Pediatric acute myeloid leukemia patients with KMT2A rearrangements: a single-center retrospective study

References

• Siegel DA, Henley SJ, Li J, et al. Rates and trends of pediatric acute lymphoblastic leukemia – United States, 2001–2014. MMWR Morb Mortal Wkly Rep. 2017;66(36):950–954.
   PubMed Web of Science ®Google Scholar
• Horibe K, Saito AM, Takimoto T, et al. Incidence and survival rates of hematological malignancies in Japanese children and adolescents (2006–2010): based on registry data from the Japanese Society of pediatric hematology. Int J Hematol. 2013;98(1):74–88.
   PubMed Web of Science ®Google Scholar
• Gamis AS, Alonzo TA, Perentesis JP, et al. Children's oncology group's 2013 blueprint for research: acute myeloid leukemia. Pediatr Blood Cancer. 2013;60(6):964–971.
   PubMed Web of Science ®Google Scholar
• Balgobind BV, Zwaan CM, Pieters R, et al. The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia. Leukemia. 2011;25(8):1239–1248.
   PubMed Web of Science ®Google Scholar
• Balgobind BV, Van den Heuvel-Eibrink MM, De Menezes RX, et al. Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia. Haematologica. 2011;96(2):221–230.
   PubMed Web of Science ®Google Scholar
• Liedtke M, Cleary ML. Therapeutic targeting of MLL. Blood. 2009;113(24):6061–6068.
   PubMed Web of Science ®Google Scholar
• Milne TA, Kim J, Wang GG, et al. Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell. 2010;38(6):853–863.
   PubMed Web of Science ®Google Scholar
• Meyer C, Burmeister T, Groger D, et al. The MLL recombinome of acute leukemias in 2017. Leukemia. 2018;32(2):273–284.
   PubMed Web of Science ®Google Scholar
• Balgobind BV, Raimondi SC, Harbott J, et al. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood. 2009;114(12):2489–2496.
   PubMed Web of Science ®Google Scholar
• von Neuhoff C, Reinhardt D, Sander A, et al. Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98. J Clin Oncol. 2010;28(16):2682–2689.
   PubMed Web of Science ®Google Scholar
• Conneely SE, Stevens AM. Acute myeloid leukemia in children: emerging paradigms in genetics and new approaches to therapy. Curr Oncol Rep. 2021;23(2):16.
   PubMed Web of Science ®Google Scholar
• Jaffe ES, Harris NL, Diebold J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. A progress report. Am J Clin Pathol. 1999;111(1 Suppl 1):S8–12.
   PubMed Web of Science ®Google Scholar
• Burnett AK, Russell NH, Hills RK, et al. Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial. J Clin Oncol. 2013;31(27):3360–3368.
   PubMed Web of Science ®Google Scholar
• Bai L, Cheng YF, Lu AD, et al. Prognosis of haploidentical hematopoietic stem cell transplantation in non-infant children with t(v;11q23)/MLL-rearranged B-cell acute lymphoblastic leukemia. Leuk Res. 2020;91:106333.
   PubMed Web of Science ®Google Scholar
• Xue YJ, Cheng YF, Lu AD, et al. Allogeneic hematopoietic stem cell transplantation, especially haploidentical, may improve long-term survival for high-risk pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia in the tyrosine kinase inhibitor era. Biol Blood Marrow Transplant. 2019;25(8):1611–1620.
   PubMed Web of Science ®Google Scholar
• Chen H, Liu KY, Xu LP, et al. Haploidentical hematopoietic stem cell transplantation for pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia in the imatinib era. Leuk Res. 2017;59:136–141.
   PubMed Web of Science ®Google Scholar
• Huang XJ, Liu DH, Liu KY, et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant. 2006;38(4):291–297.
   PubMed Web of Science ®Google Scholar
• Jagasia MH, Greinix HT, Arora M, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report. Biol Blood Marrow Transplant. 2015;21(3):389–401 e1.
   PubMed Web of Science ®Google Scholar
• Aladag E, Kelkitli E, Goker H. Acute graft-versus-host disease: a brief review. Turk J Haematol. 2020;37(1):1–4.
   PubMed Web of Science ®Google Scholar
• Harrison CJ, Hills RK, Moorman AV, et al. Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council treatment trials AML 10 and 12. J Clin Oncol. 2010;28(16):2674–2681.
   PubMed Web of Science ®Google Scholar
• Armand P, Kim HT, Zhang MJ, et al. Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a center for international blood and marrow transplant research study. Biol Blood Marrow Transplant. 2012;18(2):280–288.
   PubMed Web of Science ®Google Scholar
• Shiba N, Yoshida K, Hara Y, et al. Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia. Blood Adv. 2019;3(20):3157–3169.
   PubMed Web of Science ®Google Scholar
• Miyamura T, Kudo K, Tabuchi K, et al. Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia patients with KMT2A rearrangement; a nationwide retrospective analysis in Japan. Leuk Res. 2019;87:106263.
   PubMed Web of Science ®Google Scholar
• El Chaer F, Keng M, Ballen KK. MLL-rearranged acute lymphoblastic leukemia. Curr Hematol Malig Rep. 2020;15(2):83–89.
   PubMed Web of Science ®Google Scholar
• Tomizawa D, Miyamura T, Imamura T, et al. A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial. Blood. 2020;136(16):1813–1823.
   PubMed Web of Science ®Google Scholar
• Pigneux A, Labopin M, Maertens J, et al. Outcome of allogeneic hematopoietic stem-cell transplantation for adult patients with AML and 11q23/MLL rearrangement (MLL-r AML). Leukemia. 2015;29(12):2375–2381.
   PubMed Web of Science ®Google Scholar
• Wang T, Zhao Y, Zhang QQ, et al. [Clinical characteristics and prognostic influencing factors of adult AML patients with MLL rearrangement]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28(3):775–780.
   PubMedGoogle Scholar
• Lv M, Wang Y, Chang YJ, et al. Myeloablative haploidentical transplantation is superior to chemotherapy for patients with intermediate-risk acute myelogenous leukemia in first complete remission. Clin Cancer Res. 2019;25(6):1737–1748.
   PubMed Web of Science ®Google Scholar
• Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. Blood. 2016;127(1):62–70.
   PubMed Web of Science ®Google Scholar
• Sureda A, Bader P, Cesaro S, et al. Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015. Bone Marrow Transplant. 2015;50(8):1037–1056.
   PubMed Web of Science ®Google Scholar
• Majhail NS, Farnia SH, Carpenter PA, et al. Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for blood and marrow transplantation. Biol Blood Marrow Transplant. 2015;21(11):1863–1869.
   PubMed Web of Science ®Google Scholar
• Burnett AK, Goldstone A, Hills RK, et al. Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 2013;31(10):1293–1301.
   PubMed Web of Science ®Google Scholar
• Koreth J, Schlenk R, Kopecky KJ, et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA. 2009;301(22):2349–2361.
   PubMed Web of Science ®Google Scholar
• Imus PH, Blackford AL, Bettinotti M, et al. Severe cytokine release syndrome after haploidentical peripheral Blood stem cell transplantation. Biol Blood Marrow Transplant. 2019;25(12):2431–2437.
   PubMed Web of Science ®Google Scholar
• Jodele S, Dandoy CE, Myers KC, et al. New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Transfus Apher Sci. 2016;54(2):181–190.
   PubMed Web of Science ®Google Scholar
• Watanabe M, Kanda J. Recent progress in haploidentical transplantation: is this the optimal choice for alternative donor transplantation? Curr Opin Hematol. 2019;26(6):406–412.
   PubMed Web of Science ®Google Scholar
• Guo H, Chang YJ, Hong Y, et al. Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation. Cell Mol Immunol. 2021;18(5):1172–1185.
   PubMed Web of Science ®Google Scholar