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Case Report

Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria

, , , , , , & ORCID Icon show all
Pages 1253-1258 | Received 04 May 2022, Accepted 23 Oct 2022, Published online: 29 Nov 2022

References

  • Yoo D, Lessin LS. Drug-associated “bite cell” hemolytic anemia. Am J Med 1992;92:243–248. doi:10.1016/0002-9343(92)90071-I
  • Bracken SJ, Abraham S, MacLeod AS. Autoimmune theories of chronic spontaneous urticaria. Front Immunol. 2019;10:627. doi:10.3389/fimmu.2019.00627
  • Powell RJ, Du Toit GL, Siddique N, et al. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007;37:631–650. doi:10.1111/j.1365-2222.2007.02678.x
  • Seth S, Khan DA. The comparative safety of multiple alternative agents in refractory chronic urticaria patients. J Allergy Clin Immunol Pract. 2017;5:165–170.e2.e2. doi:10.1016/j.jaip.2016.08.010
  • Ozdemir M, Engin B, Toy H, et al. Treatment of plaque-type localized scleroderma with retinoic acid and ultraviolet A plus the photosensitizer psoralen: a case series. J Eur Acad Dermatol Venereol. 2008;22:519–521. doi:10.1111/j.1468-3083.2007.02390.x
  • Morgan M, Cooke A, Rogers L, et al. Double-blind placebo-controlled trial of dapsone in antihistamine refractory chronic idiopathic urticaria. J Allergy Clin Immunol Pract. 2014;2:601–606. doi:10.1016/j.jaip.2014.06.004
  • Wozel G, Blasum C. Dapsone in dermatology and beyond. Arch Dermatol Res 2014;306:103–124. doi:10.1007/s00403-013-1409-7
  • Booth SA, Moody CE, Dahl MV, et al. Dapsone suppresses integrin-mediated neutrophil adherence function. J Invest Dermatol. 1992;98:135–140. doi:10.1111/1523-1747.ep12555654
  • Pamba A, Richardson ND, Carter N, et al. Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. Blood. 2012;120:4123–4133. doi:10.1182/blood-2012-03-416032
  • Morris A, Bain BJ, Atta M, et al. A puzzling case of methemoglobinemia. Am J Hematol 2017;92:1103–1104. doi:10.1002/ajh.24747
  • Olteanu H, Harrington AM, George B, et al. High prevalence of Dapsone-induced oxidant hemolysis in North American SCT recipients without glucose-6-phosphate-dehydrogenase deficiency. Bone Marrow Transplant 2012;47:399–403. doi:10.1038/bmt.2011.83
  • Mitsides N, Green D, Middleton R, et al. Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. Transpl Infect Dis. 2014;16:37–43. doi:10.1111/tid.12161
  • Colella MP, Orsi FA, Alves ECF, et al. A retrospective analysis of 122 immune thrombocytopenia patients treated with dapsone: efficacy, safety and factors associated with treatment response. J Thromb Haemostasis. 2021;19:2275–2286. doi:10.1111/jth.15396
  • Belfield KD, Tichy EM. Review and drug therapy implications of glucose-6-phosphate dehydrogenase deficiency. Am J Health-Syst Pharm. 2018;75:97–104. doi:10.2146/ajhp160961
  • Opsahl M, Chen W. Blister and bite cells in G6PD deficiency. Int J Lab Hematol. 2022;44:55–56. doi:10.1111/ijlh.13689
  • Paniker U, Levine N. Dapsone and sulfapyridine. Dermatol Clin. 2001;19:79–86, viii. doi:10.1016/S0733-8635(05)70231-x.
  • Liang SE, Hoffmann R, Peterson E, et al. Use of dapsone in the treatment of chronic idiopathic and autoimmune urticaria. JAMA Dermatol. 2019;155:90–95. doi:10.1001/jamadermatol.2018.3715
  • Grossman SJ, Jollow DJ. Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia. J Pharmacol Exp Ther. 1988;244:118–125.
  • Byrd SR, Gelber RH. Effect of dapsone on haemoglobin concentration in patients with leprosy. Lepr Rev. 1991;62:171–178. doi:10.5935/0305-7518.19910020
  • Scafidi JM, Gupta V. Histology, Howell Jolly bodies. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.
  • Beutler E, Yeh M, Fairbanks VF. The Normal human female as a mosaic of X-chromosome activity: studies using the gene for G-6-PD-deficiency as a marker. Proc Natl Acad Sci USA. 1962;48:9–16. doi:10.1073/pnas.48.1.9
  • Chu CS, Bancone G, Nosten F, et al. Primaquine-induced haemolysis in females heterozygous for G6PD deficiency. Malar J 2018;17:101. doi:10.1186/s12936-018-2248-y
  • Todd P, Samaratunga IR, Pembroke A. Screening for glucose-6-phosphate dehydrogenase deficiency prior to dapsone therapy. Clin Exp Dermatol 1994;19:217–218. doi:10.1111/j.1365-2230.1994.tb01168.x
  • Bancone G, Kalnoky M, Chu CS, et al. The G6PD flow-cytometric assay is a reliable tool for diagnosis of G6PD deficiency in women and anaemic subjects. Sci Rep. 2017;7:9822. doi:10.1038/s41598-017-10045-2
  • Ganer A, Knobel B, Fryd CH, et al. Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency. Isr J Med Sci. 1981;17:703–704.
  • Keerty D, Eaton K, Haynes E. Dapsone-induced hypoxia. Cureus. 2020;12. doi:10.7759/cureus.9334
  • Puavilai S, Chutha S, Polnikorn N, et al. Incidence of anemia in leprosy patients treated with dapsone. J Med Assoc Thai. 1984;67:404–407.
  • Singh S, Sethi N, Pandith S, et al. Dapsone-induced methemoglobinemia: “Saturation gap”-the key to diagnosis. J Anaesthesiol Clin Pharmacol. 2014;30:86–88. doi:10.4103/0970-9185.125710
  • Iolascon A, Bianchi P, Andolfo I, et al. Recommendations for diagnosis and treatment of methemoglobinemia. Am J Hematol 2021;96:1666–1678. doi:10.1002/ajh.26340