3,686
Views
26
CrossRef citations to date
0
Altmetric
Review Article

Is there a role for cannabidiol in psychiatry?

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 101-116 | Received 05 Sep 2016, Accepted 16 Jan 2017, Published online: 20 Feb 2017

References

  • Allsop DJ, Copeland J, Lintzeris N, Dunlop AJ, Montebello M, Sadler C, Rivas GR, Holland RM, Muhleisen P, Norberg MM, et al. 2014. Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial. JAMA Psychiatry. 71:281–291.
  • Ashton CH, Moore PB. 2011. Endocannabinoid system dysfunction in mood and related disorders. Acta Psychiatr Scand. 124:250–261.
  • Ashton CH, Moore PB, Gallagher P, Young AH. 2005. Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. J Psychopharmacol. 19:293–300.
  • Bae JS, Kim JY, Park BL, Kim JH, Kim B, Park CS, Kim BJ, Lee CS, Lee M, Choi WH, et al. 2014. Genetic association analysis of CNR1 and CNR2 polymorphisms with schizophrenia in a Korean population. Psychiatr Genet. 24:225–229.
  • Bandelow B, Zohar J, Hollander E, Kasper S, Moller HJ, WFSBP Task Force on Treatment Guidelines for Anxiety Obsessive-Compulsive Post-Traumatic Stress Disorders. 2008. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. World J Biol Psychiatry. 9:248–312.
  • Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schroder N, Nardi AE, et al. 2011a. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 36:1219–1226.
  • Bergamaschi MM, Queiroz RH, Zuardi AW, Crippa JA. 2011b. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 6:237–249.
  • Bhattacharyya S, Crippa JA, Martin-Santos R, Winton-Brown T, Fusar-Poli P. 2009. Imaging the neural effects of cannabinoids: current status and future opportunities for psychopharmacology. Curr Pharm Des. 15:2603–2614.
  • Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T, Nosarti C, C M, O C, Seal M, Allen P, et al. 2010. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology. 35:764–774.
  • Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, Moriello AS, Davis JB, Mechoulam R, Di Marzo V. 2001. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 134:845–852.
  • Bitencourt RM, Pamplona FA, Takahashi RN. 2008. Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur Neuropsychopharmacol. 18:849–859.
  • Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. 2015. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics. 12:825–836.
  • Boers M. 2010. Updated Consolidated Standards of Reporting Trials (CONSORT): it just gets better. J Clin Epidemiol. 63:813–814.
  • Bornheim LM, Everhart ET, Li J, Correia MA. 1994. Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol. Biochem Pharmacol. 48:161–171.
  • Breuer A, Haj CG, Fogaca MV, Gomes FV, Silva NR, Pedrazzi JF, Del Bel EA, Hallak JC, Crippa JA, Zuardi AW, et al. 2016. Fluorinated cannabidiol derivatives: enhancement of activity in mice models predictive of anxiolytic, antidepressant and antipsychotic effects. PloS One. 11:e0158779.
  • Campos AC, Ferreira FR, Guimaraes FS. 2012. Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. J Psychiatr Res. 46:1501–1510.
  • Campos AC, Fogaca MV, Sonego AB, Guimaraes FS. 2016. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res. 112:119–127.
  • Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimaraes FS. 2012. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 367:3364–3378.
  • Conselho Federal de Medicina. 2014. RESOLUÇÃO CFM N° 2.113/2014 - Aprova o uso compassivo do canabidiol para o tratamento de epilepsias da criança e do adolescente refratárias aos tratamentos convencionais. In: Brasília.
  • Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL, Martin-Santos R, Simoes MV, Bhattacharyya S, Fusar-Poli P, Atakan Z, et al. 2011. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol. 25:121–130.
  • Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW. 2013. Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report. J Clin Pharm Ther. 38:162–164.
  • Crippa JA, Zuardi AW, Garrido GE, Wichert-Ana L, Guarnieri R, Ferrari L, Azevedo-Marques PM, Hallak JE, McGuire PK, Filho Busatto G. 2004. Effects of cannabidiol (CBD) on regional cerebral blood flow. Neuropsychopharmacology. 29:417–426.
  • Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, et al. 2016. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 15:270–278.
  • Di Marzo V, Piscitelli F. 2015. The endocannabinoid system and its modulation by phytocannabinoids. Neurotherapeutics. 12:692–698.
  • Eggan SM, Hashimoto T, Lewis DA. 2008. Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch Gen Psychiatry. 65:772–784.
  • Englund A, Morrison PD, Nottage J, Hague D, Kane F, Bonaccorso S, Stone JM, Reichenberg A, Brenneisen R, Holt D, et al. 2013. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol. 27:19–27.
  • Fusar-Poli P, Crippa JA, Bhattacharyya S, Borgwardt SJ, Allen P, Martin-Santos R, Seal M, Surguladze SA, O'Carrol C, Atakan Z, et al. 2009. Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Arch Gen Psychiatry. 66:95–105.
  • Gardner EL. 2005. Endocannabinoid signaling system and brain reward: emphasis on dopamine. Pharmacol Biochem Behav. 81:263–284.
  • Gomes FV, Casarotto PC, Resstel LB, Guimaraes FS. 2011. Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice. Prog Neuropsychopharmacol Biol Psychiatry. 35:434–438.
  • Gomes FV, Issy AC, Ferreira FR, Viveros MP, Del Bel EA, Guimaraes FS. 2014. Cannabidiol attenuates sensorimotor gating disruption and molecular changes induced by chronic antagonism of NMDA receptors in mice. Int J Neuropsychopharmacol. 18(5):pyu041.
  • Gomes FV, Resstel LB, Guimaraes FS. 2011. The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors. Psychopharmacology (Berl). 213:465–473.
  • Guimaraes VM, Zuardi AW, Del Bel EA, Guimaraes FS. 2004. Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sci. 75:633–638.
  • Gururajan A, Malone DT. 2016. Does cannabidiol have a role in the treatment of schizophrenia? Schizophr Res. 176:281–290.
  • GW Pharmaceuticals. 2016. GW Pharmaceuticals announces positive phase 3 pivotal study for Epidolex (cannabidiol). London. Available from: http://www.gwpharm.com/GWPharmaceuticalsAnnouncesPositivPhase3PivotalStudyResultsforEpidiolexcannabidiol.aspx .
  • Hallak JE, Dursun SM, Bosi DC, de Macedo LR, Machado-de-Sousa JP, Abrao J, Crippa JA, McGuire P, Krystal JH, Baker GB, et al. 2011. The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Prog Neuropsychopharmacol Biol Psychiatry. 35:198–202.
  • Heifets BD, Castillo PE. 2009. Endocannabinoid signaling and long-term synaptic plasticity. Annu Rev Physiol. 71:283–306.
  • Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, Ioannidis JP, Straus S, Thorlund K, Jansen JP, et al. 2015. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Int Med. 162:777–784.
  • Karniol IG, Shirakawa I, Kasinski N, Pfeferman A, Carlini EA. 1974. Cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man. Eur J Pharmacol. 28:172–177.
  • Khoury JM, Roque MAV, Queiroz DAB, Moreira FA, Garcia FD. 2016. Canabidiol em psiquiatria. In: PROPSIQ Programa de Atualização em Psiquiatria: Ciclo 5 Porto Alegre: Artmed Panamericana. p. 9–63.
  • Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. 2015. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 172:4790–4805.
  • Leweke M. 2013. The endocannabinoid system in schizophrenia - a mechanistically new approach to its pathophysiology and treatment. Schizophr Bull. 39(S1):S341.
  • Leweke FM, Giuffrida A, Wurster U, Emrich HM, Piomelli D. 1999. Elevated endogenous cannabinoids in schizophrenia. Neuroreport. 10:1665–1669.
  • Leweke FM, Koethe D. 2008. Cannabis and psychiatric disorders: it is not only addiction. Addict Biol. 13:264–275.
  • Leweke FM, Mueller JK, Lange B, Rohleder C. 2016. Therapeutic Potential of Cannabinoids in Psychosis. Biol Psychiatry. 79:604–612.
  • Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkotter J, Hellmich M, Koethe D. 2012. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2:e94.
  • Ligresti A, De Petrocellis L, Di Marzo V. 2016. From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology. Physiol Rev. 96:1593–1659.
  • Linge R, Jimenez-Sanchez L, Campa L, Pilar-Cuellar F, Vidal R, Pazos A, Adell A, Diaz A. 2016. Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. Neuropharmacology. 103:16–26.
  • Lu HC, Mackie K. 2016. An introduction to the endogenous cannabinoid system. Biol Psychiatry. 79:516–525.
  • Mechoulam R, Gaoni Y, Hashish IV. 1965. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids. Tetrahedron. 21:1223–1229.
  • Meltzer HY, Arvanitis L, Bauer D, Rein W. Meta-Trial Study G. 2004. Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder. Am J Psychiatry. 161:975–984.
  • Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F. 2013. Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol Ther. 138:18–37.
  • Moreira FA, Guimaraes FS. 2005. Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice. Eur J Pharmacol. 512:199–205.
  • Morgan CJ, Curran HV. 2008. Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. Br J Psychiatry. 192:306–307.
  • Morgan CJ, Das RK, Joye A, Curran HV, Kamboj SK. 2013. Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings. Addict Behav. 38:2433–2436.
  • Morgan CJ, Gardener C, Schafer G, Swan S, Demarchi C, Freeman TP, Warrington P, Rupasinghe I, Ramoutar A, Tan N, et al. 2012. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. Psychol Med. 42:391–400.
  • Pedrazzi JF, Issy AC, Gomes FV, Guimaraes FS, Del-Bel EA. 2015. Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine. Psychopharmacology (Berl). 232:3057–3065.
  • Pertwee RG. 2005. Pharmacological actions of cannabinoids. In: Cannabinoids. Heidelberg: Springer Berlin. p. 1–51.
  • Pertwee RG, Ross RA, Craib SJ, Thomas A. 2002. (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol. 456:99–106.
  • Prud'homme M, Cata R, Jutras-Aswad D. 2015. Cannabidiol as an intervention for addictive behaviors: a systematic review of the evidence. Substance abuse: research and treatment. 9:33–38.
  • Russo EB, Burnett A, Hall B, Parker KK. 2005. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 30:1037–1043.
  • Sagheddu C, Muntoni AL, Pistis M, Melis M. 2015. Endocannabinoid signaling in motivation, reward, and addiction: influences on mesocorticolimbic dopamine function. IntRev Neurobiol. 125:257–302.
  • Sartim AG, Guimaraes FS, Joca SR. 2016. Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal cortex-Possible involvement of 5-HT1A and CB1 receptors. Behav Brain Res. 303:218–227.
  • Schubart CD, Sommer IE, van Gastel WA, Goetgebuer RL, Kahn RS, Boks MP. 2011. Cannabis with high cannabidiol content is associated with fewer psychotic experiences. Schizophr Res. 130:216–221.
  • Shannon S, Opila-Lehman J. 2015. Cannabidiol oil for decreasing addictive use of marijuana: a case report. Integr Med (Encinitas). 14:31–35.
  • Trigo JM, Lagzdins D, Rehm J, Selby P, Gamaleddin I, Fischer B, Barnes AJ, Huestis MA, Le Foll B. 2016. Effects of fixed or self-titrated dosages of Sativex on cannabis withdrawal and cravings. Drug Alcohol Depend. 161:298–306.
  • Trigo JM, Soliman A, Staios G, Quilty L, Fischer B, George TP, Rehm J, Selby P, Barnes AJ, Huestis MA, et al. 2016. Sativex associated with behavioral-relapse prevention strategy as treatment for cannabis dependence. A case series. J Addict Med. 10:274–279.
  • U.S. Food and Drug Administration. 2015. Warning letters and test results for cannabidiol-related producs. Available from http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm435591.htm
  • WHO. 2002. Handbook for clinical research practice (GCP). In: Geneva: Office of Publications, World Health Organization.
  • Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, et al. 2015. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA. 313:2456–2473.
  • Winton-Brown TT, Allen P, Bhattacharyya S, Borgwardt SJ, Fusar-Poli P, Crippa JA, Seal ML, Martin-Santos R, Ffytche D, Zuardi AW, et al. 2011. Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study. Neuropsychopharmacology. 36:1340–1348.
  • Zanelati TV, Biojone C, Moreira FA, Guimaraes FS, Joca SR. 2010. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 159:122–128.
  • Zuardi A, Crippa J, Dursun S, Morais S, Vilela J, Sanches R, Hallak J. 2010. Cannabidiol was ineffective for manic episode of bipolar affective disorder. J Psychopharmacol. 24:135–137.
  • Zuardi AW, Cosme RA, Graeff FG, Guimaraes FS. 1993. Effects of ipsapirone and cannabidiol on human experimental anxiety. J Psychopharmacol (Oxford). 7:82–88.
  • Zuardi AW, Hallak JE, Dursun SM, Morais SL, Sanches RF, Musty RE, Crippa JA. 2006. Cannabidiol monotherapy for treatment-resistant schizophrenia. J Psychopharmacol (Oxford) 20:683–686.
  • Zuardi AW, Morais SL, Guimaraes FS, Mechoulam R. 1995. Antipsychotic effect of cannabidiol. J Clin Psychiatry. 56:485–486.
  • Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG. 1982. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl). 76:245–250.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.