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Original Investigations

Treatment strategies for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A network meta-analysis of randomised controlled trials

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Pages 162-177 | Received 01 Dec 2021, Accepted 23 May 2022, Published online: 14 Jun 2022

References

  • Abramowitz JS, Taylor S, McKay D. 2009. Obsessive-compulsive disorder. Lancet. 374(9688):491–499.
  • Afshar H, Akuchekian S, Mahaky B, Zarean E. 2014. Topiramate augmentation in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. J Res Med Sci. 19:976–981.
  • Afshar H, Roohafza H, Mohammad-Beigi H, Haghighi M, Jahangard L, Shokouh P, Sadeghi M, Hafezian H. 2012. N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 32(6):797–803.
  • Albert U, Marazziti D, Di Salvo G, Solia F, Rosso G, Maina G. 2018. A systematic review of evidence-based treatment strategies for obsessive- compulsive disorder resistant to first-line pharmacotherapy. Curr Med Chem. 25(41):5647–5661.
  • Alonso P, Cuadras D, Gabriëls L, Denys D, Goodman W, Greenberg BD, Jimenez-Ponce F, Kuhn J, Lenartz D, Mallet L, et al. 2015. Deep brain stimulation for obsessive-compulsive disorder: a meta-analysis of treatment outcome and predictors of response. PLoS One. 10(7):e0133591.
  • Amiaz R, Fostick L, Gershon A, Zohar J. 2008. Naltrexone augmentation in OCD: a double-blind placebo-controlled cross-over study. Eur Neuropsychopharmacol. 18(6):455–461.
  • Andrade C. 2015. Ondansetron augmentation of serotonin reuptake inhibitors as a treatment strategy in obsessive-compulsive disorder. J Clin Psychiatry. 76:72–75.
  • Andrade C. 2019. Augmentation with memantine in obsessive-compulsive disorder. J Clin Psychiatry. 80(6):19f13163.
  • Balachander S, Arumugham SS, Srinivas D. 2019. Ablative neurosurgery and deep brain stimulation for obsessive-compulsive disorder. Indian J Psychiatry. 61(Suppl 1):S77–S84.
  • Bandelow B, Zohar J, Hollander E, Kasper S, Möller H-J, Zohar J, Hollander E, Kasper S, Möller H-J, Bandelow B, et al. 2008. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders – first revision. World J Biol Psychiatry. 9(4):248–312.,
  • Batistuzzo MC, Hoexter MQ, Taub A, Gentil AF, Cesar RCC, Joaquim MA, D'Alcante CC, McLaughlin NC, Canteras MM, Shavitt RG, et al. 2015. Visuospatial memory improvement after gamma ventral capsulotomy in treatment refractory obsessive-compulsive disorder patients. Neuropsychopharmacology. 40(8):1837–1845.
  • Berlin HA, Koran LM, Jenike MA, Shapira NA, Chaplin W, Pallanti S, Hollander E. 2011. Double-blind, placebo-controlled trial of topiramate augmentation in treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry. 72(5):716–721.
  • Bloch MH, Landeros-Weisenberger a, Kelmendi B, Coric V, Bracken MB, Leckman JF. 2006. A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry. 11(7):622–632.
  • Brakoulias V, Stockings E. 2019. A systematic review of the use of risperidone, paliperidone and aripiprazole as augmenting agents for obsessive-compulsive disorder. Expert Opin Pharmacother. 20(1):47–53.
  • Brunelin J, Mondino M, Gassab L, Haesebaert F, Gaha L, Suaud-Chagny M-F, Saoud M, Mechri A, Poulet E. 2012. Examining Transcranial Direct-Current Stimulation (tDCS) as a treatment for hallucinations in schizophrenia. Am J Psychiatry. 169(7):719–724.
  • Bruno A, Micò U, Pandolfo G, Mallamace D, Abenavoli E, Di Nardo F, D’Arrigo C, Spina E, Zoccali RA, Muscatello MRA, et al. 2012. Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J Psychopharmacol. 26(11):1456–1462.
  • Burchi E, Pallanti S. 2019. Diagnostic issues in early-onset obsessive-compulsive disorder and their treatment implications. Curr Neuropharmacol. 17(8):672–680.
  • Carmi L, Alyagon U, Barnea-Ygael N, Zohar J, Dar R, Zangen A. 2018. Clinical and electrophysiological outcomes of deep TMS over the medial prefrontal and anterior cingulate cortices in OCD patients. Brain Stimul. 11(1):158–165.
  • Carmi L, Tendler A, Bystritsky A, Hollander E, Blumberger DM, Daskalakis J, Ward H, Lapidus K, Goodman W, Casuto L, et al. 2019. Efficacy and safety of deep transcranial magnetic stimulation for obsessive-compulsive disorder: a prospective multicenter randomized double-blind placebo-controlled trial. Am J Psychiatry. 176(11):931–938.
  • Chaimani A, Higgins JPT, Mavridis D, Spyridonos P, Salanti G. 2013. Graphical tools for network meta-analysis in STATA. PLOS One. 8(10):e76654.
  • Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, Bosch A, Schuurman R. 2010. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch Gen Psychiatry. 67(10):1061–1068.
  • Dèttore D, Pozza A, Andersson G. 2015. Efficacy of technology-delivered cognitive behavioural therapy for OCD versus control conditions, and in comparison with therapist-administered CBT: meta-analysis of randomized controlled trials. Cogn Behav Ther. 44(3):190–211.
  • Dold M, Aigner M, Lanzenberger R, Kasper S. 2013. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a meta-analysis of double-blind, randomized, placebo-controlled trials. Int J Neuropsychopharmacol. 16(3):557–574.
  • Dold M, Aigner M, Lanzenberger R, Kasper S. 2015. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: an update meta-analysis of double-blind, randomized, placebo-controlled trials. Int J Neuropsychopharmacol. 18(9):pyv047.
  • D'Urso G, Brunoni AR, Mazzaferro MP, Anastasia A, de Bartolomeis A, Mantovani A. 2016. Transcranial direct current stimulation for obsessive-compulsive disorder: a randomized, controlled, partial crossover trial. Depress Anxiety. 33(12):1132–1140.
  • Eap CB, Gründer G, Baumann P, Ansermot N, Conca A, Corruble E, Crettol S, Dahl ML, de Leon J, Greiner C, et al. 2021. Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants. World J Biol Psychiatry. 22(8):561–628.
  • Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, et al. 2011. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial. JAMA. 306(11):1224–1232.
  • Geller D, Biederman J, Jones J, Park K, Schwartz S, Shapiro S, Coffey B. 1998. Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature. J Am Acad Child Adolesc Psychiatry. 37(4):420–427.
  • Goodman WK, Foote KD, Greenberg BD, Ricciuti N, Bauer R, Ward H, Shapira NA, Wu SS, Hill CL, Rasmussen SA, et al. 2010. Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design. Biol Psychiatry. 67(6):535–542.
  • Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS. 1989. The yale-brown obsessive compulsive scale. I. Development, use, and reliability. Arch Gen Psychiatry. 46(11):1006–1011.
  • Grant PJ, Joseph LA, Farmer CA, Luckenbaugh DA, Lougee LC, Zarate CA, Swedo SE. 2014. 12-week, placebo-controlled trial of add-on riluzole in the treatment of childhood-onset obsessive-compulsive disorder. Neuropsychopharmacology. 39(6):1453–1459.
  • Haghighi M, Shayganfard M, Jahangard L, Ahmadpanah M, Bajoghli H, Pirdehghan A, Holsboer-Trachsler E, Brand S. 2015. Repetitive Transcranial Magnetic Stimulation (rTMS) improves symptoms and reduces clinical illness in patients suffering from OCD-Results from a single-blind, randomized clinical trial with sham cross-over condition. J Psychiatr Res. 68:238–244.
  • Hawken ER, Dilkov D, Kaludiev E, Simek S, Zhang F, Milev R. 2016. Transcranial magnetic stimulation of the supplementary motor area in the treatment of obsessive-compulsive disorder: a multi-site study. Int J Mol Sci. 17(3):420.
  • Hezel DM, Simpson HB. 2019. Exposure and response prevention for obsessive-compulsive disorder: a review and new directions. Indian J Psychiatry. 61(Suppl 1):S85–S92.
  • Hiemke C, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, et al. 2018. Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017. Pharmacopsychiatry. 51(1–02):9–62.
  • Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. 2022. Cochrane Handbook for Systematic Reviews of Interventions version 6.3. Available from: www.training.cochrane.org/handbook.
  • Higgins JPT, Jackson D, Barrett JK, Lu G, Ades AE, White IR. 2012. Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies. Res Synth Methods. 3(2):98–110.
  • Hirschtritt ME, Bloch MH, Mathews CA. 2017. Obsessive-compulsive disorder: advances in diagnosis and treatment. JAMA. 317(13):1358–1367.
  • Jackson D, Law M, Barrett JK, Turner R, Higgins JPT, Salanti G, White IR. 2016. Extending DerSimonian and Laird's methodology to perform network meta-analyses with random inconsistency effects. Stat Med. 35(6):819–839.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 17(1):1–12.
  • Jahangard L, Haghighi M, Shyayganfard M, Ahmadpanah M, Sadeghi Bahmani D, Bajoghli H, Holsboer-Trachsler E, Brand S. 2016. Repetitive transcranial magnetic stimulation improved symptoms of obsessive-compulsive disorder, but also cognitive performance: results from a randomized clinical trial with a cross-over design and sham condition. Neuropsychobiology. 73(4):224–232.
  • Karthik S, Sharma LP, Narayanaswamy JC. 2020. Investigating the role of glutamate in obsessive-compulsive disorder: current perspectives. Neuropsychiatr Dis Treat. 16:1003–1013.
  • Khalkhali M, Aram S, Zarrabi H, Kafie M, Heidarzadeh A. 2016. Lamotrigine augmentation versus placebo in serotonin reuptake inhibitors-resistant obsessive-compulsive disorder: a randomized controlled trial. Iran J Psychiatry. 11(2):104–114.
  • Kim D, Ryba NL, Kalabalik J, Westrich L. 2018. Critical review of the use of second-generation antipsychotics in obsessive-compulsive and related disorders. Drugs R D. 18(3):167–189.
  • Koran LM, Aboujaoude E, Ward H, Shapira NA, Sallee FR, Gamel N, Elliott M. 2006. Pulse-loaded intravenous clomipramine in treatment-resistant obsessive-compulsive disorder. J Clin Psychopharmacol. 26(1):79–83.
  • Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB. 2007. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry. 164(7 Suppl):5–53.
  • Krause M, Zhu Y, Huhn M, Schneider-Thoma J, Bighelli I, Chaimani A, Leucht S. 2018. Efficacy, acceptability, and tolerability of antipsychotics in children and adolescents with schizophrenia: a network meta-analysis. Eur Neuropsychopharmacol. 28(6):659–674.
  • Law C, Boisseau CL. 2019. Exposure and response prevention in the treatment of obsessive-compulsive disorder: current perspectives. Psychol Res Behav Manag. 12:1167–1174.
  • de Leon J, Schoretsanitis G, Kane JM, Ruan C-J. 2020. Using therapeutic drug monitoring to personalize clozapine dosing in Asians. Asia Pac Psychiatry. 12(2):e12384.
  • Li T, Puhan MA, Vedula SS, Singh S, Dickersin K. 2011. Network meta-analysis-highly attractive but more methodological research is needed. BMC Med. 9:79.
  • Lopes AC, Greenberg BD, Canteras MM, Batistuzzo MC, Hoexter MQ, Gentil AF, Pereira CAB, Joaquim MA, de Mathis ME, D'Alcante CC, et al. 2014. Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry. 71(9):1066–1076.
  • Lusicic A, Schruers KR, Pallanti S, Castle DJ. 2018. Transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: current perspectives. Neuropsychiatr Dis Treat. 14:1721–1736.
  • Martinho FP, Duarte GS, Couto F. 2020. Efficacy, effect on mood symptoms, and safety of deep brain stimulation in refractory obsessive-compulsive disorder: a systematic review and meta-analysis. J Clin Psychiatry. 81(3):19r12821.
  • McGuire JF, Wu MS, Piacentini J, McCracken JT, Storch EA. 2017. A meta-analysis of D-cycloserine in exposure-based treatment: moderators of treatment efficacy, response, and diagnostic remission. J Clin Psychiatry. 78(2):196–206.
  • McKay D, Sookman D, Neziroglu F, Wilhelm S, Stein DJ, Kyrios M, Matthews K, Veale D. 2015. Efficacy of cognitive-behavioral therapy for obsessive-compulsive disorder. Psychiatry Res. 225(3):236–246.
  • Menchon JM, Bobes J, Alamo C, Alonso P, García-Portilla MP, Ibáñez Á, Real E, Bousoño M, Saiz-Gonzalez MD, Saiz-Ruiz J, et al. 2019. Pharmacological treatment of obsessive compulsive disorder in adults: a clinical practice guideline based on the ADAPTE methodology. Rev Psiquiatr Salud Ment. 12(2):77–91.
  • Ming TS. 2016. Network meta-analyses and treatment recommendations for obsessive-compulsive disorder. Lancet Psychiatry. 3(10):920–921.
  • Modarresi A, Chaibakhsh S, Koulaeinejad N, Koupaei SR. 2019. A systematic review and meta-analysis: memantine augmentation in moderate to severe obsessive-compulsive disorder. Psychiatry Res. 282:112602.
  • Modarresi A, Sayyah M, Razooghi S, Eslami K, Javadi M, Kouti L. 2018. Memantine augmentation improves symptoms in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a randomized controlled trial. Pharmacopsychiatry. 51(6):263–269.
  • Mohr DC, Ho J, Duffecy J, Reifler D, Sokol L, Burns MN, Jin L, Siddique J. 2012. Effect of telephone-administered vs face-to-face cognitive behavioral therapy on adherence to therapy and depression outcomes among primary care patients: a randomized trial. JAMA. 307(21):2278–2285.
  • Mosley PE, Windels F, Morris J, Coyne T, Marsh R, Giorni A, Mohan A, Sachdev P, O'Leary E, Boschen M, et al. 2021. A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Transl Psychiatry. 11(1):190.
  • Mowla A, Khajeian AM, Sahraian A, Chohedri AH, Kashkoli F. 2010. Topiramate augmentation in resistant OCD: a double-blind placebo-controlled clinical trial. CNS Spectr. 15(11):613–617.
  • Muscatello MRA, Bruno A, Pandolfo G, Micò U, Scimeca G, Romeo VM, Santoro V, Settineri S, Spina E, Zoccali RA, et al. 2011. Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J Clin Psychopharmacol. 31(2):174–179.
  • National Institute for Health and Care Excellence. 2005. Obsessive-compulsive disorder and body dysmorphic disorder: treatment. Available from: https://www.nice.org.uk/guidance/cg31/evidence.
  • Olatunji BO, Davis ML, Powers MB, Smits JAJ. 2013. Cognitive-behavioral therapy for obsessive-compulsive disorder: a meta-analysis of treatment outcome and moderators. J Psychiatr Res. 47(1):33–41.
  • Olatunji BO, Rosenfield D, Monzani B, Krebs G, Heyman I, Turner C, Isomura K, Mataix-Cols D. 2015. Effects of homework compliance on cognitive-behavioral therapy with D-cycloserine augmentation for children with obsessive compulsive disorder. Depress Anxiety. 32(12):935–943.
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 372:n71.
  • Pallanti S, Bernardi S, Antonini S, Singh N, Hollander E. 2014. Ondansetron augmentation in patients with obsessive-compulsive disorder who are inadequate responders to serotonin reuptake inhibitors: Improvement with treatment and worsening following discontinuation. Eur Neuropsychopharmacol. 24(3):375–380.
  • Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, Pato M, Stein D, Zohar J. 2002. Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol. 5(2):181–191.
  • Rapinesi C, Kotzalidis GD, Ferracuti S, Sani G, Girardi P, Del Casale A. 2019. Brain stimulation in Obsessive-Compulsive Disorder (OCD): a systematic review. Curr Neuropharmacol. 17(8):787–807.
  • Reddy YJ, Sundar AS, Narayanaswamy JC, Math SB. 2017. Clinical practice guidelines for obsessive-compulsive disorder. Indian J Psychiatry. 59(5):74.
  • Rhodes KM, Turner RM, Higgins JPT. 2015. Predictive distributions were developed for the extent of heterogeneity in meta-analyses of continuous outcome data. J Clin Epidemiol. 68(1):52–60.
  • Roth Y, Tendler A, Arikan MK, Vidrine R, Kent D, Muir O, MacMillan C, Casuto L, Grammer G, Sauve W, et al. 2021. Real-world efficacy of deep TMS for obsessive-compulsive disorder: post-marketing data collected from twenty-two clinical sites. J Psychiatr Res. 137:667–672.
  • Sayyah M, Sayyah M, Boostani H, Ghaffari SM, Hoseini A. 2012. Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder (a double blind clinical trial). Depress Anxiety. 29(10):850–854.
  • Scahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, McCracken J, Tierney E, Hallett V, Katz K, et al. 2016. Sensitivity of the modified children's yale-brown obsessive compulsive scale to detect change: results from two multi-site trials. Autism. 20(2):145–152.
  • Selvi Y, Atli A, Aydin A, Besiroglu L, Ozdemir P, Ozdemir O. 2011. The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a single-blind, randomised study. Hum Psychopharmacol. 26(1):51–57.
  • Sepehrmanesh Z, Adel M, Ahmadvand A, Sehat M. 2020. Ondansetron augmentation for treatment-resistant obsessive-compulsive disorder: a randomized placebo-controlled clinical trial. Iranian Red Crescent Medical Journal. Available from: https://sites.kowsarpub.com/ircmj/articles/100918.html#abstract.
  • Serata D, Kotzalidis GD, Rapinesi C, Janiri D, Di Pietro S, Callovini G, Piacentino D, Gasperoni C, Brugnoli R, Ferri VR, et al. 2015. Are 5-HT3 antagonists effective in obsessive-compulsive disorder? A systematic review of literature. Hum Psychopharmacol. 30(2):70–84.
  • Shapira NA, Ward HE, Mandoki M, Murphy TK, Yang MC, Blier P, Goodman WK. 2004. A double-blind, placebo-controlled trial of olanzapine addition in fluoxetine-refractory obsessive-compulsive disorder. Biol. Psychiatry. 55(5):553–555.
  • Sharafkhah M, Aghakarim Alamdar M, Massoudifar A, Abdolrazaghnejad A, Ebrahimi-Monfared M, Saber R, Mohammadbeigi A. 2019. Comparing the efficacy of ondansetron and granisetron augmentation in treatment-resistant obsessive-compulsive disorder: a randomized double-blind placebo-controlled study. Int Clin Psychopharmacol. 34(5):222–233.
  • Shayganfard M, Jahangard L, Nazaribadie M, Haghighi M, Ahmadpanah M, Sadeghi Bahmani D, Bajoghli H, Holsboer-Trachsler E, Brand S. 2016. Repetitive transcranial magnetic stimulation improved symptoms of obsessive-compulsive disorders but not executive functions: results from a randomized clinical trial with crossover design and sham condition. Neuropsychobiology. 74(2):115–124.
  • Shoja Shafti S, Kaviani H. 2015. Aripiprazole versus quetiapine in treatment-resistant obsessive-compulsive disorder: a double-blind clinical trial. Ther Adv Psychopharmacol. 5(1):32–37.
  • Sijercic I, Whitfield KM, Cassin SE, Antony MM. 2020. A systematic review of cognitive-behavioral therapy for pharmacotherapy treatment-resistant obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders. 26:100532.
  • Simpson HB, Foa EB, Liebowitz MR, Huppert JD, Cahill S, Maher MJ, McLean CP, Bender J, Marcus SM, Williams MT, et al. 2013. Cognitive-behavioral therapy vs risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry. 70(11):1190–1199.
  • Skapinakis P, Caldwell DM, Hollingworth W, Bryden P, Fineberg NA, Salkovskis P, Welton NJ, Baxter H, Kessler D, Churchill R, et al. 2016. Pharmacological and psychotherapeutic int-erventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis. Lancet Psychiatry. 3(8):730–739.
  • Skapinakis P, Papatheodorou T, Mavreas V. 2007. Antipsychotic augmentation of serotonergic antidepressants in treatment-resistant obsessive-compulsive disorder: a meta-analysis of the randomized controlled trials. Eur Neuropsychopharmacol. 17(2):79–93.
  • Storch EA, Goddard AW, Grant JE, De Nadai AS, Goodman WK, Mutch PJ, Medlock C, Odlaug B, McDougle CJ, Murphy TK, et al. 2013. Double-blind, placebo-controlled, pilot trial of paliperidone augmentation in serotonin reuptake inhibitor-resistant obsessive-compulsive disorder. J Clin Psychiatry. 74(06):e527–e532.
  • Suhas S, Kumar V, Damodharan D, Sharma P, Rao NP, Varambally S, Venkatasubramanian G, Murthy P, Gangadhar BN. 2020. Do Indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? An exploratory study. Schizophrenia Res. 222:195–201.
  • Talaei A, Hosseini FF, Aghili Z, Akhondzadeh S, Asadpour E, Mehramiz NJ, Forouzanfar F. 2020. A comparative, single-blind, randomized study on quetiapine and aripiperazole augmentation in treatment of selective serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Can J Physiol Pharmacol. 98(4):236–242.
  • Trevizol AP, Shiozawa P, Cook IA, Sato IA, Kaku CB, Guimarães FB, Sachdev P, Sarkhel S, Cordeiro Q. 2016. Transcranial magnetic stimulation for obsessive-compulsive disorder: an updated systematic review and meta-analysis. J Ect. 32(4):262–266.
  • Veale D, Miles S, Smallcombe N, Ghezai H, Goldacre B, Hodsoll J. 2014. Atypical antipsychotic augmentation in SSRI treatment refractory obsessive-compulsive disorder: a systematic review and meta-analysis. BMC Psychiatry. 14:317.
  • Wheaton MG, DeSantis SM, Simpson HB. 2016. Network meta-analyses and treatment recommendations for obsessive-compulsive disorder. Lancet Psychiatry. 3(10):920.
  • White IR, Barrett JK, Jackson D, Higgins JPT. 2012. Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression. Res Synth Methods. 3(2):111–125.
  • White IR, Thomas J. 2016. Standardized mean differences in individually-randomized and cluster-randomized trials, with applications to meta-analysis: Clinical Trials. Available from: 10.1191/1740774505cn081oa.
  • Xia J, Du Y, Han J, Liu G, Wang X. 2015. D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis. Drug Des Devel Ther. 9:2101–2117.
  • Zhou D-D, Zhou X-X, Li Y, Zhang K-F, Lv Z, Chen X-R, Wan L-Y, Wang W, Wang G-M, Li D-Q, et al. 2019. Augmentation agents to serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder: a network meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 90:277–287.
  • Zhou D-D, Zhou X-X, Lv Z, Chen X-R, Wang W, Wang G-M, Liu C, Li D-Q, Kuang L. 2019. Comparative efficacy and tolerability of antipsychotics as augmentations in adults with treatment-resistant obsessive-compulsive disorder: a network meta-analysis. J Psychiatr Res. 111:51–58.

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