Impact of ZNF804A rs1344706 or CACNA1C rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis

References

• Arts B, Simons CJP, Os Jv. 2013. Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder. Psychiatr Genet. 23(1):41–42.
   PubMedGoogle Scholar
• Barch DM, Sheffield JM. 2014. Cognitive impairments in psychotic disorders: common mechanisms and measurement. World Psychiatry. 13(3):224–232.
   PubMedGoogle Scholar
• Baumeister D, Akhtar R, Ciufolini S, Pariante CM, Mondelli V. 2016. Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol Psychiatry. 21(5):642–649.
   PubMed Web of Science ®Google Scholar
• Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, Yücel M, Gama CS, Dodd S, Dean B, et al. 2011. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 35(3):804–817.
   PubMed Web of Science ®Google Scholar
• Bora E, Pantelis C. 2015. Meta-analysis of cognitive impairment in first-episode bipolar disorder: comparison with first-episode schizophrenia and healthy controls. Schizophr Bull. 41(5):1095–1104.
   PubMed Web of Science ®Google Scholar
• Burdick KE, Perez-Rodriguez M, Birnbaum R, Shanahan M, Larsen E, Harper C, Poskus J, Sklar P. 2020. A molecular approach to treating cognition in schizophrenia by calcium channel blockade: an open-label pilot study of the calcium-channel antagonist isradipine. Schizophr Res Cogn. 21.
   PubMedGoogle Scholar
• Cannon TD. 2020. The current state of the clinical high risk for psychosis research paradigm. Biol Psychiatry. 88(4):284–286.
   PubMedGoogle Scholar
• Castano M, Lopez-Jaramillo C, Navarro JCC, Arias JCS, Buitrago RL, Isaza CA. 2019. Cacna1c, ANK3 AND ZNF804A polymorphisms associated with cognitive symptoms in patients with bipolar disorder type. Eur Neuropsychopharmacol. 29:S130–S131.
   Google Scholar
• Chen M, Xu Z, Zhai J, Bao X, Zhang Q, Gu H, Shen Q, Cheng L, Chen X, Wang K, et al. 2012. Evidence of IQ-modulated association between ZNF804A gene polymorphism and cognitive function in schizophrenia patients. Neuropsychopharmacology. 37(7):1572–1578.
   PubMedGoogle Scholar
• Dauvermann MR, Donohoe G. 2019. The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder – A systematic review. Schizophr Res Cogn. 16:1–11.
   PubMedGoogle Scholar
• Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME. 2001. Signaling to the nucleus by an L-type calcium channel- calmodulin complex through the MAP kinase pathway. Science. 294(5541):333–339.
   PubMed Web of Science ®Google Scholar
• Erk S, Meyer-Lindenberg A, Schmierer P, Mohnke S, Grimm O, Garbusow M, Haddad L, Poehland L, Mühleisen TW, Witt SH, et al. 2014. Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C. Biol Psychiatry. 76(6):466–475.
   PubMedGoogle Scholar
• Finckh A, Tramèr MR. 2014. Primer: strengths and weaknesses of meta-analysis. Nat Clin Pract Rheumatol. 4(3):146–152.
   Google Scholar
• First MB, Williams JB, Karg RS, Spitzer RL. 2017. Entrevista clínica estruturada para os transtornos do DSM-5: SCID-5-CV – Versão clínica. Porto Alegre: Artmed.
   Google Scholar
• Gurung R, Prata DP. 2015. What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review. Psychol Med. 45(12):2461–2480.
   PubMed Web of Science ®Google Scholar
• Hagenston AM, Bading H. 2011. Calcium signaling in synapse-to-nucleus-communicationI. Cold Spring Harb Perspect Biol. 3(11):a004564–31.
   PubMedGoogle Scholar
• Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, et al. 2010. The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 153B(8):1459–1464.
   PubMedGoogle Scholar
• Hess JL, Glatt SJ. 2014. How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis. Am J Med Genet. 165(1):28–40.
   Google Scholar
• Honea R, Crow TJ, Passingham D, Mackay CE. 2005. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry. 162(12):2233–2245.
   PubMed Web of Science ®Google Scholar
• Hori H, Yamamoto N, Fujii T, Teraishi T, Sasayama D, Matsuo J, Kawamoto Y, Kinoshita Y, Ota M, Hattori K, et al. 2012. Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals. Sci Rep. 2(1):634.
   PubMedGoogle Scholar
• Howell KR, Floyd K, Law AJ. 2017. PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: relevance for schizophrenia. PLoS One. 12(5):e0175993.
   PubMedGoogle Scholar
• Jiang W, King TZ, Turner JA. 2019. Imaging genetics towards a refined diagnosis of schizophrenia. Front Psychiatry. 10(JULY):494.
   PubMedGoogle Scholar
• Kabir ZD, Martínez-Rivera A, Rajadhyaksha AM. 2017. From gene to behavior: L-type calcium channel mechanisms underlying neuropsychiatric symptoms. Neurotherapeutics. 14(3):588–613.
   PubMed Web of Science ®Google Scholar
• Kasznia J, Pytel A, Stańczykiewicz B, Samochowiec J, Preś J, Rachubińska K, Misiak B. 2021. Adverse childhood experiences and neurocognition in schizophrenia spectrum disorders: age at first exposure and multiplicity matter. Front Psychiatry. 12(July):684099–684099.
   PubMedGoogle Scholar
• Kuswanto CN, Woon P-S, Zheng XB, Qiu A, Sitoh Y-Y, Chan YH, Liu J, Williams H, Ong WY, Sim K, et al. 2012. Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 159B(3):255–262.
   PubMedGoogle Scholar
• Lin K, Xu G, Shi L, Lu W, Guan L, Ouyang H, Chen K, Dang Y, Zhou L, So K-F, et al. 2017. CACNA1C polymorphisms impact cognitive recovery in patients with bipolar disorder in a six-week. Sci Rep. 7(1):7022.
   PubMedGoogle Scholar
• Mallas E, Carletti F, Chaddock CA, Shergill S, Woolley J, Picchioni MM, McDonald C, Toulopoulou T, Kravariti E, Kalidindi S, et al. 2017. The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder. Genes Brain Behav. 16(4):479–488.
   PubMedGoogle Scholar
• McGorry P, Keshavan M, Goldstone S, Amminger P, Allott K, Berk M, Lavoie S, Pantelis C, Yung A, Wood S, et al. 2014. Biomarkers and clinical staging in psychiatry. World Psychiatry. 13(3):211–223.
   PubMed Web of Science ®Google Scholar
• Moon L, Haan N, Wilkinson LS, Thomas KL, Hall J. 2018. CACNA1C: association with psychiatric disorders, behavior, and neurogenesis. Schizophr Bull. 44(5):958–965.
   PubMed Web of Science ®Google Scholar
• Nenadic I, Maitra R, Basmanav FB, Schultz CC, Lorenz C, Schachtzabel C, Smesny S, Nöthen MM, Cichon S, Reichenbach JR, et al. 2015. ZNF804A genetic variation (rs1344706) affects brain grey but not white matter in schizophrenia and healthy subjects. Psychol Med. 45(1):143–152.
   PubMedGoogle Scholar
• Nickl-Jockschat T, Janouschek H, Eickhoff SB, Eickhoff CR. 2015. Lack of meta-analytic evidence for an impact of COMT Val158Met genotype on brain activation during working memory tasks. Biol Psychiatry. 78(11):e43–e46.
   PubMedGoogle Scholar
• Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 372:n71–2021.
   PubMed Web of Science ®Google Scholar
• Perrier E, Pompei F, Ruberto G, Vassos E, Collier D, Frangou S. 2011. Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder. Eur Psychiatry. 26(3):135–137.
   PubMedGoogle Scholar
• Renault VM, Rafalski VA, Morgan AA, Salih DAM, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, et al. 2009. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 5(5):527–539.
   PubMedGoogle Scholar
• Rolstad S, Sellgren Majkowitz C, Joas E, Ekman CJ, Pålsson E, Landén M. 2016. Polymorphisms of BDNF and CACNA1C are not associated with cognitive functioning in bipolar disorder or healthy controls. Cogn Neuropsychiatry. 21(3):271–278.
   PubMed Web of Science ®Google Scholar
• Scaini G, Valvassori SS, Diaz AP, Lima CN, Benevenuto D, Fries GR, Quevedo J. 2020. Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings. Braz J Psychiatry. 42(5):536–551.
   PubMedGoogle Scholar
• Schulz KF, Grimes DA. 2002. Case-control studies: research in reverse. Lancet. 359(9304):431–434.
   PubMed Web of Science ®Google Scholar
• Shonibare DO, Patel RR, Islam AH, Metcalfe AWS, Fiksenbaum L, Freeman N, MacIntosh BJ, Kennedy JL, Goldstein BI. 2021. Neurostructural phenotypes of CACNA1C rs1006737 in adolescents with bipolar disorder and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry. 104:110071.
   PubMedGoogle Scholar
• Shrivastava A, Johnston M, Tsuang M. 2011. Cannabis use and cognitive dysfunction. Indian J Psychiatry. 53(3):187–191.
   PubMedGoogle Scholar
• Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, Faerden A, Jónsdóttir H, Ringen PA, Opjordsmoen S, Melle I, et al. 2011. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull. 37(1):73–83.
   PubMed Web of Science ®Google Scholar
• Smeland OB, Bahrami S, Frei O, Shadrin A, O’Connell K, Savage J, Watanabe K, Krull F, Bettella F, Steen NE, et al. 2020. Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Mol Psychiatry. 25(4):844–853.
   PubMedGoogle Scholar
• Soeiro-de-Souza MG, Bio DS, Dias V, Vieta E, Machado-Vieira R, Moreno RA. 2013. The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder. Acta Psychiatr Scand. 128(5):362–369.
   PubMedGoogle Scholar
• Sykes L, Haddon J, Lancaster TM, Sykes A, Azzouni K, Ihssen N, Moon AL, Lin T-CE, Linden DE, Owen MJ, et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophr Bull. 45(5):1024–1032.
   PubMed Web of Science ®Google Scholar
• Tecelão D, Mendes A, Martins D, Fu C, Chaddock CA, Picchioni MM, McDonald C, Kalidindi S, Murray R, Prata DP, et al. 2019. The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function. Genes, Brain and Behavior. 18(4):e12510.
   PubMedGoogle Scholar
• Trovão N, Prata J, Vondoellinger O, Santos S, Barbosa M, Coelho R. 2019. Peripheral biomarkers for first-episode psychosis-opportunities from the neuroinflammatory hypothesis of schizophrenia. Psychiatry Investig. 16(3):177–184.
   PubMedGoogle Scholar
• Uemura T, Green M, Warsh JJ. 2016. CACNA1C SNP rs1006737 associates with bipolar I disorder independent of the Bcl-2 SNP rs956572 variant and its associated effect on intracellular calcium homeostasis. World J Biol Psychiatry. 17(7):525–534.
   PubMed Web of Science ®Google Scholar
• Vargas T, Lam PH, Azis M, Osborne KJ, Lieberman A, Mittal VA. 2019. Childhood trauma and neurocognition in adults with psychotic disorders: a systematic review and meta-analysis. Schizophr Bull. 45(6):1195–1208.
   PubMedGoogle Scholar
• Walters JTR, Corvin A, Owen MJ, Williams H, Dragovic M, Quinn EM, Judge R, Smith DJ, Norton N, Giegling I, et al. 2010. Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Arch Gen Psychiatry. 67(7):692–700.
   PubMed Web of Science ®Google Scholar
• Wang F, Mcintosh AM, He Y, Gelernter J, Blumberg HP. 2011. The association of genetic variation in CACNA1C with structure and function of a frontotemporal system. Bipolar Disorders. 13(7–8):696–700.
   PubMedGoogle Scholar
• Wei Q, Li M, Kang Z, Li L, Diao F, Zhang R, Wang J, Zheng L, Wen X, Zhang J, et al. 2015. ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls. Am J Med Genet. 168(4):265–273.
   Web of Science ®Google Scholar
• Wells G, Shea B, O‘Connell D, Peterson J, Welch V, Losos M, Tugwell P. 2011. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. The Ottawa Hospital.
   Google Scholar
• Wiegert JS, Bading H. 2011. Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium. 49(5):296–305.
   PubMed Web of Science ®Google Scholar
• Williams HJ, Norton N, Dwyer S, Moskvina V, Nikolov I, Carroll L, Georgieva L, Williams NM, Morris DW, Quinn EM, et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry. 16(4):429–441.
   PubMed Web of Science ®Google Scholar
• Zazula R, Dodd S, Dean OM, Berk M, Bortolasci CC, Verri WA, Vargas HO, Nunes SOV. 2021. Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder. World J Biol Psychiatry. 23(1):67–77.
   PubMedGoogle Scholar
• Zhang Q, Shen Q, Xu Z, Chen M, Cheng L, Zhai J, Gu H, Bao X, Chen X, Wang K, et al. 2012. The effects of CACNA1C Gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder. Neuropsychopharmacology. 37(3):677–684
   PubMedGoogle Scholar