Systems consolidation and fear memory generalisation as a potential target for trauma-related disorders

References

• Aceti M, Vetere G, Novembre G, Restivo L, Ammassari-Teule M. 2015. Progression of activity and structural changes in the anterior cingulate cortex during remote memory formation. Neurobiol Learn Mem. 123:67–71.
   PubMed Web of Science ®Google Scholar
• Agren T, Björkstrand J, Fredrikson M. 2017. Disruption of human fear reconsolidation using imaginal and in vivo extinction. Behav Brain Res. 319(319):9–15.
   PubMedGoogle Scholar
• Ahmed-Leitao F, Rosenstein D, Marx M, Young S, Korte K, Seedat S. 2019. Posttraumatic stress disorder, social anxiety disorder and childhood trauma: differences in hippocampal subfield volume. Psychiatry Res Neuroimaging. 284:45–52.
   PubMed Web of Science ®Google Scholar
• Ahmed-Leitao F, Spies G, van den Heuvel L, Seedat S. 2016. Hippocampal and amygdala volumes in adults with posttraumatic stress disorder secondary to childhood abuse or maltreatment: a systematic review. Psychiatry Res Neuroimaging. 256:33–43.
   PubMed Web of Science ®Google Scholar
• Alfei JM, De Gruy H, De Bundel D, Luyten L, Beckers T. 2021. Apparent reconsolidation interference without generalized amnesia. Prog Neuropsychopharmacol Biol Psychiatry. 108(108):110161.
   PubMedGoogle Scholar
• American Psychiatric Association. 2013. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington (VA): American Psychiatric Publishing.
   Google Scholar
• Anagnostaras SG, Maren S, Fanselow MS. 1999. Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination. J Neurosci. 19(3):1106–1114.
   PubMed Web of Science ®Google Scholar
• Apergis-Schoute AM, Gillan CM, Fineberg NA, Fernandez-Egea E, Sahakian BJ, Robbins TW. 2017. Neural basis of impaired safety signaling in Obsessive Compulsive Disorder. Proc Natl Acad Sci U S A. 114(12):3216–3221.
   PubMed Web of Science ®Google Scholar
• Arai JA, Li S, Hartley DM, Feig LA. 2009. Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment. J Neurosci. 29(5):1496–1502.
   PubMed Web of Science ®Google Scholar
• Araki M, Fuchikami M, Omura J, Miyagi T, Nagashima N, Okamoto Y, Morinobu S. 2020. The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder. Psychopharmacology (Berl). 237(7):2125–2137.
   PubMed Web of Science ®Google Scholar
• Arellano Pérez AD, Popik B, de Oliveira Alvares L. 2020. Rewarding information presented during reactivation attenuates fear memory: methylphenidate and fear memory updating. Neuropharmacology. 171:108107. https://nrdp.2015.57/nrdp.2015.57.
   PubMed Web of Science ®Google Scholar
• Asim M, Hao B, Yang YH, Fan BF, Xue L, Shi YW, Wang XG, Zhao H. 2020. Ketamine alleviates fear generalization through GluN2B-BDNF signaling in mice. Neurosci Bull. 36(2):153–164.
   PubMed Web of Science ®Google Scholar
• Asok A, Kandel ER, Rayman JB. 2018. The neurobiology of fear generalization. Front Behav Neurosci. 12:329.
   PubMed Web of Science ®Google Scholar
• Astill Wright L, Sijbrandij M, Sinnerton R, Lewis C, Roberts NP, Bisson JI. 2019. Pharmacological prevention and early treatment of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis. Transl Psychiatry. 9(1):334.
   PubMedGoogle Scholar
• Bangasser DA, Wicks B. 2017. Sex-specific mechanisms for responding to stress. J Neurosci Res. 95(1-2):75–82.
   PubMed Web of Science ®Google Scholar
• Barry DN, Coogan AN, Commins S. 2016. The time course of systems consolidation of spatial memory from recent to remote retention: a comparison of the Immediate Early Genes Zif268, c-Fos and Arc. Neurobiol Learn Mem. 128:46–55.
   PubMed Web of Science ®Google Scholar
• Bayley PJ, Hopkins RO, Squire LR. 2006. The fate of old memories after medial temporal lobe damage. J Neurosci. 26(51):13311–13317.
   PubMed Web of Science ®Google Scholar
• Bayley PJ, Squire LR. 2005. Failure to acquire new semantic knowledge in patients with large medial temporal lobe lesions. Hippocampus. 15(2):273–280.
   PubMed Web of Science ®Google Scholar
• Bender CL, Otamendi A, Calfa GD, Molina VA. 2018. Prior stress promotes the generalization of contextual fear memories: involvement of the gabaergic signaling within the basolateral amygdala complex. Prog Neuropsychopharmacol Biol Psychiatry. 83:18–26.
   PubMed Web of Science ®Google Scholar
• Berger W, Mendlowicz MV, Marques-Portella C, Kinrys G, Fontenelle LF, Marmar CR, Figueira I. 2009. Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 33(2):169–180.
   PubMed Web of Science ®Google Scholar
• Bouton ME, Westbrook RF, Corcoran KA, Maren S. 2006. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol Psychiatry. 60(4):352–360.
   PubMed Web of Science ®Google Scholar
• Brachman RA, McGowan JC, Perusini JN, Lim SC, Pham TH, Faye C, Gardier AM, Mendez-David I, David DJ, Hen R, Denny CA. 2016. Ketamine as a prophylactic against stress-induced depressive-like behavior. Biol Psychiatry. 79(9):776–786.
   PubMed Web of Science ®Google Scholar
• Brady K, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, Farfel GM. 2000. Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA. 283(14):1837–1844.
   PubMed Web of Science ®Google Scholar
• Clem RL, Huganir RL. 2010. Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science. 330(6007):1108–1112.
   PubMed Web of Science ®Google Scholar
• Craske MG, Stein MB, Eley TC, Milad MR, Holmes A, Rapee RM, Wittchen HU. 2017. Correction: anxiety disorders. Nat Rev Dis Primers. 3:17100.
   PubMed Web of Science ®Google Scholar
• Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. 2008. Optimizing inhibitory learning during exposure therapy. Behav Res Ther. 46(1):5–27.
   PubMed Web of Science ®Google Scholar
• Davidson JR, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM. 2001. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch Gen Psychiatry. 58(5):485–492.
   PubMed Web of Science ®Google Scholar
• Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA. 2021. Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. Nat Commun. 12(1):6040.
   Google Scholar
• De Bundel D, Zussy C, Espallergues J, Gerfen CR, Girault JA, Valjent E. 2016. Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala. Mol Psychiatry. 21(11):1545–1553.
   PubMed Web of Science ®Google Scholar
• De Oliveira Alvares L, Crestani AP, Cassini LF, Haubrich J, Santana F, Quillfeldt JA. 2013. Reactivation enables memory updating, precision-keeping and strengthening: exploring the possible biological roles of reconsolidation. Neuroscience. 244:42–48.
   PubMed Web of Science ®Google Scholar
• De Oliveira Alvares L, Do-Monte FH. 2021. Understanding the dynamic and destiny of memories. Neurosci Biobehav Rev. 125:592–607.
   PubMed Web of Science ®Google Scholar
• De Oliveira Alvares L, Einarsson EÖ, Santana F, Crestani AP, Haubrich J, Cassini LF, Nader K, Quillfeldt JA. 2012. Periodically reactivated context memory retains its precision and dependence on the hippocampus. Hippocampus. 22(5):1092–1095.
   PubMed Web of Science ®Google Scholar
• De Quervain D, Schwabe L, Roozendaal B. 2017. Stress, glucocorticoids and memory: implications for treating fear-related disorders. Nat Rev Neurosci. 18(1):7–19.
   PubMed Web of Science ®Google Scholar
• Debiec J, Sullivan RM. 2014. Intergenerational transmission of emotional trauma through amygdala-dependent mother-to-infant transfer of specific fear. Proc Natl Acad Sci U S A. 111(33):12222–12227.
   PubMed Web of Science ®Google Scholar
• Delahanty DL, Gabert-Quillen C, Ostrowski SA, Nugent NR, Fischer B, Morris A, Pitman RK, Bon J, Fallon W. 2013. The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: a randomized trial. CNS Spectr. 18(2):103–111.
   PubMed Web of Science ®Google Scholar
• Dos Santos Corrêa M, Vaz BDS, Grisanti GDV, de Paiva JPQ, Tiba PA, Fornari RV. 2019. Relationship between footshock intensity, post-training corticosterone release and contextual fear memory specificity over time. Psychoneuroendocrinology. 110:104447.
   PubMed Web of Science ®Google Scholar
• Dunsmoor JE, Paz R. 2015. Fear generalization and anxiety: behavioral and neural mechanisms. Biol Psychiatry. 78(5):336–343.
   PubMed Web of Science ®Google Scholar
• Dymond S, Dunsmoor JE, Vervliet B, Roche B, Hermans D. 2015. Fear generalization in humans: systematic review and implications for anxiety disorder research. Behav Ther. 46(5):561–582.
   PubMed Web of Science ®Google Scholar
• Figee M, Mayberg H. 2021. The future of personalized brain stimulation. Nat Med. 27(2):196–197.
   PubMed Web of Science ®Google Scholar
• Frankland PW, Bontempi B. 2005. The organization of recent and remote memories. Nat Rev Neurosci. 6(2):119–130.
   PubMed Web of Science ®Google Scholar
• Gazarini L, Stern CA, Piornedo RR, Takahashi RN, Bertoglio LJ. 2015. PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation. Int J Neuropsychopharmacol. 18(1):pyu026–pyu026.
   Web of Science ®Google Scholar
• Gofman M, Kivity Y, Bar-Kalifa E, Vidan Z, Hasson Ohayon I, Tuval-Mashiach R, Peri T. 2020. Narrative reconstruction as an intervention for posttraumatic stress disorder: a pilot delayed intervention quasi-randomized controlled trial. J Trauma Stress. 34:92–103.
   PubMed Web of Science ®Google Scholar
• Golier JA, Caramanica K, Demaria R, Yehuda R. 2012. A pilot study of mifepristone in combat-related PTSD. Depress Res Treat. 2012:393251.
   PubMedGoogle Scholar
• Golier JA, Caramanica K, Michaelides AC, Makotkine I, Schmeidler J, Harvey PD, Yehuda R. 2016. A randomized, double-blind, placebo-controlled, crossover trial of mifepristone in Gulf War veterans with chronic multisymptom illness. Psychoneuroendocrinology. 64:22–30.
   PubMed Web of Science ®Google Scholar
• Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, et al. 2014. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 156(1–2):261–276..
   PubMed Web of Science ®Google Scholar
• Grégoire L, Greening SG. 2019. Opening the reconsolidation window using the mind’s eye: extinction training during reconsolidation disrupts fear memory expression following mental imagery reactivation. Cognition. 183:277–281.
   PubMed Web of Science ®Google Scholar
• Grisanzio KA, Goldstein-Piekarski AN, Wang MY, Rashed Ahmed AP, Samara Z, Williams LM. 2018. Transdiagnostic symptom clusters and associations with brain, behavior, and daily function in mood, anxiety, and trauma disorders. JAMA Psychiatry. 75(2):201–209.
   PubMed Web of Science ®Google Scholar
• Grupe DW, Nitschke JB. 2013. Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective. Nat Rev Neurosci. 14(7):488–501.
   PubMed Web of Science ®Google Scholar
• Gutner CA, Galovski T, Bovin MJ, Schnurr PP. 2016. Emergence of transdiagnostic treatments for PTSD and posttraumatic distress. Curr Psychiatry Rep. 18(10):95.
   PubMed Web of Science ®Google Scholar
• Haubrich J, Crestani AP, Cassini LF, Santana F, Sierra RO, Alvares LDO, Quillfeldt JA. 2015. Reconsolidation allows fear memory to be updated to a less aversive level through the incorporation of appetitive information. Neuropsychopharmacology. 40(2):315–326.
   PubMed Web of Science ®Google Scholar
• Jasnow AM, Cullen PK, Riccio DC. 2012. Remembering another aspect of forgetting. Front Psychol. 3:175.
   PubMed Web of Science ®Google Scholar
• Jovanovic T, Ressler KJ. 2010. How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD. AJP. 167(6):648–662.
   Google Scholar
• Kaczkurkin AN, Burton PC, Chazin SM, Manbeck AB, Espensen-Sturges T, Cooper SE, Sponheim SR, Lissek S. 2017. Neural substrates of overgeneralized conditioned fear in PTSD. Am J Psychiatry. 174(2):125–134.
   PubMed Web of Science ®Google Scholar
• Kilpatrick DG, Resnick HS, Milanak ME, Miller MW, Keyes KM, Friedman MJ. 2013. National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria. J Trauma Stress. 26(5):537–547.
   PubMed Web of Science ®Google Scholar
• Kim JJ, Fanselow MS. 1992. Modality-specific retrograde amnesia of fear. Science. 256(5057):675–677. PMID: 1585183.
   PubMed Web of Science ®Google Scholar
• Kitamura T, Ogawa SK, Roy DS, Okuyama T, Morrissey MD, Smith LM, Redondo RL, Tonegawa S. 2017. Engrams and circuits crucial for systems consolidation of a memory. Science. 356(6333):73–78.
   PubMed Web of Science ®Google Scholar
• Lee JQ, Zelinski EL, McDonald RJ, Sutherland RJ. 2016. Heterarchic reinstatement of long-term memory: a concept on hippocampal amnesia in rodent memory research. Neurosci Biobehav Rev. 71:154–166.
   PubMed Web of Science ®Google Scholar
• Lesburguères E, Gobbo OL, Alaux-Cantin S, Hambucken A, Trifilieff P, Bontempi B. 2011. Early tagging of cortical networks is required for the formation of enduring associative memory. Science. 331(6019):924–928.
   PubMed Web of Science ®Google Scholar
• Likhtik E, Stujenske JM, Topiwala MA, Harris AZ, Gordon JA. 2014. Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat Neurosci. 17(1):106–113.
   PubMed Web of Science ®Google Scholar
• Lissek S, Kaczkurkin AN, Rabin S, Geraci M, Pine DS, Grillon C. 2014. Generalized anxiety disorder is associated with overgeneralization of classically conditioned fear. Biol Psychiatry. 75(11):909–915.
   PubMed Web of Science ®Google Scholar
• Lissek S, Powers AS, McClure EB, Phelps EA, Woldehawariat G, Grillon C, Pine DS. 2005. Classical fear conditioning in the anxiety disorders: a meta-analysis. Behav Res Ther. 43(11):1391–1424.
   PubMed Web of Science ®Google Scholar
• Lissek S, Rabin S, Heller RE, Lukenbaugh D, Geraci M, Pine DS, Grillon C. 2010. Overgeneralization of conditioned fear as a pathogenic marker of panic disorder. Am J Psychiatry. 167(1):47–55.
   PubMed Web of Science ®Google Scholar
• Lissek S. 2012. Toward an account of clinical anxiety predicated on basic, neurally mapped mechanisms of Pavlovian fear-learning: the case for conditioned overgeneralization. Depress Anxiety. 29(4):257–263.
   PubMed Web of Science ®Google Scholar
• Lopez J, Herbeaux K, Cosquer B, Engeln M, Muller C, Lazarus C, Kelche C, Bontempi B, Cassel JC, de Vasconcelos AP. 2012. Context-dependent modulation of hippocampal and cortical recruitment during remote spatial memory retrieval. Hippocampus. 22(4):827–841.
   PubMedGoogle Scholar
• Lynch JF, Winiecki P, Gilman TL, Adkins JM, Jasnow AM. 2017. Hippocampal GABAB(1a) receptors constrain generalized contextual fear. Neuropsychopharmacology. 42(4):914–924.
   PubMed Web of Science ®Google Scholar
• MacLeod S, Reynolds MG, Lehmann H. 2018. The mitigating effect of repeated memory reactivations on forgetting. NPJ Sci Learn. 3:9. 018-0025-x.
   PubMedGoogle Scholar
• Maeng LY, Cover KK, Taha MB, Landau AJ, Milad MR, Lebrón-Milad K. 2017. Estradiol shifts interactions between the infralimbic cortex and central amygdala to enhance fear extinction memory in female rats. J Neurosci Res. 95(1–2):163–175.
   PubMed Web of Science ®Google Scholar
• Maples-Keller JL, Post LM, Price M, Goodnight JM, Burton MS, Yasinski CW, Michopoulos V, Stevens JS, Hinrichs R, Rothbaum AO, et al. 2020. Investigation of optimal dose of early intervention to prevent posttraumatic stress disorder: a multiarm randomized trial of one and three sessions of modified prolonged exposure. Depress Anxiety. 37(5):429–437.
   PubMed Web of Science ®Google Scholar
• Marshall PR, Bredy TW. 2019. Neuroepigenetic mechanisms underlying fear extinction: emerging concepts. Psychopharmacology (Berl). 236(1):133–142.
   PubMed Web of Science ®Google Scholar
• Mastrodonato A, Martinez R, Pavlova IP, LaGamma CT, Brachman RA, Robison AJ, Denny CA. 2018. Ventral CA3 activation mediates prophylactic ketamine efficacy against stress-induced depressive-like behavior. Biol Psychiatry. 84(11):846–856.
   PubMed Web of Science ®Google Scholar
• Maviel T, Durkin TP, Menzaghi F, Bontempi B. 2004. Sites of neocortical reorganization critical for remote spatial memory. Science. 305(5680):96–99.
   PubMed Web of Science ®Google Scholar
• McGowan JC, LaGamma CT, Lim SC, Tsitsiklis M, Neria Y, Brachman RA, Denny CA. 2017. Prophylactic ketamine attenuates learned fear. Neuropsychopharmacology. 42(8):1577–1589.
   PubMed Web of Science ®Google Scholar
• McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. 2007. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. 317(5834):94–99.
   PubMed Web of Science ®Google Scholar
• McTeague LM, Lang PJ, Laplante MC, Cuthbert BN, Strauss CC, Bradley MM. 2009. Fearful imagery in social phobia: generalization, comorbidity, and physiological reactivity. Biol Psychiatry. 65(5):374–382.
   PubMed Web of Science ®Google Scholar
• Migues PV, Liu L, Archbold GE, Einarsson EÖ, Wong J, Bonasia K, Ko SH, Wang YT, Hardt O. 2016. Blocking synaptic removal of GluA2-containing AMPA receptors prevents the natural forgetting of long-term memories. J Neurosci. 36(12):3481–3494.
   PubMed Web of Science ®Google Scholar
• Miller BR, Hen R. 2015. The current state of the neurogenic theory of depression and anxiety. Curr Opin Neurobiol. 30:51–58.
   PubMed Web of Science ®Google Scholar
• Monfils MH, Lee HJ, Keller NE, Roquet RF, Quevedo S, Agee L, Cofresi R, Shumake J. 2019. Predicting extinction phenotype to optimize fear reduction. Psychopharmacology (Berl). 236(1):99–110.
   PubMed Web of Science ®Google Scholar
• Mørkved N, Hartmann K, Aarsheim LM, Holen D, Milde AM, Bomyea J, Thorp SR. 2014. A comparison of narrative exposure therapy and prolonged exposure therapy for PTSD. Clin Psychol Rev. 34(6):453–467.
   PubMed Web of Science ®Google Scholar
• Moscarello JM, Maren S. 2018. Flexibility in the face of fear: hippocampal-prefrontal regulation of fear and avoidance. Curr Opin Behav Sci. 19:44–49.
   PubMed Web of Science ®Google Scholar
• Moscovitch M, Rosenbaum RS, Gilboa A, Addis DR, Westmacott R, Grady C, McAndrews MP, Levine B, Black S, Winocur G, et al. 2005. Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory. J Anat. 207(1):35–66.
   PubMed Web of Science ®Google Scholar
• Nadel L, Samsonovich A, Ryan L, Moscovitch M. 2000. Multiple trace theory of human memory: computational, neuroimaging, and neuropsychological results. Hippocampus. 10(4):352–368.
   PubMed Web of Science ®Google Scholar
• Pabst A, Schauer M, Bernhardt K, Ruf M, Goder R, Rosentraeger R, Elbert T, Aldenhoff J, Seeck-Hirschner M. 2012. Treatment of patients with borderline personality disorder and comorbid posttraumatic stress disorder using narrative exposure therapy: a feasibility study. Psychother Psychosom. 81(1):61–63.
   PubMed Web of Science ®Google Scholar
• Pedraza LK, Sierra RO, Boos FZ, Haubrich J, Quillfeldt JA, Alvares LDO. 2016. The dynamic nature of systems consolidation: stress during learning as a switch guiding the rate of the hippocampal dependency and memory quality. Hippocampus. 26(3):362–371.
   PubMed Web of Science ®Google Scholar
• Pedraza LK, Sierra RO, Crestani AP, Quillfeldt JA, de Oliveira Alvares L. 2017. Sequential learning during contextual fear conditioning guides the rate of systems consolidation: implications for consolidation of multiple memory traces. Hippocampus. 27(5):518–528.
   PubMed Web of Science ®Google Scholar
• Pedraza LK, Sierra RO, Giachero M, Nunes-Souza W, Lotz FN, de Oliveira Alvares L. 2019. Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation. Transl Psychiatry. 9(1):53.
   PubMedGoogle Scholar
• Pedraza LK, Sierra RO, Lotz FN, de Oliveira Alvares L. 2018. Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats. Sci Rep. 8(1):7260. Erratum in: Sci Rep. 2018. 8(1), 11944.
   PubMedGoogle Scholar
• Phillips RG, LeDoux JE. 1992. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci. 106(2):274–285.
   PubMed Web of Science ®Google Scholar
• Pickens CL, Golden SA, Adams-Deutsch T, Nair SG, Shaham Y. 2009. Long-lasting incubation of conditioned fear in rats. Biol Psychiatry. 65(10):881–886.
   PubMed Web of Science ®Google Scholar
• Pitman RK, Rasmusson AM, Koenen KC, Shin LM, Orr SP, Gilbertson MW, Milad MR, Liberzon I. 2012. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 13(11):769–787.
   PubMed Web of Science ®Google Scholar
• Popik B, Amorim FE, Amaral OB, De Oliveira Alvares L. 2020. Shifting from fear to safety through deconditioning-update. Elife. 9:e51207.
   PubMed Web of Science ®Google Scholar
• Rakesh G, Morey RA, Zannas AS, Malik Z, Marx CE, Clausen AN, Kritzer MD, Szabo ST. 2019. Resilience as a translational endpoint in the treatment of PTSD. Mol Psychiatry. 24(9):1268–1283.
   PubMed Web of Science ®Google Scholar
• Ramos-Lima LF, Waikamp V, Antonelli-Salgado T, Passos IC, Freitas LHM. 2020. The use of machine learning techniques in trauma-related disorders: a systematic review. J Psychiatr Res. 121:159–172.
   PubMed Web of Science ®Google Scholar
• Ressler RL, Goode TD, Kim S, Ramanathan KR, Maren S. 2021. Covert capture and attenuation of a hippocampus-dependent fear memory. Nat Neurosci. 24(5):677–684.
   PubMed Web of Science ®Google Scholar
• Restivo L, Vetere G, Bontempi B, Ammassari-Teule M. 2009. The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex. J Neurosci. 29(25):8206–8214.
   PubMed Web of Science ®Google Scholar
• Ribot T. 1882. The diseases of memory: An essay in the positive psychology. Smith WH, Translator. London: Kegan Paul, Trench, & Co.
   Google Scholar
• Riccio DC, Ackil J, Burch-Vernon A. 1992. Forgetting of stimulus attributes: methodological implications for assessing associative phenomena. Psychol Bull. 112(3):433–445.
   PubMed Web of Science ®Google Scholar
• Richards BA, Frankland PW. 2017. The persistence and transience of memory. Neuron. 94(6):1071–1084.
   PubMed Web of Science ®Google Scholar
• Roozendaal B, McEwen BS, Chattarji S. 2009. Stress, memory and the amygdala. Nat Rev Neurosci. 10 (6):423–433.
   PubMed Web of Science ®Google Scholar
• Rothbaum BO, Kearns MC, Price M, Malcoun E, Davis M, Ressler KJ, Lang D, Houry D. 2012. Early intervention may prevent the development of posttraumatic stress disorder: a randomized pilot civilian study with modified prolonged exposure. Biol Psychiatry. 72(11):957–963.
   PubMed Web of Science ®Google Scholar
• Rothbaum BO, Kearns MC, Reiser E, Davis JS, Kerley KA, Rothbaum AO, Mercer KB, Price M, Houry D, Ressler KJ. 2014. Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study. J Clin Psychiatry. 75(12):1380–1387.
   PubMed Web of Science ®Google Scholar
• Schelling G, Roozendaal B, Krauseneck T, Schmoelz M, DE Quervain D, Briegel J. 2006. Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery. Ann N Y Acad Sci. 1071:46–53.
   PubMed Web of Science ®Google Scholar
• Schoenfeld TJ, Gould E. 2013. Differential effects of stress and glucocorticoids on adult neurogenesis. Curr Top Behav Neurosci. 15:139–164.
   PubMedGoogle Scholar
• Scoville WB, Milner B. 1957. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 20(1):11–21.
   PubMed Web of Science ®Google Scholar
• Sekeres MJ, Winocur G, Moscovitch M. 2018. The hippocampus and related neocortical structures in memory transformation. Neurosci Lett. 680:39–53.
   PubMed Web of Science ®Google Scholar
• Shumake J, Jones C, Auchter A, Monfils MH. 2018. Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats. Phil Trans R Soc B. 373(1742):20170035.
   PubMed Web of Science ®Google Scholar
• Siddiqui AS, Singh S, Ranjan V, Ugale R, Saha S, Prakash A. 2017. Enhanced histone acetylation in the infralimbic prefrontal cortex is associated with fear extinction. Cell Mol Neurobiol. 37(7):1287–1301.
   PubMed Web of Science ®Google Scholar
• Sierra RO, Cassini LF, Santana F, Crestani AP, Duran JM, Haubrich J, de Oliveira Alvares L, Quillfeldt JA. 2013. Reconsolidation may incorporate state-dependency into previously consolidated memories. Learn Mem. 20(7):379–387.
   PubMed Web of Science ®Google Scholar
• Sierra RO, Pedraza LK, Zanona QK, Santana F, Boos FZ, Crestani AP, Haubrich J, de Oliveira Alvares L, Calcagnotto ME, Quillfeldt JA. 2017. Reconsolidation-induced rescue of a remote fear memory blocked by an early cortical inhibition: involvement of the anterior cingulate cortex and the mediation by the thalamic nucleus reuniens. Hippocampus. 27(5):596–607.
   PubMed Web of Science ®Google Scholar
• Silva BA, Burns AM, Gräff J. 2019. A cFos activation map of remote fear memory attenuation. Psychopharmacology (Berl). 236(1):369–381.
   PubMed Web of Science ®Google Scholar
• Sloan DM, Marx BP, Lee DJ. 2018. Written exposure therapy vs cognitive processing therapy-reply. JAMA Psychiatry. 75(7):758–759.
   PubMed Web of Science ®Google Scholar
• Sloan DM, Marx BP, Resick PA, Young-McCaughan S, Dondanville KA, Mintz J, Litz BT, Peterson AL, STRONG STAR Consortium. 2020. Study design comparing written exposure therapy to cognitive processing therapy for PTSD among military service members: a noninferiority trial. Contemp Clin Trials Commun. 17:100507.
   PubMed Web of Science ®Google Scholar
• Squire LR, Alvarez P. 1995. Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr Opin Neurobiol. 5(2):169–177.
   PubMed Web of Science ®Google Scholar
• Stoyanov D, Maes MH. 2021. How to construct neuroscience-informed psychiatric classification? Towards nomothetic networks psychiatry. World J Psychiatry. 11(1):1–12.
   PubMed Web of Science ®Google Scholar
• Teicher MH, Anderson CM, Polcari A. 2012. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci U S A. 109(9):E563–E572.
   PubMed Web of Science ®Google Scholar
• Teixeira CM, Pomedli SR, Maei HR, Kee N, Frankland PW. 2006. Involvement of the anterior cingulate cortex in the expression of remote spatial memory. J Neurosci. 26(29):7555–7564. https://doi.org/10.1523/JNEUROSCI.1068-06.2006.
   PubMed Web of Science ®Google Scholar
• Twining RC, Vantrease JE, Love S, Padival M, Rosenkranz JA. 2017. An intra-amygdala circuit specifically regulates social fear learning. Nat Neurosci. 20(3):459–469.
   PubMed Web of Science ®Google Scholar
• Tzakis N, Bosnic T, Holahan MR. 2020. Hippocampal and anterior cingulate cortex contribution to the processing of recently-acquired and remotely stored spatial memories in rats trained during preadolescence. Neurobiol Learn Mem. 173:107271.
   PubMed Web of Science ®Google Scholar
• van den Oord EJCG, Chan RF, Aberg KA. 2018. Successes and challenges in precision medicine in psychiatry. JAMA Psychiatry. 75(12):1269–1270.
   PubMed Web of Science ®Google Scholar
• Veer IM, Oei NY, van Buchem MA, Spinhoven P, Elzinga BM, Rombouts SA. 2015. Evidence for smaller right amygdala volumes in posttraumatic stress disorder following childhood trauma. Psychiatry Res. 233(3):436–442.
   PubMed Web of Science ®Google Scholar
• Velasco ER, Florido A, Milad MR, Andero R. 2019. Sex differences in fear extinction. Neurosci Biobehav Rev. 103:81–108.
   PubMed Web of Science ®Google Scholar
• Wang Z, Neylan TC, Mueller SG, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N. 2010. Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. Arch Gen Psychiatry. 67(3):296–303.
   PubMed Web of Science ®Google Scholar
• Widagdo J, Zhao QY, Kempen MJ, Tan MC, Ratnu VS, Wei W, Leighton L, Spadaro PA, Edson J, Anggono V, et al. 2016. Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. J Neurosci. 36(25):6771–6777.
   PubMed Web of Science ®Google Scholar
• Wiltgen BJ, Silva AJ. 2007. Memory for context becomes less specific with time. Learn Mem. 14(4):313–317.
   PubMed Web of Science ®Google Scholar
• Wiltgen BJ, Zhou M, Cai Y, Balaji J, Karlsson MG, Parivash SN, Li W, Silva AJ. 2010. The hippocampus plays a selective role in the retrieval of detailed contextual memories. Curr Biol. 20(15):1336–1344.
   PubMed Web of Science ®Google Scholar
• Winocur G, McDonald RM, Moscovitch M. 2001. Anterograde and retrograde amnesia in rats with large hippocampal lesions. Hippocampus. 11(1):18–26.
   PubMed Web of Science ®Google Scholar
• Winocur G, Moscovitch M, Caruana DA, Binns MA. 2005. Retrograde amnesia in rats with lesions to the hippocampus on a test of spatial memory. Neuropsychologia. 43(11):1580–1590.
   PubMed Web of Science ®Google Scholar
• Winocur G. 1990. Anterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions. Behav Brain Res. 38(2):145–154.
   PubMed Web of Science ®Google Scholar
• Woon FL, Hedges DW. 2008. Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus. 18(8):729–736.
   PubMed Web of Science ®Google Scholar
• Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schnitzer MJ, Callaway EM, et al. 2016. Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval. Cell. 167(4):961–972.e16.
   PubMed Web of Science ®Google Scholar
• Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, Hu H. 2018. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature. 554(7692):317–322.
   PubMed Web of Science ®Google Scholar
• Yehuda R, Hoge CW, McFarlane AC, Vermetten E, Lanius RA, Nievergelt CM, Hobfoll SE, Koenen KC, Neylan TC, Hyman SE. 2015. Post-traumatic stress disorder. Nat Rev Dis Primers. 1:15057. https://doi.org/10.1038/nrdp.2015.57.
   PubMed Web of Science ®Google Scholar
• Zanos P, Gould TD. 2018. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 23(4):801–811.
   PubMed Web of Science ®Google Scholar
• Zelikowsky M, Bissiere S, Fanselow MS. 2012. Contextual fear memories formed in the absence of the dorsal hippocampus decay across time. J Neurosci. 32(10):3393–3397.
   PubMed Web of Science ®Google Scholar
• Zinn R, Leake J, Krasne FB, Corbit LH, Fanselow MS, Vissel B. 2020. Maladaptive properties of context-impoverished memories. Curr Biol. 30(12):2300–2311.e6.
   PubMed Web of Science ®Google Scholar
• Zohar J, Juven-Wetzler A, Sonnino R, Cwikel-Hamzany S, Balaban E, Cohen H. 2011. New insights into secondary prevention in post-traumatic stress disorder. Dialogues Clin Neurosci. 13(3):301–309.
   PubMedGoogle Scholar