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Hematology Volume 27, 2022 - Issue 1
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Research Article

SPRY1 promotes cell proliferation and inhibits apoptosis by activating Hedgehog pathway in acute myeloid leukemia

Guiyang LvDepartment of Hematology, Affiliated Qingdao Central Hospital, Qingdao University, Shandong, People’s Republic of China
,
Yuanyuan WangDepartment of Hematology, Affiliated Qingdao Central Hospital, Qingdao University, Shandong, People’s Republic of China
,
ChunXiao JiDepartment of Hematology, Affiliated Qingdao Central Hospital, Qingdao University, Shandong, People’s Republic of China
,
Chunlei ShiDepartment of Hematology, Affiliated Qingdao Central Hospital, Qingdao University, Shandong, People’s Republic of China
&
Ying LiDepartment of Hematology, Affiliated Qingdao Central Hospital, Qingdao University, Shandong, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9506-1209
ORCID Icon
Pages 1-10 | Published online: 27 Dec 2021

References

  • Khwaja A, Bjorkholm M, Gale RE, et al. Acute myeloid leukaemia. Nat Rev Dis Primers. 2016;2:16010–16031.
  • Chen L, Mao H, Zhang J, et al. Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia. Leukemia. 2017;31(8):1830–1834.
  • De Kouchkovsky I, Abdul-Hay M. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J. 2016;6(7):441–450.
  • Christofori G. Split personalities: the agonistic antagonist sprouty. Nat Cell Biol. 2003;5(5):377–379.
  • He Q, Jing H, Liaw L, et al. Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype. Sci Rep. 2016;6:23216–23228.
  • Masoumi-Moghaddam S, Amini A, Wei AQ, et al. Sprouty 1 predicts prognosis in human epithelial ovarian cancer. Am J Cancer Res. 2015;5(4):1531–1541.
  • Masoumi-Moghaddam S, Amini A, Ehteda A, et al. The expression of the Sprouty 1 protein inversely correlates with growth, proliferation, migration and invasion of ovarian cancer cells. J Ovarian Res. 2014;7:61–70.
  • He X, Wang J, Chen J, et al. lncRNA UCA1 predicts a poor prognosis and regulates cell proliferation and migration by repressing p21 and SPRY1 expression in GC. Mol Ther Nucleic Acids. 2019;18:605–616.
  • Chai C, Song LJ, Han SY, et al. MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3 K/AKT signaling pathway. CNS Neurosci Ther. 2018;24(5):369–380.
  • Ley TJ, Miller C, Ding L, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059–2074.
  • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the world health organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–2405.
  • Fritzsche S, Kenzelmann M, Hoffmann MJ, et al. Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma. Endocr Relat Cancer. 2006;13(3):839–849.
  • Jin XL, Sun QS, Liu F, et al. microRNA 21-mediated suppression of Sprouty1 by pokemon affects liver cancer cell growth and proliferation. J Cell Biochem. 2013;114(7):1625–1633.
  • Schaaf G, Hamdi M, Zwijnenburg D, et al. Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene. Cancer Res. 2010;70(2):762–771.
  • Montico B, Colizzi F, Giurato G, et al. Loss of Spry1 reduces growth of BRAF(V600)-mutant cutaneous melanoma and improves response to targeted therapy. Cell Death Dis. 2020;11(5):392–406.
  • Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in drosophila. Nature. 1980;287(5785):795–801.
  • Jia Y, Wang Y, Xie J. The Hedgehog pathway: role in cell differentiation, polarity and proliferation. Arch Toxicol. 2015;89(2):179–191.
  • Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 2008;22(18):2454–2472.
  • Pak E, Segal RA. Hedgehog signal transduction: Key players, oncogenic drivers, and cancer therapy. Dev Cell. 2016;38(4):333–344.
  • Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009;30(6):303–312.
  • Terao T, Minami Y. Targeting Hedgehog (Hh) pathway for the acute myeloid leukemia treatment. Cells. 2019;8(4):312–322.
  • Kim TJ, Lee JY, Hwang TK, et al. Hedgehog signaling protein expression and its association with prognostic parameters in prostate cancer: a retrospective study from the view point of new 2010 anatomic stage/prognostic groups. J Surg Oncol. 2011;104(5):472–479.
  • Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell. 2008;15(6):801–812.
  • Zhao D, Cui Z. MicroRNA-361-3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling. Exp Ther Med. 2019;17(2):1154–1162.
  • Liu X, Liu J, Zhang X, et al. MiR-520b promotes the progression of non-small cell lung cancer through activating Hedgehog pathway. J Cell Mol Med. 2019;23(1):205–215.
  • Shallis RM, Bewersdorf JP, Boddu PC, et al. Hedgehog pathway inhibition as a therapeutic target in acute myeloid leukemia. Expert Rev Anticancer Ther. 2019;19(8):717–729.
  • Tibes R, Al-Kali A, Oliver GR, et al. The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia. J Hematol Oncol. 2015;8:114–223.
  • Fukushima N, Minami Y, Kakiuchi S, et al. Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 2016;107(10):1422–1429.

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