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Hematology Volume 27, 2022 - Issue 1
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Research Article

Clinical and molecular characteristics of acute myeloid leukemia with MPL mutation

Yu Chena Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China;b National Clinical Research Center for Hematologic Diseases, Suzhou, People’s Republic of China;c Department of Hematology, the Second Affiliated Hospital of Wannan Medical College, Wuhu, People’s Republic of ChinaView further author information
,
Jundan Xiea Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China;b National Clinical Research Center for Hematologic Diseases, Suzhou, People’s Republic of ChinaView further author information
,
Zhen Shena Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China;b National Clinical Research Center for Hematologic Diseases, Suzhou, People’s Republic of ChinaView further author information
,
Jie Shia Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China;b National Clinical Research Center for Hematologic Diseases, Suzhou, People’s Republic of ChinaView further author information
,
Suning Chena Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China;b National Clinical Research Center for Hematologic Diseases, Suzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Gang Wangd Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2717-4575View further author information
ORCID Icon
Pages 530-534 | Published online: 11 May 2022

References

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  • Germeshausen M, Ballmaier M. CAMT-MPL: congenital amegakaryocytic thrombocytopenia caused by MPL mutations- heterogeneity of a monogenic disorder - comprehensive analysis of 56 patients. Haematologica. 2021;106(9):2439–2448.
  • Beer PA, Campbell PJ, Scott LM, et al. MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort. Blood. 2008;112(1):141–149.
  • Beer PA, Ortmann CA, Stegelmann F, et al. Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms. Haematologica. 2010;95(12).
  • Wang X, Haylock D, Hu CS, et al. A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells. Blood. 2016;127(26):3398–3409.
  • Cui L, Moraga I, Lerbs T, et al. Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proc Natl Acad Sci. 2021;118(2):e2017849118.

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