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Research Article

The efficacy and safety of cyclosporine A plus androgen versus androgen alone for adult patients with non-severe aplastic anemia in China: a meta-analysis of randomized controlled trials

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References

  • Rosenfeld S, Follmann D, Nunez O, et al. Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. JAMA. 2003;289:1130–1135.
  • Young NS, Calado RT, Scheinberg P. Current concepts in pathophysiology and treatment of aplastic anemia. Blood. 2006;108:2509–2519.
  • Maciejewski JP, O ‘Keefe C, Gondek L, et al. Immune-mediated bone marrow failure syndromes of progenitor and stem cells: molecular analysis of cytotoxic T cell clones. Folia Histochem Cytobiol. 2007;45:5–14.
  • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Plos Med. 2009;6:e1000097.
  • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1–12.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188.
  • Ades AE, Lu G, Higgins JP. The interpretation of random-effects meta-analysis in decision models. Med Decis Mak. 2005;25:646–654.
  • Deeks JJ, Higgins JPT, Altman DG. Analyzing data and undertaking meta-analyses. Cochrane handbook for systematic reviews of interventions 501. The Cochrane Collaboration; 2008.
  • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. Br Med J. 2003;327:557–560.
  • Tobias A. Assessing the influence of a single study in meta-analysis. Stata Tech Bull. 1999;47:17.
  • Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey Smith G, Altman DG, editor. Systematic reviews in health care: metaanalysis in context. 2nd ed. London: BMJ Books; 2001. p. 312.
  • Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. Br Med J. 1997;315:629–634.
  • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101.
  • Yu G, Zhang C, Li D. Effect of cyclosporine A combined with kangilong in the treatment of chronic aplastic anemia. Heilongjiang Med Pharm. 2001;24:21.
  • Xu H, Chen T, Zhang X, et al. Effect observation of cyclosporine A combined with androgen in the treatment of chronic aplastic anemia. Chin J Hemorh. 2004;14:477–478.
  • Dong J, Xu H, Fang F, et al. Observing the effect of cyclosporine A combined androgen on chronic aplastic anemia. Hebei Med. 2006;12:1156–1157.
  • Zhao Y, Zhu X, Yu T, et al. Cyclosporine A combined with testosterone undecanoate in the treatment of chronic aplastic anemia. Chin Hydro Med. 2007;5:270–271.
  • Tang X, Zeng Y, He W, et al. Oserving the effect of cyclosporine A combined stanozolol on chronic aplastic anaemia. West China Med J. 2007;22:528.
  • Yang G. Clinical observation of 35 cases of chronic aplastic anemia treated by cyclosporine A combined with kanglilong. Shandong Med J. 2008;48:92–93.
  • Shu H, Fang T, Ge S. Effect of cyclosporine soft capsule combined with kanglilong in the treatment of chronic aplastic anemia. Chin J Misdiag. 2008;8:3577–3578.
  • Zhu W, Li L. Therapeutic effect of cyclosporin A combined with testosterone propionate on chronic aplastic anemia. Prac Prev Med. 2009;16:1557–1558.
  • Wang P, He Y, Fu H. Effect of cyclosporine A combined with kangilong in the treatment of chronic aplastic anemia. Chin Prac Med. 2009;4:161–162.
  • Xia Z. Effect observation of cyclosporine A combined with kangilong in the treatment of 29 cases of chronic aplastic anemia. Huazhong Med J. 2009;33:345–346.
  • Zhou Z, Wang Z, Zhao X. Clinical observation of cyclosporine A combined therapy for chronic aplastic anemia. J Qiqihar Med Coll. 2009;30:2763–2764.
  • Li Y, Pan H. Effect of cyclosporine A combined with testosterone undecatrate in the treatment of chronic aplastic anemia. Youjiang Med. 2010;38:427–428.
  • Dai Q, Xu X, Meng W, et al. Effect of cyclosporine A combined with kanglilong in the treatment of chronic aplastic anemia. J Clin Med Prac. 2010;14:52–53.
  • Zeng X. Observation on the curative effect of cyclosporine A combined with kangilong in the treatment of chronic aplastic anemia. Hebei Med J. 2010;32:37–38.
  • Zhao J. Observation on the curative effect of cyclosporine A combined with kangilong in the treatment of chronic aplastic anemia. Chin Commun Phys. 2010;15:16.
  • Yang J. Effect of cyclosporine A combined with kanglilong in the treatment of 31 cases of chronic aplastic anemia. Guide Chin Med. 2011;9:72–73.
  • Feng G. The effect of cyclosporine A combined with kangilong in the treatment of 52 cases of chronic aplastic anemia. Chin Prac Med. 2011;6:135–136.
  • Yu H, Zhang Z, Wu T. The clinical observation of cyclosporine A combined with stanozolol used in chronic aplastic anemia. Chin Mod Doct. 2011;49:52–53.
  • Liang Y, Lu L, Cui X, et al. Clinical observation of cyclosporine A combined with stazolium in the treatment of chronic aplastic anemia. Chin J Chin Ration Drug Use. 2012;5:65–66.
  • Huang W. Evaluation of efficacy on stanozolol tablets joint ciclosporine capsules in the treatment of 30 patients with chronic aplastic anemia. Chin Med Pharm. 2012;2:84–85.
  • Tang W, Chen J. Evaluation of efficacy on stanozolol tablets joint cyclosporine capsules in the treatment of 50 patients with chronic aplastic anemia. Chin Foreign Med. 2012;32:73–74.
  • Liu X. Effect of cyclosporine A combined with kanglilong in the treatment of chronic aplastic anemia. J Med Theor Prac. 2013;26:2185–2186.
  • Yin Y. Cyclosporin A joint stanozolol tablets in treatment of chronic aplastic anemia clinical curative effect. Chin J Trau Disab Med. 2013;21:19–21.
  • Wei T, Gong Z. Clinical effects of ciclopirin A combined with stanozolol in treatment of chronic aplastic anemia. Chin J Coal Indus Med. 2013;16:1802–1804.
  • Yilidaer A, Dilinazi A, Hao J, et al. Clinical treatment of chronic aplastic anemia. Med Infor. 2013;26:223.
  • Hu H. Clinical analysis of stanzole combined with cyclosporine A in the treatment of chronic aplastic anemia. Chin Prac Med. 2013;8:112–113.
  • Sun T, Yang L, Zhang Y. Clinical efficacy of cyclosporine A combined with kangilong in the treatment of chronic aplastic anemia. J Aerospace Med. 2014;25:1705–1706.
  • Liu W, Wu R, Li L. Effect analysis of cyclosporine A combined with kangilong in the treatment of chronic aplastic anemia. Chin J Prev Contr Chron Dis. 2014;22:106–107.
  • Zhuang W. Clinical analysis of 90 cases of chronic aplastic anemia. Med Infor. 2015;28:228.
  • Du Z, Dai C. Effects of cyclosporine A combined with kangilong on bone marrow stromal cell-related cytokines in patients with chronic aplastic anemia. Chin J Gerontol. 2015;35:955–957.
  • Xiong H. Clinical observation of cyclosporine A combined with statazole in the treatment of non-severe aplastic anemia. Chin Prac Med. 2015;10:134–135.
  • Liang Y, Zhang Y, Qin Y, et al. The treatment effect and adverse reaction of cyclosporin A combined testosterone undecanoate on chronic aplastic anemia. J Clin Exper Med. 2016;15:1604–1606.
  • Pang H. Clinical effect of cyclosporine A in the treatment of chronic aplastic anemia (CAA). Chin Health Stand Manag. 2016;7:95–96.
  • Zhou S. The clinical value of stazoll and cyclosporine A in the treatment of chronic aplastic anemia. Chin J Trau Disab Med. 2016;24:25–26.
  • Tian J. Analysis of treatment and outcome of non-severe aplastic anemia. World Clin Med. 2017;11:39–40.
  • Chen Q. Clinical observation of cyclosporine A combined with kanglilong in the treatment of patients with chronic aplastic anemia. Med Front. 2017;7:87–88.
  • Yang X. Observation on the effect of cyclosporine A combined with kanglilong in the treatment of patients with chronic aplastic anemia. Med Front. 2017;7:226–227.
  • Ru W. Study on the clinical effect of kangilong combined with cyclosporine A in the treatment of chronic aplastic anemia. Clin Res. 2018;26:100–101.
  • Yang Q. Treatment of chronic aplastic anemia with stanzole and cyclosporine A. Shenzhen J Integrat Tradit Chin West Med. 2018;28:162–163.
  • Hu X. Effect observation and effect analysis of effectiveness of kangilong combined with cyclosporine A in the treatment of chronic aplastic anemia. J Clin Med. 2019;6:29–30.
  • Sun D, Zhang Z. Effect of cyclosporine A combined with kanglilong in the treatment of chronic aplastic anemia. Guide Chin Med. 2019;17:42–43.
  • Zhang Z, Li Z, Yang X, et al. Efficacy of cyclosporine A combined with stazolium in the treatment of patients with chronic aplastic anemia. Prac Clin J Integrat Tradit Chin West Med. 2019;19:24–26.
  • Yao C. Clinical observation of cyclosporine A combined with stazolium in the treatment of chronic aplastic anemia. Public Med Forum Magaz. 2020;24:79–80.
  • Duvall S, Tweedie R. A nonparametric “trim and fill” method for assessing publication bias in meta-analysis. J Am Stat Assoc. 2000;95:89–98.
  • Kwon JH, Kim I, Lee YG, et al. Clinical course of non-severe aplastic anemia in adults. Int J Hematol. 2010;91:770–775.
  • Matsuda K, Koya J, Arai S, et al. Cyclosporine therapy in patients with transfusion-independent non-severe aplastic anemia: a retrospective analysis. Intern Med. 2019;58:355–360.
  • Mandal PK, Baul S, Dolai TK, et al. Outcome of cyclosporine monotherapy in patients of aplastic anemia: experience of a tertiary care hospital in eastern India. Indian J Hematol Blood Transfus. 2017;33:144–147.
  • Piedras J, Hernández G, López-Karpovitch X. Effect of androgen therapy and anemia on serum erythropoietin levels in patients with aplastic anemia and myelodysplastic syndromes. Am J Hematol. 1998;57:113–118.