Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL

References

• Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, Smith CL, Shafa R, Aeali B, Carnevale J, et al. 2006. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet. 15:3132–3145.
   PubMed Web of Science ®Google Scholar
• Abrahamson EE, Moore RY. 2001. Suprachiasmatic nucleus in the mouse: Retinal innervation, intrinsic organisation and efferent projections. Brain Res. 916:172–191.
   PubMed Web of Science ®Google Scholar
• Balasubramanian D, Deng AXE, Doudney K, Hampton MB, Kennedy MA. 2015. Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology. 99:79–88.
   PubMed Web of Science ®Google Scholar
• Benedetti F, Dallaspezia S, Colombo C, Pirovano A, Marino E, Smeraldi E. 2008. A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci Lett. 445:184–187.
   PubMed Web of Science ®Google Scholar
• Bengesser S, Reininghaus E. 2013. Genetics of bipolar disorder. Frankfurt am Main: Peter-Lang.
   Google Scholar
• Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, et al. 2011. Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behaviour in the ClockDelta19 mouse model of mania. Neuropsychopharmacology. 36:1478–1488.
   PubMed Web of Science ®Google Scholar
• Dallaspezia S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E, Benedetti F. 2011. Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder. Eur Psychiatry. 26:138–140.
   PubMed Web of Science ®Google Scholar
• Dilling H. 2010. Taschenführer zur ICD-10-Klassifikation Psychischer Störungen. Vol. 5. p. 1–532. Bern: Hans Huber Verlag.
   Google Scholar
• Dmitrzak-Weglarz MP, Pawlak JM, Maciukiewicz M, Moczko J, Wilkosc M, Leszczynska-Rodziewicz A, Zaremba D, Hauser J. 2015. Clock gene variants differentiate mood disorders. Mol Biol Rep. 42:277–288.
   PubMed Web of Science ®Google Scholar
• Gao X, Zhang Y, Breitling LP, Brenner H. 2016. Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration. Oncotarget. doi:10.18632/oncotarget.9795 [Epub ahead of print].
   Web of Science ®Google Scholar
• Gavin DP, Chase KA, Sharma RP. 2013. Active DNA demethylation in post-mitotic neurons: a reason for optimism. Neuropharmacology. 75:233–245.
   PubMed Web of Science ®Google Scholar
• Hampp G, Albrecht U. 2008. The circadian clock and mood-related behavior. Commun Integr Biol. 1:1–3.
   PubMedGoogle Scholar
• Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Perreau-Lenz S, Brunk I, Spanagel R, Ahnert-Hilger G, Meijer JH, et al. 2008. Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol. 18:678–683.
   PubMed Web of Science ®Google Scholar
• Iitaka C, Miyazaki K, Akaike T, Ishida N. 2005. A role for glycogen synthase kinase-3beta in the mammalian circadian clock. J Biol Chem. 280:29397–29402.
   PubMed Web of Science ®Google Scholar
• Iwahana E, Akiyama M, Miyakawa K, Uchida A, Kasahara J, Fukunaga K, Hamada T, Shibata S. 2004. Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei. Eur J Neurosci. 19:2281–2287.
   PubMed Web of Science ®Google Scholar
• Kao CY, Hsu YC, Liu JW, Lee DC, Chung YF, Chiu IM. 2013. The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities. J Neurochem. 126:4–18.
   PubMed Web of Science ®Google Scholar
• Knippers R. 2001. Molekulare genetik. Thieme. 8:1–586.
   Google Scholar
• Kripke DF, Nievergelt CM, Joo E, Shekhtman T, Kelsoe JR. 2009. Circadian polymorphisms associated with affective disorders. J Circadian Rhythms. 7:2.
   PubMedGoogle Scholar
• Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT, McMahon FJ, Schork NJ, Nurnberger JI, Jr., Niculescu AB. 3rd. 2009. Convergent functional genomics of genome-wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms. Am J Med Genet B Neuropsychiatr Genet. 150B:155–181.
   PubMed Web of Science ®Google Scholar
• Machado-Vieira R, Ibrahim L, Zarate CA. Jr. 2011. Histone deacetylases and mood disorders: Epigenetic programming in gene-environment interactions. CNS Neurosci Ther. 17:699–704.
   PubMed Web of Science ®Google Scholar
• Mansour HA, Wood J, Logue T, Chowdari KV, Dayal M, Kupfer DJ, Monk TH, Devlin B, Nimgaonkar VL. 2006. Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav. 5:150–157.
   PubMed Web of Science ®Google Scholar
• Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, et al. 2009. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 11:701–710.
   PubMed Web of Science ®Google Scholar
• Milagro FI, Gomez-Abellan P, Campion J, Martinez JA, Ordovas JM, Garaulet M. 2012. CLOCK, PER2 and BMAL1 DNA methylation: Association with obesity and metabolic syndrome characteristics and monounsaturated fat intake. Chronobiol Int. 29:1180–1194.
   PubMed Web of Science ®Google Scholar
• Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Jr, Schork NJ, Kelsoe JR. 2006. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 141B:234–241.
   PubMed Web of Science ®Google Scholar
• Nohesara S, Ghadirivasfi M, Mostafavi S, Eskandari MR, Ahmadkhaniha H, Thiagalingam S, Abdolmaleky HM. 2011. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res. 45:1432–1438.
   PubMed Web of Science ®Google Scholar
• Rybakowski JK, Dmitrzak-Weglar M, Kliwicki S, Hauser J. 2014a. Polymorphism of circadian clock genes and prophylactic lithium response. Bipolar Disord. 16:151–158.
   PubMed Web of Science ®Google Scholar
• Rybakowski JK, Dmitrzak-Weglarz M, Dembinska-Krajewska D, Hauser J, Akiskal KK, Akiskal HH. 2014b. Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder. J Affect Disord. 159:80–84.
   PubMed Web of Science ®Google Scholar
• Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C. 2008. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet. 147B:1047–1055.
   PubMed Web of Science ®Google Scholar
• Smoller JW, Finn CT. 2003. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet. 123C:48–58.
   PubMed Web of Science ®Google Scholar
• Starnawska A, Demontis D, Pen A, Hedemand A, Nielsen AL, Staunstrup NH, Grove J, Als TD, Jarram A, O'Brien NL, et al. 2016. CACNA1C hypermethylation is associated with bipolar disorder. Transl Psychiatry. 6:e831.
   PubMed Web of Science ®Google Scholar
• Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M. 2009. Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Res. 69:8447–8454.
   PubMed Web of Science ®Google Scholar
• Teroganova N, Girshkin L, Suter CM, Green MJ. 2016. DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review. BMC Genet. 17:27.
   PubMed Web of Science ®Google Scholar
• Tremolizzo L, Conti E, Bomba M, Uccellini O, Rossi MS, Marfone M, Corbetta F, Santarone ME, Raggi ME, Neri F, et al. 2014. Decreased whole-blood global DNA methylation is related to serum hormones in anorexia nervosa adolescents. World J Biol Psychiatry. 15:327–333.
   PubMed Web of Science ®Google Scholar
• Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M. 1997. SKID-I. Strukturiertes Klinisches Interview für DSM-IV; Achse I: Psychische Störungen. Göttingen: Hogrefe.
   Google Scholar
• Yara S, Lavoie JC, Levy E. 2015. Oxidative stress and DNA methylation regulation in the metabolic syndrome. Epigenomics. 7:283–300.
   PubMed Web of Science ®Google Scholar
• Yeh CM, Shay J, Zeng TC, Chou JL, Huang TH, Lai HC, Chan MW. 2014. Epigenetic silencing of ARNTL, a circadian gene and potential tumor suppressor in ovarian cancer. Int J Oncol. 45:2101–2107.
   PubMed Web of Science ®Google Scholar