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Hematology Volume 27, 2022 - Issue 1
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Research Article

High dose melphalan is an adequate preparative regimen for autologous hematopoietic stem cell transplantation in relapsed/refractory lymphoma

José A. Fernández-Gutiérreza Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;b Universidad Popular Autónoma del Estado de Puebla, Puebla, MéxicoORCID Iconhttps://orcid.org/0000-0002-9036-4312
ORCID Icon,
Oscar A. Reyes-Cisnerosa Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;c Universidad Anáhuac Puebla, Puebla, MéxicoORCID Iconhttps://orcid.org/0000-0002-8180-5171
ORCID Icon,
Mark R. Litzowd Hematology, Mayo Clinic Minnesota, Rochester, MN, USA
,
Lorena Bojalil-Álvareza Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;b Universidad Popular Autónoma del Estado de Puebla, Puebla, MéxicoORCID Iconhttps://orcid.org/0000-0001-5119-6312
ORCID Icon,
Elizabeth García-Villaseñora Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;e Benemérita Universidad Autónoma de Puebla, Puebla, MéxicoORCID Iconhttps://orcid.org/0000-0002-1223-5072
ORCID Icon,
Eliezer Tomas Gómez-Gomezf Hematología, Hospital Universitario de Nuevo León “José Eleuterio González”, Monterrey, Mexico
,
Iván Murrieta-Álvareza Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;b Universidad Popular Autónoma del Estado de Puebla, Puebla, MéxicoORCID Iconhttps://orcid.org/0000-0002-8284-333X
ORCID Icon,
David Gomez-Almaguerf Hematología, Hospital Universitario de Nuevo León “José Eleuterio González”, Monterrey, MexicoORCID Iconhttps://orcid.org/0000-0002-0460-6427
ORCID Icon,
Cesar H. Gutierrez-Aguirref Hematología, Hospital Universitario de Nuevo León “José Eleuterio González”, Monterrey, MexicoORCID Iconhttps://orcid.org/0000-0002-9876-3633
ORCID Icon,
Amado J. Karduss-Uruetag Instituto de Cancerología, Clínica Las Americas, Medellín, ColombiaORCID Iconhttps://orcid.org/0000-0001-8372-102X
ORCID Icon,
Guillermo J. Ruiz-Delgadoa Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;b Universidad Popular Autónoma del Estado de Puebla, Puebla, México;h Laboratorios Ruiz, Puebla, MéxicoORCID Iconhttps://orcid.org/0000-0003-3068-0644
ORCID Icon &
Guillermo José Ruiz-Argüellesa Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico;b Universidad Popular Autónoma del Estado de Puebla, Puebla, México;h Laboratorios Ruiz, Puebla, MéxicoCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9335-0653
ORCID Icon show all
Pages 449-455 | Published online: 12 Apr 2022

References

  • Gutiérrez-Aguirre CH, Ruiz-Argüelles G, Cantú-Rodríguez OG, et al. Outpatient reduced-intensity allogeneic stem cell transplantation for patients with refractory or relapsed lymphomas compared with autologous stem cell transplantation using a simplified method. Ann Hematol. 2010;89:1045–1052.
  • Sánchez-Valledor LF, Habermann TM, Murrieta-Alvarez I, et al. Long-term results of the treatment of Hodgkin’s lymphoma in a resource-constrained setting: real-world data from a single center. World J Clin Oncol. 2021;12:800–807.
  • Appelbaum FR, Herzig GP, Ziegler JL, et al. Successful engraftment of cryopreserved autologous bone marrow in patients with malignant lymphoma. Blood. 1978;52:85–95.
  • Anderson CC, Goldstone AH, Souhami RL, et al. Very high dose chemotherapy with autologous bone marrow rescue in adult patients with resistant relapsed lymphoma. Cancer Chemother Pharmacol. 1986;16:170–175.
  • Olivieri J, Mosna F, Pelosini M, et al. A comparison of the conditioning regimens BEAM and FEAM for autologous hematopoietic stem cell transplantation in lymphoma: An observational study on 1038 patients from Fondazione Italiana Linfomi. Biol Blood Marrow Transpl. 2018;24:1814–1822.
  • Joffe E, Rosenberg D, Rozovski U, et al. Replacing carmustine by thiotepa and cyclophosphamide for autologous stem cell transplantation in Hodgkin’s and non-Hodgkin’s B-cell lymphoma. Bone Marrow Transpl. 2021;53:29–33.
  • Marchesi F, Capria S, Pedata M, et al. BEAM conditioning regimen ensures better progression-free survival compared with TEAM but not with FEAM in lymphoma patients undergoing autologous stem cell transplant. Leukemia Lymph. 2020;61:2238–2241.
  • Kim K, Kim W, Kim S, et al. Treatment with intravenous busulfan, melphalan, and etoposide followed by autologous stem cell transplantation in patients with non-Hodgkin’s lymphoma: a multicenter study from the consortium for improving survival of lymphoma. Transpl Int. 2020;33:1211–1219.
  • López-Otero A, Ruiz-Delgado GJ, Ruiz-Argüelles GJ. A simplified method for stem cell autografting in multiple myeloma: a single institution experience. Bone Marrow Transplant. 2009;44:715–719.
  • Ruiz-Argüelles GJ, Gómez-Rangel D, Ruiz-Delgado GJ, et al. Results of an autologous noncryopreserved, unmanipulated peripheral blood hematopoietic stem cell transplant program: a single-institution, 10-year experience. Acta Haematol. 2003;110:179–183.
  • Karduss-Urueta A, Gale RP, Gutiérrez-Aguirre CH, et al. Freezing the graft is not necessary for autotransplants for plasma cell myeloma and lymphomas. Bone Marrow Transplant. 2018;53:457–460.
  • Sugimoto M, Ito S, Mashima K, et al. Retrospective evaluation of the MEAM regimen as a conditioning regimen before autologous peripheral blood stem cell transplantation for lymphoma in two centers with different dosing schedules of melphalan. Ann Hematol. 2016;95(9):1513–1519.
  • Al Hashmi H, Kaloyannidis P, Kafnar S, et al. Single-agent high-dose melphalan as conditioning regimen in autologous hematopoietic stem cell transplantation for Hodgkin’s lymphoma: safety, and long-term efficacy. Biol Blood Marrow Transpl. 2018;24:S132–S1S3.
  • Ruiz-Argüelles GJ. Whither the bone marrow transplant? Hematology. 2010;15:1–3.
  • Pai AA, Devasia AJ, Panetta JC, et al. Pharmacokinetics and efficacy of generic melphalan is comparable to innovator formulation in patients with multiple myeloma undergoing autologous stem cell transplantation. Clin Lymphoma Myeloma Leuk. 2020;20:130–135.
  • Ruiz-Argüelles GJ. Lessons learned starting a bone marrow transplantation programme in a resource-constrained setting. Lancet Haematol. 2020;7:e509–e10.
  • Gale RP, Ruiz-Argüelles GJ. The big freeze may be over: a contracting universe for cryopreservation? Bone Marrow Transpl. 2018;53:947–948.

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