar
• Azmitia EC. Chapter 1 Evolution of serotonin: sunlight to suicide. Handb Behav Neurosci. 2020;31:3–22.
   Google Scholar
• Forsyth JA, Erland LA, Shipley PR, Murch SJ. Plant perception of light: The role of indoleamines in scutellaria species. Melatonin Res. 2020;3(2):161–176. doi:10.32794/mr11250054.
   Google Scholar
• Yeleswaram K, Lg M, Knipe JO, Schabdach D. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications. J Pineal Res. 1997;22(1):45–51. doi:10.1111/j.1600-079X.1997.tb00302.x.
   PubMed Web of Science ®Google Scholar
• Rebollo-Hernanz M, Aguilera Y, Herrera T, Cayuelas LT, DueñDueñAs M, Rodríguez-Rodríguez P, Ramiro-Cortijo D, Arribas SM, Martín-Cabrejas MA. Bioavailability of melatonin from lentil sprouts and its role in the plasmatic antioxidant status in rats. Foods. 2020;9(3):330. doi:10.3390/foods9030330.
   PubMed Web of Science ®Google Scholar
• Madigan AP, Egidi E, Bedon F, Franks AE, Plummer KM. Bacterial and fungal communities are differentially modified by melatonin in agricultural soils under abiotic stress. Front Microbiol. 2019;10:2616. doi:10.3389/fmicb.2019.02616.
   PubMedGoogle Scholar
• Arnao MB, Hernández-Ruiz J. Melatonin as a chemical substance or as phytomelatonin rich-extracts for use as plant protector and/or biostimulant in accordance with EC legislation. Agronomy. 2019;9(10):570–27. doi:10.3390/agronomy9100570.
   Google Scholar
• Arnao MB, Hernández‐Ruiz J. Melatonin as a plant biostimulant in crops and during post‐harvest: a new approach is needed. J Sci Food Agric. 2021;101(13):5297–5304. doi:10.1002/jsfa.11318.
   PubMed Web of Science ®Google Scholar
• Bhatla SC, Ranjan P, Singh N, Gogna M. Pure biochemicals and nanomaterials as next generation biostimulants for sustainable agriculture under abiotic stress – recent advances and future scope. Plant Signal Behav. 2023;18(1):2290336. doi:10.1080/15592324.2023.2290336.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Roy S, Arnao MB. Nanovehicles for melatonin: a new journey for agriculture. Trends Plant Sci. 2024;29(2):232–248. doi:10.1016/j.tplants.2023.11.016.
   PubMed Web of Science ®Google Scholar
• Song Y, Wang B, Qiu D, Xie Z, Dai S, Li C, Xu S, Zheng Y, Li S, Jiang M. Melatonin enhances metallic oxide nanoparticle stress tolerance in rice via inducing tetrapyrrole biosynthesis and amino acid metabolism. Environ Sci Nano. 2021;8(8):2310–2323. doi:10.1039/D1EN00244A.
   Web of Science ®Google Scholar
• Andersen LPH, Gögenur I, Rosenberg J, Reiter RJ. The safety of melatonin in humans. Clin Drug Investig. 2016;36(3):169–175. doi:10.1007/s40261-015-0368-5.
   PubMed Web of Science ®Google Scholar
• Jan S, Singh B, Bhardwaj R, Kapoor D, Kour J, Singh R, Alam P, Noureldeen A, Darwish H. Application of melatonin and PGPR alleviates thiamethoxam induced toxicity by regulating the TCA cycle in Brassica Juncea L. Saudi J Biol Sci. 2022;29(3):1348–1354. doi:10.1016/j.sjbs.2022.01.039.
   PubMed Web of Science ®Google Scholar
• Johns NP, Johns J, Supatra P, Plaimee P, Sae-Teaw M. Dietary intake of melatonin from tropical fruit altered urinary excretion of 6-sulfatoxymelatonin in healthy volunteers. J Agr Food Chem. 2013;61(4):913–919. doi:10.1021/jf300359a.
   PubMed Web of Science ®Google Scholar
• Pranil T, Moongngarm A, Manwiwattanakul G, Loypimai P, Kerr WL. Melatonin and its derivative contents in tropical fruits and fruit tablets. J Food Compos Anal. 2021;103:104109. doi:10.1016/j.jfca.2021.104109.
   Web of Science ®Google Scholar
• Mhlongo MI, Piater LA, Steenkamp PA, Labuschagne N, Dubery IA. Metabolomic evaluation of tissue-specific defense responses in tomato plants modulated by PGPR-priming against Phytophthora capsici infection. Plants. 2021;10(8):1530. doi:10.3390/plants10081530.
   Google Scholar
• Shen J, Chen D, Zhang X, Song L, Dong J, Xu Q, Hu M, Cheng Y, Shen F, Wang W. Mitigation of salt stress response in upland cotton (Gossypium hirsutum) by exogenous melatonin. J Plant Res. 2021;134(4):857–871. doi:10.1007/s10265-021-01284-6.
   PubMed Web of Science ®Google Scholar
• Giebelhaus RT, Biggs L, Murch SJ, Erland LAE. Untargeted and targeted metabolomics to understand plant growth regulation and evolution in wollemi pine (wollemia nobilis). Botany. 2023;101(9):377–380. doi:10.1139/cjb-2023-0017.
   Google Scholar
• Uğur Y. Extraction and quantification of melatonin in cornelian cherry (Cornus mas L.) by ultra-fast liquid chromatography coupled to fluorescence detector (UFLC-FD). Acta Chromatogr. 2023;35(3):219–226. doi:10.1556/1326.2022.01052.
   Web of Science ®Google Scholar
• Esen E, Osman B, Demir MN. Molecularly imprinted solid-phase extractıon sorbent for selective determınatıon of melatonin. Microchem J. 2021;170:106666. doi:10.1016/j.microc.2021.106666.
   Web of Science ®Google Scholar
• Dou J, Wang J, Tang Z, Yu J, Wu Y, Liu Z, Wang J, Wang G, Tian Q. Application of exogenous melatonin improves tomato fruit quality by promoting the accumulation of primary and secondary metabolites. Foods. 2022;11(24):4097. doi:10.3390/foods11244097.
   PubMed Web of Science ®Google Scholar
• Vafadar F, Ehsanzadeh P. Synergistic effects of calcium and melatonin on physiological and phytochemical attributes of Dracocephalum kotschyi genotypes under salinity stress. Physiol Plant. 2023;175(3):e13912. doi:10.1111/ppl.13912.
   PubMed Web of Science ®Google Scholar
• Guevara L, MÁ D-A, Ortigosa A, González-Gordo S, Díaz C, Vicente F, Corpas FJ, Del PJ, Palma JM. Identification of compounds with potential therapeutic uses from sweet pepper (Capsicum annuum L.) fruits and their modulation by nitric oxide (NO). Int J Mol Sci. 2021;22(9):4476. doi:10.3390/ijms22094476.
   PubMed Web of Science ®Google Scholar
• Tereucán G, Ruiz A, Nahuelcura J, Oyarzún P, Santander C, Winterhalter P, Ferreira PAA, Cornejo P. Shifts in biochemical and physiological responses by the inoculation of arbuscular mycorrhizal fungi in Triticum aestivum growing under drought conditions. J Sci Food Agric. 2022;102(5):1927–1938. doi:10.1002/jsfa.11530.
   PubMed Web of Science ®Google Scholar
• Qin B, Zou J, Cao L, Wang M, Zhang Y-X. Melatonin regulates material transport to reduce carbon emissions and increase yield under different nitrogen in rice. Agric Ecosyst Environ. 2023;342:108235. doi:10.1016/j.agee.2022.108235.
   Web of Science ®Google Scholar
• Gupta P, De B. Influence of calcium channel modulators on the production of serotonin, gentisic acid, and a few other biosynthetically related phenolic metabolites in seedling leaves of salt tolerant rice variety Nonabokra. Plant Signal Behav. 2021;16(10):1929732. doi:10.1080/15592324.2021.1929732.
   PubMed Web of Science ®Google Scholar
• Yadav S, Elansary HO, Mattar MA, Elhindi KM, Alotaibi MA, Mishra A. Differential accumulation of metabolites in Suaeda species provides new insights into abiotic stress tolerance in C4-halophytic species in elevated CO2 conditions. Agronomy. 2021;11(1):131. doi:10.3390/agronomy11010131.
   Google Scholar
• Pesti-Asbóth G, Molnár-Bíróné P, Forgács I, Remenyik J, Dobránszki J. Ultrasonication affects the melatonin and auxin levels and the antioxidant system in potato in vitro. Front Plant Sci. 2022;13:979141. doi:10.3389/fpls.2022.979141.
   PubMed Web of Science ®Google Scholar
• Arabia A, Munné-Bosch S, Muñoz P. Melatonin triggers tissue-specific changes in anthocyanin and hormonal contents during postharvest decay of Angeleno plums. Plant Sci. 2022;320:111287. doi:10.1016/j.plantsci.2022.111287.
   PubMed Web of Science ®Google Scholar
• Ko J, Ryu JE, Noh S-W, Choi H-K. Melatonin treatment enhances the growth and productivity of useful metabolites in the in vitro culture of spirodela polyrhiza. J Agric Food Chem. 2023;71(3):1748–1757. doi:10.1021/acs.jafc.2c07147.
   PubMedGoogle Scholar
• Mukherjee S, Bhatla SC. Endogenous serotonin accumulation coincides with reorganization of auxin efflux protein (PIN1) and actin (ACT8) accompanying primary root growth inhibition in NaCl-stress-induced etiolated sunflower (Helianthus annuus; cv. KBSH 44) seedlings. J Plant Growth Regul. 2023;42(8):5192–5202. doi:10.1007/s00344-023-11046-4.
   Web of Science ®Google Scholar
• Janceva S, Andersone A, Lauberte L, Bikovens O, Nikolajeva V, Jashina L, Zaharova N, Telysheva G, Senkovs M, Rieksts G. et al. Sea Buckthorn (Hippophae rhamnoides) waste biomass after harvesting as a source of valuable biologically active compounds with nutraceutical and antibacterial potential. Plants. 2022;11(5):642. doi:10.3390/plants11050642.
   Google Scholar
• MdZ U, Paul A, Rakib A, Sami SA, Mahmud S, MdS R, Hossain S, Tareq AM, Dutta M, Emran TB. et al. Chemical profiles and pharmacological properties with in silico studies on elatostema papillosum wedd. Molecules. 2021;26(4):809. doi:10.3390/molecules26040809.
   PubMed Web of Science ®Google Scholar