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Original Investigations

Vitamin B12, homocysteine, and folic acid in patients suffering from bipolar disorders: Relationship with suicide

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Pages 476-484 | Received 08 Aug 2022, Accepted 06 Oct 2022, Published online: 23 Nov 2022

References

  • Agricultural Research Service. 2020. What we eat in America. NHANES 2017–2018. U.S. Department of Agriculture; [accessed 2022 May 14]. https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/1718/Key%20Points%20Using%20WWEIA%20NHANES%202017-2018.pdf.
  • Airola P. 1977. Hypoglycemia: a better approach. Phoenix (AZ): Health Plus Publishers.
  • Allen LH. 2009. How common is vitamin B-12 deficiency? Am J Clin Nutr. 89(2):693S–696S.
  • Allen LH. 2010. Bioavailability of vitamin B12. Int J Vitam Nutr Res. 80:330–335.
  • [APA] American Psychiatric Association. 2013. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington (VA): American Psychiatric Association.
  • Andersson A, Brattström L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. 1992. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest. 22(2):79–87.
  • Andres E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blicklé JF. 2004. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 171(3):251–259.
  • Brattström L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, Hamfelt A. 1992. Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest. 22:214–221.
  • Carmel R. 2008. How I treat cobalamin (vitamin B12) deficiency. Blood. 112(6):2214–2221.
  • Chiarani F, Tramontina JF, Ceresér KM, Kunz M, Paim L, Vargas CR, Sitta A, Machado SP, Wyse AT, Kapczinski FP. 2013. Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder. Braz J Psychiatry. 35(2):157–160.
  • Coppen A, Bolander-Gouaille C. 2005. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 19(1):59–65.
  • Coşar A, Ipçioğlu OM, Ozcan O, Gültepe M. 2014. Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry. Turk J Med Sci. 44(1):1–9.
  • Devalia V, Hamilton MS, Molloy AM. 2014. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 166(4):496–513.
  • Doets EL, In 't Veld PH, Szczecińska A, Dhonukshe-Rutten RA, Cavelaars AE, van 't Veer P, Brzozowska A, de Groot LC. 2013. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 62(4):311–322.
  • Ebesunun MO, Eruvulobi HU, Olagunju T, Owoeye OA. 2012. Elevated plasma homocysteine in association with decreased vitamin B(12), folate, serotonin, lipids and lipoproteins in depressed patients. Afr J Psychiatry. 15(1):25–9.
  • Esnafoglu E, Ozturan DD. 2020. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 25(4): 249–255.
  • Ghanizadeh A, Singh AB, Berk M, Torabi-Nami M. 2015. Homocysteine as a potential biomarker in bipolar disorders: a critical review and suggestions for improved studies. Expert Opin Ther Targets. 19(7):927–939.
  • Gilbody S, Lightfoot T, Sheldon T. 2007. Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Community Health. 61(7):631–637.
  • Goggans FC. 1984. A case of mania secondary to vitamin B12 deficiency. Am J Psychiatry. 141(2):300–301.
  • Gomez-Bernal GJ, Bernal-Perez M. 2007. Vitamin B12 deficiency manifested as mania: a case report. Prim Care Companion J Clin Psychiatry. 9(3):238.
  • Green R, Miller JW. 2007. Vitamin B12. In: Zempleni J, Rucker RB, Suttie JW, McCormick DB, editors. Handbook of vitamins. 2nd ed. Boca Raton (FL): CRC Press; p. 413–457.
  • Green R, Mitra AD. 2017. Megaloblastic anemias: nutritional and other causes. Med Clin North Am. 101(2):297–317.
  • Hamilton M. 1960. A rating scale for depression. J Neurol Neurosurg Psychiatry. 23(1):56–62.
  • Hsieh YC, Chou LS, Lin CH, Wu HC, Li DJ, Tseng PT. 2019. Serum folate levels in bipolar disorder: a systematic review and meta-analysis. BMC Psychiatry. 19(1):305.
  • IBM Corp. 2020. IBM SPSS statistics for windows. Version 27.0. Armonk (NY): IBM Corp.
  • Laird E, O'Halloran AM, Molloy AM, Healy M, Hernandez B, O'Connor D, Kenny RA, Briggs R. 2021. Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4 year longitudinal study. Br J Nutr. 1–22.
  • Lerner V, Kanevsky M, Dwolatzky T, Rouach T, Kamin R, Miodownik C. 2006. Vitamin B12 and folate serum levels in newly admitted psychiatric patients. Clin Nutr. 25(1):60–67.
  • Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH. 1988. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 318(26):1720–1728.
  • Majumder S, Soriano J, Louie Cruz A, Dasanu CA. 2013. Vitamin B12 deficiency in patients undergoing bariatric surgery: preventive strategies and key recommendations. Surg Obes Relat Dis. 9(6):1013–1019.
  • Mann JJ. 2002. A current perspective of suicide and attempted suicide. Ann Intern Med. 136:302–311.
  • Marazziti D, Rutigliano G, Baroni S, Landi P, Dell'Osso L. 2014. Metabolic syndrome and major depression. CNS Spectr. 19(4):293–304.
  • Markun S, Gravestock I, Jäger L, Rosemann T, Pichierri G, Burgstaller JM. 2021. Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression. Nutrients. 13(3):923.
  • Miller JW, Green R. 2014. Vitamin B12. In: Zempleni J, editor. Handbook of vitamins. Boca Raton (FL): Taylor & Francis; p. 447–489.
  • Morillo Z, Guzmán DS, Ortiz Y. 2018. Intento suicida y psicosis debida a déficit de vitamina B12, a propósito de un caso. Ciencia y Salud. 2(3):55–61.
  • Morris AL, Thomas AB, Francis JK, Jerome L, Loren RM, Richard W. 1973. Megavitamin and orthomolecular therapy in psychiatry: excerpts from a report of the American Psychiatric Association Task Force on vitamin therapy in psychiatry. Nutr Rev. 32:44–47.
  • Nielsen MJ, Rasmussen MR, Andersen CB, Nexo E, Moestrup SK. 2012. Vitamin B12 transport from food to the body's cells – a sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol. 9(6):345–354.
  • Nielsen J, Steiness I. 1968. Vitamin B 12 deficiency and mental illness. Int Pharmacopsychiatry. 1:129–133.
  • Ozdogan MG, Aydin EF, Ustundag MF, Ceyhun HA, Oral E, Bakan E. 2020. Homocysteine, chronotype and clinical course in bipolar disorder patients. Nord J Psychiatry. 74(5):340–345.
  • Permoda-Osip A, Dorszewska J, Skibinska M, Chlopocka-Wozniak M, Rybakowski JK. 2013. Hyperhomocysteinemia in bipolar depression: clinical and biochemical correlates. Neuropsychobiology. 68(4):193–196.
  • Plans L, Barrot C, Nieto E, Rios J, Schulze TG, Papiol S, Mitjans M, Vieta E, Benabarre A. 2019. Association between completed suicide and bipolar disorder: a systematic review of the literature. J Affect Disord. 242:111–122.
  • Ponsoni A, Branco LD, Cotrena C, Shansis FM, Grassi-Oliveira R, Fonseca RP. 2018. Self-reported inhibition predicts history of suicide attempts in bipolar disorder and major depression. Compr Psychiatry. 82:89–94.
  • Roos D, Willanger R. 1977. Various degrees of dementia in a selected group of gastrectomized patients with low serum B12. Acta Neurol Scand. 55(5):363–376.
  • Sahu P, Thippeswamy H, Chaturvedi SK. 2022. Neuropsychiatric manifestations in vitamin B12 deficiency. Vitam Horm. 119:457–470.
  • Salagre E, Vizuete AF, Leite M, Brownstein DJ, McGuinness A, Jacka F, Dodd S, Stubbs B, Köhler CA, Vieta E, Carvalho AF, Berk M, Fernandes BS. 2017. Homocysteine as a peripheral biomarker in bipolar disorder: a meta-analysis. Eur Psychiatry. 43:81–91.
  • Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. 2020. Vitamin B12 supplementation: preventing onset and improving prognosis of depression. Cureus. 12(10):e11169.
  • Schaffer A, Isometsä ET, Tondo L, Moreno DH, Sinyor M, Kessing LV, Turecki G, Weizman A, Azorin JM, Ha K, Reis C, Cassidy F, Goldstein T, Rihmer Z, Beautrais A, Chou YH, Diazgranados N, Levitt AJ, Zarate CA Jr., Yatham L. 2015. Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: part I of a report of the International Society for Bipolar Disorders Task Force on suicide in bipolar disorder. Aust N Z J Psychiatry. 49(9):785–802.
  • Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. 1998. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 59(Suppl 20):22–33.
  • Skarupski KA, Tangney C, Li H, Ouyang B, Evans DA, Morris MC. 2010. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutrit. 92(2):330–335.
  • Sozer K, Gorgulu Y, Bulent Sonmez M, Kose Cinar R. 2019. Psychotic depression after obesity surgery and recovery with vitamin B12 replacement. Düşünen Adam. 32:65–68.
  • Stabler SP. 2013. Clinical practice. Vitamin B12 deficiency. N Engl J Med. 368(2):149–160.
  • Todorov A, Chumpalova-Tumbeva P, Stoimenova-Popova MY, Popova VS, Todorieva-Todorova DK, Tzvetkov N, Hristov IG, Georgiev G, Valtchev V, Krasteva NA, Ilieva RG, Dimitrova E, Tumbev LZ, Ruseva AL. 2017. Correlation between depression and anxiety and the level of vitamin B12 in patients with depression and anxiety and healthy controls. J Biomed Clin Res. 10(2):140–145.
  • Tufan AE, Bilici R, Usta G, Erdoğan A. 2012. Mood disorder with mixed, psychotic features due to vitamin B12 deficiency in an adolescent: case report. Child Adolesc Psychiatry Ment Health. 6(1):25.
  • Tunbridge EM, Attenburrow MJ, Gardiner A, Rendell JM, Hinds C, Goodwin GM, Harrison PJ, Geddes JR. 2017. Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: analysis of the CEQUEL clinical trial. Bipolar Disord. 19(6):477–486.
  • Watanabe F, Bito T. 2018. Vitamin B12 sources and microbial interaction. Exp Biol Med. 243(2):148–158.
  • [WHO] World Health Organization. 2017. Depression and other common mental disorders: global health estimates. [accessed 2021 Jun 17]. https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf?sequence=1&isAllowed=y.
  • [WHO] World Health Organization. 2018. Mental health atlas 2017. [accessed 2019 Jun 10]. https://apps.who.int/iris/bitstream/handle/10665/272735/9789241514019-eng.pdf?ua=1.
  • Wu Y, Zhang L, Li S, Zhang D. 2022. Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutr Rev. 80(3):351–366.
  • Young RC, Biggs JT, Ziegler VE, Meyer DA. 1978. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 133:429–435.

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