408
Views
11
CrossRef citations to date
0
Altmetric
Original Investigation

Characterising phospholipids and free fatty acids in patients with schizophrenia: A case-control study

ORCID Icon, , , , , & ORCID Icon show all
Pages 161-174 | Received 15 Jan 2020, Accepted 05 May 2020, Published online: 17 Jul 2020

References

  • Addington J, Addington D. 1999. Neurocognitive and social functioning in schizophrenia. Schizophr Bull. 25(1):173–182.
  • Brosche T, Brueckmann M, Haase KK, Sieber C, Bertsch T. 2007. Decreased plasmalogen concentration as a surrogate marker of oxidative stress in patients presenting with acute coronary syndromes or supraventricular tachycardias. Clin Chem Lab Med. 45(5):689–691.
  • Bylesj M, Rantalainen M, Cloarec O, Nicholson JK, Holmes E, Trygg J. 2006. OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification. J Chemometrics. 20(8–10):341–351.
  • Cao B, Wang D, Brietzke E, McIntyre RS, Pan Z, Cha D, Rosenblat JD, Zuckerman H, Liu Y, Xie Q, et al. 2018. Characterizing amino-acid biosignatures amongst individuals with schizophrenia: a case-control study. Amino acids. 50(8):1013–1023.
  • Castillo RI, Rojo LE, Henriquez-Henriquez M, Silva H, Maturana A, Villar MJ, Fuentes M, Gaspar PA. 2016. From molecules to the clinic: linking schizophrenia and metabolic syndrome through sphingolipids metabolism. Front Neurosci. 10:488.
  • Chadeau-Hyam M, Ebbels TMD, Brown IJ, Chan Q, Stamler J, Huang CC, Daviglus ML, Ueshima H, Zhao L, Holmes E, et al. 2010. Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification. J Proteome Res. 9(9):4620–4627.
  • Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V. 2003. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry. 60(5):443–456.
  • Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. 2011. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev. 111(10):6130–6185.
  • Engelmann B, Bräutigam C, Kulschar R, Duhm J, Prenner E, Hermetter A, Richter WO, Thiery J, Seidel D. 1994. Reversible reduction of phospholipid bound arachidonic acid after low density lipoprotein apheresis. Evidence for rapid incorporation of plasmalogen phosphatidylethanolamine into the red blood cell membrane. Biochim Biophys Acta. 1196(2):154–164.
  • Flynn SW, Lang DJ, Mackay AL, Goghari V, Vavasour IM, Whittall KP, Smith GN, Arango V, Mann JJ, Dwork AJ, et al. 2003. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Mol Psychiatry. 8(9):811–820.
  • Ghosh S, Dyer RA, Beasley CL. 2017. Evidence for altered cell membrane lipid composition in postmortem prefrontal white matter in bipolar disorder and schizophrenia. J Psychiatr Res. 95:135–142.
  • Gonzalez-Liencres C, Tas C, Brown EC, Erdin S, Onur E, Cubukcoglu Z, Aydemir O, Esen-Danaci A, Brüne M. 2014. Oxidative stress in schizophrenia: a case-control study on the effects on social cognition and neurocognition. BMC Psychiatry. 14:268
  • Gu H, Gowda GA, Raftery D. 2012. Metabolic profiling: are we en route to better diagnostic tests for cancer? Future Oncol. 8(10):1207–1210.
  • Hamazaki K, Choi KH, Kim HY. 2010. Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: no changes in docosahexaenoic acid species. J Psychiatr Res. 44(11):688–693.
  • Hasegawa H, Lei J, Matsumoto T, Onishi S, Suemori K, Yasukawa M. 2011. Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production. Biochem Biophys Res Commun. 415(3):526–531.
  • Holmes E, Wilson ID, Nicholson JK. 2008. Metabolic phenotyping in health and disease. Cell. 134(5):714–717.
  • Kaddurah-Daouk R, McEvoy J, Baillie R, Zhu H, K Yao J, Nimgaonkar VL, Buckley PF, Keshavan MS, Georgiades A, Nasrallah HA, et al. 2012. Impaired plasmalogens in patients with schizophrenia. Psychiatry Res. 198(3):347–352.
  • Kaddurah-Daouk R, McEvoy J, Baillie RA, Lee D, Yao JK, Doraiswamy PM, Krishnan KRR. 2007. Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Mol Psychiatry. 12(10):934–945.
  • Keshavan MS, Mallinger AG, Pettegrew JW, Dippold C. 1993. Erythrocyte membrane phospholipids in psychotic patients. Psychiatry Res. 49(1):89–95.
  • Koerkamp MG, Rep M, Bussemaker HJ, Hardy GPMA, Mul A, Piekarska K, Szigyarto CA-K, De Mattos JMT, Tabak HF. 2002. Dissection of transient oxidative stress response in Saccharomyces cerevisiae by using DNA microarrays. Mol Biol Cell. 13(8):2783–2794.
  • Leppik L, Parksepp M, Janno S, Koido K, Haring L, Vasar E, Zilmer M. 2020. Profiling of lipidomics before and after antipsychotic treatment in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci. 270(1):59–70.
  • Liu X, Zheng P, Zhao X, Zhang Y, Hu C, Li J, Zhao J, Zhou J, Xie P, Xu G, et al. 2015. Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry. J Proteome Res. 14(5):2322–2330.
  • Mahadevan S, Shah SL, Marrie TJ, Slupsky CM. 2008. Analysis of metabolomic data using support vector machines. Anal Chem. 80(19):7562–7570.
  • McEvoy J, Baillie RA, Zhu H, Buckley P, Keshavan MS, Nasrallah HA, Dougherty GG, Yao JK, Kaddurah-Daouk R. 2013. Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics. PLoS One. 8(7):e68717
  • McGrath J, Saha S, Chant D, Welham J. 2008. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev. 30:67–76.
  • Misiak B, Stańczykiewicz B, Łaczmański Ł, Frydecka D. 2017. Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: a systematic review and meta-analysis. Schizophr Res. 190:18–27.
  • Nigam S, Schewe T. 2000. Phospholipase A(2)s and lipid peroxidation. Biochim Biophys Acta. 1488(1–2):167–181.
  • Nuss P, Tessier C, Ferreri F, De Hert M, Peuskens J, Trugnan G, Masliah J, Wolf C. 2009. Abnormal transbilayer distribution of phospholipids in red blood cell membranes in schizophrenia. Psychiatry Res. 169(2):91–96.
  • Park JY, Lee SH, Shin MJ, Hwang GS. 2015. Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. PLoS One. 10(8):e0135228
  • Pedrini M, Massuda R, Fries GR, de Bittencourt Pasquali MA, Schnorr CE, Moreira JCF, Teixeira AL, Lobato MIR, Walz JC, Belmonte-de-Abreu PS, et al. 2012. Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity. J Psychiatr Res. 46(6):819–824.
  • Ponizovsky AM, Modai I, Nechamkin Y, Barshtein G, Ritsner MS, Yedgar S, Lecht S, Bergelson LD. 2001. Phospholipid patterns of erythrocytes in schizophrenia: relationships to symptomatology. Schizophr Res. 52(1–2):121–126.
  • Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT-J, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, et al. 2004. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry. 9(7):684–697.
  • Reichel M, Hönig S, Liebisch G, Lüth A, Kleuser B, Gulbins E, Schmitz G, Kornhuber J. 2015. Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. Biochim Biophys Acta. 1851(11):1501–1510.
  • Roberts LD, Souza AL, Gerszten RE, Clish CB. 2012. Targeted metabolomics. Curr Protoc Mol Biol. 98(1):30.2.1–30.2.24.
  • Salim S. 2014. Oxidative stress and psychological disorders. Curr Neuropharmacol. 12(2):140–147.
  • Sastry PS. 1985. Lipids of nervous tissue: composition and metabolism. Prog Lipid Res. 24(2):69–176.
  • Schmitt A, Wilczek K, Blennow K, Maras A, Jatzko A, Petroianu G, Braus DF, Gattaz WF. 2004. Altered thalamic membrane phospholipids in schizophrenia: a postmortem study. Biol Psychiatry. 56(1):41–45.
  • Schmitz G, Ruebsaamen K. 2010. Metabolism and atherogenic disease association of lysophosphatidylcholine. Atherosclerosis. 208(1):10–18.
  • Schwarz E, Prabakaran S, Whitfield P, Major H, Leweke FM, Koethe D, McKenna P, Bahn S. 2008. High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides. J Proteome Res. 7(10):4266–4277.
  • Sekas G, Patton GM, Lincoln EC, Robins SJ. 1985. Origin of plasma lysophosphatidylcholine: evidence for direct hepatic secretion in the rat. J Lab Clin Med. 105(2):190–194.
  • Sethi S, Brietzke E. 2015. Omics-based biomarkers: application of metabolomics in neuropsychiatric disorders. Int J Neuropsychopharmacol. 19(3):pyv096.
  • Sethi S, Hayashi MA, Barbosa BS, Pontes JG, Tasic L, Brietzke E. 2017a. Lipidomics, biomarkers, and schizophrenia: a current perspective. Adv Exp Med Biol. 965:265–290.
  • Sethi S, Hayashi MA, Sussulini A, Tasic L, Brietzke E. 2017b. Analytical approaches for lipidomics and its potential applications in neuropsychiatric disorders. World J Biol Psychiatry. 18(7):506–520.
  • Skosnik PD, Yao JK. 2003. From membrane phospholipid defects to altered neurotransmission: is arachidonic acid a nexus in the pathophysiology of schizophrenia? Prostaglandins Leukot Essent Fatty Acids. 69(6):367–384.
  • Stenvinkel P, Diczfalusy U, Lindholm B, Heimburger O. 2004. Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy. Nephrol Dial Transplant. 19(4):972–976.
  • Tessier C, Sweers K, Frajerman A, Bergaoui H, Ferreri F, Delva C, Lapidus N, Lamaziere A, Roiser JP, De Hert M, et al. 2016. Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations. Transl Psychiatry. 6(10):e906.
  • van der Kemp WJ, Klomp DW, Kahn RS, Luijten PR, Hulshoff Pol HE. 2012. A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia. Schizophr Res 141(2–3):153–161.
  • Vance JE, Tasseva G. 2013. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim Biophys Acta. 1831(3):543–554.
  • Wang D, Cheng SL, Fei Q, Gu H, Raftery D, Cao B, Sun X, Yan J, Zhang C, Wang J, et al. 2019. Metabolic profiling identifies phospholipids as potential serum biomarkers for schizophrenia. Psychiatry Res. 272:18–29.
  • Warensjo E, Ohrvall M, Vessby B. 2006. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis. 16(2):128–136.
  • Weber-Fahr W, Englisch S, Esser A, Tunc-Skarka N, Meyer-Lindenberg A, Ende G, Zink M. 2013. Altered phospholipid metabolism in schizophrenia: a phosphorus 31 nuclear magnetic resonance spectroscopy study. Psychiatry Res. 214(3):365–373.
  • Wood PL, Holderman NR. 2015. Dysfunctional glycosynapses in schizophrenia: disease and regional specificity. Schizophr Res. 166(1–3):235–237.
  • Wood PL, Unfried G, Whitehead W, Phillipps A, Wood JA. 2015. Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia. Schizophr Res. 161(2–3):506–510.
  • Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, et al. 2013. Potential metabolite markers of schizophrenia. Mol Psychiatry. 18(1):67–78.
  • Yang X, Sun L, Zhao A, Hu X, Qing Y, Jiang J, Yang C, Xu T, Wang P, Liu J, et al. 2017. Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study. Transl Psychiatry. 7(7):e1176.
  • Yao JK, Leonard S, Reddy R. 2006. Altered glutathione redox state in schizophrenia. Dis Markers. 22(1–2):83–93.
  • Yao JK, Leonard S, Reddy RD. 2000. Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients. Schizophr Res. 42(1):7–17.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.