Advanced search
Publication Cover
Hematology Volume 27, 2022 - Issue 1
Submit an article Journal homepage
1,466
Views
2
CrossRef citations to date
0
Altmetric
Research Article

The -α3.7III subtype of α+-thalassemia was identified in China

Xiuqin Baoa Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaView further author information
,
Jicheng Wanga Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaView further author information
,
Danqing Qina Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaView further author information
,
Rui Zhangd Prenatal Diagnosis Center, Huizhou Second Maternal and Child Health Care Hospital, Huizhou, People’s Republic of ChinaView further author information
,
Cuize Yaoa Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaView further author information
,
Jie Lianga Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaView further author information
,
Kailing Lianga Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaView further author information
&
Li Dua Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;b Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China;c Thalassemia Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
 show all
Pages 826-830 | Published online: 02 Aug 2022

References

  • Higgs DR, Gibbons RJ. The molecular basis of alpha-thalassemia: a model for understanding human molecular genetics. Hematol Oncol Clin North Am. 2010;24:1033–1054.
  • Yin A, Li B, Luo M, et al. The prevalence and molecular spectrum of alpha- and beta-globin gene mutations in 14,332 families of Guangdong Province, China. Plos One. 2014;9:e89855.
  • Xiong F, Sun M, Zhang X, et al. Molecular epidemiological survey of haemoglobinopathies in the Guangxi Zhuang autonomous region of southern China. Clin Genet. 2010;78:139–148.
  • Shang X, Peng Z, Ye Y, et al. Rapid targeted next-generation sequencing platform for molecular screening and clinical genotyping in subjects with hemoglobinopathies. EBioMedicine. 2017;23:150–159.
  • Harteveld CL, Higgs DR. Alpha-thalassaemia. Orphanet J Rare Dis. 2010;5:13.
  • Hill AV, Bowden DK, Trent RJ, et al. Melanesians and polynesians share a unique alpha-thalassemia mutation. Am J Hum Genet. 1985;37:571–580.
  • Kariuki SN, Williams TN. Human genetics and malaria resistance. Hum Genet. 2020;139:801–811.
  • Philippon G, Martinson JJ, Rugless MJ, et al. Alpha-thalassaemia and globin gene rearrangements in French Polynesia. Eur J Haematol. 1995;55:171–177.
  • Charoenwijitkul T, Singha K, Fucharoen G, et al. Molecular characteristics of alpha(+)-thalassemia (3.7 kb deletion) in Southeast Asia: Molecular subtypes, haplotypic heterogeneity, multiple founder effects and laboratory diagnostics. Clin Biochem. 2019;71:31–37.
  • Bao X, Qin D, Ma J, et al. Accurate detection of alpha-globin gene copy number variants with two reactions using droplet digital PCR. Hematology. 2022;27:198–203.
  • Shaulov A, Filon D, Rund D. Haplotype analysis of alpha-thalassemia chromosomes reveals heterogeneity and multiple founders in Ashkenazi Jews. Eur J Med Genet. 2016;59:555–558.
  • Xu L, Mao A, Liu H, et al. Long-molecule sequencing: A new approach for identification of clinically significant DNA variants in alpha-thalassemia and beta-thalassemia carriers. J Mol Diagn. 2020;22:1087–1095.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.